Journal of Translational Gastroenterology,
Год журнала:
2024,
Номер
2(2), С. 109 - 124
Опубликована: Июнь 28, 2024
Gluten
has
multiple
harmful
effects
that
compromise
human
health,
not
only
in
gluten-dependent
diseases
but
also
non-gluten-affected
chronic
inflammatory
conditions.
After
consumption,
the
indigestible
gluten
peptides
are
modified
by
luminal
microbial
transglutaminase
or
transported
through
gut
epithelium
to
interact
with
highly
populated
mucosal
immune
cells.
As
a
disruptor
of
permeability,
tight
junction
integrity,
allowing
foreign
immunogenic
molecules
reach
internal
compartments.
Gliadin
distributed
systemically
remote
organs,
where
they
encounter
endogenous
tissue
transglutaminase.
Following
post-translational
deamidation
transamidation,
become
and
pro-inflammatory,
inducing
organ
dysfunction
pathology.
Cross-reactivity
sequence
homology
between
gluten/gliadin
epitopes
may
contribute
molecular
mimicry
autoimmunity
induction.
A
gluten-free
diet
can
prevent
these
phenomena
various
mechanisms.
proof
concept,
withdrawal
alleviates
disease
activity
inflammatory,
metabolic,
autoimmune
conditions,
even
neurodegeneration.
We
recommend
combining
Mediterranean
diets
leverage
advantages
both.
Before
recommending
for
non-gluten-dependent
patients
should
be
asked
about
symptomatology
screened
celiac-associated
antibodies.
The
current
list
gluten-induced
includes
celiac
disease,
dermatitis
herpetiformis,
ataxia,
allergy,
non-celiac
sensitivity.
In
view
being
universal
pro-inflammatory
molecule,
other
autoinflammatory
neurodegenerative
conditions
investigated
potential
avoidance.
Genes,
Год журнала:
2023,
Номер
14(7), С. 1506 - 1506
Опубликована: Июль 24, 2023
Nutrition
and
metabolism
modify
epigenetic
signatures
like
histone
acetylation
DNA
methylation.
Histone
methylation
in
the
central
nervous
system
(CNS)
can
be
altered
by
bioactive
nutrients
gut
microbiome
via
gut-brain
axis,
which
turn
modulate
neuronal
activity
behavior.
Notably,
microbiome,
with
more
than
1000
bacterial
species,
collectively
contains
almost
three
million
functional
genes
whose
products
interact
millions
of
human
marks
30,000
a
dynamic
manner.
However,
genetic
makeup
shapes
composition,
food/nutrient
metabolism,
landscape,
as
well.
Here,
we
first
discuss
effect
changes
microbial
structure
composition
shaping
specific
alterations
brain
their
role
onset
progression
major
mental
disorders.
Afterward,
potential
interactions
among
maternal
diet/environmental
factors,
nutrition,
gastrointestinal
roles
accelerating
or
delaying
severe
illnesses
will
discussed.
We
also
provide
an
overview
association
between
oxidative
stress,
inflammation
through
mechanisms.
Finally,
present
some
underlying
mechanisms
involved
mediating
influence
probiotics
on
health
modifications.
Recent
evidence
has
suggested
that
changes
in
maternal
gut
microbiota
early
life
may
generate
neurobiological
consequences
associated
with
psychiatric-related
abnormalities.
However,
the
number
of
studies
on
humans
investigating
this
problem
is
limited,
and
preclinical
findings
sometimes
conflict.
Therefore,
we
run
a
meta-analysis
to
examine
whether
disturbance
(MMD)
during
neurodevelopment
might
affect
offspring
adulthood.
We
found
thirteen
studies,
from
set
459
records
selected
by
strategy
registered
PROSPERO
(#289224),
target
evaluated
behavioral
outcomes
rodents
generated
dams
submitted
perinatal
enteric
perturbation.
The
analysis
revealed
significant
effect
size
(SMD
=
−0.51,
95%
CI
−0.79
−0.22,
p
<
.001,
T2
0.54,
I2
79.85%),
indicating
MMD
provoke
impairments
adult
offspring.
also
induces
for
reduction
sociability
behavior
−0.63,
−1.18
−0.07,
0.011,
0.30,
76.11%)
obsessive-compulsive-like
−0.68,
−0.01
−1.36,
0.009,
0.25,
62.82%)
parameters.
was
not
or
inconclusive
memory
anxiety-like
behavior,
schizophrenia-like
depressive-like
behavior.
experimental
vertically
transmitted
offspring,
negatively
impacting
parameters
related
psychiatric
disorders.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16464 - 16464
Опубликована: Ноя. 17, 2023
It
is
well
established
that
cells,
tissues,
and
organisms
exposed
to
low
doses
of
ionizing
radiation
can
induce
effects
in
non-irradiated
neighbors
(non-targeted
or
NTE),
but
the
mechanisms
remain
unclear.
This
especially
true
initial
steps
leading
release
signaling
molecules
contained
exosomes.
Voltage-gated
ion
channels,
photon
emissions,
calcium
fluxes
are
all
involved
precise
sequence
events
not
yet
known.
We
identified
what
may
be
a
quantum
entanglement
type
effect
this
prompted
us
consider
whether
aspects
biology
such
as
tunneling
underlie
NTE.
review
field
where
it
relevant
processes.
These
include
NTE,
low-dose
hyper-radiosensitivity,
hormesis,
adaptive
response.
Finally,
we
present
possible
biological-based
model
for
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8352 - 8352
Опубликована: Июль 30, 2024
Adipose
tissue
dysfunction,
which
is
associated
with
an
increased
risk
of
colorectal
cancer
(CRC),
a
significant
factor
in
the
pathophysiology
obesity.
Obesity-related
inflammation
and
extracellular
matrix
(ECM)
remodeling
promote
metastasis
(CRCM)
by
shaping
tumor
microenvironment
(TME).
When
CRC
occurs,
metabolic
symbiosis
cells
recruits
adjacent
adipocytes
into
TME
to
supply
energy.
Meanwhile,
abundant
immune
cells,
from
adipose
blood,
are
recruited
TME,
stimulated
pro-inflammatory
factors
triggers
chronic
local
TME.
Dysregulated
ECM
proteins
cell
surface
adhesion
molecules
enhance
further
increase
contractibility
between
stromal
promotes
epithelial-mesenchymal
transition
(EMT).
EMT
increases
migration
invasion
surrounding
tissues
or
vessels
accelerates
CRCM.
Colorectal
symbiotic
microbiota
also
plays
important
role
promotion
In
this
review,
we
provide
its
contributions
CRC,
special
emphasis
on
adipocytes,
macrophages,
neutrophils,
T
ECM,
gut
progression
their
microenvironment.
We
highlight
interactions
potential
therapeutic
approaches
target
these
interactions.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 4, 2023
Introduction
The
timing
of
maternal
exposure
to
air
pollution
is
crucial
define
metabolic
changes
in
the
offspring.
Here
we
aimed
determine
most
critical
period
particulate
matter
(PM
2.5
)
that
impairs
offspring's
energy
metabolism
and
gut
microbiota
composition.
Methods
Unexposed
female
male
C57BL/6J
mice
were
mated.
PM
or
filtered
(FA)
occurred
only
gestation
/FA)
lactation
(FA/PM
).
We
studied
offspring
both
genders.
Results
during
increased
body
weight
(BW)
at
birth
from
weaning
young
adulthood.
Leptin
levels,
food
intake,
Agrp,
Npy
levels
hypothalamus
also
Ikbke,
Tnf
/FA.
Males
FA/PM
group
protected
these
phenotypes
showing
higher
O
2
consumption
Ucp1
brown
adipose
tissue.
In
offspring,
did
not
see
BW
weaning.
However,
adult
females
/FA
displayed
leptin
despite
expenditure
thermogenesis.
This
showed
a
slight
increase
intake.
,
BW,
elevated.
mild
To
if
could
affect
offspring’s
microbiota,
analyzed
alpha
diversity
by
Shannon
Simpson
indexes
beta
Linear
Discriminant
Analysis
(LDA)
30
weeks.
Unlike
males,
led
adiposity
maintenance
this
age.
Gestation
was
associated
with
decreased
Discussion
Our
data
support
more
harmful
than
lactation.
Male
had
an
unfavorable
phenotype
older
age,
kept
adiposity.
Ultimately,
our
highlight
importance
controlling
pollution,
especially
gestation.
