Effect of long-term exercise on circulating ghrelin in overweight and obese individuals: a systematic review and meta-analysis

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 23, 2025

Objective Ghrelin, also known as the “hunger hormone,” is a pivotal hormone in controlling appetite, and it only gastrointestinal that promotes food intake, contributing to regulation of energy balance body weight. However, studies on long-term effects exercise ghrelin levels obese populations have shown conflicting results. This study aims summarize RCT experiments exploring changes following or overweight individuals through meta-analysis. Methods employed meta-analytical techniques, searching databases such PubMed, Web Science, EMBASE, gather research ghrelin. The quality was assessed according Cochrane Handbook standards, data analysis for ghrelin, BMI, weight performed using RevMan 5.4 Stata 16.0 software. A total 13 interventions involving 944 participants were included systematically investigate regulatory individuals. Meta-analytical results calculated standardized mean differences (SMDs). Results Exercise significantly increased (SMD =1.16, 95% CI = 0.52 1.80, p < 0.0001), with high inter-study heterogeneity ( I 2 90%). Subgroup suggested RT AE + more effective than AE. For led significant reduction −0.43, −0.69 −0.16, 0.002), low 21%). Similarly, reduced −0.54, −0.98 −0.11, 0.01), though 75%). These suggest effectively improves levels, Conclusion Prolonged demonstrated statistically effect levels. indicates can elevate which may be associated reductions BMI Systematic review registration https://www.crd.york.ac.uk/prospero/ , CRD42024588259.

Язык: Английский

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Multicomponent (bio)markers for obesity risk prediction: a scoping review protocol

BMJ Open, Год журнала: 2024, Номер 14(3), С. e083558 - e083558

Опубликована: Март 1, 2024

Introduction Despite international efforts, the number of individuals struggling with obesity is still increasing. An important aspect prevention relates to identifying at risk early stage, allowing for timely stratification and initiation countermeasures. However, complex multifactorial by nature, one isolated (bio)marker unlikely enable an optimal prognosis individual; rather, a combined set required. Such multicomponent interpretation would integrate biomarkers from various domains, such as classical markers (eg, anthropometrics, blood lipids), multiomics genetics, proteomics, metabolomics), lifestyle behavioural attributes diet, physical activity, sleep patterns), psychological traits (mental health status depression) additional host factors gut microbiota diversity), also means advanced tools machine learning. In this paper, we will present protocol that be employed scoping review attempts summarise map state-of-the-art in area (bio)markers related obesity, focusing on usability effectiveness biomarkers. Methods analysis PubMed, Scopus, CINAHL Embase databases searched using predefined key terms identify peer-reviewed articles published English until January 2024. Once downloaded into EndNote deduplication, CADIMA select abstracts full-text two-step procedure, two independent reviewers. Data extraction then carried out several Preferred Reporting Items Systematic Reviews Meta-Analyses extension Scoping Peer Review Electronic Search Strategies guidelines followed. Combinations employing least different domains mapped discussed. Ethics dissemination Ethical approval not required; data rely articles. Findings open access journal. This allow guiding future directions research public strategies prevention, paving way towards interventions.

Язык: Английский

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Mapping QTL underlying body weight changes that act at different times during high-fat diet challenge in collaborative cross mice

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Март 29, 2024

Abstract Background Over one billion people worldwide suffer from obesity, and the number is continually rising. This epidemic partly caused by modern lifestyle, which defined excessive eating of food high in calories little physical activity. However, genetic variation sets stage affects how disease develops advances. Animal models, especially mice are crucial to identifying components complex disorders exploring potential applications these findings. The body weight animals used research often measured regularly monitor their health. Only endpoint measurements, like ultimate weight, examined quantitative trait locus (QTL) studies; time series data, such as weekly or biweekly usually disregarded. QTL mapping utilizing measurements may be particularly intriguing examining gain obesity more genes connected with related metabolic problems. Results study focused on underlying changes analyzing collaborative cross (CC) maintained a high-fat diet for 12 weeks. analysis, 525 55 CC lines (308 male 217 female), revealed genome-wide significant different chromosomes over unveiled 62 QTLs, among 28 novels associated traits were observed found not reported previously. In addition, 34 QTLs fine-mapped genomic interval positions previously identified. Conclusions These findings illuminate regions influencing emphasize utility data uncovering novel factors.

Язык: Английский

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Recent Progress in Saliva-Based Sensors for Continuous Monitoring of Heavy Metal Levels Linked with Diabetes and Obesity

Chemosensors, Год журнала: 2024, Номер 12(12), С. 269 - 269

Опубликована: Дек. 19, 2024

Sensors are versatile technologies that provide rapid and efficient diagnostic results, making them invaluable tools in public health for measuring monitoring community exposure to environmental contaminants. Heavy metals such as lead, mercury, cadmium, commonly found food water, can accumulate the body have toxic effects, contributing development of conditions like obesity diabetes. Traditional methods detecting these often require invasive blood samples; however, sensors utilize saliva, offering a noninvasive simplified approach screening. The use saliva fluid represents major advance population due its low cost, noninvasiveness, ease collection. Recent advances sensor technology enabled tests link heavy metal levels with risk developing Optimizing could facilitate identification individuals or groups at risk, enabling targeted, personalized preventive measures. hold promise diagnosing preventing metabolic diseases, providing valuable insights into between health.

Язык: Английский

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Identification of additional body weight QTLs in the Berlin Fat Mouse BFMI861 lines using time series data

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 14, 2024

The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and metabolic syndrome. sublines BFMI861-S1 BFMI861-S2 differ in weight despite high genetic similarity shared obesity-related locus. This study focused on identifying additional body quantitative trait loci (QTLs) by analyzing weekly measurements male population of the advanced intercross x BFMI861-S2. QTL analysis, utilizing 200 selectively genotyped mice (GigaMUGA) 197 males top SNPs, revealed genome-wide significant Chr 15 (68.46 to 81.40 Mb) between weeks 9 20. Notably, this disappeared (weeks 21 23) reappeared 24 25) coinciding with diet change. Additionally, 16 (3.89 22.79 was identified from 6 25. Candidate genes, including Gpt, Cbx6, Apol6, Apol8, Sun2 (Chr 15) Trap1, Rrn3, Mapk1 16), were prioritized. unveiled two QTLs, one which novel responsive changes. These findings illuminate genomic regions influencing BFMI emphasize utility time series data uncovering factors.

Язык: Английский

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The Therapeutic Effectiveness of Laparoscopic Sleeve Gastrectomy Among Individuals with Low BMI Obesity (30-35 Kg/m2) and the Relationship of BMI to Weight Loss

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 1521 - 1531

Опубликована: Апрель 1, 2024

Purpose: Investigating the therapeutic efficacy of Laparoscopic Sleeve Gastrectomy (LSG) in low BMI (30-35 kg/m 2 ) patients with obesity, and exploring correlation between patients' preoperative postoperative weight loss.Methods: Comparing loss, remission comorbidities, occurrence complications, quality life among different who underwent LSG.Analyzing relationship percentage excess loss (%EWL) by using Spearman analysis linear regression analysis.Results: The %EWL at 12 months after surgical procedure was (104.26±16.41)%,(90.36±9.98)%,and (78.30±14.64)%for Class I, II, III respectively, P<0.05.Spearman coefficients 1, 3, 6, surgery were R=-0.334(P<0.001),R=-0.389 (P<0.001), R=-0.442 (P<0.001),R=-0.641 (P<0.001),respectively.The hypertension, diabetes dyslipidaemia did not differ significantly groups (P>0.05).Conclusion: Individuals obesity for varying can experience favorable outcomes following LSG surgery.It is advisable to consider treatment I obesity.

Язык: Английский

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Influence of Chronic Low-Grade Inflammation (Obesity) on the Systemic Inflammatory Response

IntechOpen eBooks, Год журнала: 2023, Номер unknown

Опубликована: Окт. 5, 2023

The chronic inflammatory state is a common condition in obesity. It has become health problem with pandemic proportions that, some developing countries, jointly to overweight, affects more than 50% of their population. As part the scenario, we observe how significant proportion people overweight or obesity have raised acute response markers. This situation shows us this can trigger aggressive phenomena critically ill patients other clinical conditions, occasioning torpid evolution, ominous results, and low-rate survival. chapter pretends describe influence low-grade on outcome who develop systemic response.

Язык: Английский

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Critical Analysis of the Efficacy and Limitations of GLP-1 Pharmaceuticals in Obesity Management: A Comprehensive Literature Review

Journal of Education Health and Sport, Год журнала: 2024, Номер 55, С. 87 - 103

Опубликована: Янв. 26, 2024

Introduction and purpose Obesity, a pervasive global pandemic intricately linked to various comorbidities, necessitates comprehensive nuanced approach. This article delves into the intricate realm of obesity guidelines, underscoring significance lifestyle modifications, preventive measures for childhood obesity, population-based strategies, clinical management protocols, vigilant monitoring. GLP-1 drugs, originally designed type 2 diabetes management, exhibit multifaceted effects beyond glycemic control. They influence appetite regulation, gastric emptying dynamics, potentially contribute cardiovascular health improvements. However, commendable come with caveat - potential side necessitating careful consideration in decision-making. Despite gaining popularity through celebrity endorsements, this firmly underscores need view pharmacotherapy as recommended intervention rather than miraculous solution. A brief description state knowledge Integral discourse is imperative address weight stigma, demanding evidence-based approaches both public domains. The narrative extends future landscape pharmacotherapy, contemplating role probiotics. Emphasizing necessity long-term studies randomized trials, it positions probiotics low-risk alternative significant mitigating while simultaneously addressing concerns related antibiotic resistance. Summary pursuit balanced effective approach understanding medical interventions, societal perceptions, exploration innovative possibilities within evolving healthcare.

Язык: Английский

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The 26RFa (QRFP)/GPR103 Neuropeptidergic System: A Key Regulator of Energy and Glucose Metabolism

Neuroendocrinology, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Апрель 10, 2024

<b><i>Background:</i></b> Obesity and type 2 diabetes are strongly associated pathologies, currently considered as a worldwide epidemic problem. Understanding the mechanisms that drive development of these diseases would enable to develop new therapeutic strategies for their prevention treatment. Particularly, role brain in energy glucose homeostasis has been studied decades. In specific, hypothalamus contains well-identified neural networks regulate appetite potentially also homeostasis. A concept thus emerged, suggesting obesity could be due dysfunction same, still poorly understood, networks. <b><i>Summary:</i></b> The neuropeptide 26RFa (also termed QRFP) belongs family RFamide regulatory peptides identified endogenous ligand human G protein-coupled receptor GPR103 (QRFPR). primary structure is conserved during vertebrate evolution, its crucial roles control vital functions. Indeed, 26RFa/GPR103 peptidergic system reported involved various neuroendocrine functions, notably metabolism which it plays an important role, both centrally peripherally, since regulates feeding behavior, thermogenesis lipogenesis. Moreover, where acts incretin, centrally, relays insulin signaling metabolism. <b><i>Key Messages:</i></b> This review gives comprehensive overview key player pathophysiological context, this neuropeptidergic represents prime target whose highly relevant decipher.

Язык: Английский

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Multiple factor assessment for determining resting metabolic rate in young adults

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 23, 2024

Abstract Existing formulas cannot fully explain the variation of resting metabolic rate (RMR). This study aims to examine potential influencing factors beyond anthropometric measurements and develop more accurate equations using accessible parameters. 324 healthy adults (230 females; 18–32 years old) participated in study. Height, fat-free mass (FFM), fat (FM) RMR were measured. Menstrual cycle, stress levels, living habits, frequency consuming caffeinated foods collected. Measured compared with predictive values new previous 11 equations. Mean for men women was 1825.2 ± 248.8 1345.1 178.7 kcal/day, respectively. adjusted FFM 0.66 FM 0.066 positively correlated BMI. The multiple regression model showed that can be predicted this population 1 (with FFM, FM, age, sex daily sun exposure duration) or 2 weight height replacing FM). accuracy 75.31% 70.68% 2. had overall improved performance when existing formula consider duration improve prediction young adults. Additional investigation is required among individuals middle-aged elderly demographic.

Язык: Английский

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