polyethylene
glycol
(PEG),
to
evade
the
immune
system;
ii)
NCs
modified
with
HA,
CD44-HA
binding
and
iii)
non-modified
(carboxyl
moiety).Macrophages
previously
exposed
were
co-cultured
AML
cells
uptake
delivery
of
analyzed
by
flow
cytometry.As
a
consequence
CD44
increased
intensity,
(PLGA)-PEG-HA
adhered
membrane
pro-leukemic
macrophages.Also,
delivered
blasts
cell-to-cell
interaction,
accumulating
into
leukemic
cell
increasing
cancer
cells'
death.Overall,
our
results
suggest
that
macrophage-based
deliver
(PLGA)PEG-HA
loaded
ATO
is
promising
platform
treat
as
can
improve
targetability
adhering
AML-related
macrophages
reduce
viability
in
vitro.
Frontiers in Cell and Developmental Biology,
Год журнала:
2021,
Номер
9
Опубликована: Дек. 10, 2021
The
Golgi
apparatus
plays
a
central
role
in
normal
cell
physiology
by
promoting
survival,
facilitating
proliferation,
and
enabling
cell-cell
communication
migration.
These
roles
are
partially
mediated
well-known
functions,
including
post-translational
modifications,
lipid
biosynthesis,
intracellular
trafficking,
protein
secretion.
In
addition,
accumulating
evidence
indicates
that
the
critical
sensing
integrating
external
internal
cues
to
promote
cellular
homeostasis.
Indeed,
unique
structure
of
mammalian
can
be
fine-tuned
adapt
different
functions
specific
needs.
This
is
particularly
relevant
context
cancer,
where
unrestrained
proliferation
aberrant
survival
migration
increase
demands
as
well
need
for
Golgi-dependent
adaptation
intrinsic
extrinsic
stressors.
Here,
we
review
discuss
current
understanding
how
function
influenced
oncogenic
transformation,
this
may
facilitate
cancer
invasion
metastasis.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(14), С. 7683 - 7683
Опубликована: Июль 12, 2022
The
fine-tuning
of
the
physicochemical
properties
gold
nanoparticles
has
facilitated
rapid
development
multifunctional
gold-based
nanomaterials
with
diagnostic,
therapeutic,
and
therapeutic
applications.
Work
on
is
increasingly
focusing
their
cancer
application.
This
review
provides
a
summary
main
biological
effects
exerted
by
cells
highlights
some
critical
factors
involved
in
interaction
process
(protein
corona,
tumor
microenvironment,
surface
functionalization).
also
contains
brief
discussion
application
target
discovery.
Immunology,
Год журнала:
2024,
Номер
173(1), С. 33 - 52
Опубликована: Май 14, 2024
Aberrant
glycosylation
recently
emerged
as
an
unmissable
hallmark
of
cancer
progression
in
many
cancers.
In
melanoma,
there
is
growing
evidence
that
the
tumour
'glycocode'
plays
a
major
role
promoting
cell
proliferation,
invasion,
migration,
but
also
dictates
nature
immune
infiltrate,
which
strongly
affects
function,
and
clinical
outcome.
patterns
dismantle
anti-tumour
defence
through
interactions
with
lectins
on
cells,
are
crucial
to
shape
immunity
trigger
evasion.
The
glycan/lectin
axis
represents
new
subversion
pathway
exploited
by
melanoma
hijack
cells
escape
from
control.
this
review,
we
describe
features
further
gather
findings
related
progression,
deciphering
detail
its
impact
immunity.
We
depict
glycan-based
strategies
aiming
at
restoring
functional
response
patients.
Glycans/lectins
emerge
key
checkpoints
promising
translational
properties.
Exploitation
these
pathways
could
reshape
potent
while
impeding
immunosuppressive
circuits
triggered
aberrant
patterns,
holding
great
promise
for
therapy.
The Chemical Record,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Triple-negative
breast
cancer
(TNBC)
represents
a
highly
aggressive
and
prognostically
unfavorable
subtype
of
cancer,
characterized
by
the
absence
common
hormone
receptors,
which
renders
conventional
therapies
largely
ineffective.
This
review
comprehensively
examines
molecular
clinical
characteristics
TNBC,
underscoring
substantial
challenges
inherent
in
its
treatment
innovative
potential
targeted
nanoprobes
advancing
both
diagnostic
therapeutic
paradigms.
Through
modification
targeting
molecules,
can
deliver
agents
specific
to
TNBC
cells,
thus
significantly
improving
sensitivity
modalities
efficacy
interventions.
Our
discussion
systematically
explores
application
various
molecules
their
advantages
limitations.
In
addition,
this
presents
series
multifunctional
that
are
designed
perform
functions,
providing
synergistic
approach
TNBC.
These
advanced
enable
precise
tumor
localization
while
monitoring
response
real
time,
facilitating
more
personalized
dynamic
regimen.
The
major
obstacles
encountered
during
translation
discussed
detail.
use
leap
forward
medicine
for
current
research
efforts
will
continue
refine
these
technologies
improve
applicability.
