Detection and risk assessment of bisphenol-A and phthalate esters in bottled water: implications for public health DOI

Namrata Pal,

Poonam Sharma, Samradhi Singh

et al.

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 13, 2025

The global consumption of bottled water has surged, particularly where safe drinking is scarce Plastic bottles may leachharmful Endocrine Disrupting Chemicals (EDCs), including bisphenol-A (BPA) and phthalate esters (PAEs), into the water. This study analyzes BPA six PAEs in from various brands Central India, utilizing gas chromatography-mass spectrometry (GC-MS). A total 39 samples 13 were analyzed. results show detectable levels (35.397 µg/L to 273.513 µg/L) (ND 1147.340 µg/L), with significant concentrations di-n-butyl (DBP), bis(2-ethylhexyl) (DEHP), BPA, posing potential health risks. risk assessment based on hazard quotients (HQ) indicated that DEHP exceeded exposure thresholds for non-carcinogenic anti-androgenic Additionally, exhibited a carcinogenic risk. These findings emphasize need stricter regulations continuous monitoring mitigate risks associated EDC

Language: Английский

Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics DOI Open Access
Samradhi Singh,

Namrata Pal,

Swasti Shubham

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(4), P. 1454 - 1454

Published: Feb. 11, 2023

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, obesity are among the risk factors that predispose females to PCOS. These might contribute upsurging causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, irregular menstrual cycles. Dysbiosis of microbiota may play pathogenic role in development The restoration probiotics, prebiotics, fecal transplant (FMT) serve as an innovative, efficient, noninvasive way prevent mitigate This review deliberates on variety potentially involved etiology, prevalence, modulation PCOS, addition plausible therapeutic interventions, including miRNA therapy eubiosis microbiota, help treat manage

Language: Английский

Citations

192
Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases DOI
Shuang Liu,

Yinling He,

Yin Jia

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 134054 - 134054

Published: March 15, 2024

Language: Английский

Citations

32
Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach DOI Creative Commons
Mahsa Rezazadegan,

Bita Forootani,

Yeganeh Hoveyda

et al.

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 27, 2025

Language: Английский

Citations

2
Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders DOI
Samradhi Singh, Devojit Kumar Sarma, Vinod Verma

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2023, Volume and Issue: 682, P. 1 - 20

Published: Sept. 29, 2023

Language: Английский

Citations

40
Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer DOI Open Access
Samradhi Singh, Poonam Sharma, Devojit Kumar Sarma

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1913 - 1913

Published: March 22, 2023

The complexity and variety of gut microbiomes within among individuals have been extensively studied in recent years connection to human health diseases. Our growing understanding the bidirectional communication between metabolic diseases microbiome has also highlighted significance dysbiosis genesis development obesity-related cancers. Therefore, it is crucial comprehend possible role microbiota crosstalk obesity colorectal cancer (CRC). Through induction microbial dysbiosis, epithelial barrier impairment, metabolomic dysregulation, chronic inflammation, or dysregulation energy harvesting, may promote tumors. It well known that strategies for prevention treatment are most effective when combined with a healthy diet, physical activity, active lifestyle choices. Recent studies suggest an improved complex linkages various cancers as can potentially improve treatments overall outcomes. In this context, we herein review summarize clinical experimental evidence supporting functional pathogenesis progression CRC concerning its correlates, which pave way novel prognostic tools prevention. Therapeutic approaches restoring homeostasis conjunction discussed herein.

Language: Английский

Citations

36
Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms DOI Creative Commons
Jeongmin Lee,

Poornima D. E. Weerasinghe-Mudiyanselage,

Bohye Kim

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 266, P. 115565 - 115565

Published: Oct. 11, 2023

Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there growing interest in investigating the possible relationship between PM exposure onset progression neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis. However, precise mechanism by which affects neurodegeneration is still unclear, even though several epidemiological animal model studies have provided mechanistic insights. This article presents review current research on neurotoxicity its impact diseases. summarizes findings from collected through searches Google Scholar, PubMed, Web Science, Scopus. paper also discusses reported effects central nervous system highlights gaps future directions. The information presented this may inform public policies aimed at reducing contribute development new treatments for Further therapeutic will be needed fully understand

Language: Английский

Citations

26
The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies DOI Creative Commons
Simona Porru, Ana Esplugues, Sabrina Llop

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123732 - 123732

Published: March 8, 2024

The gut-brain axis is a crucial interface between the central nervous system and gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in microbiota, which may affect communication, impacting aspects of brain function behavior. This systematic review literature aims evaluate whether deleterious effects on due metal could be mediated by changes microbiota profile. Animal studies involving metals comparison with control group evaluated neuropsychological outcomes and/or molecular along analysis composition were reviewed. authors independently assessed for inclusion, extracted data risk bias using protocol Systematic Review Center Laboratory Experimentation (SYRCLE) preclinical studies. A search 3 databases yielded 16 eligible focused lead (n = 10), cadmium 1), mercury 3), manganese combined Pb Mn 1). animal species rats 7), mice 4), zebrafish carp 1) fruit fly Heavy found adversely cognitive function, behavior, neuronal morphology. Moreover, was associated abundance specific bacterial phyla, Firmicutes Proteobacteria, play roles health. In some studies, these alterations correlated learning memory impairments mood disorders. interplay suggests induce direct indirect through contributing neurotoxicity development However, small number papers under makes it difficult draw definitive conclusions. Further research warranted unravel underlying mechanisms translational implications human

Language: Английский

Citations

15
Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression DOI Creative Commons

Ameer Luqman,

Mei He, Adil Hassan

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 9, 2024

Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in CNS by regulating it through chemical, immunological, hormonal, neurological processes. Various studies have found bidirectional link between brain gut, emphasizing onset depression therapies. biological molecular processes underlying microbiota are required, association may represent novel study. However, profound insights into stratification diversity still uncommon. This article investigates emerging evidence bacterial relationship brain’s system potential pathogenicity relevance. interplay immune system, nervous neurotransmitter synthesis, neuroplasticity transitions widely studied. consequences stress, dietary fibers, probiotics, prebiotics, antibiotics GB axis being Multiple revealed this led development effective microbiota-based drugs for both prevention treatment. Therefore, results support hypothesis that influences provide promising area research improved knowledge etiology disease future

Language: Английский

Citations

11
Deleterious Effect of Air Pollution on Human Microbial Community and Bacterial Flora: A Short Review DOI Open Access
Nishant Gupta, Virendra Kumar Yadav, Amel Gacem

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(23), P. 15494 - 15494

Published: Nov. 22, 2022

A balanced microbiota composition is requisite for normal physiological functions of the human body. However, several environmental factors such as air pollutants may perturb composition. It noticeable that currently around 99% world’s population breathing polluted air. Air pollution’s debilitating health impacts have been studied scrupulously, including in gut microbiota. Nevertheless, impact on other microbiotas body less understood so far. In present review, authors summarized and discussed recent studies’ outcomes related to pollution-driven microbiotas’ dysbiosis (including oral, nasal, respiratory, gut, skin, thyroid microbiotas) its potential multi-organ risks.

Language: Английский

Citations

28
Epigenetic Aberrations in Major Psychiatric Diseases Related to Diet and Gut Microbiome Alterations DOI Open Access
Shabnam Nohesara, Hamid M. Abdolmaleky, Sam Thiagalingam

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1506 - 1506

Published: July 24, 2023

Nutrition and metabolism modify epigenetic signatures like histone acetylation DNA methylation. Histone methylation in the central nervous system (CNS) can be altered by bioactive nutrients gut microbiome via gut-brain axis, which turn modulate neuronal activity behavior. Notably, microbiome, with more than 1000 bacterial species, collectively contains almost three million functional genes whose products interact millions of human marks 30,000 a dynamic manner. However, genetic makeup shapes composition, food/nutrient metabolism, landscape, as well. Here, we first discuss effect changes microbial structure composition shaping specific alterations brain their role onset progression major mental disorders. Afterward, potential interactions among maternal diet/environmental factors, nutrition, gastrointestinal roles accelerating or delaying severe illnesses will discussed. We also provide an overview association between oxidative stress, inflammation through mechanisms. Finally, present some underlying mechanisms involved mediating influence probiotics on health modifications.

Language: Английский

Citations

20