Carbohydrate Polymers, Год журнала: 2023, Номер 327, С. 121664 - 121664
Опубликована: Дек. 8, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 1, 2024
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.
Язык: Английский
Процитировано
83
Gels, Год журнала: 2024, Номер 10(7), С. 440 - 440
Опубликована: Июль 1, 2024
Cancer is a highly heterogeneous disease and remains global health challenge affecting millions of human lives worldwide. Despite advancements in conventional treatments like surgery, chemotherapy, immunotherapy, the rise multidrug resistance, tumor recurrence, their severe side effects complex nature microenvironment (TME) necessitates innovative therapeutic approaches. Recently, stimulus-responsive nanomedicines designed to target TME characteristics (e.g., pH alterations, redox conditions, enzyme secretion) have gained attention for potential enhance anticancer efficacy while minimizing adverse chemotherapeutics/bioactive compounds. Among various nanocarriers, hydrogels are intriguing due high-water content, adjustable mechanical characteristics, responsiveness external internal stimuli, making them promising candidates cancer therapy. These properties make an ideal nanocarrier controlled drug release within TME. This review comprehensively surveys latest area therapy, exploring stimuli-responsive mechanisms, including biological pH, redox), chemical enzymes, glucose), physical temperature, light), as well dual- or multi-stimuli responsiveness. Furthermore, this addresses current developments challenges treatment. Our aim provide readers with comprehensive understanding treatment, offering novel perspectives on development therapy other medical applications.
Язык: Английский
Процитировано
11
Polymer-Plastics Technology and Materials, Год журнала: 2024, Номер 64(4), С. 397 - 438
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
11
Molecules, Год журнала: 2024, Номер 29(10), С. 2278 - 2278
Опубликована: Май 12, 2024
In the past few decades, considerable scientific strides have been made in subject of drug analysis human biological samples. However, risk caused by incorrect plasma levels patients still remains an important concern. This review paper attempts to investigate advances over last ten years common sample preparation techniques (SPT) for samples based on solid sorbents, including solid-phase extraction (SPE) and micro-extraction (SPME), particular field molecularly imprinted polymers (MIPs), non-stimuli-responsive stimuli-responsive adsorbents. class materials is known as ‘smart adsorbents’, exhibiting tailored responses various stimuli such magnetic fields, pH, temperature, light. Details are provided how these advanced SPT changing landscape modern their coupling with liquid chromatography-mass spectrometry (LC-MS) analytical techniques, a general term that includes high-performance chromatography (HPLC) ultra-high performance (UHPLC), well any variation MS, tandem (MS/MS), multiple-stage (MSn), high-resolution (HRMS) mass spectrometry. Some notes also less-performing ultraviolet (HPLC-UV) diode array detection (HPLC-DAD) detection. Finally, we provide difficulties benefits proposed approaches future prospects this research area.
Язык: Английский
Процитировано
9
Research, Год журнала: 2024, Номер 7
Опубликована: Янв. 1, 2024
Photochromic polymer is defined as a series of materials based on photochromic units in chains, which produces reversible color changes under irradiation with particular wavelength. Currently, the research progresses, it shows increasing potential applications various fields, such anti-counterfeiting, information storage, super-resolution imaging, and logic gates. However, there paucity published reviews topic polymers. Herein, this review discusses summarizes progress prospects materials, mainly summarizing basic mechanisms, classification, azobenzene, spiropyran, diarylethene Moreover, 3-dimensional (3D) printable polymers are worthy to be summarized specifically because its innovative approach for practical application; meanwhile, developing 3D printing technology has shown opportunities better applications. Finally, current challenges future directions summarized.
Язык: Английский
Процитировано
8
International Journal of Pharmaceutics, Год журнала: 2024, Номер 665, С. 124687 - 124687
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
8
Advanced Materials Technologies, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Abstract 4D printing combines advancements in 3D with smart materials that change properties response to external stimuli, enabling the fabrication of functional devices directly from printer. Microscale is rapidly growing, driving discovery and applications new strategies. The interest microscale comes its potential propel industrial transformation across different sectors, ranging advanced healthcare cryptography. However, this requires rational design a good understanding material response. This review starts by describing for printing. technologies micrometer resolution their use are then discussed. focus shifts stimuli respond to, mechanism behind obtained shape changes respect applied methods implemented so far realize complex changing behaviors. Examples within sensing, microactuation, data encryption, cargo transport shown. After discussing current challenges mitigation strategies, suggestions on direction field can take given, starting systematic iterative approach developing microstructures.
Язык: Английский
Процитировано
1
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 59, С. 100665 - 100665
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
5
Опубликована: Июнь 14, 2024
Cancer is a highly heterogeneous disease and remains global health challenge affecting millions of human lives worldwide. Despite advancements in conventional treatments like surgery, chemotherapy, immunotherapy, the rise multidrug resistance, tumor recurrence, severe side effects necessitates innovative therapeutic approaches. The complex nature microenvironment (TME) further compromises efficacy traditional chemotherapy drugs. Recently, stimulus-responsive nanomedicines designed to target TME characteristics (e.g., pH, redox, enzymes) have gained attention for their potential enhance anticancer while minimizing adverse effects. Among various nanocarriers, hydrogels are an interesting class nanocarriers used cancer therapy due high water content, adjustable mechanical characteristics, ability respond external/internal stimuli. These properties make ideal nanocarrier controlled drug release within TME. This review comprehensively surveys latest therapy, exploring stimuli-responsive mechanisms, including biological redox), chemical enzymes, glucose), physical temperature, light), as well dual- or multi-stimuli responsiveness. will offer novel perspectives on development therapy.
Язык: Английский
Процитировано
4
Biomacromolecules, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
We report on the synthesis, characterization, and properties of dextran polymers, which are covalently bridged/cross-linked by azobenzene moieties. The reversible photoactivity azo moiety is retained in kinetics E/Z isomerization depend dextran/azobenzene ratio. Together with simple preparation, our approach provides convenient access to photoresponsive sustainable materials. Moreover, based water-soluble we have prepared hydrogels, soften upon UV irradiation. Our findings spectroscopy (UV/vis, IR, NMR/DOSY), size exclusion chromatography, rheology.
Язык: Английский
Процитировано
0