Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 36(1)
Published: Dec. 13, 2024
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Language: Английский
Citations
6
Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(1)
Published: Jan. 1, 2025
Language: Английский
Citations
3
Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100205 - 100205
Published: Jan. 1, 2024
Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.
Language: Английский
Citations
18
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Metal–organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based systems. This review explores various advantages that MOFs offer terms catalytic activity, low-cost, stability, structural versatility. With a primary focus on their application biochemical sensing, oxidases demonstrated remarkable utility, prompting thorough exploration design modification strategies. Moreover, aims to provide comprehensive analysis strategies employed rational MOF structures optimize key parameters such sensitivity, selectivity, stability context sensors. Through an exhaustive examination recent research developments, this article seeks insights into nuanced interplay between performance, shedding light mechanisms underpin effectiveness mimics. Finally, addresses challenges opportunities associated with aiming drive further advancements structure development highly effective sensors for diverse applications.
Language: Английский
Citations
14
Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Developing sensitive and highly active nanozymes for antioxidant analysis is of the utmost significance in medical diagnosis health monitoring due to their essential roles as free reactive oxygen species scavengers. Here, six metal-organic frameworks (MOFs)-based are developed a dual-mode absorbance/image colorimetric sensor array simultaneous discrimination determination various antioxidants with comparable structural or chemical properties. The catalysts exhibit wide range potent oxidase-like catalytic activities, verified by kinetic parameters, presence dispersed transition metallic bimetallic redox nodes. These efficiently catalyze oxidation colorless 3,3',5,5'-tetramethylbenzidine (TMB) blue TMBox, resulting noticeable absorption RGB color changes at 650 nm. Various demonstrate different reducing capabilities leading generation fingerprint-like spectral patterns. pattern recognition chemometrics methods including principal component (PCA) linear discriminant (LDA) represent well-separated clustering ascorbic acid, dopamine, uric cysteine, glutathione, thiocyanate, tannic gallic acid. assay provides detection (0.1-75 μM) limits low 30 nM. successfully discriminated concentrations, mixtures, interferences. Furthermore, sensor's applicability biologically relevant was validated urine plasma samples. Overall, MOF-based nanozyme offers promising platform discriminating determining potential applications.
Language: Английский
Citations
2
Biosensors, Journal Year: 2025, Volume and Issue: 15(3), P. 142 - 142
Published: Feb. 24, 2025
With the growing interest in nucleic acids and nanozymes, acid nanozymes (NANs) have emerged as a promising alternative to traditional enzyme catalysts, combining advantages of nanomaterials, are widely applied field biosensing. This review provides comprehensive overview recent studies on NAN-based biosensors. It classifies NANs based six distinct enzymatic activities: peroxidase-like, oxidase-like, catalase-like, superoxide dismutase-like, laccase-like, glucose oxidase-like. emphasizes how catalytic activity is significantly influenced by properties explores regulatory mechanisms governing NANs. Additionally, it systematically reviews important research progress colorimetric, fluorescent, electrochemical, SERS, chemiluminescent sensors, offering insights into development NAN biosensor applications.
Language: Английский
Citations
1
Biosensors, Journal Year: 2024, Volume and Issue: 14(11), P. 520 - 520
Published: Oct. 23, 2024
Nanozymes are nanomaterials that exhibit enzyme-like catalytic activity, which have drawn increasing attention on account of their unique superiorities including very high robustness, low cost, and ease modification. Metal-organic frameworks (MOFs) covalent-organic (COFs) emerged as promising candidates for nanozymes due to abundant activity centers, inherent porosity, tunable chemical functionalities. In this review, we first compare the enzyme-mimicking centers mechanisms between MOF COF nanozymes, then summarize recent research designing modifying with activity. Moreover, typical examples sensing applications based these presented, well translation enzyme into a visible signal response. At last, discussion current challenges is followed by some future prospects provide guidance nanozyme sensors MOFs COFs practical applications.
Language: Английский
Citations
4
Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(12)
Published: Nov. 13, 2024
Language: Английский
Citations
4
Published: Jan. 1, 2025
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0