Journal of Animal Science and Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 1, 2024
The
main
objective
of
this
study
was
to
investigate
the
effects
pollen
patty
with
supplementation
different
concentrations
curcumin-steviol
glycoside
complex
(CSG)
in
<italic>Apis
mellifera
</italic>(<italic>A.
mellifera</italic>).
Twelve
colonies
<italic>A.
mellifera</italic>
were
conducted
from
July
10th
August
21st
for
42
days.
assigned
four
dietary
treatments
3
replicates
equal
size
as
follows:
(NC,
no
patty;
PC,
basal
T1,
diets
+
0.04%
CSG;
T2,
0.08%
CSG).
percentage
CSG
calculated
based
on
total
weight
patties.
Thorax
significantly
increased
(<italic>p</italic>
<
0.05)
T2
diet
compared
NC
and
PC
diet.
There
significant
difference
>
patties
consumption
among
diets.
T1
showed
higher
honey
production
than
Also,
brood
area
at
28
In
addition,
areas
catalase
superoxide
dismutase
(SOD)
1
gene
expression
thioredoxin
reductase
(Trxr)
diet,
decreased
order
SOD2
(<italic>p
</italic><
lower
Therefore,
might
be
ideal
strategy
improve
</italic>performances.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 13, 2023
Mitochondria
are
the
primary
source
of
energy
production
in
cells,
supporting
metabolic
demand
tissue.
The
dysfunctional
mitochondria
implicated
various
diseases
ranging
from
neurodegeneration
to
cancer.
Therefore,
regulating
offers
a
new
therapeutic
opportunity
for
with
mitochondrial
dysfunction.
Natural
products
pleiotropic
and
readily
obtainable
sources
agents,
which
have
broad
prospects
drug
discovery.
Recently,
many
mitochondria-targeting
natural
been
extensively
studied
shown
promising
pharmacological
activity
Hence,
we
summarize
recent
advances
targeting
dysfunction
this
review.
We
discuss
terms
their
mechanisms
on
dysfunction,
including
modulating
quality
control
system
functions.
In
addition,
describe
future
perspective
challenges
development
products,
emphasizing
potential
value
Applied Organometallic Chemistry,
Год журнала:
2024,
Номер
38(5)
Опубликована: Март 5, 2024
As
clinically
used
anticancer
Pt(II)
drugs
have
severe
side
effects,
there
is
a
growing
interest
for
new
metal
complexes
with
great
potential
cancer
therapy.
The
current
work
aimed
to
prepare
and
characterize
Pd(II)
saccharinate
(sac)
bearing
pyridyl‐
benzyldiphenylphosphines
(PPh
2
Py
PPh
Bz,
respectively),
cis
‐[Pd(sac)
Py)
]
(
1
),
‐[PtCl(sac)(PPh
]·0.5DMF
Bz)
]·DMF
3
)
trans
4
as
promising
antiangiogenic
drugs.
activity
of
the
was
screened
against
seven
cell
lines
including
HCT116
(colon),
HepG2
(liver),
MDA‐MB‐231
(breast),
PANC‐1
(pancreatic),
A549
(lung),
C6
(glioma),
DU145
(prostate)
normal
human
lung
epithelial
cells
(BEAS‐2B).
did
not
show
biological
below
20
μM
at
48
h,
whereas
displayed
significant
cytotoxic
effect
on
cells.
most
potent
complex
(IC
50
=
2.2–12.1
μM)
much
greater
cytotoxicity
than
cisplatin
in
all
lines.
caused
apoptosis
evidenced
by
annexin
V
positivity
caspase
3/7
assays.
Furthermore,
inhibition
antiapoptotic
Bcl‐2
proteins
suggested
intrinsic
apoptosis.
In
addition,
greatly
enhanced
generation
intracellular
reactive
oxygen
species
(ROS)
consequently
remarkable
DNA
double‐strand
breaks
Moreover,
chick
chorioallantoic
membrane
(CAM)
assay
evaluate
.
effectively
inhibited
angiogenesis
dose
ng,
suggesting
it
multi‐targeted
agent
treatment.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Май 7, 2024
Abstract
Metal
complexes
have
recently
attracted
a
lot
of
attention,
particularly
as
anticancer
and
antibacterial
agents,
owing
to
their
versatile
mechanisms
easily
tunable
characteristics.
However,
the
application
such
compounds
in
medical
context,
especially
cancer
treatment,
has
been
hampered
due
limited
solubility
stability
water
aqueous
solutions,
well
lack
selectivity.
To
address
these
limitations,
several
approaches
developed
improve
targeted
delivery
solubility.
The
first
strategy
involves
physical
encapsulation
metal
within
carriers
facilitate
controlled
drug
release.
second
covalently
linking
polymers,
creating
prodrugs
that
can
be
converted
active
drugs
at
more
controllable
rate.
Despite
increasing
variety
polymers
available,
need
develop
those
able
metabolized
by
body,
producing
non‐toxic
residues,
remains
crucial
for
effective
area
diseases
cancer.
In
this
perspective
article,
an
overview
recent
developments
using
biodegradable
therapy
is
provided.
It
specifically
highlighting
how
formed
nanoparticles
(NPs)
enhance
selectivity
toxicity
toward
cells
compared
parent
complex,
while
simultaneously
reducing
harmful
side
effects
traditional
chemotherapies,
opening
door
them
combination
therapies
(PDT,
PTT).
Anticancer
agents
that
exhibit
catalytic
mechanisms
of
action
offer
a
unique
multi-targeting
strategy
to
overcome
drug
resistance.
Nonetheless,
many
in-cell
catalysts
in
development
are
hindered
by
deactivation
endogenous
nucleophiles.
We
have
synthesised
highly
potent,
stable
Os-based
16-electron
half-sandwich
('piano
stool')
catalyst
introducing
permanent
covalent
tether
between
the
arene
and
chelated
diamine
ligand.
This
exhibits
antiproliferative
activity
comparable
clinical
cisplatin
towards
triple-negative
breast
cancer
cells
can
tamoxifen
Speciation
experiments
revealed
Os
be
almost
exclusively
albumin-bound
extracellular
medium,
while
cellular
accumulation
studies
identified
an
energy-dependent,
protein-mediated
pathway,
consistent
with
albumin-mediated
uptake.
Importantly,
tethered
complex
was
active
for
transfer
hydrogenation
catalysis,
initiated
co-administration
non-toxic
dose
sodium
formate
as
source
hydride,
indicating
is
delivered
cytosol
intact.
The
mechanism
involves
generation
reactive
oxygen
species
(ROS),
thus
exploiting
inherent
redox
vulnerability
cells,
accompanied
selectivity
cancerous
over
non-tumorigenic
cells.
Results in Chemistry,
Год журнала:
2023,
Номер
6, С. 101179 - 101179
Опубликована: Окт. 27, 2023
Three
prominent
health
challenges
affecting
our
society
include
cancer,
diabetes,
and
antibiotic-resistant
infections.
Despite
the
availability
of
conventional
drugs
for
these
conditions,
pervasive
problem
multidrug
resistance
significantly
diminishes
their
effectiveness.
Consequently,
it
is
paramount
to
prioritize
development
novel
drug
compounds
endowed
with
improved
desirable
therapeutic
properties.
Utilizing
metal-based
has
proven
be
an
effective
strategy
in
realm
anticancer
treatment
this
approach
holds
significant
promise
enhanced
multi-resistant
infections
diabetes.
Schiff
bases,
being
bioactive
organic
compounds,
have
attracted
considerable
attention.
Researchers
been
actively
exploring
potential
applications
metallo-based
including
heterocyclic
molecules
and/or
aromatic
rings
adorned
diverse
functional
groups
across
various
illnesses.
This
review
catalogs
(2010
2023)
classification
base
that
incorporate
groups,
which
possess
antimicrobial,
antidiabetic,
qualities.
These
insights
can
assist
medical
chemist
identifying
suitable
candidates
developing
innovative
pharmaceuticals.
Drug Development Research,
Год журнала:
2024,
Номер
85(7)
Опубликована: Сен. 27, 2024
Abstract
To
inhibit
the
growth
and
metastasis
of
triple‐negative
breast
cancer
(TNBC),
two
Fe(III)
thiosemicarbazone
complexes
(
Fe1
Fe2
)
were
designed
synthesized.
The
structures
characterized
by
single
crystal
X‐ray
diffraction.
antiproliferative
activity
against
four
lines
(MDA‐MB‐231,
T98G,
HepG2,
143B)
human
renal
proximal
tubular
epithelial
cell
line
(HK‐2)
was
evaluated
MTT
assay.
Among
all
cells,
showed
significant
cytotoxicity
to
TNBC
cells
(MDA‐MB‐231),
with
an
IC
50
value
12.38
μM.
Furthermore,
less
toxicity
HK‐2
cells.
can
produce
excess
reactive
oxygen
species,
decrease
mitochondrial
membrane
potential,
induce
DNA
damage,
then
lead
apoptosis
MDA‐MB‐231
In
addition,
also
migration
invasion
This
study
provides
guidance
for
development
metal
that
TNBC.
