Beta-glucan: An overview in biological activities, derivatives, properties, modifications and current advancements in food, health and industrial applications.

Process Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Functional Scaffolds for Bone Tissue Regeneration: A Comprehensive Review of Materials, Methods, and Future Directions

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(10), P. 280 - 280

Published: Sept. 25, 2024

Bone tissue regeneration is a rapidly evolving field aimed at the development of biocompatible materials and devices, such as scaffolds, to treat diseased damaged osseous tissue. Functional scaffolds maintain structural integrity provide mechanical support defect site during healing process, while simultaneously enabling or improving through amplified cellular cues between scaffold native tissues. Ample research on functionalization has been conducted improve scaffold–host interaction, including fabrication techniques, biomaterial selection, surface modifications, integration bioactive molecular additives, post-processing modifications. Each these methods plays crucial role in not only but actively participate process bone joint surgery. This review provides state-of-the-art, comprehensive overview scaffold-based strategies used engineering, specifically for regeneration. Critical issues obstacles are highlighted, applications advances described, future directions identified.

Language: Английский

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Nanoparticles in Bone Regeneration: A Narrative Review of Current Advances and Future Directions in Tissue Engineering

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(9), P. 241 - 241

Published: Aug. 23, 2024

The rising demand for effective bone regeneration has underscored the limitations of traditional methods like autografts and allografts, including donor site morbidity insufficient biological signaling. This review examines nanoparticles (NPs) in tissue engineering (TE) to address these challenges, evaluating polymers, metals, ceramics, composites their potential enhance osteogenesis angiogenesis by mimicking extracellular matrix (ECM) nanostructure. involved synthesizing characterizing nanoparticle-based scaffoldsand integrating hydroxyapatite (HAp) with polymers mechanical properties osteogenic potential. results showed that NPs significantly promote cell growth, differentiation, formation, carbon-based graphene carbon nanotubes showing promise. offer versatile, biocompatible, customizable scaffolds drug delivery support repair. Despite promising results, challenges cytotoxicity, biodistribution, immune responses remain. Addressing issues through surface modifications biocompatible molecules can improve biocompatibility efficacy nanomaterials. Future research should focus on long-term vivo studies assess safety NP-based explore synergistic effects other bioactive or growth factors. underscores transformative advancing BTE calls further optimize technologies clinical applications.

Language: Английский

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Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computation, Journal Year: 2024, Volume and Issue: 12(4), P. 74 - 74

Published: April 4, 2024

Three-dimensional porous scaffolds are substitutes for traditional bone grafts in tissue engineering (BTE) applications to restore and treat injuries defects. The use of computational modelling is gaining momentum predict the parameters involved healing cell seeding procedures perfusion bioreactors reach final goal optimal growth. Computational based on finite element method (FEM) fluid dynamics (CFD) two standard methodologies utilised investigate equivalent mechanical properties scaffolds, as well flow characteristics inside respectively. success a simulation hinges selection relevant mathematical model with proper initial boundary conditions. This review paper aims provide insights researchers regarding appropriate (FE) models different materials CFD regimes bioreactors. Thus, these FEM/CFD may help create efficient designs by predicting their structural haemodynamic responses prior vitro vivo (TE) applications.

Language: Английский

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ESOT Roadmap for Advanced Therapy Medicinal Products in Transplantation: Navigating Regulatory Challenges to Enhance Access and Care

Transplant International, Journal Year: 2024, Volume and Issue: 37

Published: Oct. 14, 2024

The field of organ transplantation is experiencing a transformative shift with the rise Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption hindered by complex regulatory frameworks, high production costs, inconsistent access across Europe. ESOT ATMP Task Force’s position paper analyzes these challenges from research to clinical application, advocating coordinated strategy Europe as leader in development. It proposes specific actions such streamlining pathways accelerate approvals, boosting funding research, creating specialized facilities development implementation. also highlights critical roles patient engagement real-world evidence optimizing practices.

Language: Английский

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Recent Advances in Hydrogel-Based 3D Disease Modeling and Drug Screening Platforms

Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Advances in bioink-based 3D printed scaffolds: optimizing biocompatibility and mechanical properties for bone regeneration

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The development of bioink-based 3D-printed scaffolds has revolutionized bone tissue engineering (BTE) by enabling patient-specific and biomimetic constructs for regeneration.

Language: Английский

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Adipose derived stem cells – Sources, differentiation capacity and a new target for reconstructive and regenerative medicine

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118036 - 118036

Published: April 8, 2025

Language: Английский

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Enhancing Orthopaedic and Traumatology Implant Efficacy: Innovations in Surface Modification Techniques

Published: Jan. 1, 2025

Language: Английский

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Biopolymer-Based Biomimetic Aerogel for Biomedical Applications

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 397 - 397

Published: June 30, 2024

Aerogels are lightweight and highly porous materials that have been found to great potential in biomedical research because of some their unique properties, such as high surface area, tunable porosity, biocompatibility. Researchers exploring ways use aerogels create biomimetic scaffolds inspired by natural extracellular matrices (ECMs) for various applications. Aerogel can serve three-dimensional (3D) templates cell growth tissue regeneration, promoting wound healing repair. Additionally, aerogel-based controlled drug delivery systems, where area porosity enable the efficient loading release therapeutic agents. In this review, we discuss biopolymer-based aerogel engineering, delivery, biosensors. Finally, also directions development scaffolds.

Language: Английский

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