Folia Microbiologica, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Язык: Английский
Biomedicines, Год журнала: 2025, Номер 13(4), С. 791 - 791
Опубликована: Март 25, 2025
The skin microbiome, a diverse and dynamic ecosystem of microorganisms, plays pivotal role in maintaining health by interacting with cells, immune components, structural barriers. It is essential for homeostasis, defense, protection against pathogenic colonization. Dysbiosis the microbiome has been implicated numerous dermatological conditions, including acne, eczema, psoriasis, rosacea. Acne, most prevalent condition, affects up to 85% individuals at some point their lives, while eczema psoriasis impose significant public economic burdens. composition varies across types anatomical sites, sebaceous, moist, dry areas fostering distinct microbial communities. Emerging therapeutic strategies such as microbiome-targeted treatments offer novel avenues addressing diseases. Among these approaches, postbiotics have gained attention safety efficacy. Unlike probiotics, are non-viable cells or metabolites, which reduce concerns providing functional benefits UV wound healing. This review consolidates current insights into disease, emphasizing promising strategy exploring clinical commercial potential microbiome-based treatments, particularly postbiotics, ability redefine care improve patient outcomes.
Язык: Английский
Процитировано
3
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Дек. 19, 2023
Postbiotics, which are bioactive substances derived from the metabolic processes of beneficial microbes, have received considerable attention in field microbiome science recent years, presenting a promising path for exploration and innovation. This comprehensive analysis looks into multidimensional terrain postbiotic production, including an extensive examination diverse classes, revealing their sophisticated mechanisms action highlighting future applications that might significantly affect human health. The authors thoroughly investigate various support ranging conventional fermentation procedures to cutting-edge enzyme conversion synthetic biology approaches. review, as acknowledgment field’s developing nature, not only highlights current achievements but also navigates through problems inherent production. In order successfully include postbiotics therapeutic interventions production functional food ingredients, emphasis is given critical elements, improving yields, bolstering stability, assuring safety. knowledge presented herein sheds light on expanding potential revolutionize development novel therapeutics ingredients.
Язык: Английский
Процитировано
39
The Journal of Microbiology, Год журнала: 2024, Номер 62(3), С. 181 - 199
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
11
Journal of Cosmetic Dermatology, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background The skin microbiota, a complex community of microorganisms residing on the skin, plays crucial role in maintaining health and overall homeostasis. Recent research has suggested that alterations composition function microbiota may influence aging process. However, causal relationships between specific biological remain unclear. Mendelian randomization (MR) analysis provides powerful tool to explore these links by utilizing genetic variants as instrumental variables, thereby minimizing confounding factors reverse causality often complicate observational studies. Methods We utilized two‐sample MR approach with population‐based cross‐sectional data from two German cohorts, KORA FF4 ( n = 324) PopGen 273). In total, GWAS summary 1656 samples datasets accelerated age were analyzed investigate relationship aging. primary was performed using inverse variance weighted (IVW) method random effects further supported MR‐Egger regression, Cochran's Q test, range sensitivity analyses. Results revealed for acceleration (BioageAccel), IVW identified protective certain including Alphaproteobacteria_Dry p 0.046), Asv033_sebaceous 0.043), Burkholderiales_Moist 0.008), Proteobacteria_Moist 0.042). Similar observed 0.045) 0.012) median analysis. contrast, Paracoccus_Moist 0.013) Proteobacteria_Sebaceous 0.005) associated When PhenoAge outcome, linked like Asv005_Dry 0.026), ASV039_Dry 0.003), Betaproteobacteria_Sebaceous 0.038), Chryseobacterium_Moist findings also ASV011_Dry 0.021), ASV023_Dry 0.040), Bacteroidales_Dry 0.022), Enhydrobacter_Moist 0.002), Rothia_Moist 0.038). Conclusions This study reveals potential confirm findings, randomized controlled trials (RCTs) are necessary.
Язык: Английский
Процитировано
1
Microorganisms, Год журнала: 2025, Номер 13(4), С. 814 - 814
Опубликована: Апрель 3, 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.
Язык: Английский
Процитировано
1
Immunological Investigations, Год журнала: 2024, Номер 53(3), С. 348 - 415
Опубликована: Янв. 19, 2024
Psoriasis is a chronic inflammatory disease characterized by squamous and erythematous plaques on the skin involvement of immune system. Global prevalence for psoriasis has been reported around 1–3% with higher incidence in adults similar proportions between men women. The risk factors associated are both extrinsic intrinsic, out which polygenic predisposition highlight latter. etiology not yet fully described, but several hypothesis have proposed: 1) autoimmunity based over-expression antimicrobial peptides such as LL-37, proteins ADAMTSL5, K17, hsp27, or lipids synthesized PLA2G4D enzyme, all may serve autoantigens to promote differentiation autoreactive lymphocytes T unleash response; 2) dysbiosis microbiota gained relevance due observations loss diversity participation pathogenic bacteria Streptococcus spp. Staphylococcus fungi Malassezia Candida virus HPV, HCV, HIV psoriatic plaques; 3) oxidative stress hypothesis, most recent one, describes that cell injury release proinflammatory mediators leads activate Th1/Th17 axis observed caused reactive oxygen species imbalance oxidant antioxidant mechanisms. This review aims describe mechanisms involved three hypotheses etiopathogeneses psoriasis.
Язык: Английский
Процитировано
9
Cosmetics, Год журнала: 2023, Номер 10(5), С. 142 - 142
Опубликована: Окт. 12, 2023
Lifestyle health has been recognized as an evidence-based innovation that defines how everyday behaviors and routines influence the avoidance therapy of illness provides important adjunctive component to overall health. Specifically, approach with small changes over time can have a dramatic impact on well-being individuals not only, in general, but also be applied skin However, lifestyle factors improve discussed extensively and/or well promulgated. The narrative for this overview focuses providing summary topic background information, more importantly, presents four dermal [i.e., factor 1: nutrition—diet; 2: rest (sleep); 3: movement/physical exercise, 4: social community associations]. This was accomplished by identifying preceding journal reports/reviews covering especially last five years (January 2018 July 2023; 164 out 205 references cited or 80%) using scientific search databases. main conclusions encourage concept such nutrition/diet, rest/sleep, community/social interactions support enhanced aging. Plus, media interventions aim promote dietary, sleep physical activity might application future.
Язык: Английский
Процитировано
15
Nutrients, Год журнала: 2024, Номер 16(20), С. 3559 - 3559
Опубликована: Окт. 20, 2024
Diet is one of the major determinants composition and function gut microbiome, diverse studies have established directional connections between microbiome dysbiosis skin dyshomeostasis. Furthermore, a significant link certain skin-related disorders has been reported. This work reviews mechanisms underlying relationship nutritional factors, diseases such as acne vulgaris, alopecia, atopic dermatitis. In addition, it explores how modulation human through diet various microbial strategies, including probiotics, synbiotics, postbiotics, fecal microbiota transplantation, may serve future treatments for diseases, possibly replacing traditional methods antibiotic, topical corticosteroid, laser therapies.
Язык: Английский
Процитировано
4
Deleted Journal, Год журнала: 2025, Номер unknown, С. 100073 - 100073
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 185, С. 117975 - 117975
Опубликована: Март 12, 2025
Язык: Английский
Процитировано
0