Vitamin A carotenoids, but not retinoids, mediate the impact of a healthy diet on gut microbial diversity DOI Creative Commons
Ana M. Valdes, Panayiotis Louca, Alessia Visconti

и другие.

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Авг. 7, 2024

Abstract Background Vitamin A is essential for physiological processes like vision and immunity. A’s effect on gut microbiome composition, which affects absorption metabolism of other vitamins, still unknown. Here we examined the relationship between metagenome composition six vitamin A-related metabolites (two retinoid: -retinol, 4 oxoretinoic acid (oxoRA) four carotenoid metabolites, including beta-cryptoxanthin three carotene diols). Methods We included 1053 individuals from TwinsUK cohort with measured in serum faeces, diet history, assessed by shotgun sequencing. Results were replicated 327 women ZOE PREDICT-1 study. Five positively correlated alpha diversity ( r = 0.15 to 0.20, p < × 10 −6 ). Carotenoid compounds short-chain fatty-acid-producing bacteria Faecalibacterium prausnitzii Coprococcus eutactus. Retinol was not associated any microbial species. found that could predict circulating levels carotenoids AUCs ranging 0.66 0.74 using random forest models, but retinol (AUC 0.52). The healthy eating index (HEI) strongly all compounds, retinoids. investigated mediating role a diversity, finding significantly mediated 18 25% HEI diversity. Conclusions Our results show strong links potential pattern.

Язык: Английский

Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review DOI Open Access

Min’an Zhao,

Jiayi Chu,

Shiyao Feng

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 114985 - 114985

Опубликована: Июнь 11, 2023

The gut microbiota is indispensable for maintaining host health by enhancing the host's digestive capacity, safeguarding intestinal epithelial barrier, and preventing pathogen invasion. Additionally, exhibits a bidirectional interaction with immune system promotes of to mature. Dysbiosis microbiota, primarily caused factors such as genetic susceptibility, age, BMI, diet, drug abuse, significant contributor inflammatory diseases. However, mechanisms underlying diseases resulting from dysbiosis lack systematic categorization. In this study, we summarize normal physiological functions symbiotic in healthy state demonstrate that when occurs due various external factors, are lost, leading pathological damage lining, metabolic disorders, barrier damage. This, turn, triggers disorders eventually causes systems. These discoveries provide fresh perspectives on how diagnose treat unrecognized variables might affect link between illnesses need further studies extensive basic clinical research will still be required investigate relationship future.

Язык: Английский

Процитировано

152
Molecular Basis of Bile Acid-FXR-FGF15/19 Signaling Axis DOI Open Access

Takeshi Katafuchi,

Makoto Makishima

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(11), С. 6046 - 6046

Опубликована: Май 27, 2022

Bile acids (BAs) are a group of amphiphilic molecules consisting rigid steroid core attached to hydroxyl with varying number, position, and orientation, hydrophilic side chain. While BAs act as detergents solubilize lipophilic nutrients in the small intestine during digestion absorption, they also hormones. Farnesoid X receptor (FXR) is nuclear that forms heterodimer retinoid α (RXRα), activated by enterohepatic circulation reabsorbed via transporters ileum colon, plays critical role regulating gene expression involved cholesterol, BA, lipid metabolism liver. The FXR/RXRα exists distal regulates production fibroblast growth factor (FGF) 15/FGF19, hormone traveling activates hepatic FGF 4 (FGFR4)-β-klotho complex metabolism, well those cell proliferation. Agonists for FXR analogs FGF15/19 currently recognized promising therapeutic target metabolic syndrome cholestatic diseases.

Язык: Английский

Процитировано

95
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity DOI Creative Commons
Lei Su,

Yunhuan Gao,

Rongcun Yang

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 15, 2023

Bile acids (BAs) as cholesterol-derived molecules play an essential role in some physiological processes such nutrient absorption, glucose homeostasis and regulation of energy expenditure. They are synthesized the liver primary BAs cholic acid (CA), chenodeoxycholic (CDCA) conjugated forms. A variety secondary deoxycholic (DCA) lithocholic (LCA) their derivatives is intestine through involvement various microorganisms. In addition to functions, metabolites also involved differentiation functions innate adaptive immune cells macrophages (Macs), dendritic (DCs), myeloid derived suppressive (MDSCs), regulatory T (Treg), Breg cells, helper (Th)17 CD4 Th1 Th2 CD8 B NKT cells. Dysregulation affects development diseases inflammatory bowel diseases. We here summarize recent advances how maintain gut systemic homeostasis, including metabolism derivatives, function effects on immune-associated disorders.

Язык: Английский

Процитировано

56
Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis DOI

Hongyan Liu,

Xue Guo, Kexin Jiang

и другие.

Food Chemistry, Год журнала: 2024, Номер 446, С. 138739 - 138739

Опубликована: Фев. 16, 2024

Язык: Английский

Процитировано

20
The role of the gut microbiota in health and cardiovascular diseases DOI Creative Commons
Lu Wang, Shiqi Wang, Qing Zhang

и другие.

Molecular Biomedicine, Год журнала: 2022, Номер 3(1)

Опубликована: Окт. 11, 2022

Abstract The gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithelial barrier, regulating immune function, producing vitamins and hormones, metabolites interact with host. Meanwhile, increasing evidence indicates that has a strong correlation occurrence, progression treatment of cardiovascular diseases (CVDs). In patients CVDs corresponding risk factors, composition ratio have significant differences compared their healthy counterparts. Therefore, dysbiosis, microbiota-generated metabolites, related signaling pathway may serve explanations for some mechanisms about occurrence development CVDs. Several studies also demonstrated many traditional latest therapeutic treatments are associated its generated pathways. Given information, we summarized advances in current research regarding effect on main CVDs, highlighted roles several introduced promising microbiota. this review mainly focuses exploring role potential which eventually provide better solutions well prevention

Язык: Английский

Процитировано

71
Bifidobacterium breve and Bifidobacterium longum Attenuate Choline-Induced Plasma Trimethylamine N-Oxide Production by Modulating Gut Microbiota in Mice DOI Open Access

Qianqian Wang,

Min Guo, Yang Liu

и другие.

Nutrients, Год журнала: 2022, Номер 14(6), С. 1222 - 1222

Опубликована: Март 14, 2022

Atherosclerosis is the main cause of myocardial infarction and stroke, morbidity mortality rates cardiovascular disease are among highest any worldwide. Excessive plasma trimethylamine-N-oxide (TMAO), an intestinal metabolite, promotes development atherosclerosis. Therefore, effective measures for reducing TMAO production can contribute to preventing Probiotics living microorganisms that beneficial human body, some them attenuate production. To explore effects probiotic supplementation on in choline-fed mice, we intragastrically administered eight strains Bifidobacterium breve longum mice 6 weeks. B. Bb4 BL1 BL7 significantly reduced cecal trimethylamine concentrations. However, hepatic flavin monooxygenase (FMO) activity, flavin-containing 3 (FMO3), farnesoid X receptor (FXR) protein expression fractional excretion were not affected by supplementation. The treatment modulated abundances several genera such as Ruminococcaceae UCG-009, UCG-010, which belong Firmicutes has been reported with cut gene clusters, may be related reduction TMA TMAO. Additionally, a indicates circulating glucose lipids, another pathway reduce risk effect Bacteroides also suggests relationship between abundance this genus concentrations gut. mechanism underlying these changes might gut microbiota regulation. These have therapeutic potential alleviating TMAO-related diseases.

Язык: Английский

Процитировано

59
Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies DOI
Muthukumaran Jayachandran, Shen Qu

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 24(6), С. 1189 - 1204

Опубликована: Окт. 16, 2023

Язык: Английский

Процитировано

37
Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice DOI Creative Commons
H. Steigerwald, Frank Blanco‐Pérez, Andrea Macías‐Camero

и другие.

Carbohydrate Polymers, Год журнала: 2024, Номер 334, С. 122007 - 122007

Опубликована: Март 5, 2024

Pectins are dietary fibers that attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low (LMP). The aim this study was to investigate effects methyl-esterification intestinal microbiota and its properties in naive mice. Supplementation diet LMP HMP induced changes composition mice toward Bacteroides, which mainly promoted by HMP. Metabolome analysis stool samples from pectin-fed showed a different effect two types levels short-chain fatty acids bile acids, consistent highly efficient vivo fermentation LMP. Analysis serum antibody significant increase IgG IgA both pectins, while FACS revealed decrease infiltrating inflammatory cells lamina propria Our structural investigated determine fermentability, microbial composition, metabolite production, modulation immune responses. Consumption preferentially altered gut suppressed pro-inflammatory responses, suggesting role diseases.

Язык: Английский

Процитировано

11
The role of intestinal microbiota and metabolites in intestinal inflammation DOI
Wenwen Ma, Zhiqiang Huang, Kun Liu

и другие.

Microbiological Research, Год журнала: 2024, Номер 288, С. 127838 - 127838

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

10
Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity DOI Creative Commons

Gihyeon Kim,

Youngmin Yoon,

Jin‐Ho Park

и другие.

Microbiome, Год журнала: 2022, Номер 10(1)

Опубликована: Ноя. 4, 2022

Abstract Background Comparisons of the gut microbiome lean and obese humans have revealed that obesity is associated with plus changes in numerous environmental factors, including high-fat diet (HFD). Here, we report two species Bifidobacterium are crucial to controlling metabolic parameters Korean population. Results Based on microbial analysis from 99 individuals, observed abundance longum bifidum was markedly reduced individuals increased visceral adipose tissue (VAT), body mass index (BMI), blood triglyceride (TG), fatty liver. Bacterial transcriptomic carbohydrate/nucleoside processes were protecting against diet-induced obesity. Oral treatment specific commercial enhanced bile acid signaling contributing potentiate oxidative phosphorylation (OXPHOS) tissues, leading reduction weight gain improvement hepatic steatosis glucose homeostasis. or manipulated intestinal sterol biosynthetic protect germ-free mice. Conclusions Our findings support notion processes-enriched would be a novel therapeutic strategy for reprograming host homeostasis syndromes,

Язык: Английский

Процитировано

35