Postbiotic production: harnessing the power of microbial metabolites for health applications

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Дек. 19, 2023

Postbiotics, which are bioactive substances derived from the metabolic processes of beneficial microbes, have received considerable attention in field microbiome science recent years, presenting a promising path for exploration and innovation. This comprehensive analysis looks into multidimensional terrain postbiotic production, including an extensive examination diverse classes, revealing their sophisticated mechanisms action highlighting future applications that might significantly affect human health. The authors thoroughly investigate various support ranging conventional fermentation procedures to cutting-edge enzyme conversion synthetic biology approaches. review, as acknowledgment field’s developing nature, not only highlights current achievements but also navigates through problems inherent production. In order successfully include postbiotics therapeutic interventions production functional food ingredients, emphasis is given critical elements, improving yields, bolstering stability, assuring safety. knowledge presented herein sheds light on expanding potential revolutionize development novel therapeutics ingredients.

Язык: Английский

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Etiopathogenesis of Psoriasis: Integration of Proposed Theories

Immunological Investigations, Год журнала: 2024, Номер 53(3), С. 348 - 415

Опубликована: Янв. 19, 2024

Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin involvement of immune system. Global prevalence for psoriasis has been reported around 1–3% with higher incidence in adults similar proportions between men women. The risk factors associated are both extrinsic intrinsic, out which polygenic predisposition highlight latter. etiology not yet fully described, but several hypothesis have proposed: 1) autoimmunity based over-expression antimicrobial peptides such as LL-37, proteins ADAMTSL5, K17, hsp27, or lipids synthesized PLA2G4D enzyme, all may serve autoantigens to promote differentiation autoreactive lymphocytes T unleash response; 2) dysbiosis microbiota gained relevance due observations loss diversity participation pathogenic bacteria Streptococcus spp. Staphylococcus fungi Malassezia Candida virus HPV, HCV, HIV psoriatic plaques; 3) oxidative stress hypothesis, most recent one, describes that cell injury release proinflammatory mediators leads activate Th1/Th17 axis observed caused reactive oxygen species imbalance oxidant antioxidant mechanisms. This review aims describe mechanisms involved three hypotheses etiopathogeneses psoriasis.

Язык: Английский

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Skin Deep: The Potential of Microbiome Cosmetics

The Journal of Microbiology, Год журнала: 2024, Номер 62(3), С. 181 - 199

Опубликована: Март 1, 2024

Язык: Английский

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Enhancing Skin Anti-Aging through Healthy Lifestyle Factors

Cosmetics, Год журнала: 2023, Номер 10(5), С. 142 - 142

Опубликована: Окт. 12, 2023

Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.

Язык: Английский

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A Comparative, Multicenter, Prospective, Randomized Study to Evaluate the Efficacy, Safety, and Delay of Relapse of Ceramide-Based Post-biotic Moisturizer Versus Paraffin-Based Moisturizer in Mild to Moderate Atopic Dermatitis

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Atopic dermatitis (AD) is a chronic relapsing inflammatory disease that impacts the quality of life affected individuals as well their families. Its pathogenesis involves impaired skin barrier function and immune dysregulation. Moisturizers are used in AD management they help repairing barrier. The objective this study was to compare efficacy, safety, prevention relapse with ceramide-based post-biotic moisturizer against paraffin-based mild moderate AD. A total 160 patients were grouped into two: Group I received desonide cream 0.05% II moisturizer. Both groups given treatment for four weeks. Patients who achieved complete resolution entered maintenance phase maximum duration three months. They followed up every two weeks telephonically or when patient experienced relapse. All completely cured at week 4. 96/160 (71.25%) relapsed, 44 relapses (55%) 52 (65%) (p=0.25). However, terms mean time, had 72.52±15.01 day remission period, whereas 47.44±21.49 period (p=0.0001). Moreover, showed statistically significantly prolonged estimated median time compared (median: 85 days versus 71 days, p=0.05). moisturizers tolerated very well. Although both effective resolving symptoms phase, more significant extending

Язык: Английский

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Genetic Causal Association Between Skin Microbiota and Biological Aging: Evidence From a Mendelian Randomization Analysis

Journal of Cosmetic Dermatology, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 1, 2025

ABSTRACT Background The skin microbiota, a complex community of microorganisms residing on the skin, plays crucial role in maintaining health and overall homeostasis. Recent research has suggested that alterations composition function microbiota may influence aging process. However, causal relationships between specific biological remain unclear. Mendelian randomization (MR) analysis provides powerful tool to explore these links by utilizing genetic variants as instrumental variables, thereby minimizing confounding factors reverse causality often complicate observational studies. Methods We utilized two‐sample MR approach with population‐based cross‐sectional data from two German cohorts, KORA FF4 ( n = 324) PopGen 273). In total, GWAS summary 1656 samples datasets accelerated age were analyzed investigate relationship aging. primary was performed using inverse variance weighted (IVW) method random effects further supported MR‐Egger regression, Cochran's Q test, range sensitivity analyses. Results revealed for acceleration (BioageAccel), IVW identified protective certain including Alphaproteobacteria_Dry p 0.046), Asv033_sebaceous 0.043), Burkholderiales_Moist 0.008), Proteobacteria_Moist 0.042). Similar observed 0.045) 0.012) median analysis. contrast, Paracoccus_Moist 0.013) Proteobacteria_Sebaceous 0.005) associated When PhenoAge outcome, linked like Asv005_Dry 0.026), ASV039_Dry 0.003), Betaproteobacteria_Sebaceous 0.038), Chryseobacterium_Moist findings also ASV011_Dry 0.021), ASV023_Dry 0.040), Bacteroidales_Dry 0.022), Enhydrobacter_Moist 0.002), Rothia_Moist 0.038). Conclusions This study reveals potential confirm findings, randomized controlled trials (RCTs) are necessary.

Язык: Английский

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Prevention of microbial infections by postbiotic

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 427 - 436

Опубликована: Янв. 1, 2025

Язык: Английский

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Key players inducing skin diseases and skin aging and potential preventive or therapeutic strategies using phytochemicals

Deleted Journal, Год журнала: 2025, Номер unknown, С. 100073 - 100073

Опубликована: Фев. 1, 2025

Язык: Английский

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Evaluating the clinical and economic impact of ceramide-infused skin barriers in patients with Intestinal and urinary stomas: A systematic review and meta-analysis

Clinical Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Highlights•Ceramide-infused skin barriers (CIBs) reduce peristomal complications by 77% versus standard care.•Using CIBs cuts patient costs an average of $140,000 per patient.•Patients gain higher quality-adjusted life days, enhancing well-being and outcomes.•Gross domestic product healthcare spending are related to cost-effectiveness variability.AbstractPurposeCeramide-infused applied stoma care hold potential benefits, which thus far not summarized. This study aims summarize the literature on in patients with intestinal urinary stomas quantitatively compare clinical, economic, outcomes against (SOC) these patients.MethodsSystematic review random-effect meta-analysis following Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) statement, including meta-regression analyses explore sources heterogeneity. PubMed, CINAHL, Scopus, Web Science, Embase, Google Scholar, clinicaltrials.gov were searched studies published up November 2024. Studies involving any age or treated SOC. Outcomes included (PSCs), cost-effectiveness, days (QALDs).FindingsCIBs increased odds preventing PSCs compared SOC (OR = 1.77, 95% CI: 1.40, 2.23). Cost savings averaged -140,000 USD (95% -142,000 USD, -139,000 USD), although varied significantly (I² 100%, P < 0.001). Meta-regression identified gross (GDP) capita (β -7.31, 0.010) expenditure -169.33, 0.001) as key contributors cost variability. also improved QALDs (MD 0.35, 0.33, 0.37), quality life.ImplicationsCIBs PSCs, generate savings, improve QALDs, demonstrating widespread clinical adoption. However, economic benefits vary across systems, warranting further research into their long-term impact country-specific cost-effectiveness.

Язык: Английский

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Streptococcus thermophilus CNCM I-5570 lysate counteracts the aging process in human dermal fibroblast cells by neutralizing harmful free radicals and impacting antioxidant and anti-inflammatory pathways, thus restoring their physiological functions

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 185, С. 117975 - 117975

Опубликована: Март 12, 2025

Язык: Английский

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