Dual-drug delivery by thermo-responsive Janus nanogel for improved cellular uptake, sustained release, and combination chemo-thermal therapy DOI
Sakine Shirvalilou, Samideh Khoei, Sepideh Khoee

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123888 - 123888

Опубликована: Фев. 10, 2024

Язык: Английский

Riding the metal wave: A review of the latest developments in metal-based anticancer agents DOI

Sara Abdolmaleki,

Alireza Aliabadi, Samad Khaksar

и другие.

Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215579 - 215579

Опубликована: Ноя. 28, 2023

Язык: Английский

Процитировано

66

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach DOI Creative Commons
G. Bharath, Muhammad Ashraf Sabri,

Abdul Hai

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 868 - 868

Опубликована: Март 7, 2023

The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools diagnosis treatment in the future. Due to their tunable morphologies superior properties, multifunctional magnetic nanomaterials hybrid nanostructures can designed as specific carriers drugs, imaging agents, theranostics. Multifunctional are promising theranostic agents due ability diagnose combine therapies. This review provides a comprehensive overview development advanced combining optical providing photoresponsive platforms medical applications. Moreover, this discusses various innovative developments using nanostructures, including drug delivery, treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal resonance imaging, tissue engineering. Additionally, artificial intelligence (AI) used optimize material properties based on predicted interactions with cell membranes, vasculature, biological fluid, immune system enhance effectiveness therapeutic agents. Furthermore, an AI approaches assess practical utility Finally, presents current knowledge perspectives systems models.

Язык: Английский

Процитировано

55

Catalyzing innovation: Exploring iron oxide nanoparticles - Origins, advancements, and future application horizons DOI
Pankaj Kumar, Nikesh Thakur, Kuldeep Kumar

и другие.

Coordination Chemistry Reviews, Год журнала: 2024, Номер 507, С. 215750 - 215750

Опубликована: Фев. 29, 2024

Язык: Английский

Процитировано

48

Comprehensive Review on Non-Newtonian Nanofluids, Preparation, Characterization, and Applications DOI Creative Commons
Muhammad Tawalbeh,

Ibrahim Shomope,

Amani Al‐Othman

и другие.

International Journal of Thermofluids, Год журнала: 2024, Номер 22, С. 100705 - 100705

Опубликована: Май 1, 2024

Nanofluids, comprising nanoparticles and a base fluid, have captured substantial interest due to remarkable enhancements in thermal conductivity other crucial thermophysical properties. These advancements facilitate diverse applications across various industrial processes, including biomedical drug research. This review centers on non-Newtonian nanofluids, which diverge from Newton's law of viscosity, rendering them more adaptable versatile. Through comprehensive examination the latest research, preparation methods, both one-step two-step techniques, their formulations oil-based, water-based, ethylene glycol-based solutions are systematically explored. The study synthesizes findings that highlight significant improvements heat transfer efficiency introduces novel sectors, such as engineering energy systems. Furthermore, an in-depth characterization nanofluids is provided, covering rheological, dispersion, transport, magnetic, optical, radiative fluids increasingly utilized exchangers, automotive radiators, engines, solar collectors, electronic coolants, demonstrating broad spectrum practical applications. shows ongoing challenges primarily centered preparation, stability, commercialization nanofluids. Conclusively, paper underscores potential revolutionize technological areas advocates for continued research develop stable efficient formulations, paving way innovative scientific

Язык: Английский

Процитировано

23

Evaluating the applications and effectiveness of magnetic nanoparticle-based hyperthermia for cancer treatment: A systematic review DOI
Zahra Farzanegan, Marziyeh Tahmasbi

Applied Radiation and Isotopes, Год журнала: 2023, Номер 198, С. 110873 - 110873

Опубликована: Май 25, 2023

Язык: Английский

Процитировано

32

Iron Oxide Nanoparticles in Cancer Treatment: Cell Responses and the Potency to Improve Radiosensitivity DOI Creative Commons
Maria V. Shestovskaya, Anna L. Luss, Bezborodova Si

и другие.

Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2406 - 2406

Опубликована: Сен. 30, 2023

The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.

Язык: Английский

Процитировано

27

Magnetite Nanoparticle Co-precipitation Synthesis, Characterization, and Applications: Mini Review DOI
Haitham Al‐Madhagi,

Valantina Yazbik,

Wassim Abdelwahed

и другие.

BioNanoScience, Год журнала: 2023, Номер 13(2), С. 853 - 859

Опубликована: Апрель 29, 2023

Язык: Английский

Процитировано

26

Recent trends and advances in novel formulations as an armament in Bcl-2/Bax targeted breast cancer DOI

Shaikh Samia,

Padakanti Sandeep Chary, Omar M. Khan

и другие.

International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123889 - 123889

Опубликована: Фев. 10, 2024

Язык: Английский

Процитировано

18

Nanoparticle-Based Combinational Strategies for Overcoming the Blood-Brain Barrier and Blood-Tumor Barrier DOI Creative Commons
Su Hyun Lim, Gi Taek Yee, Dongwoo Khang

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 2529 - 2552

Опубликована: Март 1, 2024

Abstract: The blood-brain barrier (BBB) and blood-tumor (BTB) pose substantial challenges to efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor prognosis. Nanoparticle-based combinational strategies have emerged as promising modalities overcome these barriers enhance penetration into the parenchyma. This review discusses various nanoparticle-based combinatorial approaches that combine nanoparticles cell-based delivery, viral focused ultrasound, magnetic field, intranasal permeability across BBB BTB. Cell-based involves using engineered cells carriers nanoparticles, taking advantage of their intrinsic migratory homing capabilities facilitate transport therapeutic payloads Viral uses vectors deliver genes or specific within GBM microenvironment. Focused coupled microbubbles can temporarily disrupt increase permeability. Magnetic field-guided exploits targeted under an external field. Intranasal offers minimally invasive avenue bypass agents directly via olfactory trigeminal pathways. By combining strategies, synergistic effects efficiency, improve efficacy, reduce off-target effects. Future research should focus on optimizing nanoparticle design, exploring new combination advancing preclinical clinical investigations promote translation therapies GBM. Keywords: glioblastoma, barrier, nanoparticle, strategy, ultrasound-wave,

Язык: Английский

Процитировано

17

Investigating the effect of magnetic field and nanoparticles characteristics in the treatment of glioblastoma by magnetic hyperthermia method: An in silico study DOI Creative Commons
Yasaman Mozhdehbakhsh Mofrad, Sasan Asiaei, Hossein Shaygani

и другие.

Results in Engineering, Год журнала: 2024, Номер 23, С. 102473 - 102473

Опубликована: Июнь 28, 2024

This study investigated the use of magnetic fluid hyperthermia (MFH) for treating glioblastoma multiforme (GBM), a deadly and treatment-resistant tumor. It considers effects nanoparticle (MNP) (different sizes materials), alternating field (AMF) characteristics (frequency strength field), MFH duration, injection number, using realistic brain phantom, considering its blood circulation system, tumor, healthy tissue properties. Results demonstrated that is more sensitive to frequency, increasing frequency causing greater temperature thermoablation than field. The can be increased at fixed control increase in mild treatment reliably. size MNP significantly impacts when exceeding 15.8 nm, while smaller particles do not affect obtained. Also, tumor's concentration increases uniformly disperses as number sites increases. examined duration (30–60 min), it important optimize prevent irreparable damage cases from 46 °C. In conclusion, effectively manage generated destruction malignant minimizing tissue, multiple hyperthermia-related parameters must adjusted simultaneously.

Язык: Английский

Процитировано

10