The role of lipids in cancer progression and metastasis

Cell Metabolism, Год журнала: 2022, Номер 34(11), С. 1675 - 1699

Опубликована: Окт. 18, 2022

Язык: Английский

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IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Март 15, 2022

Breast cancer is the most commonly diagnosed in women. Metastasis primary cause of mortality for breast patients. Multiple mechanisms underlie metastatic dissemination, including interleukin-6 (IL-6)-mediated signaling pathway. IL-6 a pleiotropic cytokine that plays an important role multiple physiological processes cell proliferation, immune surveillance, acute inflammation, metabolism, and bone remodeling. binds to receptor (IL-6Rα) which subsequently glycoprotein 130 (gp130) creating signal transducing hexameric complex. Janus kinases (JAKs) are recruited activated; activated JAKs, turn, phosphorylate transducer activator transcription 3 (STAT3) activation, leading gene regulation. Constitutively active IL-6/JAK/STAT3 drives proliferation invasiveness while suppressing apoptosis, STAT3 enhances promote vicious inflammatory loop. Aberrant expression occurs types associated with poor clinical prognosis metastasis. In cancer, pathway frequently activated, can metastasis simultaneously anti-tumor response. Given these roles human cancers, components promising targets therapeutics currently being evaluated preclinically clinically cancer. This review covers current biological understanding its impact on metastasis, as well as, therapeutic interventions target including: IL-6, IL-6Rα, gp130 receptor, STAT3.

Язык: Английский

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STAT3-EMT axis in tumors: Modulation of cancer metastasis, stemness and therapy response

Pharmacological Research, Год журнала: 2022, Номер 182, С. 106311 - 106311

Опубликована: Июнь 15, 2022

Язык: Английский

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Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

Nature Microbiology, Год журнала: 2023, Номер 8(8), С. 1534 - 1548

Опубликована: Июнь 29, 2023

Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease, and characterized by inflammation fat accumulation. Dietary interventions, such as fibre, have been shown to alleviate this metabolic disorder in mice via gut microbiota. Here, we investigated mechanistic role microbiota ameliorating NASH dietary fibre mice. Soluble inulin was found be more effective than insoluble cellulose suppress progression mice, reduced hepatic steatosis, necro-inflammation, ballooning fibrosis. We employed stable isotope probing trace incorporation 13C-inulin into bacterial genomes metabolites during progression. Shotgun metagenome sequencing revealed that commensal Parabacteroides distasonis enriched 13C-inulin. Integration metagenomes metabolomes suggested P. used produce pentadecanoic acid, an odd-chain which confirmed vitro germ-free or acid protective against Mechanistically, inulin, restored barrier function models, serum lipopolysaccharide pro-inflammatory cytokine expression. Overall shows members can use generate beneficial disease.

Язык: Английский

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Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 28, 2024

Ulcerative colitis (UC) is a debilitating inflammatory bowel disease characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options available. This study systematically investigates the therapeutic potential of synbiotic composed galactooligosaccharides (GOS) Limosilactobacillus reuteri in murine model colitis, revealing that GOS L. synergistically protect against inflammation dysfunction promoting synthesis pentadecanoic acid, an odd-chain fatty from Bacteroides acidifaciens. Notably, synbiotic, B. acidifaciens, acid are each capable suppressing enhancing tight junction inhibiting NF-κB activation. Furthermore, similar reduction acidifaciens levels also observed feces both human UC patients lipopolysaccharide-induced pigs. Our findings elucidate protective mechanism highlight its potential, along for other disorders. Here, Yujun Wu colleagues report alleviates gut animals enriching showing treating ulcerative colitis.

Язык: Английский

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Update on food sources and biological activity of odd-chain, branched and cyclic fatty acids –– A review

Trends in Food Science & Technology, Год журнала: 2021, Номер 119, С. 514 - 529

Опубликована: Дек. 20, 2021

Язык: Английский

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Broader and safer clinically-relevant activities of pentadecanoic acid compared to omega-3: Evaluation of an emerging essential fatty acid across twelve primary human cell-based disease systems

PLoS ONE, Год журнала: 2022, Номер 17(5), С. e0268778 - e0268778

Опубликована: Май 26, 2022

A growing body of evidence supports that pentadecanoic acid (C15:0), an odd-chain saturated fat found in butter, is essential fatty necessary the diet to support long-term metabolic and heart health. Here, dose dependent clinically relevant cell-based activities pure C15:0 (FA15 TM ) were compared eicosapentaenoic (EPA), a leading omega-3 acid, as well additional 4,500 compounds. These studies included 148 biomarkers measured across 12 primary human cell systems, mimicking various disease states, treated with at four different concentrations (1.9 50 μM) non-treated control systems. was non-cytotoxic all had dependent, broad anti-inflammatory antiproliferative involving 36 10 In contrast, EPA cytotoxic systems μM. While shared between 17 μM, 28 activities, especially anti-inflammatory, not present EPA. Further, 1.9 5.6 properties similar bupropion (Pearson’s scores 0.78), compound commonly used treat depression other mood disorders. At mimicked two antimicrobials, climabazole clarithromycin 0.76 0.75, respectively), matched common anti-cancer therapeutics, gemcitabine paclitaxel 0.77 0.74, respectively). summary, dose-dependent numerous broader safer than EPA, paralleled therapeutics for disorders, microbial infections, cancer. further emerging role acid.

Язык: Английский

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Role, molecular mechanism and the potential target of breast cancer stem cells in breast cancer development

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112616 - 112616

Опубликована: Янв. 7, 2022

Breast cancer (BC) is one of the most common malignant tumors in women globally, and its occurrence has surpassed lung become biggest threat for women. At present, breast treatment includes surgical resection or postoperative chemotherapy radiotherapy. However, tumor relapse metastasis usually lead to current therapy failure thanks stem cells (BCSCs)-mediated tumorigenicity drug resistance. Drug resistance mainly due long-term quiescent G0 phase, strong DNA repairability, high expression ABC transporter, reflected activation various proliferation pathways related BCSCs. Therefore, understanding characteristics BCSCs their intracellular extracellular molecular mechanisms crucial development targeted drugs To this end, we discussed latest developments research, focusing on analysis specific markers, critical signaling that maintain stemness BCSCs，such as NOTCH, Wnt/β-catenin, STAT3, Hedgehog, Hippo-YAP signaling, immunomicroenviroment summarizes targeting strategies maintenance differentiation, which provides a theoretical basis further exploration treating preventing derived from

Язык: Английский

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Enhancing Bioenergy Production from the Raw and Defatted Microalgal Biomass Using Wastewater as the Cultivation Medium

Bioengineering, Год журнала: 2022, Номер 9(11), С. 637 - 637

Опубликована: Ноя. 2, 2022

Improving the efficiency of using energy and decreasing impacts on environment will be an inevitable choice for future development. Based this direction, three kinds medium (modified anaerobic digestion wastewater, wastewater a standard growth BG11) were used to culture microalgae towards achieving high-quality biodiesel products. The results showed that culturing with digestate could increase lipid content (21.8%); however, modified can boost microalgal biomass production 0.78 ± 0.01 g/L when compared (0.35–0.54 g/L) other two groups. Besides first step extraction, elemental composition, thermogravimetric pyrolysis products defatted residues also analysed delve into utilisation potential biomass. Defatted from by at 650 °C resulted in total valuable (39.47%) no significant difference toxic compounds Moreover, life cycle assessment environmental impact (388.9 mPET2000) was lower than raw (418.1 (497.3 mPET2000)-cultivated Consequently, method pyrolyzing algal has renewable reduce impact.

Язык: Английский

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Therapeutic Potential and Nutraceutical Profiling of North Bornean Seaweeds: A Review

Marine Drugs, Год журнала: 2022, Номер 20(2), С. 101 - 101

Опубликована: Янв. 25, 2022

Malaysia has a long coastline surrounded by various islands, including North Borneo, that provide suitable environment for the growth of diverse species seaweeds. Some important Bornean seaweed are

Язык: Английский

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