Double-Network Chitosan-Based Hydrogels with Improved Mechanical, Conductive, Antimicrobial, and Antibiofouling Properties

Gels, Год журнала: 2023, Номер 9(4), С. 278 - 278

Опубликована: Март 29, 2023

In recent years, the antimicrobial activity of chitosan-based hydrogels has been at forefront research in wound healing and prevention medical device contamination. Anti-infective therapy is a serious challenge given increasing prevalence bacterial resistance to antibiotics as well their ability form biofilms. Unfortunately, hydrogel biocompatibility do not always meet demands biomedical applications. As result, development double-network could be solution these issues. This review discusses most techniques for creating with improved structural functional properties. The applications are also discussed terms tissue recovery after injuries, infection prevention, biofouling devices surfaces pharmaceutical

Язык: Английский

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A novel transdermal delivery route for energy supplements: Electrospun chitosan/polyvinyl alcohol nanofiber patches loaded with vitamin B12

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123187 - 123187

Опубликована: Янв. 7, 2023

Язык: Английский

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Analyzing Mushroom Structural Patterns of a Highly Compressible and Expandable Hemostatic Foam for Gastric Perforation Repair

Advanced Science, Год журнала: 2024, Номер 11(21)

Опубликована: Март 4, 2024

Abstract Nature presents the most beautiful patterns through evolving. Here, a layered porous pattern in golden ratio (0.618) is reported from type of mushroom ‐ Dictyophora Rubrovalvata stipe (DRS). The hierarchical structure shows mathematical correlation with ratio. This unique leads to superior mechanical properties. gradient outside innermost endows it asymmetrical hydrophilicity. A model then developed predict and apply 3D printed structures. explored repair gastric perforation because stomach continuous peristaltic organ, perforated site subject repeated movements pressure changes. At present, endoscopic clipping ineffective treating ulcerative fragile surrounding tissues. Although implant occlusion provides new direction for treatment ulcers, but metal or plastic occluder needs be removed, requiring second intervention. Decellularized DRS (DDRS) found asymmetric water absorption rate, super‐compressive elasticity, shape memory, biocompatibility, making suitable perforation. efficacy blocking promoting healing confirmed by observation tissue analysis during 2‐month study.

Язык: Английский

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Preparation techniques, functional properties, and applications of nanochitin in food and agriculture: A review

Trends in Food Science & Technology, Год журнала: 2024, Номер 148, С. 104525 - 104525

Опубликована: Май 6, 2024

Язык: Английский

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Polymeric Materials for Hemostatic Wound Healing

Pharmaceutics, Год журнала: 2021, Номер 13(12), С. 2127 - 2127

Опубликована: Дек. 9, 2021

Hemorrhage is one of the greatest threats to life on battlefield, accounting for 50% total deaths. Nearly 86% combat deaths occur within first 30 min after wounding. While external wound injuries can be treated mostly using visual inspection, abdominal or internal hemorrhages are more challenging treat with regular hemostatic dressings because deep wounds and points injury that cannot located properly. The need trauma from limbs, abdomen, liver, stomach, colon, spleen, arterial, venous, and/or parenchymal hemorrhage accompanied by severe bleeding requires an immediate solution responders apply reduce rapid exsanguinations wounds, including in military operations. This necessitates development a unique, easy-to-use, FDA-approved treatment deliver agent less than s stop 1 2 at point without application manual pressure wounded area.

Язык: Английский

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Chitin derivatives ameliorate DSS-induced ulcerative colitis by changing gut microbiota and restoring intestinal barrier function

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 202, С. 375 - 387

Опубликована: Янв. 19, 2022

Язык: Английский

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Application Progress of Modified Chitosan and Its Composite Biomaterials for Bone Tissue Engineering

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(12), С. 6574 - 6574

Опубликована: Июнь 12, 2022

In recent years, bone tissue engineering (BTE), as a multidisciplinary field, has shown considerable promise in replacing traditional treatment modalities (i.e., autografts, allografts, and xenografts). Since is such complex dynamic structure, the construction of composite materials become an attractive strategy to guide growth regeneration. Chitosan its derivatives have been promising vehicles for BTE owing their unique physical chemical properties. With intrinsic physicochemical characteristics closeness extracellular matrix bones, chitosan-based scaffolds proved be candidate providing successful regeneration defect repair capacity. Advances produced efficient efficacious bio-properties via material structural design different modifications. Efforts put into modification chitosan overcome limitations, including insolubility water, faster depolymerization body, blood incompatibility. Herein, we discuss various methods that expand fields application, which would pave way future applied research biomedical innovation regenerative medicine.

Язык: Английский

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Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials

Bioactive Materials, Год журнала: 2023, Номер 27, С. 574 - 593

Опубликована: Май 15, 2023

This opinion-led review paper highlights the need for novel translational research in vital-pulp-treatment (VPT), but also discusses challenges translating evidence to clinics. Traditional dentistry is expensive, invasive and relies on an outmoded mechanical understanding of dental disease, rather than employing a biological perspective that harnesses cell activity regenerative-capacity. Recent has focussed developing minimally-invasive biologically-based 'fillings' preserve pulp; shifting paradigm from expensive high-technology dentistry, with high failure rates, smart restorations targeted at processes. Current VPTs promote repair by recruiting odontoblast-like cells material-dependent process. Therefore, exciting opportunities exist development next-generation biomaterials regenerative processes dentin-pulp complex. article analyses recent using pharmacological-inhibitors therapeutically-target histone-deacetylase (HDAC) enzymes dental-pulp-cells (DPCs) stimulate pro-regenerative effects limited loss viability. Consequently, HDAC-inhibitors have potential enhance biomaterial-driven tissue responses low concentration influencing cellular minimal side-effects, providing opportunity develop topically-placed, inexpensive bio-inductive pulp-capping material. Despite positive results, clinical translation these innovations requires enterprise counteract regulatory obstacles, dental-industry priorities strong academic/industry partnerships. The aim this discuss role therapeutically-targeting epigenetic modifications as part topical VPT strategy treatment damaged pulp, while considering next steps, material considerations, future therapeutics or other 'smart' VPT.

Язык: Английский

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Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Microbiology Spectrum, Год журнала: 2023, Номер 11(2)

Опубликована: Март 28, 2023

Effects of Clostridium butyricum and chitooligosaccharides (COS), singly in synbiotic combination, were evaluated a C57BL/6 mouse model dextran sulfate (DSS)-induced acute ulcerative colitis (UC). Treatment with C. and/or COS ameliorated UC symptoms vivo, the strongest effects observed for combination terms reduced mortality rates disease activity indices, increased body weight colon length, improved histological features. The achieved following: (i) regulated levels inflammation-related cytokines (tumor necrosis factor alpha [TNF-α], interleukin-1β [IL-1β], IL-6, IL-10) had stronger anti-inflammatory effect than either component alone, based on inhibition Toll-like receptor 4 (TLR-4)/NF-κB/MAPK signaling pathway activation; (ii) enhanced intestinal barrier function by restoring tight junction proteins (occludin, claudin-1, ZO-1) MUC2; (iii) abundance diversity beneficial bacteria (gut microbiota) pathogenic bacteria; (iv) production short-chain fatty acids. Our findings indicate that has strong potential as therapeutic adjuvant UC. IMPORTANCE Ulcerative (UC), an idiopathic characterized continuous remission/relapse inflammatory cycles colonic mucosal layer, adverse patients' quality life considerable costs health care systems. Probiotics, prebiotics, synbiotics are regarded agents UC, safety efficacy. In this study, we present detailed evaluation DSS-induced composed (molecular [MW], 2,500 Da). We found synergistic (synbiotic) action is more effective alone prevention therapy regulating gut microbiota function. development anti-UC drugs or pharmaceutical, food, livestock industries. Highlights include following. clinical morphology. displayed antioxidant effects. expression proteins. inhibited TRL-4/NF-κB/MAPK pathway. (v) modulated composition.

Язык: Английский

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Material matters: exploring the interplay between natural biomaterials and host immune system

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Окт. 23, 2023

Biomaterials are widely used for various medical purposes, instance, implants, tissue engineering, devices, and drug delivery systems. Natural biomaterials can be obtained from proteins, carbohydrates, cell-specific sources. However, when these introduced into the body, they trigger an immune response which may lead to rejection failure of implanted device or tissue. The system recognizes natural as foreign substances triggers activation several cells, macrophages, dendritic T cells. These cells release pro-inflammatory cytokines chemokines, recruit other implantation site. inflammatory response, beneficial detrimental, depending on type biomaterial extent response. also influence by modulating behavior For example, with specific surface properties, such charge hydrophobicity, affect differentiation Additionally, engineered immunomodulatory factors, anti-inflammatory cytokines, promote a tolerogenic In conclusion, interaction between body’s is intricate procedure potential consequences effectiveness therapeutics devices. A better understanding this interplay help design that favorable responses minimize adverse reactions.

Язык: Английский

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