Unveiling the Toxicity of Micro-Nanoplastics: A Systematic Exploration of Understanding Environmental and Health Implications DOI Creative Commons
Saurabh Shukla, Sakshum Khanna, Kushagra Khanna

и другие.

Toxicology Reports, Год журнала: 2024, Номер 14, С. 101844 - 101844

Опубликована: Дек. 12, 2024

The surge in plastic production has spurred a global crisis as pollution intensifies, with microplastics and nanoplastics emerging notable environmental threats. Due to their miniature size, these particles are ubiquitous across ecosystems pose severe hazards they ingested bioaccumulate within organisms. Although reached an alarming 400.3 MTs, recycling efforts remain limited, only 18.5 MTs being recycled. Currently, out of the total waste, 49.6 % is converted into energy, 27 recycled, 23.5 recovered material, indicating need for better waste management practices combat escalating levels. Research studies on micro-nanoplastics have primarily concentrated presence laboratory-based toxicity studies. This review critically examines sources detection methods micro-nanoplastics, emphasising toxicological effects ecological impacts. Organisms like zebrafish rats serve key models studying particle's bioaccumulative potential, showcasing adverse that extend DNA damage, oxidative stress, cellular apoptosis. Studies reveal can permeate biological barriers, including blood-brain barrier, neurological imbalance, cardiac, respiratory, dermatological disorders. These health risks, particularly relevant humans, underscore urgency broader, real-world beyond controlled laboratory conditions. Additionally, discusses innovative energy-harvesting technologies sustainable alternatives utilisation, valuable energy-deficient regions. strategies aim simultaneously address energy demands mitigate waste. approach aligns sustainability goals, providing promising avenue both reduction generation. calls further research enhance techniques, assess long-term impacts, explore solutions integrate recovery mitigation, especially regions most affected by shortages increased

Язык: Английский

Exploring Toxicological Pathways of Microplastics and Nanoplastics: Insights from Animal and Cellular Models DOI Creative Commons

Luna Bridgeman,

Alessandra Cimbalo,

David López-Rodríguez

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137795 - 137795

Опубликована: Март 1, 2025

Microplastics (MPs) and nanoplastics (NPs) represent an emerging issue for human animal health. This review critically examines in vitro vivo studies to elucidate their mechanisms of action toxicological effects. Key objectives included: providing a comprehensive overview MP-NPs literature, assessing experimental conditions relative real environmental scenarios, identifying pathways at the molecular level. The findings revealed significant progress understanding impacts. In particular, it has been observed promotion inflammation, oxidative stress, apoptosis, autophagy, endoplasmic reticulum (ER) stress via specific signaling axes. Reproductive toxicity emerged as primary research focus, particularly male models, whereas effects on gastrointestinal, neurological, cardiovascular systems were insufficiently studied, especially affected. Most disproportionately focused polystyrene particles, neglecting other prevalent polymers such polyethylene polypropylene. Furthermore, reliance synthetic microspheres non-realistic concentrations limits relevance real-world conditions. Limited long-term exposure further constrain persistence risks. view this, future should integrate environmentally relevant particles doses, size composition, assessments, advanced methodologies omics computational modeling. addition, therapeutic interventions targeting ER inflammation apoptosis may be excellent solution mitigate toxicity. At same time, standardized global approach is needed fully understand risks posed by MP-NPs, attempting safeguard public

Язык: Английский

Процитировано

1
Copper-Nanoparticle-Induced Neurotoxic Effect and Oxidative Stress in the Early Developmental Stage of Zebrafish (Danio rerio) DOI Creative Commons
Na Liu,

Luyao Tong,

Kunjie Li

и другие.

Molecules, Год журнала: 2024, Номер 29(11), С. 2414 - 2414

Опубликована: Май 21, 2024

Copper nanoparticles (CuNPs) are extensively used in electronics, cosmetics, fungicides, and various other fields due to their distinctive qualities. However, this widespread usage can contribute environmental contamination heightened health risks for living organisms. Despite prevalent use, the ecological impacts biosafety of CuNPs remain inadequately understood. The present study aims delve into potential toxic effects on zebrafish (Danio rerio) embryos, focusing multiple indexes such as embryonic development, neurotoxicity, oxidative stress, inflammatory response. results revealed a notable increase death rate deformity rate, alongside varying degrees decrease hatching heart following exposure. Particularly, frequency spontaneous tail coiling significantly declined under exposure at concentrations 500 µg/L. Furthermore, induced alterations transcriptional expression GABA signaling pathway-related genes (gabra1, gad, abat, gat1), indicating synthesis, release, catabolism, recovery, receptor binding. Additionally, triggered evidenced by disruption superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) activities, along with elevated malondialdehyde (MDA) levels. This stress subsequently led proinflammatory cascade, demonstrated increased markers (il-1β, tnf-α, il-6, il-8). Comparative analysis copper ion (provided CuCl2) highlighted more significant changes most CuCl2, greater toxicity compared equivalent concentrations. In conclusion, these findings provide valuable insights embryo development neurotransmitter conduction. they technical methodologies assessing associated CuNPs, contributing better understanding impact.

Язык: Английский

Процитировано

7
Promising protective potential of MiR-103a-3p against polystyrene microplastic neurotoxicity in rats DOI Creative Commons

Leila Mohammadi,

Tourandokht Baluchnejadmojarad,

Mina Goudarzi

и другие.

Frontiers in Toxicology, Год журнала: 2025, Номер 7

Опубликована: Апрель 1, 2025

Introduction: Microplastics are ubiquitous environmental pollutants with potential neurotoxic effects that can impair learning and memory. MicroRNAs essential regulators of a number physiological pathological processes, but detailed information on the impact miRNAs microplastics is lacking. Methods: In present study, polystyrene (PS-MPs) were administered orally miR-103a-3p was injected intracerebroventricularly as treatment for PS-MPs-induced neurotoxicity. Results Discussion: Performance in novel object discrimination Y-maze Barnes maze tests indicated mitigates deleterious PS-MPs Oxidative stress, pyroptosis, apoptosis inflammation induced by modulated after miR- 103a-3p injection reducing malondialdehyde, protein carbonyl, nitrite, caspase 3, 1, TNFα, NLRP3 levels hippocampal tissue. Our results also showed reverse astrocytic reaction SIRT1 BDNF levels. MiR-103a-3p alleviated endoplasmic reticulum (ER) stress through PERK, CHOP GRP78. These findings imply exerts neuroprotective influence against cognitive deficits exposure to PS-MPs. This achieved inflammation, oxidative stress.

Язык: Английский

Процитировано

0
Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lepem1hwl/Korl Mice DOI Open Access

Yu-Jeong Roh,

Ji‐Eun Kim,

Hee-Jin Song

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4964 - 4964

Опубликована: Май 2, 2024

The impact of microplastics (MPs) on the metabolic functions liver is currently unclear and not completely understood. To investigate effects administration MPs hepatic metabolism normal obese mice, alterations in lipid, glucose (Glu), amino acid regulation pathways were analyzed adipose tissues C57BL/6Korl (wild type, WT) or C57BL/6-Lepem1hwl/Korl mice (leptin knockout, Lep KO) orally administered polystyrene (PS) for 9 weeks. Significant lipid accumulation, adipogenesis, lipogenesis, lipolysis detected tissue MP-treated WT KO compared to vehicle-treated group. These their accompanied by an upregulation serum profile, as well mice. Specifically, level leptin was increased without any change food intake. Also, MP-induced disruptions glycogenolysis, Glu transporter type 4 (GLUT4)-5′ AMP-activated protein kinase (AMPK) signaling pathway, levels intermediates, insulin resistance observed. Furthermore, seven endogenous metabolites remarkably changed after MP administrations. Finally, observed both types further verified differentiated 3T3-L1 adipocytes HepG2 cells. Thus, these results suggest that oral weeks may be associated with disruption Glu,

Язык: Английский

Процитировано

3
Plastic nanoparticles interfere with extracellular vesicle pathway in primary astrocytes DOI Creative Commons

Kamil Adamiak,

Marta Sidoryk‐Węgrzynowicz, Beata Dąbrowska‐Bouta

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117180 - 117180

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

3
Preparation of PLA Nanoparticles and Study of Their Influencing Factors DOI Creative Commons
Xinyu Zhang, Qing Luo, Fengying Zhang

и другие.

Molecules, Год журнала: 2024, Номер 29(23), С. 5566 - 5566

Опубликована: Ноя. 25, 2024

Nanoparticles (NPs) have attractive properties that received impressive consideration in the last few decades. Polylactic acid nanoparticles (PLA-NPs) stand out as a biodegradable polyester with excellent biocompatibility. This investigation introduces PLA-NPs prepared by using emulsification-solvent volatilization (O/W) method. The effects of ultrasonication time, organic-to-aqueous phase volume ratio, surfactant Tween-20, and PLA on particle size well polydispersity index (PDI) were investigated one-factor combination Response Surface Methodology (RSM). result indicates that, one hand, was key factor affecting size, which gradually increased amount from 0.01 to 0.1 g. NPs decreased Tween-20 0.25 mL 1 aqueous phase. ratio organic 1:10 1:1, initially decreasing (from 1:5) subsequently increasing 1:5 1:1). As time 20 min 40 min, 25 30 min) then min). On other main PDI, increase PDI changed significantly rapidly. resulting stabilization subsequent gradual decrease PDI. With (20-40 min), tended be stable after increase. effect not significant, change concentration did cause significant

Язык: Английский

Процитировано

0
Prenatal exposure on nanoplastics: a study of spatial transcriptomics in hippocampal offspring DOI
Lei Tian, Jiang Chen, Xuan Liu

и другие.

Environmental Pollution, Год журнала: 2024, Номер 366, С. 125480 - 125480

Опубликована: Дек. 5, 2024

Язык: Английский

Процитировано

0
Unveiling the Toxicity of Micro-Nanoplastics: A Systematic Exploration of Understanding Environmental and Health Implications DOI Creative Commons
Saurabh Shukla, Sakshum Khanna, Kushagra Khanna

и другие.

Toxicology Reports, Год журнала: 2024, Номер 14, С. 101844 - 101844

Опубликована: Дек. 12, 2024

The surge in plastic production has spurred a global crisis as pollution intensifies, with microplastics and nanoplastics emerging notable environmental threats. Due to their miniature size, these particles are ubiquitous across ecosystems pose severe hazards they ingested bioaccumulate within organisms. Although reached an alarming 400.3 MTs, recycling efforts remain limited, only 18.5 MTs being recycled. Currently, out of the total waste, 49.6 % is converted into energy, 27 recycled, 23.5 recovered material, indicating need for better waste management practices combat escalating levels. Research studies on micro-nanoplastics have primarily concentrated presence laboratory-based toxicity studies. This review critically examines sources detection methods micro-nanoplastics, emphasising toxicological effects ecological impacts. Organisms like zebrafish rats serve key models studying particle's bioaccumulative potential, showcasing adverse that extend DNA damage, oxidative stress, cellular apoptosis. Studies reveal can permeate biological barriers, including blood-brain barrier, neurological imbalance, cardiac, respiratory, dermatological disorders. These health risks, particularly relevant humans, underscore urgency broader, real-world beyond controlled laboratory conditions. Additionally, discusses innovative energy-harvesting technologies sustainable alternatives utilisation, valuable energy-deficient regions. strategies aim simultaneously address energy demands mitigate waste. approach aligns sustainability goals, providing promising avenue both reduction generation. calls further research enhance techniques, assess long-term impacts, explore solutions integrate recovery mitigation, especially regions most affected by shortages increased

Язык: Английский

Процитировано

0