Natural Product Communications,
Год журнала:
2025,
Номер
20(4)
Опубликована: Апрель 1, 2025
Background:
Acute
myocardial
necrosis,
or
infarction
(MI),
is
the
most
deadly
form
of
coronary
artery
disease
(CAD),
which
typically
occurs
when
blood
flow
to
a
portion
heart
stops,
damaging
muscles.
The
synthetic
nonselective
β-adrenergic
agonist
isoproterenol
known
cause
cardiac
conditions
like
energy
depletion,
hypotension,
oxidative
stress,
and
calcium
overload.
Hemorrhoids,
diabetes,
muscle
spasms,
chronic
inflammation,
cardiovascular
disorders,
Alzheimer's
disease,
stroke,
other
can
all
be
treated
with
nattokinase
(N.K).
Radiation-induced
(RIHD)
syndrome,
includes
pericarditis,
cardiomyopathy,
valvular
conduction
abnormality,
caused
by
radiation
exposure
cells.
present
study
aims
investigate
effectiveness
against
ISO
injection
in
rats
undergoing
whole-body
fractionated
gamma
irradiation.
Methods:
Rats
received
an
oral
aqueous
suspension
N.K.
(720
FU/kg
body
weight/day)
for
ten
days
5
Gy
(0.5
per
day;
consecutive
(dose
rate
0.401
Gy/min),
while
was
injected
subcutaneously
(at
dose
150
mg/kg
weight/day
two
starting
on
first
day
experiment).
Results:
obtained
data
showed
that
concentration
ANP
(29.49%),
TROPONIN
(29.37%),
GSH
(35.63%),
MDA
(23.5%),
TNFα
(28.29%),
Enos
(51.02%)
contents
heart,
were
significantly
improved
groups
N.K
along
γ-radaition
compared
group
γ-rays.
In
addition,
indicators
renal
status
include
NGAL
(35.58%),
ALDOSTERONE
(43.93%),
ANG-II
(28.57%),
eNOS
(39.27%),
besides
KIM-1
(38.97%),
(26.09%),
(59.49%),
TNF-α
(17.82%)
kidney
tissue
are
improved.
Moreover,
serum
inflammatory
index
IL-18
(29.45%)
organ
damage
LDH
(69.4%)
Serum
modified.
conclusion,
N.K.,
its
antioxidant
anti-inflammatory
capabilities,
preserves
myocardium
from
disruption
processes
resulting
increased
burden
after
Isoproterenol
radiation,
through
multiple
routes
action,
including
activation
(ANP/cTnI/GSH-H/MDA/TNF-α/),
stimulation
(KIM-1/ANG-II/aldosterone/NGAL),
IL-18/LDH
suppression
ENOS.
Food Bioengineering,
Год журнала:
2024,
Номер
3(1), С. 41 - 64
Опубликована: Март 1, 2024
Abstract
Probiotics
have
become
increasingly
popular
over
the
past
two
decades
due
to
continuously
expanding
scientific
evidence
indicating
their
beneficial
effects
on
human
health.
Therefore,
they
been
applied
in
food
industry
produce
functional
food,
which
plays
a
significant
role
health
and
reduces
disease
risk.
However,
maintaining
viability
of
probiotics
targeting
successful
delivery
gastrointestinal
tract
remain
challenging
tasks
applications.
Specifically,
this
paper
reviews
potentially
properties
probiotics,
highlighting
use
challenges
application
associated
benefits.
Of
foremost
importance,
also
explores
potential
underlying
molecular
mechanisms
enhanced
effect
epithelial
cells,
including
discussion
various
surface
adhesion‐related
proteins
probiotic
cell
that
facilitate
colonization.
Fermentation,
Год журнала:
2023,
Номер
9(5), С. 463 - 463
Опубликована: Май 12, 2023
The
cosmetic
segment
is
a
rapidly
growing
industry
that
has
been
challenged
in
recent
years
due
to
the
origin
and
impact
of
its
ingredients
manufacturing
techniques.
With
focus
on
reducing
carbon
dioxide
emissions
improving
degradability
products,
many
conventional
are
being
dismissed
meet
more
exigent
regulations
consumer
ethical
demands.
Biotechnology,
fermentation
as
core
technology,
solution
support
drive
sustainable
growth
for
industry.
This
review
presents
latest
research
development
applied
cosmetics
showcases
multiple
examples
throughout
all
classes
ingredients:
from
functional
compounds,
such
oil
surfactants,
multi-faceted
molecules
with
wide
spectrum
formulations
skin
benefits
derived
their
emulsifying,
antimicrobial
or
antioxidant
properties.
bottlenecks
associated
commercialization
ingredients,
together
successful
examples,
also
discussed.
shift
towards
bio-based
beauty
requires
combination
technical,
regulatory
marketing
efforts.
Fermentation
strategies
better
utilize
low-cost
substrates
optimize
microorganisms
processes
will
reduce
overall
costs,
price
gap
traditional
methods
production.
testing,
standardization
regulation
these
new
need
catch
up
fast
happening
field.
Finally,
communication
key
achieve
introduction
biotech
market.
Foods,
Год журнала:
2023,
Номер
12(6), С. 1293 - 1293
Опубликована: Март 18, 2023
Isoflavones
are
phenolic
compounds
(considered
as
phytoestrogens)
with
estrogenic
and
antioxidant
function,
which
highly
beneficial
for
human
health,
especially
in
the
aged
population.
However,
isoflavones
foods
not
bioavailable
and,
therefore,
have
low
biological
activity.
Additionally,
their
transformation
into
bioactive
by
microorganisms
is
necessary
to
obtain
effects
on
health.
Many
lactic
acid
bacteria
(LAB)
can
transform
methylated
glycosylated
forms
of
naturally
present
more
aglycones,
such
daidzein,
genistein
glycitein.
In
addition,
certain
LAB
strains
capable
transforming
isoflavone
aglycones
a
greater
activity,
dihydrodaidzein
(DHD),
O-desmethylangolensin
(O-DMA),
dihydrogenistein
(DHG)
6-hydroxy-O-desmethylangolensin
(6-OH-O-DMA).
Moreover,
Lactococcus
garviae
20-92
able
produce
equol.
Another
strategy
bioconversion
heterologous
expression
genes
from
Slackia
isoflavoniconvertens
DSM22006,
allowed
production
DHD,
DHG,
equol
5-hydroxy-equol
high
concentrations
engineered
strains.
Accordingly,
consequences
metabolism
its
application
development
enriched
isoflavones,
well
health
benefits
attributed
consumption,
will
be
addressed
this
work.
Frontiers in Bioscience-Elite,
Год журнала:
2024,
Номер
16(1), С. 3 - 3
Опубликована: Янв. 31, 2024
Tempeh
is
an
Indonesian
traditional
food
made
from
fermented
soybeans,
which
offers
wide
culinary
use
in
East
Asian
countries.
Similar
to
all
foods,
its
preparation
the
purpose
of
preservation.
However,
preclinical
studies
have
highlighted
that
microbial
action
leads
a
modification
nutritional
composition
food's
matrix.
Although
there
availability
data
on
beneficial
effect
soy,
tempeh
remains
relatively
unexplored,
perhaps
due
limited
diffusion
world,
limits
research
availability.
available
suggest
may
confer
health
effects
high
bioavailability
nutrients
and
phytochemicals,
showing
ameliorative
oxidative
stress,
glycaemic
control,
blood
lipid
levels.
Furthermore,
biological
value
means
it
can
be
used
optimize
protein
caloric
intake
athletes,
vegetarians,
children.
Moreover,
fermentation
production
tempeh,
addition
improving
minerals,
proteins,
fibre,
vitamins,
isoflavones,
produces
biopeptides
whose
currently
great
interest.
employed
preparations
as
well
second-generation
such
plant-based
meat
substitutes,
provide
functional
properties
higher
eco-friendly
option
compared
animal
foods.
This
review
aims
overview
tempeh's
properties,
regarding
human
future
perspectives.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Traditionally
fermented
sufu
is
popular
because
of
its
flavor,
abundance
nutrients,
and
long
shelf
life.
However,
traditional
difficult
to
produce
via
industrial
processes
dominant
microorganism
attenuation
during
fermentation.
Herein,
specific
protease‐producing
strains
were
isolated
from
sufu.
After
strain
identification,
mutation,
domestication,
the
applied
in
The
taste,
texture,
nutrient
flavor
components
fermentation
products
investigated
organoleptic,
textural
HPLC
HS‐GC‐IMS
analyses.
Results
revealed
that
Bacillus
subtilis
(DF1)
derived
DF1v
DF1vd
had
increased
protease
activity
relative
other
strains.
When
these
for
fermentation,
production
period
significantly
shortened
6–8
days
pehtzes
20–26
postripening.
compound
composition
both
improved,
including
increases
water‐soluble
proteins,
amino
acids,
substances
with
beany
umami
aromas
decreases
nonbeneficial
biogenic
amines
moldy
odor‐imparting
substances.
Among
strains,
showed
greatest
benefits
sufu‐assisted
In
summary,
a
modified
(DF1vd)
producing
was
isolated,
which
improved
profile
period.
Frontiers in Nutrition,
Год журнала:
2023,
Номер
9
Опубликована: Янв. 6, 2023
Lactic
acid-fermented
soymilk
as
a
new
plant-based
food
has
aroused
extensive
attention
because
of
its
effects
on
nutrition
and
health.
This
study
was
conducted
to
delve
into
the
antioxidative
anti-inflammatory
activities
lactic
soymilk.
To
elucidate
key
factors
that
affect
antioxidant
properties
fermented
soymilk,
strains
preparation
process
were
investigated.
Findings
show
prepared
using
hot-water
blanching
method
(BT-80)
demonstrated
better
activity
than
conventional
(CN-20).
Besides,
huge
difference
observed
among
soymilks
with
different
strains.
Among
them,
YF-L903
highest
ABTS
radical
scavenging
ability,
which
is
about
twofold
unfermented
1.8-fold
L571
soy
milk.
In
vitro
experiments
analysis
H2O2-induced
oxidative
damage
model
in
Caco-2
cells
showed
acid-fermentation
could
improve
DPPH
while
reducing
content
reactive
oxygen
species
(ROS)
malondialdehyde
(MDA)
induced
by
H2O2,
increasing
superoxide
dismutase
(SOD).
Consequently,
are
protected
from
caused
active
oxidation,
repair
ability
enhanced.
identify
role
intestinal
health,
we
investigate
preventive
effect
dextran
sodium
sulfate-induced
colitis
mouse
models.
Results
revealed
can
significantly
health
conditions
mice,
including
alleviated
weight
loss,
relieved
colonic
injury,
balanced
spleen-to-body
ratio,
reduced
disease
index,
suppressed
inflammatory
cytokines
oxidant
indexes
release.
These
results
suggest
promising
natural
sources
agents
for
industry.
We
believe
this
work
paves
way
elucidating
provides
reference
higher
nutritional
value.
Preventive Nutrition and Food Science,
Год журнала:
2023,
Номер
28(4), С. 514 - 519
Опубликована: Дек. 27, 2023
In
this
study,
we
investigated
the
physicochemical
and
antioxidative
properties
of
traditional
Korean
confectionery,
Yanggaeng,
when
various
amounts
tempeh
powder
(TP)
were
added.We
replaced
a
portion
white
bean
paste
in
Yanggaeng
with
TP
at
percentages
0%
(CON),
2%
(TP2),
4%
(TP4),
6%
(TP6)
by
total
weight.The
proximate
composition
results
showed
that
TP6
exhibited
highest
crude
ash
protein
contents,
but
its
moisture
content
carbohydrate
lowest
compared
to
CON.Tempeh
addition
altered
colorimetric
increasing
L*
value,
b*
browning
index;
however,
did
not
alter
a*
value.The
also
gradually
decreased
pH
Yanggaeng.The
Brix
value
was
TP2;
TP4
TP6,
decreased,
these
formulations
lower
values
than
CON.Furthermore,
induced
capacities,
as
evidenced
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)
radical
scavenging
activities.The
study
demonstrate
alters
capacity.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 7, 2024
Abstract
Nattokinase,
from
the
Japanese
fermented
food
natto,
is
a
protease
with
fibrinolytic
activity
that
can
thus
degrade
conventional
blood
clots.
In
some
cases,
however,
including
in
Long
COVID,
fibrinogen
polymerise
into
an
anomalous
amyloid
form
to
create
clots
are
resistant
normal
fibrinolysis
and
we
refer
as
fibrinaloid
microclots.
These
be
detected
fluorogenic
stain
thioflavin
T.
We
describe
automated
microscopic
technique
for
quantification
of
microclot
formation,
which
also
allows
kinetics
their
formation
aggregation
recorded.
here
show
recombinant
nattokinase
effective
at
degrading
microclots
vitro
.
This
adds
otherwise
largely
anecdotal
evidence,
review,
might
anticipated
have
value
part
therapeutic
treatments
individuals
COVID
related
disorders
involve