Опубликована: Янв. 1, 2025
Язык: Английский
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102669 - 102669
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Frontiers in Neuroscience, Год журнала: 2023, Номер 17
Опубликована: Май 31, 2023
Spinal cord injury (SCI) is a disease of the central nervous system often caused by accidents, and its prognosis unsatisfactory, with long-term adverse effects on patients’ lives. The key to treatment lies in improvement microenvironment at reconstruction axons, tissue repair promising therapeutic strategy. Hydrogel three-dimensional mesh structure high water content, which has advantages biocompatibility, degradability, adjustability, can be used fill pathological defects injectable flowing hydrophilic material situ accurately adapt size shape injury. Hydrogels mimic natural extracellular matrix for cell colonization, guide axon extension, act as biological scaffold, an excellent carrier participate SCI. addition different materials make composite hydrogel scaffolds further enhance their performance all aspects. In this paper, we introduce several typical hydrogels review research progress SCI provide reference clinical application therapy
Язык: Английский
Процитировано
22
Bioscience Reports, Год журнала: 2023, Номер 43(2)
Опубликована: Янв. 11, 2023
Nanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size nanoparticles lies between 1 100 nm. Due to their small large surface area-to-volume ratio, exhibit high reactivity, greater stability adsorption capacity. These important physicochemical properties attract scientific community utilize them in biomedical field. Various types (inorganic organic) have broad applications medical field ranging from imaging gene therapy. are also effective drug carriers. In recent times, utilized circumvent different treatment limitations. For example, ability cross blood-brain barrier having a certain degree specificity towards amyloid deposits makes themselves candidates for Alzheimer's disease. Furthermore, nanotechnology has been used extensively overcome several pertinent issues like drug-resistance phenomenon, side effects conventional drugs targeted delivery issue leprosy, tuberculosis cancer. Thus, this review, application these four diseases (Alzheimer's disease, tuberculosis, leprosy cancer) as well presented systematically. Although nanoformulations many advantages over traditional therapeutics treating diseases, nanotoxicity major concern discussed subsequently. Lastly, we promising future prospective alternative therapeutics. section, about futuristic approach(es) could provide candidate(s) diseases.
Язык: Английский
Процитировано
20
Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 151 - 151
Опубликована: Янв. 19, 2023
Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there an urgent need to address this situation. This review presents state art drug discovery and developments in targeting dementia. Several approaches are discussed, such as repurposing, use small molecules, phosphodiesterase inhibitors. Furthermore, also provides insights into clinical trials these molecules. Emphasis has been placed on molecules multi-target-directed ligands, well disease-modifying therapies. Finally, attention drawn possibilities applications nanotechnology managing
Язык: Английский
Процитировано
20
Neurochemistry International, Год журнала: 2023, Номер 170, С. 105612 - 105612
Опубликована: Сен. 15, 2023
Язык: Английский
Процитировано
18
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Июль 9, 2024
Abstract Alzheimer's disease (AD) is the most common age‐related neurodegenerative disorder leading to cognitive decline. Excessive cytosolic calcium (Ca 2+ ) accumulation plays a critical role in pathogenesis of AD since it activates NOD‐like receptor family, pyrin domain containing 3 (NLRP3), switches endoplasmic reticulum (ER) unfolded protein response (UPR) toward proapoptotic signaling and promotes A β seeding. Herein, liposomal nanodrug (felodipine@LND) developed incorporating channel antagonist felodipine for treatment through low‐intensity pulse ultrasound (LIPUS) irradiation‐assisted blood brain barrier (BBB)‐crossing drug delivery. The multifunctional felodipine@LND effectively delivered diseased applying LIPUS irradiation skull, which resulted series positive effects against AD. Markedly, switched ER UPR antioxidant signaling, prevented surface translocation calreticulin (CALR) microglia, inhibited NLRP3 activation In addition, promoted degradation damaged mitochondria via mitophagy, thereby inhibiting neuronal apoptosis. Therefore, anxiety‐like behavior impairment 5xFAD mice with significantly ameliorated, manifested potential – assisted BBB‐crossing delivery serve as paradigm therapy based on well‐recognized clinically available felodipine.
Язык: Английский
Процитировано
7
Ibrain, Год журнала: 2023, Номер 9(3), С. 298 - 315
Опубликована: Авг. 14, 2023
Abstract Neurodegenerative diseases (NDs) impose substantial medical and public health burdens on people worldwide represent one of the major threats to human health. The prevalence these age‐dependent disorders is dramatically increasing over time, a process intrinsically related constantly rising percentage elderly population in recent years. Among all NDs, Alzheimer's Parkinson's are considered most debilitating as they cause memory cognitive loss, well severely affecting basic physiological conditions such ability move, speak, breathe. There an extreme need for new more effective therapies counteract devastating diseases, available treatments only able slow down pathogenic without really stopping or resolving it. This review aims elucidate current nanotechnology‐based tools representing future hope NDs treatment. Noble metal nano‐systems, that is, gold silver nanoparticles (NPs), have indeed unique physicochemical characteristics enabling them deliver any pharmacological treatment way within central nervous system. can potentially make NPs reversing actual therapeutic strategy based slowing irreversible into permanent
Язык: Английский
Процитировано
14
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105067 - 105067
Опубликована: Окт. 16, 2023
Язык: Английский
Процитировано
11
Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер 451, С. 115498 - 115498
Опубликована: Янв. 29, 2024
Язык: Английский
Процитировано
4
Small, Год журнала: 2025, Номер 21(9)
Опубликована: Янв. 22, 2025
Abstract Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which focus research. Stimulus‐responsive nanodrug delivery systems (SRDDS) stand out as sophisticated class nanocarriers that release drugs response to environmental cues. Due complex pathogenesis multifaceted pathological environment nervous system, developing accurate effective drug therapy low side‐effects is formidable task. In recent years, SRDDS been widely used treatment neurological diseases. By customizing align specific microenvironment system tissues or external stimulation, efficacy enhanced. This review provides an in‐depth look at characteristics diseases highlights case studies tailored treat these disorders based on unique stimulation criteria triggers. Additionally, this comprehensive overview progress future prospects technology diseases, providing valuable guidance for its transition from fundamental research clinical application.
Язык: Английский
Процитировано
0