Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 28, 2023
Abstract
The
Berlin
Fat
Mouse
Inbred
line
(BFMI)
is
a
model
for
obesity
and
metabolic
syndrome.
sublines
BFMI861-S1
BFMI861-S2
differ
in
weight
despite
high
genetic
similarity
shared
obesity-related
locus.
This
study
focused
on
identifying
additional
body
quantitative
trait
loci
(QTLs)
by
analyzing
weekly
measurements
male
population
of
the
advanced
intercross
BFMI861-S1xBFMI861-S2.
QTL
analysis,
utilizing
200
selectively
genotyped
mice
(GigaMUGA)
197
males
top
SNPs,
revealed
genome-wide
significant
Chr
15
(68.46
to
81.40
Mb)
between
weeks
9
20.
Notably,
this
disappeared
(weeks
21
23)
reappeared
24
25)
coinciding
with
diet
change.
Additionally,
16
(3.89
22.79
was
identified
from
6
25.
Candidate
genes,
including
Gpt
,
Cbx6
Apol6
Apol8
Sun2
(Chr
15)
Trap1
Rrn3
Mapk1
16),
were
prioritized.
unveiled
two
QTLs,
one
which
novel
responsive
changes.
These
findings
illuminate
genomic
regions
influencing
BFMI
emphasize
utility
time
series
data
uncovering
factors.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
ABSTRACT
Obesity,
along
with
its
associated
health
risks
such
as
hypertension,
hyperlipidemia,
Type
2
diabetes,
stroke,
metabolic
syndrome,
asthma,
and
cancer,
constitutes
a
significant
global
burden,
contributing
substantially
to
morbidity
mortality.
Cytokines,
group
of
secreted
signaling
proteins,
are
crucial
in
initiating,
maintaining,
resolving
immune
responses.
Although
cytokines
have
unique
advantages
regulating
functions,
their
therapeutic
application
for
obesity
remains
limited
clinical
practice.
Natural
compounds,
known
structural
diversity
low
toxicity,
become
valuable
resource
drug
development.
Many
natural
compounds
shown
anti‐obesity
effects.
This
review
comprehensively
examines
the
mechanisms
underlying
obesity,
specific
focus
on
roles
cytokines,
inflammatory
adipokines,
growth
factors.
Additionally,
it
highlights
regulatory
interactions
between
gut
microbiota
obesity.
The
critically
analyzes
current
pharmacological
interventions
summarizes
advanced
methodologies
identifying
potential
compounds.
Finally,
identifies
promising
that
modulate
cytokine
activity
prevent
or
treat
assesses
complementary
alternative
therapies.
BMJ Open,
Год журнала:
2024,
Номер
14(3), С. e083558 - e083558
Опубликована: Март 1, 2024
Introduction
Despite
international
efforts,
the
number
of
individuals
struggling
with
obesity
is
still
increasing.
An
important
aspect
prevention
relates
to
identifying
at
risk
early
stage,
allowing
for
timely
stratification
and
initiation
countermeasures.
However,
complex
multifactorial
by
nature,
one
isolated
(bio)marker
unlikely
enable
an
optimal
prognosis
individual;
rather,
a
combined
set
required.
Such
multicomponent
interpretation
would
integrate
biomarkers
from
various
domains,
such
as
classical
markers
(eg,
anthropometrics,
blood
lipids),
multiomics
genetics,
proteomics,
metabolomics),
lifestyle
behavioural
attributes
diet,
physical
activity,
sleep
patterns),
psychological
traits
(mental
health
status
depression)
additional
host
factors
gut
microbiota
diversity),
also
means
advanced
tools
machine
learning.
In
this
paper,
we
will
present
protocol
that
be
employed
scoping
review
attempts
summarise
map
state-of-the-art
in
area
(bio)markers
related
obesity,
focusing
on
usability
effectiveness
biomarkers.
Methods
analysis
PubMed,
Scopus,
CINAHL
Embase
databases
searched
using
predefined
key
terms
identify
peer-reviewed
articles
published
English
until
January
2024.
Once
downloaded
into
EndNote
deduplication,
CADIMA
select
abstracts
full-text
two-step
procedure,
two
independent
reviewers.
Data
extraction
then
carried
out
several
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
extension
Scoping
Peer
Review
Electronic
Search
Strategies
guidelines
followed.
Combinations
employing
least
different
domains
mapped
discussed.
Ethics
dissemination
Ethical
approval
not
required;
data
rely
articles.
Findings
open
access
journal.
This
allow
guiding
future
directions
research
public
strategies
prevention,
paving
way
towards
interventions.
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 23, 2025
Objective
Ghrelin,
also
known
as
the
“hunger
hormone,”
is
a
pivotal
hormone
in
controlling
appetite,
and
it
only
gastrointestinal
that
promotes
food
intake,
contributing
to
regulation
of
energy
balance
body
weight.
However,
studies
on
long-term
effects
exercise
ghrelin
levels
obese
populations
have
shown
conflicting
results.
This
study
aims
summarize
RCT
experiments
exploring
changes
following
or
overweight
individuals
through
meta-analysis.
Methods
employed
meta-analytical
techniques,
searching
databases
such
PubMed,
Web
Science,
EMBASE,
gather
research
ghrelin.
The
quality
was
assessed
according
Cochrane
Handbook
standards,
data
analysis
for
ghrelin,
BMI,
weight
performed
using
RevMan
5.4
Stata
16.0
software.
A
total
13
interventions
involving
944
participants
were
included
systematically
investigate
regulatory
individuals.
Meta-analytical
results
calculated
standardized
mean
differences
(SMDs).
Results
Exercise
significantly
increased
(SMD
=1.16,
95%
CI
=
0.52
1.80,
p
<
0.0001),
with
high
inter-study
heterogeneity
(
I
2
90%).
Subgroup
suggested
RT
AE
+
more
effective
than
AE.
For
led
significant
reduction
−0.43,
−0.69
−0.16,
0.002),
low
21%).
Similarly,
reduced
−0.54,
−0.98
−0.11,
0.01),
though
75%).
These
suggest
effectively
improves
levels,
Conclusion
Prolonged
demonstrated
statistically
effect
levels.
indicates
can
elevate
which
may
be
associated
reductions
BMI
Systematic
review
registration
https://www.crd.york.ac.uk/prospero/
,
CRD42024588259.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 29, 2024
Abstract
Background
Over
one
billion
people
worldwide
suffer
from
obesity,
and
the
number
is
continually
rising.
This
epidemic
partly
caused
by
modern
lifestyle,
which
defined
excessive
eating
of
food
high
in
calories
little
physical
activity.
However,
genetic
variation
sets
stage
affects
how
disease
develops
advances.
Animal
models,
especially
mice
are
crucial
to
identifying
components
complex
disorders
exploring
potential
applications
these
findings.
The
body
weight
animals
used
research
often
measured
regularly
monitor
their
health.
Only
endpoint
measurements,
like
ultimate
weight,
examined
quantitative
trait
locus
(QTL)
studies;
time
series
data,
such
as
weekly
or
biweekly
usually
disregarded.
QTL
mapping
utilizing
measurements
may
be
particularly
intriguing
examining
gain
obesity
more
genes
connected
with
related
metabolic
problems.
Results
study
focused
on
underlying
changes
analyzing
collaborative
cross
(CC)
maintained
a
high-fat
diet
for
12
weeks.
analysis,
525
55
CC
lines
(308
male
217
female),
revealed
genome-wide
significant
different
chromosomes
over
unveiled
62
QTLs,
among
28
novels
associated
traits
were
observed
found
not
reported
previously.
In
addition,
34
QTLs
fine-mapped
genomic
interval
positions
previously
identified.
Conclusions
These
findings
illuminate
regions
influencing
emphasize
utility
data
uncovering
novel
factors.
Neuroendocrinology,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Апрель 10, 2024
<b><i>Background:</i></b>
Obesity
and
type
2
diabetes
are
strongly
associated
pathologies,
currently
considered
as
a
worldwide
epidemic
problem.
Understanding
the
mechanisms
that
drive
development
of
these
diseases
would
enable
to
develop
new
therapeutic
strategies
for
their
prevention
treatment.
Particularly,
role
brain
in
energy
glucose
homeostasis
has
been
studied
decades.
In
specific,
hypothalamus
contains
well-identified
neural
networks
regulate
appetite
potentially
also
homeostasis.
A
concept
thus
emerged,
suggesting
obesity
could
be
due
dysfunction
same,
still
poorly
understood,
networks.
<b><i>Summary:</i></b>
The
neuropeptide
26RFa
(also
termed
QRFP)
belongs
family
RFamide
regulatory
peptides
identified
endogenous
ligand
human
G
protein-coupled
receptor
GPR103
(QRFPR).
primary
structure
is
conserved
during
vertebrate
evolution,
its
crucial
roles
control
vital
functions.
Indeed,
26RFa/GPR103
peptidergic
system
reported
involved
various
neuroendocrine
functions,
notably
metabolism
which
it
plays
an
important
role,
both
centrally
peripherally,
since
regulates
feeding
behavior,
thermogenesis
lipogenesis.
Moreover,
where
acts
incretin,
centrally,
relays
insulin
signaling
metabolism.
<b><i>Key
Messages:</i></b>
This
review
gives
comprehensive
overview
key
player
pathophysiological
context,
this
neuropeptidergic
represents
prime
target
whose
highly
relevant
decipher.
Chemosensors,
Год журнала:
2024,
Номер
12(12), С. 269 - 269
Опубликована: Дек. 19, 2024
Sensors
are
versatile
technologies
that
provide
rapid
and
efficient
diagnostic
results,
making
them
invaluable
tools
in
public
health
for
measuring
monitoring
community
exposure
to
environmental
contaminants.
Heavy
metals
such
as
lead,
mercury,
cadmium,
commonly
found
food
water,
can
accumulate
the
body
have
toxic
effects,
contributing
development
of
conditions
like
obesity
diabetes.
Traditional
methods
detecting
these
often
require
invasive
blood
samples;
however,
sensors
utilize
saliva,
offering
a
noninvasive
simplified
approach
screening.
The
use
saliva
fluid
represents
major
advance
population
due
its
low
cost,
noninvasiveness,
ease
collection.
Recent
advances
sensor
technology
enabled
tests
link
heavy
metal
levels
with
risk
developing
Optimizing
could
facilitate
identification
individuals
or
groups
at
risk,
enabling
targeted,
personalized
preventive
measures.
hold
promise
diagnosing
preventing
metabolic
diseases,
providing
valuable
insights
into
between
health.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 14, 2024
The
Berlin
Fat
Mouse
Inbred
line
(BFMI)
is
a
model
for
obesity
and
metabolic
syndrome.
sublines
BFMI861-S1
BFMI861-S2
differ
in
weight
despite
high
genetic
similarity
shared
obesity-related
locus.
This
study
focused
on
identifying
additional
body
quantitative
trait
loci
(QTLs)
by
analyzing
weekly
measurements
male
population
of
the
advanced
intercross
x
BFMI861-S2.
QTL
analysis,
utilizing
200
selectively
genotyped
mice
(GigaMUGA)
197
males
top
SNPs,
revealed
genome-wide
significant
Chr
15
(68.46
to
81.40
Mb)
between
weeks
9
20.
Notably,
this
disappeared
(weeks
21
23)
reappeared
24
25)
coinciding
with
diet
change.
Additionally,
16
(3.89
22.79
was
identified
from
6
25.
Candidate
genes,
including
Gpt,
Cbx6,
Apol6,
Apol8,
Sun2
(Chr
15)
Trap1,
Rrn3,
Mapk1
16),
were
prioritized.
unveiled
two
QTLs,
one
which
novel
responsive
changes.
These
findings
illuminate
genomic
regions
influencing
BFMI
emphasize
utility
time
series
data
uncovering
factors.
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 1521 - 1531
Опубликована: Апрель 1, 2024
Purpose:
Investigating
the
therapeutic
efficacy
of
Laparoscopic
Sleeve
Gastrectomy
(LSG)
in
low
BMI
(30-35
kg/m
2
)
patients
with
obesity,
and
exploring
correlation
between
patients'
preoperative
postoperative
weight
loss.Methods:
Comparing
loss,
remission
comorbidities,
occurrence
complications,
quality
life
among
different
who
underwent
LSG.Analyzing
relationship
percentage
excess
loss
(%EWL)
by
using
Spearman
analysis
linear
regression
analysis.Results:
The
%EWL
at
12
months
after
surgical
procedure
was
(104.26±16.41)%,(90.36±9.98)%,and
(78.30±14.64)%for
Class
I,
II,
III
respectively,
P<0.05.Spearman
coefficients
1,
3,
6,
surgery
were
R=-0.334(P<0.001),R=-0.389
(P<0.001),
R=-0.442
(P<0.001),R=-0.641
(P<0.001),respectively.The
hypertension,
diabetes
dyslipidaemia
did
not
differ
significantly
groups
(P>0.05).Conclusion:
Individuals
obesity
for
varying
can
experience
favorable
outcomes
following
LSG
surgery.It
is
advisable
to
consider
treatment
I
obesity.
IntechOpen eBooks,
Год журнала:
2023,
Номер
unknown
Опубликована: Окт. 5, 2023
The
chronic
inflammatory
state
is
a
common
condition
in
obesity.
It
has
become
health
problem
with
pandemic
proportions
that,
some
developing
countries,
jointly
to
overweight,
affects
more
than
50%
of
their
population.
As
part
the
scenario,
we
observe
how
significant
proportion
people
overweight
or
obesity
have
raised
acute
response
markers.
This
situation
shows
us
this
can
trigger
aggressive
phenomena
critically
ill
patients
other
clinical
conditions,
occasioning
torpid
evolution,
ominous
results,
and
low-rate
survival.
chapter
pretends
describe
influence
low-grade
on
outcome
who
develop
systemic
response.
