Theoretical analysis of electrical double layer effects on the multiphase flow of Jeffrey fluid through a divergent channel with lubricated walls DOI
Mubbashar Nazeer, Farooq Hussain, M. Ijaz Khan

et al.

Waves in Random and Complex Media, Journal Year: 2022, Volume and Issue: unknown, P. 1 - 15

Published: Sept. 23, 2022

A theoretical study of two-phase non-Newtonian fluid with heat transfer is presented in this article. Jeffrey model used as the base liquid to form a multiphase suspension help gold particles. Heating effects have also been applied on an electro-osmotic flow through divergent channel. The lubrication dampen skin friction opposite walls. An analytical solution obtained for nonlinear transfer. Separate expressions volumetric rate and pressure gradient are determined via complex mathematical manipulation. concise parametric reveals that slippery walls channel prominent influence momentum both phases.

Language: Английский

Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications DOI Creative Commons
Nimeet Desai,

Dhwani Rana,

Sagar Salave

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1313 - 1313

Published: April 21, 2023

Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.

Language: Английский

Citations

262

<p>Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy</p> DOI Creative Commons
Yao Chen, Juan Yang, Shaozhi Fu

et al.

International Journal of Nanomedicine, Journal Year: 2020, Volume and Issue: Volume 15, P. 9407 - 9430

Published: Nov. 1, 2020

Abstract: The rapid development of nanotechnology offers a variety potential therapeutic strategies for cancer treatment. High atomic element nanomaterials are often utilized as radiosensitizers due to their unique photoelectric decay characteristics. Among them, gold nanoparticles (GNPs) one the most widely investigated and considered be an ideal radiotherapy high X-ray absorption physicochemical properties. Over last few decades, multi-disciplinary studies have focused on design optimization GNPs achieve greater dosing capability higher effects highlight mechanisms radiosensitization GNPs. Although radiosensitizing has been recognized, its clinical translation still faces many challenges. This review analyses different roles in summarizes recent advances. In addition, underlying GNP radiosensitization, including physical, chemical biological discussed, which may provide new directions transformation next-generation Keywords: nanoparticles, radiotherapy,

Language: Английский

Citations

225

Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene DOI Open Access

Manish Gaur,

Charu Misra,

Awadh Bihari Yadav

et al.

Materials, Journal Year: 2021, Volume and Issue: 14(20), P. 5978 - 5978

Published: Oct. 11, 2021

Carbon nanomaterials (CNMs) have received tremendous interest in the area of nanotechnology due to their unique properties and flexible dimensional structure. CNMs excellent electrical, thermal, optical that make them promising materials for drug delivery, bioimaging, biosensing, tissue engineering applications. Currently, there are many types CNMs, such as quantum dots, nanotubes, nanosheets, nanoribbons; others development promise exciting applications future. The surface functionalization modifies chemical physical properties, which enhances loading/release capacity, ability target delivery specific sites, dispersibility suitability biological systems. Thus, been effectively used different biomedical This review explores physical, chemical, allow improve on state art currently discussion also embraces emerging including targeted medical implants, engineering, wound healing, vaccination, photodynamic therapy.

Language: Английский

Citations

202

Recent trends in cancer therapy: A review on the current state of gene delivery DOI
Esam Bashir Yahya,

Amaal Mohammed Alqadhi

Life Sciences, Journal Year: 2021, Volume and Issue: 269, P. 119087 - 119087

Published: Jan. 19, 2021

Language: Английский

Citations

178

Recent advances and prospects of carbon dots in phototherapy DOI
Baoling Li,

Shaojing Zhao,

Huang Li

et al.

Chemical Engineering Journal, Journal Year: 2020, Volume and Issue: 408, P. 127245 - 127245

Published: Oct. 8, 2020

Language: Английский

Citations

167

pH-Sensitive Biomaterials for Drug Delivery DOI Creative Commons

Shijie Zhuo,

Feng Zhang,

Junyu Yu

et al.

Molecules, Journal Year: 2020, Volume and Issue: 25(23), P. 5649 - 5649

Published: Nov. 30, 2020

The development of precise and personalized medicine requires novel formulation strategies to deliver the therapeutic payloads pathological tissues, producing enhanced outcome reduced side effects. As many diseased tissues are feathered with acidic characteristics microenvironment, pH-sensitive biomaterials for drug delivery present great promise purpose, which could protect from metabolism degradation during in vivo circulation exhibit responsive release therapeutics triggered by especially cancer treatment. In past decades, methodologies, such as cleavage linkage, have been applied fabrication pH-responsive materials both vitro applications. this review, we will summarize some system medical application, mainly focusing on linkage bonds biomaterials.

Language: Английский

Citations

159

Transition metal dichalcogenides: Synthesis and use in the development of electrochemical sensors and biosensors DOI
Somayeh Tajik,

Zahra Dourandish,

Fariba Garkani Nejad

et al.

Biosensors and Bioelectronics, Journal Year: 2022, Volume and Issue: 216, P. 114674 - 114674

Published: Sept. 1, 2022

Language: Английский

Citations

140

Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment DOI Open Access
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin

et al.

Polymers, Journal Year: 2021, Volume and Issue: 13(11), P. 1717 - 1717

Published: May 24, 2021

Breast cancer remains one of the world's most dangerous diseases because difficulty finding cost-effective and specific targets for effective efficient treatment methods. The biodegradability biocompatibility properties chitosan-based nanoparticles (ChNPs) have good prospects targeted drug delivery systems. ChNPs can transfer various antitumor drugs to sites via passive active targeting pathways. modification has attracted researcher loading cells. objective our review was summarize discuss in delivering anticancer against breast cells from published papers recorded Scopus, PubMed, Google Scholar. In order improve cellular uptake, accumulation, cytotoxicity, selectivity, we examined different kinds ChNPs. Notably, these forms use characteristics enhanced permeability retention (EPR) effect as a proper parameter biological ligands, such proteins, peptides, monoclonal antibodies, small particles. addition, system, provided significantly improved into (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). conclusion, promising technique is presented increasing efficacy, effectiveness candidate carriers cancer.

Language: Английский

Citations

134

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review DOI Creative Commons
Mahnaz Ahmadi, Seyed Mohammad Ayyoubzadeh, Fatemeh Ghorbani‐Bidkorbeh

et al.

Heliyon, Journal Year: 2021, Volume and Issue: 7(4), P. e06914 - e06914

Published: April 1, 2021

Metal-organic frameworks (MOFs) are a fascinating class of crystalline porous materials composed metal ions and organic ligands. Due to their attractive properties, MOFs can potentially offer biomedical field applications, such as drug delivery imaging. This study aimed systematically identify the affecting factors on MOF characteristics effects structural biological characteristics. An electronic search was performed in four databases containing PubMed, Scopus, Web Science, Embase, using relevant keywords. After analyzing studies, 20 eligible studies were included this review. As result, various additives ligand influence size structure MOFs. Additives that compete with may affect nucleation growth processes and, consequently, particle size. The nature influential determining MOF. Moreover, synthesis parameters like reaction time initial reagents ratio critical should be optimized regulate structure. Of note is suitable additive control porosity more extended ligands aid forming large pores. choice metallic nodes ligand, concentration important since they determine toxicity biocompatibility final physicochemical properties MOFs, hydrophobicity, nanoparticles. increase hydrophobicity causes increased biodegradability MOF, another property, depends ion environmental conditions pH. Photocleavable served for controlled degradation Generally, by optimizing these factors, desirable will obtained applications.

Language: Английский

Citations

112

Multifunctional Iron Oxide Magnetic Nanoparticles for Biomedical Applications: A Review DOI Open Access
Hung-Vu Tran, Nhat M. Ngo, Riddhiman Medhi

et al.

Materials, Journal Year: 2022, Volume and Issue: 15(2), P. 503 - 503

Published: Jan. 10, 2022

Due to their good magnetic properties, excellent biocompatibility, and low price, iron oxide nanoparticles (IONPs) are the most commonly used nanomaterials have been extensively explored in biomedical applications. Although IONPs can be for a variety of applications biomedicine, practical require IONP-based platforms that perform several tasks parallel. Thus, appropriate engineering integration with different classes organic inorganic materials produce multifunctional nanoplatforms functions simultaneously, allowing application broad spectrum fields. This review article summarizes fabrication current composite based on dyes, biomolecules (e.g., lipids, DNAs, aptamers, antibodies), quantum dots, noble metal NPs, stimuli-responsive polymers. We also highlight recent technological advances achieved from such integrated potential use applications, including dual-mode imaging biomolecule detection, targeted drug delivery, photodynamic therapy, chemotherapy, hyperthermia therapy.

Language: Английский

Citations

103