Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications

Polymers, Год журнала: 2022, Номер 14(5), С. 1032 - 1032

Опубликована: Март 4, 2022

The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues organs for repair or replacement. Due their large surface area ability interact with proteins peptides, graphene oxides offer valuable physiochemical biological features biomedical applications have been successfully employed optimizing scaffold architectures a wide range organs, from the skin cardiac tissue. This review critically focuses on opportunities employ protein-graphene oxide structures either nanocomposites biocomplexes highlights effects carbonaceous nanostructures protein conformation structural stability in regenerative medicine. Herein, recent activity nanocomposite bioconjugates are analyzed respect cell viability proliferation, along these constructs sustain formation new Novel strategies approaches based stem therapy, well involvement extracellular matrix design smart nanoplatforms, discussed.

Язык: Английский

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Research on Graphene and Its Derivatives in Oral Disease Treatment

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 4737 - 4737

Опубликована: Апрель 25, 2022

Oral diseases present a global public health problem that imposes heavy financial burdens on individuals and health-care systems. Most oral conditions can be treated in their early stage. Even if the symptoms of do not seem to cause significant discomfort, prompt treatment is essential for preventing progression. Biomaterials with superior properties enable dental therapies applications restoration, therapeutic drug/protein delivery, tissue regeneration. Graphene nanomaterials have many unique mechanical physiochemical respond complex microenvironment, which includes microbiota colonization high masticatory force. Research graphene dentistry, especially caries, periodontitis therapy, implant coatings, progressing rapidly. Here, we review development its derivatives disease therapy.

Язык: Английский

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Recent advances and challenges in graphene‐based nanocomposite scaffolds for tissue engineering application

Journal of Biomedical Materials Research Part A, Год журнала: 2022, Номер 110(10), С. 1695 - 1721

Опубликована: Июнь 28, 2022

Abstract Graphene‐based nanocomposites have recently attracted increasing attention in tissue engineering because of their extraordinary features. These biocompatible substances, the presence an apt microenvironment, can stimulate and sustain growth differentiation stem cells into different lineages. This review discusses characteristics graphene its derivatives, such as excellent electrical signal transduction, carrier mobility, outstanding mechanical strength with improving surface characteristics, self‐lubrication, antiwear properties, enormous specific area, ease functional group modification. Moreover, safety issues application derivatives terms biocompatibility, toxicity, interaction immune are discussed. We also describe applicability graphene‐based healing organ regeneration, particularly bone, cartilage, teeth, neurons, heart, skeletal muscle, skin. The impacts special textural structural nanomaterials on regeneration various tissues highlighted. Finally, present gives some hints future research for transformation these exciting materials clinical studies.

Язык: Английский

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Spotlighting graphene-based nanomaterials for the mitigation of hazardous water pollutants: A review

Inorganic Chemistry Communications, Год журнала: 2024, Номер 166, С. 112618 - 112618

Опубликована: Май 31, 2024

Язык: Английский

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Nanoceria-GO-intercalated multicellular spheroids revascularize and salvage critical ischemic limbs through anti-apoptotic and pro-angiogenic functions

Biomaterials, Год журнала: 2022, Номер 292, С. 121914 - 121914

Опубликована: Ноя. 14, 2022

Язык: Английский

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Progress in the application of graphene and its derivatives to osteogenesis

Heliyon, Год журнала: 2023, Номер 9(11), С. e21872 - e21872

Опубликована: Ноя. 1, 2023

As bone and joint injuries from various causes become increasingly prominent, how to effectively reconstruct repair defects presents a difficult problem for clinicians researchers. In recent years, graphene its derivatives have been the subject of growing body research found promote proliferation osteogenic differentiation stem cells. This provides new idea solving clinical defects. However, as numerous articles address aspects not fully systematized, there is an urgent need classify summarize them. this paper, first time, effects on cells in solution, 2D 3D structures vivo their possible mechanisms are reviewed, cytotoxic were summarized analyzed. The toxicity further reviewed. addition, we suggest future development directions tissue engineering applications provide reference application.

Язык: Английский

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Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior – A Systematic Literature Review

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6201 - 6228

Опубликована: Июнь 1, 2024

Abstract: Due to their ability replicate the in vivo microenvironment through cell interaction and induce cells stimulate function, three-dimensional culture models can overcome limitations of two-dimensional models. Organoids are 3D that demonstrate natural structure an organ. In most organoid tissue cultures, matrigel made a mouse tumor extracellular matrix protein mixture is essential ingredient. However, its tumor-derived origin, batch-to-batch variation, high cost, safety concerns have limited usefulness drug development regenerative medicine. Its clinical application has also been hindered by fact generation dependent on use poorly defined matrices. Therefore, optimization crucial step developing introduces alternatives as different materials. Recently, variety substitute materials reportedly replaced matrigel. The purpose this study review significance latest advances for applications how they enhance build network systems generating proper behavior. Excellence behavior evaluated from characteristics, proliferation, differentiation, even gene expression. As result, graphene oxide demonstrated potency Graphene promote good well known having biocompatibility. Hence, provide opportunities future advanced Keywords: organoid, culture, graphene, matrigel, alternative behavior, host-pathogen

Язык: Английский

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A new graphene-based nanomaterial increases lipolysis and reduces body weight gain through integrin linked kinase (ILK)

Biomaterials Science, Год журнала: 2023, Номер 11(14), С. 4916 - 4929

Опубликована: Янв. 1, 2023

Graphene-based GMC binds to integrinβ1/ILK cluster reduce adipocyte triglyceride storage in hypertrophied subcutaneous adipose tissue and increases, turn, ILK expression lipolysis.

Язык: Английский

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The Role of Mitochondrial Homeostasis in Mesenchymal Stem Cell Therapy—Potential Implications in the Treatment of Osteogenesis Imperfecta

Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1297 - 1297

Опубликована: Сен. 29, 2024

Osteogenesis imperfecta (OI) is a hereditary disorder characterized by bones that are fragile and prone to breaking. The efficacy of existing therapies for OI limited, they associated with potentially harmful side effects. primarily due mutation collagen type I hence impairs bone regeneration. Mesenchymal stem cell (MSC) therapy an attractive strategy take advantage the potential benefits these multipotent cells address underlying molecular defects differentiating osteoblasts, paracrine effects, or immunomodulation. maintenance mitochondrial homeostasis essential component improving curative MSCs in affecting differentiation, signaling, immunomodulatory functions MSCs. In this review, we highlight MSC-based pathway introduce MSC regulation mechanism homeostasis. Strategies aiming modulate metabolism reduce oxidative stress, as well innovative strategies based on use compounds (resveratrol, NAD+, α-KG), antioxidants, nanomaterials, analyzed. These findings may enable development new treatment OI, ultimately resulting improved patient outcomes.

Язык: Английский

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Carbon-based nanocomposite decorated with bioactive glass and CoNi2S4 nanoparticles with potential for bone tissue engineering

OpenNano, Год журнала: 2022, Номер 8, С. 100102 - 100102

Опубликована: Ноя. 1, 2022

In this work, for the first time, different forms of nanocomposites based on rGO and MWCNT were prepared in conjoining with bioactive glass (BioGlass). carbonic layers, a highly toxic nanoparticle, CoNi2S4, was intercalated, role nanoparticle alkaline phosphatase activity, relative cell viability lines, also effect walls morphologies investigated. From another perspective, ability chemotherapy drug loading to investigated, use leaf extracts thought as green method lower cytotoxicity regulate genotoxicity generated nanocomposite. The results showed that without had higher than drug-loaded nanocomposites. reached new range when extract applied surface. Thus, utilizing raise would be considered novel unique technique. ALP activity nanocomposites, along nanoparticles, promising appropriate cell-seeded factors. regard, morphology cells after seeding treatment each other hBMSCs HEK-293 lines findings demonstrated shape has significantly changed result wall degradations aggregations; treated line's morphology, however, shows no significant changes 4 h.

Язык: Английский

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