Marine Drugs,
Год журнала:
2023,
Номер
21(12), С. 615 - 615
Опубликована: Ноя. 28, 2023
The
majority
of
natural
products
utilized
to
treat
a
diverse
array
human
conditions
and
diseases
are
derived
from
terrestrial
sources.
In
recent
years,
marine
ecosystems
have
proven
be
valuable
resource
that
generated
defend
support
their
growth.
Such
sources
offer
large
opportunity
for
the
identification
novel
compounds
may
guide
future
development
new
drugs
therapies.
Using
National
Oceanic
Atmospheric
Administration
(NOAA)
portal,
we
explore
deep-sea
coral
sponge
species
inhabiting
segment
U.S.
Exclusive
Economic
Zone,
specifically
off
western
coast
Florida.
This
area
spans
~100,000
km2,
containing
at
sea
depths
up
3000
m.
Utilizing
PubMed,
uncovered
current
knowledge
on
gaps
across
subset
these
sessile
organisms
with
regards
mechanisms
altering
cytoskeleton,
protein
trafficking,
signaling
pathways.
Since
exploitation
such
could
disrupt
ecosystem
leading
supply
issues
would
limit
quantities
bioactive
compounds,
surveyed
methods
technological
advances
necessary
sustaining
drug
discovery
pipeline
including
in
vitro
aquaculture
systems
preserving
our
ecological
community
future.
Collectively,
efforts
establish
foundation
supporting
research
marine-based
mechanism
action
develop
therapies
improving
treatment
regimens
diseases.
World Journal of Clinical Oncology,
Год журнала:
2024,
Номер
15(2), С. 302 - 316
Опубликована: Фев. 19, 2024
Bladder
cancer
(BC)
is
the
most
common
urological
tumor.
It
has
a
high
recurrence
rate,
displays
tutor
heterogeneity,
and
resists
chemotherapy.
Furthermore,
long-term
survival
rate
of
BC
patients
remained
unchanged
for
decades,
which
seriously
affects
quality
patient
survival.
To
improve
prognosis
patients,
it
necessary
to
explore
molecular
mechanisms
development
progression
identify
targets
treatment
intervention.
Transmembrane
9
superfamily
member
1
(TM9SF1),
also
known
as
MP70
HMP70,
family
nine
transmembrane
proteins,
was
first
identified
in
1997.
Marine Drugs,
Год журнала:
2024,
Номер
22(4), С. 143 - 143
Опубликована: Март 23, 2024
The
inadequate
vascularization
seen
in
fast-growing
solid
tumors
gives
rise
to
hypoxic
areas,
fostering
specific
changes
gene
expression
that
bolster
tumor
cell
survival
and
metastasis,
ultimately
leading
unfavorable
clinical
prognoses
across
different
cancer
types.
Hypoxia-inducible
factors
(HIF-1
HIF-2)
emerge
as
druggable
pivotal
players
orchestrating
metastasis
angiogenesis,
thus
positioning
them
prime
targets
for
treatment.
A
range
of
HIF
inhibitors,
notably
natural
compounds
originating
from
marine
organisms,
exhibit
encouraging
anticancer
properties,
underscoring
their
significance
promising
therapeutic
options.
Bioprospection
the
environment
is
now
a
well-settled
approach
discovery
development
agents
might
have
medicinal
chemistry
developed
into
candidates.
However,
despite
massive
increase
number
products
classified
‘anticancer
leads,’
most
which
correspond
general
cytotoxic
agents,
only
few
been
characterized
regarding
molecular
mechanisms
action.
current
review
presents
critical
analysis
inhibitors
HIF-1
HIF-2
hypoxia-selective
sourced
organisms
act
new
chemotherapeutic
candidates
or
serve
templates
structurally
similar
derivatives
with
improved
efficacy.
ABSTRACT
Background
The
World
Health
Organization
has
mentioned
breast
cancer
holds
the
highest
incidence
rate
among
all
types
of
globally.
Death‐associated
protein
kinase
2
(
DAPK2
)
is
a
serine/threonine
linked
to
various
forms
malignancy,
such
as
cancer.
This
assumes
pivotal
function
in
multitude
cellular
mechanisms,
including
apoptosis,
autophagy,
and
cell
migration.
Aims
study
aimed
LOC101928988
regulatory
effect
on
expression
Methods
In
this
study,
38
paired
tumoral
normal
tissues
were
selected
from
patients.
Quantitative
real‐time
PCR
was
used
analyze
.
interactions
its
intermediate
elements
with
predicted
by
docking
analysis.
Results
downregulated
tumor
compared
control
group.
Further
analysis
revealed
significant
positive
correlation
between
levels
adjacent
tissues.
A
comparison
gene
different
grades,
stages,
HER2
statuses
showed
findings.
ROC
curve
77%
72%
AUC
for
BC
tissue,
respectively.
Conclusions
Overall,
our
results
suggest
that
alterations
may
be
involved
initiation
progression
It
also
been
reported
probably
role
regulating
through
interaction
transcription
factors.
Current Issues in Molecular Biology,
Год журнала:
2023,
Номер
45(10), С. 8138 - 8151
Опубликована: Окт. 7, 2023
EGFR
tyrosine
kinase
inhibitors
(TKIs)
are
the
first-line
treatment
for
advanced
EGFR-mutated
non-small-cell
lung
cancer
(NSCLC).
However,
NSCLC
patients
with
wild-type
and
KRAS
mutation
ineligible
EGFR-TKIs.
Therefore,
discovery
of
new
therapeutic
agents
is
urgently
needed
who
cannot
receive
targeted
therapies.
Natural
products
possess
tremendous
chemical
diversity
have
been
extensively
investigated
their
anticancer
activity.
In
this
study,
we
found
that
Cucurbitacin
E
(Cu
E),
a
triterpene
cucurbitacins
widely
presented
in
edible
plants
Cucurbitaceae
family,
significantly
inhibits
viability
proliferation
A549
cells
harbor
mutation.
Our
results
revealed
Cu
increases
cell-cycle
arrest
at
G2/M
subG1
phase.
Mechanistically,
phosphorylation
protein
levels
regulatory
proteins
hinders
progression.
Meanwhile,
resulted
DNA
damage
response
apoptosis.
For
first
time,
observed
induces
incomplete
autophagy
as
evidenced
by
increased
LC3B-II
expression
p62-accumulation.
Knockdown
p62
rescued
from
E-mediated
anti-proliferative
effect,
apoptosis,
damage,
ROS
production.
These
findings
suggest
promising
drug
candidate
NSCLC.
