Detection and risk assessment of bisphenol-A and phthalate esters in bottled water: implications for public health DOI

Namrata Pal,

Poonam Sharma, Samradhi Singh

et al.

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: Feb. 13, 2025

The global consumption of bottled water has surged, particularly where safe drinking is scarce Plastic bottles may leachharmful Endocrine Disrupting Chemicals (EDCs), including bisphenol-A (BPA) and phthalate esters (PAEs), into the water. This study analyzes BPA six PAEs in from various brands Central India, utilizing gas chromatography-mass spectrometry (GC-MS). A total 39 samples 13 were analyzed. results show detectable levels (35.397 µg/L to 273.513 µg/L) (ND 1147.340 µg/L), with significant concentrations di-n-butyl (DBP), bis(2-ethylhexyl) (DEHP), BPA, posing potential health risks. risk assessment based on hazard quotients (HQ) indicated that DEHP exceeded exposure thresholds for non-carcinogenic anti-androgenic Additionally, exhibited a carcinogenic risk. These findings emphasize need stricter regulations continuous monitoring mitigate risks associated EDC

Language: Английский

'Environmental standard limit concentration' arsenic exposure is associated with anxiety, depression, and autism-like changes in early-life stage zebrafish DOI
Yuanhui Zhu,

Qianlei Yang,

Jie Gu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 469, P. 133953 - 133953

Published: March 5, 2024

Language: Английский

Citations

8
Analysis and remediation of phthalates in aquatic matrices: current perspectives DOI

A. Tuli,

Gayatri Suresh,

Nabanita Halder

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(16), P. 23408 - 23434

Published: March 8, 2024

Language: Английский

Citations

6
Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure DOI

Anfei Liu,

Yunting Li,

Lifan Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134360 - 134360

Published: April 19, 2024

Language: Английский

Citations

6
Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis DOI Creative Commons
Lucas Hassib, Cilene Lino de Oliveira,

Guilherme Araujo Rouvier

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: July 3, 2023

Recent evidence has suggested that changes in maternal gut microbiota early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether disturbance (MMD) during neurodevelopment might affect offspring adulthood. We found thirteen studies, from set 459 records selected by strategy registered PROSPERO (#289224), target evaluated behavioral outcomes rodents generated dams submitted perinatal enteric perturbation. The analysis revealed significant effect size (SMD = −0.51, 95% CI −0.79 −0.22, p < .001, T2 0.54, I2 79.85%), indicating MMD provoke impairments adult offspring. also induces for reduction sociability behavior −0.63, −1.18 −0.07, 0.011, 0.30, 76.11%) obsessive-compulsive-like −0.68, −0.01 −1.36, 0.009, 0.25, 62.82%) parameters. was not or inconclusive memory anxiety-like behavior, schizophrenia-like depressive-like behavior. experimental vertically transmitted offspring, negatively impacting parameters related psychiatric disorders.

Language: Английский

Citations

15
Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model DOI Open Access
Bruno F. E. Matarèse,

Andrej Rusin,

Colin Seymour

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16464 - 16464

Published: Nov. 17, 2023

It is well established that cells, tissues, and organisms exposed to low doses of ionizing radiation can induce effects in non-irradiated neighbors (non-targeted or NTE), but the mechanisms remain unclear. This especially true initial steps leading release signaling molecules contained exosomes. Voltage-gated ion channels, photon emissions, calcium fluxes are all involved precise sequence events not yet known. We identified what may be a quantum entanglement type effect this prompted us consider whether aspects biology such as tunneling underlie NTE. review field where it relevant processes. These include NTE, low-dose hyper-radiosensitivity, hormesis, adaptive response. Finally, we present possible biological-based model for

Language: Английский

Citations

14
Maternal exposure to air pollution alters energy balance transiently according to gender and changes gut microbiota DOI Creative Commons
Olívia Pizetta Zordão, Clara Machado Campolim, Victor Yuji Yariwake

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: April 4, 2023

Introduction The timing of maternal exposure to air pollution is crucial define metabolic changes in the offspring. Here we aimed determine most critical period particulate matter (PM 2.5 ) that impairs offspring's energy metabolism and gut microbiota composition. Methods Unexposed female male C57BL/6J mice were mated. PM or filtered (FA) occurred only gestation /FA) lactation (FA/PM ). We studied offspring both genders. Results during increased body weight (BW) at birth from weaning young adulthood. Leptin levels, food intake, Agrp, Npy levels hypothalamus also Ikbke, Tnf /FA. Males FA/PM group protected these phenotypes showing higher O 2 consumption Ucp1 brown adipose tissue. In offspring, did not see BW weaning. However, adult females /FA displayed leptin despite expenditure thermogenesis. This showed a slight increase intake. , BW, elevated. mild To if could affect offspring’s microbiota, analyzed alpha diversity by Shannon Simpson indexes beta Linear Discriminant Analysis (LDA) 30 weeks. Unlike males, led adiposity maintenance this age. Gestation was associated with decreased Discussion Our data support more harmful than lactation. Male had an unfavorable phenotype older age, kept adiposity. Ultimately, our highlight importance controlling pollution, especially gestation.

Language: Английский

Citations

13
The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases DOI Open Access
Yunxia Ma, Miljana Nenkov,

Yuan Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8352 - 8352

Published: July 30, 2024

Adipose tissue dysfunction, which is associated with an increased risk of colorectal cancer (CRC), a significant factor in the pathophysiology obesity. Obesity-related inflammation and extracellular matrix (ECM) remodeling promote metastasis (CRCM) by shaping tumor microenvironment (TME). When CRC occurs, metabolic symbiosis cells recruits adjacent adipocytes into TME to supply energy. Meanwhile, abundant immune cells, from adipose blood, are recruited TME, stimulated pro-inflammatory factors triggers chronic local TME. Dysregulated ECM proteins cell surface adhesion molecules enhance further increase contractibility between stromal promotes epithelial-mesenchymal transition (EMT). EMT increases migration invasion surrounding tissues or vessels accelerates CRCM. Colorectal symbiotic microbiota also plays important role promotion In this review, we provide its contributions CRC, special emphasis on adipocytes, macrophages, neutrophils, T ECM, gut progression their microenvironment. We highlight interactions potential therapeutic approaches target these interactions.

Language: Английский

Citations

5
Inflammation and cardiometabolic diseases induced by persistent organic pollutants and nutritional interventions: Effects of multi-organ interactions DOI
Zhongmin Wang,

Yixuan Zhou,

Xia Xiao

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 339, P. 122756 - 122756

Published: Oct. 14, 2023

Language: Английский

Citations

12
Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: A review DOI

Ranjay Kumar Sah,

Amritasree Nandan,

K V Athira

et al.

Asian Journal of Psychiatry, Journal Year: 2023, Volume and Issue: 91, P. 103861 - 103861

Published: Dec. 13, 2023

Language: Английский

Citations

12
Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review DOI Creative Commons
Samradhi Singh, Mona Kriti,

Anamika K.S.

et al.

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100287 - 100287

Published: May 19, 2024

The complex and multidimensional landscape of type 2 diabetes mellitus (T2D) is a major global concern. Despite several years extensive research, the precise underlying causes T2D remain elusive, but evidence suggests that it influenced by myriad interconnected risk factors such as epigenetics, genetics, gut microbiome, environmental factors, organelle stress, dietary habits. number influencing pathogenesis increasing day which worsens scenario; meanwhile, interconnections shoot up frame. By gaining deeper insights into contributing we may pave way for development personalized medicine, could unlock more impactful treatment pathways individuals with T2D. This review summarizes state knowledge about pathogenesis, focusing on interplay between various their implications future therapeutic strategies. Understanding these lead to tailored treatments targeting specific inform prevention efforts population level, ultimately improving outcomes reducing its burden globally.

Language: Английский

Citations

4