ABSTRACT
Natural
polymers
have
recently
been
investigated
for
various
applications,
such
as
3D
printing
and
healthcare,
including
treating
infections.
Among
microbial
infections,
fungal
diseases
remain
overlooked,
with
limited
therapeutic
options
high
recurrence.
Cutaneous
cryptococcosis
is
an
opportunistic
infection
triggered
by
mechanical
inoculation
or
hematogenous
dissemination
of
the
yeast
that
causes
cryptococcal
pneumonia
meningitis.
Every
year,
Cryptococcus
neoformans
endanger
lives
immunosuppressed
hosts,
resulting
in
180,000
deaths
per
year.
Nonetheless,
healthy
individuals
can
also
be
affected
this
infection.
Cryptococcosis
has
a
restricted
expensive
regimen
no
topical
approach
to
skin
manifestations.
This
study
sought
create
printable
biodegradable
polymeric
hydrogel
carrying
ketoconazole,
low‐cost
antifungal
drug
reported
anticryptococcal
activity.
The
developed
exhibited
good
printability
rheological
properties,
pseudoplastic
behavior.
FTIR
spectra
cross‐linked
hydrogels
revealed
interactions
between
alginate
Ca
+2
,
referred
egg‐box
model,
indicated
decrease
peaks
at
1600
1410
cm
−1
.
Furthermore,
loaded
ketoconazole
showed
remarkable
activity
against
C.
strains
inhibition
zones,
which
cross‐linking
did
not
seem
affect
its
performance.
material
remained
structurally
stable
up
12
days
(288
h)
swelling
studies,
preliminary
cytotoxicity
performed
V79
cells
indicates
potential
vivo
studies
application.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Фев. 22, 2024
Tooth
loss
or
damage
poses
great
threaten
to
oral
and
general
health.
While
contemporary
clinical
treatments
have
enabled
tooth
restoration
a
certain
extent,
achieving
functional
regeneration
remains
challenging
task
due
the
intricate
hierarchically
organized
architecture
of
teeth.
The
past
few
decades
seen
rapid
development
three-dimensional
(3D)
printing
technology,
which
has
provided
new
breakthroughs
in
field
tissue
engineering
regenerative
dentistry.
This
review
outlined
bioactive
materials
stem/progenitor
cells
used
dental
regeneration,
summarized
recent
advancements
application
3D
technology
for
tooth-supporting
including
pulp,
dentin,
periodontal
ligament,
alveolar
bone
so
on.
It
also
discussed
current
obstacles
potential
future
directions,
aiming
inspire
innovative
ideas
encourage
further
medicine.
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(2), С. 45 - 45
Опубликована: Янв. 30, 2025
Chitosan
is
a
positively
charged
natural
polymer
with
several
properties
conducive
to
wound-healing
applications,
such
as
biodegradability,
structural
integrity,
hydrophilicity,
adhesiveness
tissue,
and
bacteriostatic
potential.
Along
other
mechanical
properties,
some
of
the
discussed
in
this
review
are
antibacterial
mucoadhesive
biocompatibility,
high
fluid
absorption
capacity,
anti-inflammatory
response.
forms
stable
complexes
oppositely
polymers,
arising
from
electrostatic
interactions
between
(+)
amino
groups
chitosan
(−)
polymers.
These
polyelectrolyte
(PECs)
can
be
manufactured
using
various
materials
methods,
which
brings
diversity
formulations
that
optimized
for
specific
wound
healing
well
applications.
For
example,
chitosan-based
PEC
made
into
dressings/films,
hydrogels,
membranes.
There
pros
cons
associated
manufacturing
dressings;
instance,
layer-by-layer
casting
technique
optimize
nanoparticle
release
affect
strength
due
formation
heterostructure.
Furthermore,
chitosan’s
molecular
weight
degree
deacetylation,
nature
negatively
biomaterial
it
cross-linked,
major
factors
govern
biodegradation
kinetics
dressing.
The
use
care
products
forecasted
drive
growth
global
market,
expected
increase
by
approximately
14.3%
within
next
decade.
This
driven
chitoderm-containing
ointments,
provide
scaffolding
skin
cell
regeneration.
Despite
significant
advancements,
there
remains
critical
gap
translating
biomaterials
research
clinical
Biomolecules,
Год журнала:
2023,
Номер
13(9), С. 1389 - 1389
Опубликована: Сен. 14, 2023
The
clinical
demand
for
tissue-engineered
vascular
grafts
is
still
rising,
and
there
are
many
challenges
that
need
to
be
overcome,
in
particular,
obtain
functional
small-diameter
grafts.
advances
made
cell
culture,
biomaterials,
manufacturing
techniques,
tissue
engineering
methods
have
led
various
promising
solutions
graft
production,
with
available
options
able
recapitulate
both
biological
mechanical
properties
of
native
blood
vessels.
Due
the
rising
interest
materials
bioactive
potentials,
from
natural
sources
also
recently
gained
more
attention
engineering,
new
strategies
been
developed
solve
disadvantages
related
their
use.
In
this
review,
progress
production
discussed.
We
highlight,
use
as
scaffolds
engineering.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(15)
Опубликована: Март 4, 2024
Abstract
Abdominal
wall
defects
are
common
clinical
diseases,
and
mesh
repair
is
the
standard
treatment
method.
The
most
commonly
used
polypropylene
(PP)
in
practice
has
advantages
of
good
mechanical
properties,
stable
performance,
effective
tissue
integration
effect.
However,
direct
contact
between
abdominal
viscera
PP
can
lead
to
severe
adhesions.
To
prevent
this,
development
a
hydrogel‐PP
composite
with
anti‐adhesive
properties
may
be
an
measure.
Herein,
biofunctional
hydrogel
loaded
rosmarinic
acid
developed
by
modifying
chitosan
Pluronic
F127,
which
possesses
suitable
physical
chemical
commendable
vitro
biocompatibility.
In
full‐thickness
rats,
hydrogels
injected
onto
surface
applied
intraperitoneal
repair.
results
indicate
that
use
alleviate
adhesions
resulting
from
traditional
implantation
decreasing
local
inflammatory
response,
reducing
oxidative
stress,
regulating
fibrinolytic
system.
Combined
ability
mesh,
great
potential
for
repairing
defects.
