In Vivo Neuropharmacological Effects of Neophytadiene

Molecules, Год журнала: 2023, Номер 28(8), С. 3457 - 3457

Опубликована: Апрель 14, 2023

Neophytadiene (NPT) is a diterpene found in the methanolic extracts of Crataeva nurvala and Blumea lacera, plants reported with anxiolytic-like activity, sedative properties, antidepressant-like actions; however, contribution neophytadiene to these effects unknown. This study determined neuropharmacological (anxiolytic-like, antidepressant-like, anticonvulsant, sedative) (0.1–10 mg/kg p.o.) mechanisms action involved actions using inhibitors such as flumazenil analyzing possible interaction GABA receptors molecular docking study. The behavioral tests were evaluated light–dark box, elevated plus-maze, open field, hole-board, convulsion, tail suspension, pentobarbital-induced sleeping, rotarod. results showed that exhibited activity only high dose (10 mg/kg) plus-maze hole-board tests, anticonvulsant 4-aminopyridine pentylenetetrazole-induced seizures test. abolished pre-treatment 2 flumazenil. In addition, low antidepressant (about 3-fold lower) compared fluoxetine. On other hand, had no or locomotor effects. conclusion, exerts activities probable participation GABAergic system.

Язык: Английский

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Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

Molecules, Год журнала: 2023, Номер 28(3), С. 1365 - 1365

Опубликована: Янв. 31, 2023

Marine algae have excellent bioresource properties with potential nutritional and bioactive therapeutic benefits, but studies regarding Caulerpa lentillifera are limited. This study aims to explore the metabolites profile antioxidant, anticancer, anti-obesity, in vitro cytotoxicity of fractionated ethanolic extract C. using two maceration soxhlet extraction methods. Dried simplicia was mashed extracted ethanol solvent, concentrated evaporated, then sequentially partitioned equal volumes ethyl acetate n-Hexane. Six samples were used this study, consisting ME (Maceration-Ethanol), MEA (Maceration-Ethyl Acetate), MH (Maceration-n-Hexane), SE (Soxhletation-Ethanol), SEA (Soxhletation-Ethyl SH (Soxhletation-n-Hexane). Non-targeted metabolomic profiling determined LC-HRMS, while anticancer DPPH ABTS, lipase inhibition, MTT assay, respectively. demonstrates that has several functional metabolites, antioxidant capacity (EC50 is very close EC50 Trolox), as well anti-obesity < orlistat, an inhibitor lipid hydrolyzing enzymes), which useful precursors for new approaches improving obesity-related diseases. More interestingly, ME, MH, novel agents drugs, especially hepatoma, breast, colorectal, leukemia cancers. Finally, can be a nutraceutical great benefits.

Язык: Английский

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A Review on the Electrospinning of Polymer Nanofibers and Its Biomedical Applications

Journal of Composites Science, Год журнала: 2024, Номер 8(1), С. 32 - 32

Опубликована: Янв. 15, 2024

Polymeric nanofibers have emerged as a captivating medium for crafting structures with biomedical applications. Spinning methods garnered substantial attention in the context of medical applications and neural tissue engineering, ultimately leading to production polymer fibers. In comparison microfibers, boasting nanometer-scale diameters offer significantly larger surface areas, facilitating enhanced functionalization. Consequently, nanofiber mats are presently undergoing rigorous evaluation myriad applications, including filters, scaffolds protective equipment, reinforcement composite materials, sensors. This review offers an exhaustive overview latest advancements processing characterization. Additionally, it engages discourse regarding research challenges, forthcoming developments production, diverse types its Electrospinning has been used convert broad range polymers into nanoparticle nanofibers, may be only approach significant potential industrial manufacturing. The basics these spinning techniques, highlighting uses well nanostructured fibers drug delivery, disease modeling, regenerative medicine, bio-sensing explored.

Язык: Английский

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Skin Ageing: A Progressive, Multi-Factorial Condition Demanding an Integrated, Multilayer-Targeted Remedy

Clinical Cosmetic and Investigational Dermatology, Год журнала: 2023, Номер Volume 16, С. 1215 - 1229

Опубликована: Май 1, 2023

Abstract: Of the human organs, skin is most visible one that displays manifestations of ageing. It has a very intricate microanatomical structure and performs several key physiological functions. The pathophysiology cutaneous ageing characterized by deterioration structural stability functional integrity, implying continuous reduction in maximal function reserve capacity, as result accumulating damage due to both intrinsic extrinsic factors. Elimination unfavorable expressions associated with facial patient demand aesthetic dermatology. Even though progress been made nonsurgical therapies like fillers lasers, non-invasive interventions using care products designed for rejuvenation at an early stage are popular accessible solution among people. In this review, we have scrutinized ageing-associated changes molecular, cellular tissue levels. To optimize process towards healthy skin, propose integrated, multilayer-targeted intervention, which involves topical application anti-ageing formulations from outside oral supplementation inside. Additionally, promising naturally derived ingredients reviewed anti-aging perspective. Most them possess various bioactivities may contribute development mentioned remedy. Keywords: barrier, ageing, causative factors, remedy,

Язык: Английский

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Seaweed Derived Lipids Are a Potential Anti-Inflammatory Agent: A Review

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 20(1), С. 730 - 730

Опубликована: Дек. 30, 2022

Chronic, low-grade inflammation is linked to the development of non-communicable diseases, including cancer, cardiovascular disease, obesity, insulin resistance, diabetes, and others which together contribute more than 50% deaths globally. Modulation inflammatory responses may be a promising strategy, n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) offer new therapeutic option in conditions. Seaweeds are characterised by high nutritional quality good source many bioactive compounds, LC-PUFA. This review addresses potential anti-inflammatory properties seaweed derived lipids, their immunomodulating mechanisms order identify possible applications as an functional food ingredient or dietary supplement. A few studies have evaluated activity lipids using crude lipid extracts, fractions isolated complex from several seaweeds belonging Ochrophyta Rhodophyta phyla, with only three Ulva rigida, sp. Codium tomentosum within Chlorophyta phylum. It was reported that suppress inducible nitric oxide synthase cyclooxygenase-2 expression reduce nuclear factor κB p100 myeloid differentiation primary response 88 protein levels leading downregulation production pro-inflammatory cytokines oxide. Further investigations required unravel underlying preventive action against chronic use and/or health

Язык: Английский

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Plant-Based Functional Foods from Borneo

Nutrients, Год журнала: 2025, Номер 17(2), С. 200 - 200

Опубликована: Янв. 7, 2025

Borneo, the third-largest island in world, is shared between Malaysia (Sabah and Sarawak), Indonesia (Kalimantan) Brunei. As a biodiversity hotspot, it home to about 15,000 flowering plants 3000 tree species, of which many are endemic region. Locally derived plant-based foods gaining popularity due their lower environmental impact, contribution food sustainability health benefits. The local fruits vegetables Borneo have been used traditionally by indigenous community for medicinal purposes. This knowledge can provide valuable guide potential use as functional foods. review explores contemporary from including fruit, vegetables, seaweeds plant-derived products that locally consumed. findings show unique tropical groups wide diversity phytochemical compositions possess array biological activities anti-inflammatory, antioxidant, anti-microbial, anti-proliferative, anti-fungal, wound healing expectorant properties. range deserves further development wider applications

Язык: Английский

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Different molecular responses of Mytilus mantle to lipopolysaccharide and peptidoglycan challenges

Fish & Shellfish Immunology, Год журнала: 2025, Номер 161, С. 110246 - 110246

Опубликована: Март 2, 2025

Язык: Английский

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Amelioration of obesity-related metabolic disorders via supplementation of Caulerpa lentillifera in rats fed with a high-fat and high-cholesterol diet

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Сен. 15, 2022

Dietary modification, including functional foods, could reduce comorbidities due to obesity. An increase in serum glucose and lipids is often seen Furthermore, obesity also characterized by a decrease antioxidant capacity (i.e., superoxide dismutase/SOD) downregulation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). It has been well established that PGC-1α important regulate mitochondrial biogenesis. Sea grapes (Caulerpa lentillifera) are known as traditional food many Asia-Pacific countries. Recent evidence suggests sea have beneficial properties foods may potential therapeutic functions. We investigated the effect (C. on glucose, lipids, PGC-1α, protein levels SOD liver Rattus norvegicus, which induced with high-fat high-cholesterol diet. A total four groups were made, each containing ten male norvegicus; group received standard dry pellet diet control, B cholesterol- fat-enriched diets (CFED), C D CFED 150 450 mg/kg body weight (BW) grape extract, respectively, for 4 weeks. Serum cholesterol assessed using blood auto-analyzer. was measured ELISA. calculated dismutase assay kit Sigma-Aldrich taken from tissue. In this study, extracts improved better than normal groups. The efficacy improvement similar between two doses extract. extract increased PCG-1α levels, especially dose BW. Blood lower Interestingly, treated exhibited higher compared To conclude, promising anti-hyperglycemia anti-hypercholesterolemia, reducing oxidative stress, providing various health benefits metabolic disorders.

Язык: Английский

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Antiparasitic Potential of Methanol Extract of Brown Alga Sargassum polycystum (Phaeophyceae) and Its LC-MS/MS Metabolite Profiling

Diversity, Год журнала: 2022, Номер 14(10), С. 796 - 796

Опубликована: Сен. 24, 2022

In Southeast Asian nations, cultured hybrid groupers are facing serious infestation by the marine parasitic leech Zeylanicobdella arugamensis (Annelida, Hirudinea). They attach to sucking and biting on surface of skin, paving way for secondary infection upon fish. The objective study is utilize locally available seaweed control leeches. methanol extracts brown alga Sargassum polycystum C. Agardh, 1824 (Phaeophyceae) from Sabah were prepared investigated antiparasitic efficacy against Z. through in vitro bioassay. A total 126 adult leeches host obtained fish hatchery. treated with S. 180 min preparing five different dosages at concentrations 100, 50, 25, 12.5, 6.25 mg/mL. was found have high efficacy, resulting 100% mortality over a short period time. It showed highest (total leeches) time limit 0.96 ± 0.44 min, 100 mg/mL extract. Observations behavior positive extract treatments vigorous swimming before mortality. LC-MS/MS analysis used reveal phytochemical composition understand nature main components responsible its activities. 29 metabolites identified via Q Exactive HF Orbitrap mass spectrometry, including two flavonoids (ephedrannin hinokiflavone), organoarsenics (1-dimethylarsinoyl-heptadecane cacodylic acid), four heterocyclic compounds, chlorophyll breakdown products. presence bioactive compounds could increase rate Thus, this concludes that activities can be effectively applied treatment grouper aquaculture farms sustainable aquaculture.

Язык: Английский

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Anti-Obesity Effects of Marine Macroalgae Extract Caulerpa lentillifera in a Caenorhabditis elegans Model

Marine Drugs, Год журнала: 2023, Номер 21(11), С. 577 - 577

Опубликована: Ноя. 3, 2023

Obesity is a multifactorial disease characterized by an excessive accumulation of fat, which in turn poses significant risk to health. Bioactive compounds obtained from macroalgae have demonstrated their efficacy combating obesity various animal models. The green Caulerpa lentillifera (CL) contains numerous active constituents. Hence, the present study, we aimed elucidate beneficial anti-obesity effects extracts derived C. using Caenorhabditis elegans model. ethanol (CLET) and ethyl acetate (CLEA) caused decrease fat consumption, reaching up approximately 50–60%. Triglyceride levels 50 mM glucose-fed worms were significantly reduced 200%. GFP-labeled dhs-3, marker for lipid droplets, exhibited reduction its level 30%. Furthermore, intracellular ROS displayed 18.26 23.91% high-glucose-fed treated with CL extracts, while lifespan remained unchanged. Additionally, mRNA expression genes associated lipogenesis, such as sbp-1, showed down-regulation following treatment extracts. This finding was supported (at 16.22–18.29%) sbp-1 gene expression. These results suggest that may facilitate total induced glucose through pathways. In summary, this study highlights potential model obesity, mediated suppression lipogenesis

Язык: Английский

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