Environmental Science and Pollution Research, Год журнала: 2024, Номер 31(13), С. 19396 - 19408
Опубликована: Фев. 15, 2024
Язык: Английский
Chinese Journal of Natural Medicines, Год журнала: 2024, Номер 22(3), С. 195 - 211
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
108
Food Science & Nutrition, Год журнала: 2024, Номер 12(5), С. 3097 - 3111
Опубликована: Фев. 16, 2024
Abstract Liver diseases, encompassing conditions such as cirrhosis, present a substantial global health challenge with diverse etiologies, including viral infections, alcohol consumption, and non‐alcoholic fatty liver disease (NAFLD). The exploration of natural compounds therapeutic agents has gained traction, notably the herbal remedy milk thistle ( Silybum marianum ), its active extract, silymarin, demonstrating remarkable antioxidant hepatoprotective properties in extensive preclinical investigations. It can protect healthy cells or those that have not yet sustained permanent damage by reducing oxidative stress mitigating cytotoxicity. Silymarin, compound properties, anti‐inflammatory effects, antifibrotic activity, shown potential treating caused alcohol, NAFLD, drug‐induced toxicity, hepatitis. Legalon® is top‐rated medication excellent oral bioavailability, effective absorption, effectiveness. Its component, Eurosil 85® also, commercial product, lipophilic enhanced special formulation processes. during clinical trials, shows improvements function, reduced mortality rates, alleviation symptoms across various disorders, safety assessments showing low adverse effects. Overall, silymarin emerges promising multifaceted diseases.
Язык: Английский
Процитировано
21
Egyptian Liver Journal, Год журнала: 2023, Номер 13(1)
Опубликована: Март 29, 2023
Abstract Background Natural bioactive components derived from plant secondary metabolites have been pronounced as valuable alternatives for anticipating and subsiding hepatotoxic effects its chronic complications based on experimental verification. The focus of this review is to elucidate the commonly used modern medicine treatment liver disease how major phytoconstituents tested hepatoprotective activity, mechanism action some promising agents natural sources, clinical trial data treating in patients with different diseases by aid phytoconstituents. Main text shows fifteen isolated phytoconstituents, their biological chemical structures, utilized parts, type extracts used, assay method, possible hepatoprotection. Nine leads sources chemistry are mentioned briefly. further includes recent studies outcome patients. Scientific revealed that antioxidant properties central subside pathways upsurging defense system cells, scavenging free radicals, down surging lipid peroxidation, improving anti-inflammatory potential, protecting hepatic cell injury. In review, we summarize development product-based curative potential various sort diseases. Furthermore, usefulness hit lead molecules significant benefit discover new drug molecule downsizing problems medication chemical-induced extrapolated. Conclusion Further research encouraged pharmacological principle these natural-based which will stimulate future pharmaceutical therapeutically beneficial regimens.
Язык: Английский
Процитировано
36
Phytomedicine, Год журнала: 2023, Номер 122, С. 155142 - 155142
Опубликована: Окт. 11, 2023
Язык: Английский
Процитировано
34
Journal of Functional Foods, Год журнала: 2023, Номер 104, С. 105502 - 105502
Опубликована: Март 21, 2023
Cancer is identified as second leading causes of death and imposes a significant psychological economic burden on societies. Due to its high prevalence, main cause worldwide, there continuing need discover new potential anticancer compounds. Plant-derived compounds have recently attracted more attention among researchers for their potent anti-cancer properties. A numerous research, including in-vitro, in-vivo, preclinical, clinical, epidemiological studies, has indicated that the flavonoid silymarin comprehensive preventive therapeutic effects array inflammation-driven diseases, cancer. Silymarin clear activities through distinctive mechanisms modulation apoptosis in-vitro survival in-vivo. The chemoprotection constituent suggest they could be promising agents in various cancer types. This review focus vivo vitro variety cancers, explores signaling pathways modulated by this compound.
Язык: Английский
Процитировано
29
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134809 - 134809
Опубликована: Авг. 16, 2024
Язык: Английский
Процитировано
12
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(9), С. 7017 - 7036
Опубликована: Апрель 17, 2024
Язык: Английский
Процитировано
11
Phytotherapy Research, Год журнала: 2024, Номер 38(5), С. 2572 - 2593
Опубликована: Март 12, 2024
Abstract It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review dose–response meta‐analysis assessed the impact of SIL administration certain hepatic, renal, oxidative stress markers. A search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled (RCTs) evaluated effects markers were included. random‐effects model used for analysis 41 RCTs The pooled results indicated led a significant reduction serum levels alkaline phosphatase, alanine transaminase, creatinine, aspartate aminotransferase, along substantial elevation glutathione SIL‐treated group compared their untreated counterparts. In addition, there nonsignificant decrease gamma‐glutamyl transferase, malondialdehyde (MDA), total bilirubin, albumin (Alb), antioxidant capacity, blood urea nitrogen. Sub‐group analyses revealed considerable decline MDA Alb values among participants disease longer duration (≥12 weeks). These findings suggest may ameliorate potential hepatoprotective effects, specifically long‐term high‐dose supplementation. However, its nephroprotective not observed. Additional high‐quality durations are required determine clinical efficacy renal
Язык: Английский
Процитировано
10
Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.
Язык: Английский
Процитировано
2
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 21, 2025
Abstract Cancer, one of the deadliest diseases, has remained epicenter biological research for more than seven decades. Yet all efforts a perfect therapeutic cure come with certain limitations. The use medicinal plants and their phytochemicals as therapeutics received much attention in recent years. Silymarin, polyphenolic flavonoid variety anti-cancerous properties, was isolated from plant Silybum marianum . present review centres on function silymarin controlling important signalling pathways related to apoptosis survival, such JAK/STAT pathway, PI3K/Akt/mTOR, Bcl-2/Bax, Fas/FasL. It is emphasised that silymarin's capacity target these key mechanism behind its anticancer effects against malignancies. By upregulating pro-apoptotic downregulating anti-apoptotic proteins, controls series events result tumor suppression cell death cancer types. low bioavailability limited efficacy are improved by application various nano-delivery systems. As efficient carriers, liposomes, polymeric micelles, lipid- metal-based nanoparticles, increase solubility distribution tissues. Lastly, number preclinical studies provide basis upcoming interventions highlighted review, providing encouraging directions additional advancement.
Язык: Английский
Процитировано
1