International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123888 - 123888
Опубликована: Фев. 10, 2024
Язык: Английский
Coordination Chemistry Reviews, Год журнала: 2023, Номер 501, С. 215579 - 215579
Опубликована: Ноя. 28, 2023
Язык: Английский
Процитировано
66
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 868 - 868
Опубликована: Март 7, 2023
The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools diagnosis treatment in the future. Due to their tunable morphologies superior properties, multifunctional magnetic nanomaterials hybrid nanostructures can designed as specific carriers drugs, imaging agents, theranostics. Multifunctional are promising theranostic agents due ability diagnose combine therapies. This review provides a comprehensive overview development advanced combining optical providing photoresponsive platforms medical applications. Moreover, this discusses various innovative developments using nanostructures, including drug delivery, treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal resonance imaging, tissue engineering. Additionally, artificial intelligence (AI) used optimize material properties based on predicted interactions with cell membranes, vasculature, biological fluid, immune system enhance effectiveness therapeutic agents. Furthermore, an AI approaches assess practical utility Finally, presents current knowledge perspectives systems models.
Язык: Английский
Процитировано
54
Coordination Chemistry Reviews, Год журнала: 2024, Номер 507, С. 215750 - 215750
Опубликована: Фев. 29, 2024
Язык: Английский
Процитировано
46
International Journal of Thermofluids, Год журнала: 2024, Номер 22, С. 100705 - 100705
Опубликована: Май 1, 2024
Nanofluids, comprising nanoparticles and a base fluid, have captured substantial interest due to remarkable enhancements in thermal conductivity other crucial thermophysical properties. These advancements facilitate diverse applications across various industrial processes, including biomedical drug research. This review centers on non-Newtonian nanofluids, which diverge from Newton's law of viscosity, rendering them more adaptable versatile. Through comprehensive examination the latest research, preparation methods, both one-step two-step techniques, their formulations oil-based, water-based, ethylene glycol-based solutions are systematically explored. The study synthesizes findings that highlight significant improvements heat transfer efficiency introduces novel sectors, such as engineering energy systems. Furthermore, an in-depth characterization nanofluids is provided, covering rheological, dispersion, transport, magnetic, optical, radiative fluids increasingly utilized exchangers, automotive radiators, engines, solar collectors, electronic coolants, demonstrating broad spectrum practical applications. shows ongoing challenges primarily centered preparation, stability, commercialization nanofluids. Conclusively, paper underscores potential revolutionize technological areas advocates for continued research develop stable efficient formulations, paving way innovative scientific
Язык: Английский
Процитировано
23
Applied Radiation and Isotopes, Год журнала: 2023, Номер 198, С. 110873 - 110873
Опубликована: Май 25, 2023
Язык: Английский
Процитировано
32
BioNanoScience, Год журнала: 2023, Номер 13(2), С. 853 - 859
Опубликована: Апрель 29, 2023
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2406 - 2406
Опубликована: Сен. 30, 2023
The main concept of radiosensitization is making the tumor tissue more responsive to ionizing radiation, which leads an increase in potency radiation therapy and allows for decreasing dose concomitant side effects. Radiosensitization by metal oxide nanoparticles widely discussed, but range mechanisms studied not sufficiently codified often does reflect ability nanocarriers have a specific impact on cells. This review focused magnetic iron while they occupied special niche among prospective radiosensitizers due unique physicochemical characteristics reactivity. We collected data about possible molecular underlying radiosensitizing effects (IONPs) approaches their therapeutic efficacy variable modifications.
Язык: Английский
Процитировано
26
Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 771 - 771
Опубликована: Фев. 26, 2023
A magnetic nanocomposite (MNC) is an integrated nanoplatform that combines a set of functions two types materials. successful combination can give rise to completely new material with unique physical, chemical, and biological properties. The core MNC provides the possibility resonance or particle imaging, field-influenced targeted delivery, hyperthermia, other outstanding applications. Recently, gained attention for external field-guided specific delivery cancer tissue. Further, drug loading enhancement, construction stability, biocompatibility improvement may lead high progress in area. Herein, novel method nanoscale Fe3O4@CaCO3 composites synthesis was proposed. For procedure, oleic acid-modified Fe3O4 nanoparticles were coated porous CaCO3 using ion coprecipitation technique. PEG-2000, Tween 20, DMEM cell media successfully used as stabilization agent template synthesis. Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS) data MNC's characterization. To improve properties, concentration varied, yielding optimal size, polydispersity, aggregation ability. resulting had size 135 nm narrow distributions, which suitable biomedical stability experiment various pH, media, fetal bovine serum also evaluated. showed low cytotoxicity biocompatibility. An excellent anticancer doxorubicin (DOX) up 1900 µg/mg (DOX/MNC) demonstrated. Fe3O4@CaCO3/DOX displayed at neutral pH efficient acid-responsive release. series DOX-loaded MNCs indicated effective inhibition Hela MCF-7 lines, IC 50 values calculated. Moreover, 1.5 μg sufficient inhibit 50% cells, shows prospect treatment. experiments human albumin solution release due formation protein corona. presented "pitfalls" nanocomposites provided step-by-step guidance on efficient, smart, nanoconstruction fabrication. Thus, exhibits good performance treatment
Язык: Английский
Процитировано
24
International Journal of Pharmaceutics, Год журнала: 2024, Номер 653, С. 123889 - 123889
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
18
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 2529 - 2552
Опубликована: Март 1, 2024
Abstract: The blood-brain barrier (BBB) and blood-tumor (BTB) pose substantial challenges to efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor prognosis. Nanoparticle-based combinational strategies have emerged as promising modalities overcome these barriers enhance penetration into the parenchyma. This review discusses various nanoparticle-based combinatorial approaches that combine nanoparticles cell-based delivery, viral focused ultrasound, magnetic field, intranasal permeability across BBB BTB. Cell-based involves using engineered cells carriers nanoparticles, taking advantage of their intrinsic migratory homing capabilities facilitate transport therapeutic payloads Viral uses vectors deliver genes or specific within GBM microenvironment. Focused coupled microbubbles can temporarily disrupt increase permeability. Magnetic field-guided exploits targeted under an external field. Intranasal offers minimally invasive avenue bypass agents directly via olfactory trigeminal pathways. By combining strategies, synergistic effects efficiency, improve efficacy, reduce off-target effects. Future research should focus on optimizing nanoparticle design, exploring new combination advancing preclinical clinical investigations promote translation therapies GBM. Keywords: glioblastoma, barrier, nanoparticle, strategy, ultrasound-wave,
Язык: Английский
Процитировано
17