Effects of Globularia cordifolia on colon cancer cells: antioxidant activity, inflammatory cytokine analysis and molecular docking studies DOI Open Access
Emine İncilay Torunoğlu, Erdi Can Aytar, Betül Aydın

и другие.

Journal of the Science of Food and Agriculture, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Abstract BACKGROUND The present study aimed to comprehensively evaluate the anticancer, anti‐inflammatory, and antioxidant properties of Globularia cordifolia L. samples. plant material was collected extracted using maceration method. Antioxidant activities were assessed through DPPH (i.e. 2,2‐diphenyl‐1‐picrylhydrazyl) iron chelation assays, whereas phenolic flavonoid contents measured spectrophotometric methods. Gas chromatography‐mass spectrometry analysis performed identify biologically active compounds. cytotoxic effect on colon cancer cells evaluated MTT [i.e. 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide] inflammatory cytokine levels an enzyme‐linked immunosorbent assay. Molecular docking studies investigated interactions bioactive compounds with 4UYA protein, ADME absorption, distribution, metabolism, excretion toxicity) modeling predicted their toxicity. RESULTS revealed that extract exhibited strong activity a median 50% inhibitory concentration (IC 50 ) value 39.48 ± 2.15 μg mL −1 in assay effective capacity IC 4.28 0.19 mg . total content 662.51 20.95 gallic acid equivalents g , 114.99 0.51 quercetin demonstrating extract's richness Significant antiproliferative effects observed at dose 250 Inflammatory indicated reduction pro‐inflammatory responses. showed binding affinities between suggesting mechanisms action. CONCLUSION findings indicate G. exhibits antioxidant, anti‐inflammatory properties, making it promising biomolecular agent for therapy. high contents, combined compounds' key molecular targets, underscore its potential therapeutic applications. © 2024 Society Chemical Industry.

Язык: Английский

Impact of nanopollution on plant growth, photosynthesis, toxicity, and metabolism in the agricultural sector: An updated review DOI
Muthu Thiruvengadam, Hee Yong Youn, Seung‐Hyun Kim

и другие.

Plant Physiology and Biochemistry, Год журнала: 2024, Номер 207, С. 108370 - 108370

Опубликована: Янв. 14, 2024

Язык: Английский

Процитировано

16

De Novo synthesis of selenium-doped CeO2@Fe3O4 nanoparticles for improving secondary metabolite biosynthesis in Carthamus tinctorius cell suspension culture DOI
Kamran Ashraf, Zebo Liu, Qamar uz Zaman

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159705 - 159705

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Unlock Laboratory Waste Potential to Turn into Sustainable Bi-metallic Nanoparticles with Dyes Degradation and Therapeutic Activities DOI
Selma Hamimed,

Mohammed Zakaria Khelifati,

Rayene Hamimed

и другие.

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Язык: Английский

Процитировано

0

Changes in Growth and Secondary Metabolite Production in Cannabis Sativa L. in Response to Simultaneous Treatment with Plasma Activated water, Melatonin and Nano-Zinc DOI
Hakimeh Oloumi,

Fatemeh Nasibi,

Zakie Poorsheikhali

и другие.

BioNanoScience, Год журнала: 2025, Номер 15(2)

Опубликована: Апрель 4, 2025

Язык: Английский

Процитировано

0

Biological Effects of Green Synthesized Al-ZnO Nanoparticles Using Leaf Extract from Anisomeles indica (L.) Kuntze on Living Organisms DOI Creative Commons

S. K. Johnsy Sugitha,

R. Latha,

Raja Venkatesan

и другие.

Nanomaterials, Год журнала: 2024, Номер 14(17), С. 1407 - 1407

Опубликована: Авг. 28, 2024

The synthesis of Al-ZnO nanoparticles (NPs) was achieved using a green approach, utilizing leaf extract from Anisomeles indica (L.) in straightforward co-precipitation method. goal this study to investigate the production through reduction and capping method extract. powder X-ray diffraction, UV spectroscopy, Fourier transform infrared scanning electron microscopy with EDAX analysis were used analyze nanoparticles. diffraction confirmed presence spherical structures an average grain size 40 nm diameter, while UV–visible spectroscopy revealed prominent absorption peak at 360 nm. FTIR spectra demonstrated stretching vibrations associated O-H, N-H, C=C, C-N, C=O as well C-Cl groups indicating their involvement stabilization SEM image spongy, spherical, porous agglomerated nanoparticles, confirming chemical composition use technique. showed increased bactericidal activity against both Gram-positive Gram-negative bacteria. antioxidant property synthesized by DPPH radical scavenging IC50 value 23.52 excellent capability. Green shown vivo studies on HeLa cell lines be effective for cancer treatment. Additionally, α-amylase inhibition assay α-glucosidase potent anti-diabetic activities. Moving forward, current methodology suggests that phenolic groups, flavonoids, amines exhibit significant promise eliciting biological responses, including effects, realms biomedical pharmaceutical applications.

Язык: Английский

Процитировано

3

Nanoparticles as new elicitors for the production of bioactive and phytochemicals in vitro and in vivo plant culture DOI

Mahsa Darbahani,

M. Ghiyasi,

Mahdi Rahaie

и другие.

Phytochemistry Reviews, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

2

Upregulated synthesis and production of bioactive compounds in Lotus arabicus L. by in vitro feeding with dried powder of date palm seeds DOI Creative Commons
Doaa E. Elsherif, Fatmah Ahmed Safhi, Asmaa M. Khalifa

и другие.

BMC Plant Biology, Год журнала: 2024, Номер 24(1)

Опубликована: Март 27, 2024

Abstract Background Plants are considered the primary source of many principal bioactive compounds that have been utilized in a wide range applications including pharmaceutical and biotechnological industries. Therefore, there is an imperative need to modulate production natural components. The present study aimed determine importance dried pulverized date palm seeds (DPS) as elicitor for synthesis secondary metabolites Lotus arabicus L. Results presence various antioxidant compounds, simple sugars, amino acids, fatty acids reasonable mineral contents was distinct phytochemical characterization DPS. major components detected DPS analysis were 5-(hydroxymethyl) furfural 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone. induced callus (seven weeks old) supplemented with at different concentrations (0, 2, 4, 8 10 g/l) culture media. Treatment g/l highest capacity, ascorbic acid content (total phenolics flavonoids) produced callus. Stress biomarkers (hydrogen peroxide malondialdehyde) found control ranges except expression patterns key genes involoved metabolism modulation, such phenylalanine ammonia lyase ( PAL ), chalcone synthase CHS isomerase CHI flavonol FLS ) deoxyxylulose phosphate reductoisomerase DXR triggered after treatments. Moreover, quantitative profiling phenolic flavonoid showed supplementation DPS, especially g/l, led pronounced increases most measured compounds. Conclusion marked upregulation eliciting-responsive overproduction provide molecular-based evidence intensifying pathways phenylpropanoid, terpenoid biosynthesis. Overall, vitro highlights stimulating capacity utilization improve physiological molecular levels, enhancing its potential medicinal herb.

Язык: Английский

Процитировано

1

Evaluation and efficacy of plant extracts in eradicating medically important mosquitoes: a review DOI
K. Dass

Toxicology and Environmental Health Sciences, Год журнала: 2024, Номер 16(4), С. 413 - 458

Опубликована: Апрель 21, 2024

Язык: Английский

Процитировано

1

Biologically Synthesized Nanoparticles for Enhancing Secondary Metabolites in Plant Tissue Cultures DOI

Athira Sajeev,

Insha Asheem,

Ravishankar Patil

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

1

Nanoparticles as Elicitors and Harvesters of Economically Important Secondary Metabolites in Plants DOI
Sanchaita Lala

Reference series in phytochemistry, Год журнала: 2024, Номер unknown, С. 1 - 50

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0