Phytochemicals
refer
to
a
large
group
of
non-nutritious
but
bioactive
compounds
derived
from
plant
foods
including
fruits,
vegetables,
and
grains.
Due
the
considerable
diversity
in
their
chemical
structures,
phytochemicals
can
be
divided
into
phenolic
compounds,
carotenoids,
terpenoids,
organosulfur
glucosinolates,
saponins,
phytoestrogens,
phytic
acid,
phytosterols,
etc.
are
not
only
important
for
growth,
also
helpful
plants
survive
under
various
environmental
stresses
resist
infections
viruses,
bacteria,
yeasts,
fungi.
At
same
time,
beneficial
roles
improving
human
health,
such
as
protecting
against
coronary
heart
disease,
diabetes,
cancers,
hypertension,
inflammation,
other
chronic
diseases,
have
gained
increasing
interest
recent
years.
In
this
chapter,
we
summarized
definition,
classification,
physicochemical
property,
pharmacokinetics,
biological
effects,
health
functions
phytochemicals.
Saudi Journal of Biological Sciences,
Год журнала:
2021,
Номер
28(10), С. 5823 - 5832
Опубликована: Июнь 19, 2021
The
ancient
Egyptians
practiced
medicine
with
highly
professional
methods.
They
had
advanced
knowledge
of
anatomy
and
surgery.
Also,
they
treated
a
lot
diseases
including
dental,
gynecological,
gastrointestinal,
urinary
disorders.
could
diagnose
diabetes
cancer.
used
therapeutics
extended
from
different
plants
to
include
several
animal
products
minerals.
Some
these
are
still
in
the
present
day.
Fortunately,
documented
their
life
details
by
carving
on
stone,
clay,
or
papyri.
Although
records
have
been
lost
destroyed,
surviving
documents
represent
huge
source
scientific
aspects
medicine.
This
review
article
is
an
attempt
understand
some
information
about
traditional
Egypt,
we
will
look
closely
at
basics,
sources
Egyptian
addition
common
this
great
civilization.
Molecules,
Год журнала:
2022,
Номер
27(13), С. 4060 - 4060
Опубликована: Июнь 24, 2022
Ethnopharmacology,
through
the
description
of
beneficial
effects
plants,
has
provided
an
early
framework
for
therapeutic
use
natural
compounds.
Natural
products,
either
in
their
native
form
or
after
crude
extraction
active
ingredients,
have
long
been
used
by
different
populations
and
explored
as
invaluable
sources
drug
design.
The
transition
from
traditional
ethnopharmacology
to
discovery
followed
a
straightforward
path,
assisted
evolution
isolation
characterization
methods,
increase
computational
power,
development
specific
chemoinformatic
methods.
deriving
extensive
exploitation
product
chemical
space
led
novel
compounds
with
pharmaceutical
properties,
although
this
was
not
analogous
drugs.
In
work,
we
discuss
ideas
silico
discovery,
applied
products.
We
point
out
that,
past,
starting
plant
itself,
identified
sustained
ethnopharmacological
research,
compound
analysis
testing.
contrast,
recent
years,
substance
pinpointed
methods
(in
docking
molecular
dynamics,
network
pharmacology),
identification
plant(s)
containing
ingredient,
existing
putative
information.
further
stress
potential
pitfalls
absolute
need
vitro
vivo
validation
requirement.
Finally,
present
our
contribution
products'
discussing
examples,
applying
whole
continuum
rapidly
evolving
field.
detail,
report
antiviral
compounds,
based
on
products
against
influenza
SARS-CoV-2
substances
GPCR,
OXER1.
Food & Function,
Год журнала:
2020,
Номер
12(2), С. 494 - 518
Опубликована: Дек. 17, 2020
Panax
ginseng
C.
A.
Meyer
(P.
ginseng)
has
a
long
history
of
medicinal
use
and
can
treat
variety
diseases.
P.
contains
active
ingredients,
such
as
saponins,
polypeptides,
volatile
oils,
polysaccharides.
Among
them,
saponins
have
always
been
considered
the
main
components
responsible
for
its
pharmacological
activities.
However,
more
studies
shown
that
polysaccharides
play
an
indispensable
role
in
value
ginseng.
Modern
biological
medical
found
complex
structural
characteristics
diverse
activities,
immune
regulation,
anti-tumor,
antioxidant,
hypoglycemic,
anti-radiation
functions,
among
others.
Additionally,
are
closely
related
to
their
activity.
In
this
review,
research
background,
extraction,
purification,
characteristics,
activities
from
different
parts
(roots,
flowers
stems
leaves,
berries)
under
growth
conditions
(artificially
cultivated
ginseng,
mountain
wild
summarized.
The
purified
were
reviewed.
Meanwhile,
introduced,
some
possible
mechanisms
listed.
Furthermore,
structure-activity
relationship
was
discussed.
Some
perspectives
study
also
provided.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(13), С. 6912 - 6912
Опубликована: Июнь 21, 2022
In
continuation
of
our
antecedent
work
against
COVID-19,
three
natural
compounds,
namely,
Luteoside
C
(130),
Kahalalide
E
(184),
and
Streptovaricin
B
(278)
were
determined
as
the
most
promising
SARS-CoV-2
main
protease
(Mpro)
inhibitors
among
310
naturally
originated
antiviral
compounds.
This
was
performed
via
a
multi-step
in
silico
method.
At
first,
molecular
structure
similarity
study
done
with
PRD_002214,
co-crystallized
ligand
Mpro
(PDB
ID:
6LU7),
favored
thirty
Subsequently,
fingerprint
respect
to
PRD_002214
resulted
election
sixteen
compounds
(7,
128,
130,
156,
157,
158,
180,
184,
203,
204,
210,
237,
264,
276,
277,
278).
Then,
results
docking
versus
PDB
6LU7
eight
(128,
278)
based
on
their
binding
affinities.
toxicity
studies
for
revealed
that
all
them
have
good
profiles.
Finally,
dynamic
(MD)
simulation
experiments
carried
out
278,
which
exhibited
best
modes
Mpro.
MD
tests
luteoside
(130)
has
greatest
potential
inhibit
protease.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(15), С. 8407 - 8407
Опубликована: Июль 29, 2022
Among
a
group
of
310
natural
antiviral
metabolites,
our
team
identified
three
compounds
as
the
most
potent
inhibitors
against
SARS-CoV-2
main
protease
(PDB
ID:
5R84),
Mpro.
The
are
sattazolin
and
caprolactin
A
B.
validated
multistage
in
silico
study
was
conducted
using
several
techniques.
First,
molecular
structures
selected
metabolites
were
compared
with
that
GWS,
co-crystallized
ligand
Mpro,
structural
similarity
study.
aim
this
to
determine
thirty
similar
(10%)
may
bind
Mpro
GWS.
Then,
docking
pharmacophore
studies
led
choice
five
exhibited
good
binding
modes
fit
values
generated
model.
them,
chosen
according
ADMET
studies.
promising
inhibitor
determined
by
toxicity
DFT
be
(292).
Finally,
dynamics
(MD)
simulation
performed
for
confirm
obtained
results
understand
thermodynamic
characteristics
binding.
It
is
hoped
accomplished
could
represent
positive
step
battle
COVID-19
through
further
vitro
vivo
on
compounds.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 15
Опубликована: Апрель 20, 2022
Ginsenosides
are
a
class
of
active
components
extracted
from
ginseng
plants
(such
as
Panax
ginseng,
quinquefolium,
and
notoginseng).
have
significant
protective
effects
on
the
nervous
system,
cardiovascular
immune
so
they
been
widely
used
in
treatment
related
diseases.
Entry
variety
endogenous
or
exogenous
harmful
substances
into
body
can
lead
to
an
imbalance
between
antioxidant
defense
system
reactive
oxygen
species,
thus
producing
toxic
tissues
cells.
In
addition,
oxidative
stress
alter
multiple
signaling
pathways,
including
Keap1/Nrf2/ARE,
PI3K/AKT,
Wnt/β-catenin,
NF-κB
pathways.
With
deepening
research
this
field,
various
ginsenoside
monomers
reported
exert
through
pathways
good
application
prospects.
This
article
summarized
advancements
regarding
antioxidative
mechanisms
ginsenosides,
providing
theoretical
basis
for
experimental
clinical
with
ginsenosides.
