The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Год журнала: 2023, Номер 15(15), С. 3368 - 3368

Опубликована: Июль 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Язык: Английский

---

Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease

Biomedicines, Год журнала: 2025, Номер 13(1), С. 217 - 217

Опубликована: Янв. 16, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic worldwide and affects nearly 30% of adult population 10% pediatric population. It estimated that this number will double by 2030. MASLD one leading causes hepatocellular carcinoma, cirrhosis, transplantation, as well a significant risk factor for cardiovascular mortality. Due to ever-increasing patients, long-term asymptomatic course disease, serious complications, lack preventive programs, insufficient awareness among patients doctors themselves, growing interdisciplinary problem real challenge modern medicine. The main cause an inappropriate lifestyle—inadequate nutrition physical activity, which lead various components metabolic syndrome. Lifestyle changes—appropriate diet, weight reduction, systematic activity—are also basis prevention treatment MASLD. Hence, in recent years, so much importance has been attached lifestyle medicine, non-pharmacological diseases. narrative review presents possible therapeutic options management best documented available diets used were discussed, focusing on benefits drawbacks Mediterranean, high-protein, ketogenic, intermittent fasting diets. In addition, recommendations regarding activity are summarized.

Язык: Английский

---

Effect of a very low-carbohydrate ketogenic diet vs recommended diets in patients with type 2 diabetes: a meta-analysis

Nutrition Reviews, Год журнала: 2021, Номер 80(3), С. 488 - 502

Опубликована: Май 20, 2021

There is renewed interest in using very low-carbohydrate ketogenic (VLCK) diets to manage diabetes. Many clinical trials have been published, often with mixed results.This meta-analysis compares the effect of a VLCK diet on glycemic control, body weight, lipid profile, medication use, and dropouts that recommended for 12 weeks or longer people type 2 diabetes.Ovid MEDLINE, Ovid Embase, CENTRAL, CINAHL databases were searched (January 1980 through September 2019).Two authors independently reviewed search results select randomized controlled (RCTs) comparing (carbohydrate intake < 50 g/d 10% total energy) any diabetes adults. Discrepancies resolved after consulting third author.Eight RCTs 648 participants identified.Compared control diets, resulted greater decrease hemoglobin A1c 3 months (weighted mean difference[WMD]: -6.7 mmol/mol; 95%CI, -9.0 -4.4) (WMD: -0.61%; -0.82 -0.40; P 0.001; moderate-certainty evidence) 6 -6.3 -9.3 -3.5) -0.58%; -0.85 -0.32; low-certainty evidence). was significantly weight loss -2.91 kg; -4.88 -0.95; -2.84 -5.29 -0.39; The not better than months. It superior decreasing triglyceride levels, increasing high-density lipoprotein cholesterol reducing use antidiabetic medications up months.The appears glycemia obesity Beneficial changes serum triglycerides cholesterol, along reductions medications, continued group until However, quality currently available evidence sufficient recommend diets. A major limitation patients' lack adherence carbohydrate restriction.PROSPERO registration number CRD42020154700.

Язык: Английский

---

The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer

Nutrients, Год журнала: 2022, Номер 14(17), С. 3499 - 3499

Опубликована: Авг. 25, 2022

Cardiovascular disease (CVD) and cancer are the first second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that incidence is elevated in patients with CVD vice versa. However, these conditions usually regarded as separate events despite presence shared risk factors between both conditions, such metabolic abnormalities lifestyle. Cohort studies suggested controlling for may have an impact on incidence. Therefore, it could be concluded interventions improve potentially effective preventing treating diseases. The ketogenic diet (KD), a low-carbohydrate high-fat diet, been widely prescribed weight loss programs abnormalities. Furthermore, recent research investigated effects KD treatment numerous diseases, including cancer, due to its role promoting ketolysis, ketogenesis, modifying many other pathways potential favorable health effects. there still great debate regarding prescribing either or cancer. Considering number this topic, clear need summarize mechanisms through which can cardiovascular control cell proliferation. In review, we explained history KD, types, physiological discussed how play prevention.

Язык: Английский

---

Effect of the Ketogenic Diet on the Prophylaxis and Treatment of Diabetes Mellitus: A Review of the Meta-Analyses and Clinical Trials

Nutrients, Год журнала: 2023, Номер 15(3), С. 500 - 500

Опубликована: Янв. 18, 2023

The exponentially growing frequency of diagnosing diabetes mellitus means that a verification the previous dietetic approach to treating disease seems justified. simultaneous growth interest in ketogenic diet and development knowledge this field have contributed increasingly frequent application treatment. This paper also deals with issue; its aim includes an extensive analysis influence on prophylaxis treatment diabetes. has been prepared based wide, meticulous available literature subject. Among other findings, favorable effect nutrition model demonstrated values glycated hemoglobin, glucose, insulin, or metabolic parameters patients. pharmacotherapy type 1 2 presented compared standard nutritional management plan recommended for disease. Further research is needed field, especially studies long follow-up period. discussed articles report interesting therapeutic advantages comparison diets.

Язык: Английский

---

The Effect of a Low-Carbohydrate High-Fat Diet on Laboratory Parameters in Women with Lipedema in Comparison to Overweight/Obese Women

Nutrients, Год журнала: 2023, Номер 15(11), С. 2619 - 2619

Опубликована: Июнь 2, 2023

The aim of this study was to evaluate alterations in blood parameters after a low-carbohydrate high-fat (LCHF) diet women with lipedema comparison overweight or obese women. A total 115 were classified into two groups: the group and overweight/obesity group. Both groups followed caloric-restricted LCHF for 7 months. 48 completed study. reduction body weight observed both groups. significant decrease triglycerides an increase HDL-C concentrations Despite concentration LDL-C group, changes differed between individual patients. Improvements liver parameters, glucose tolerance, fasting insulin levels observed, although they less pronounced than Kidney thyroid functions similar before may be valuable nutritional strategy overweight/obese women, beneficial effect on weight, profile, function, triglycerides, no kidney function.

Язык: Английский

---

Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Фев. 1, 2023

Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.

Язык: Английский

---

Effect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials

Nutrients, Год журнала: 2023, Номер 15(14), С. 3156 - 3156

Опубликована: Июль 15, 2023

Background: Dietary patterns play a critical role in diabetes management, while the best dietary pattern for Type 2 (T2DM) patients is still unclear. The aim of this network meta-analysis was to compare impacts various approaches on glycemic control T2DM patients. Methods: Relevant studies were retrieved from PubMed, Embase, Web Knowledge, Cochrane Central Register Controlled Trials (CENTRAL), and other additional records (1949 31 July 2022). Eligible RCTs those comparing different against each or diet individuals with at least 6 months. We assessed risk bias included tool confidence estimates Grading Recommendations Assessment, Development, Evaluation approach meta-analyses. In order determine pooled effect relative other, we performed (NMA) interventions both HbA1c fasting glucose, which enabled us estimate intervention effects by combing direct indirect trial evidence. Results: Forty-two comprising 4809 NMA, 10 (low-carbohydrate, moderate-carbohydrate, ketogenic, low-fat, high-protein, Mediterranean, Vegetarian/Vegan, low index, recommended, diets). total, 83.3% lower had some concerns. Findings NMA revealed that low-carbohydrate, low-fat diets significantly effective reducing (viz., −0.73 (−1.19, −0.28), −0.69 (−1.32, −0.06), −1.82 (−2.93, −0.71)), glucose −1.30 (−1.92, −0.67), −1.26 (−2.26, −0.27), −0.95 (−1.51, −0.38), −0.89 (−1.60, −0.18) −0.75 (−1.24, −0.27)) compared diet. clustered ranking plot combined outcomes indicated index promising controlling glucose. univariate meta-regressions showed mean reductions only related weight change subjects. Conclusions: For patients, ketogenic diet, Mediterranean moderate-carbohydrate options. Although study found superior, further high-quality long-term are needed strengthen its credibility.

Язык: Английский

---

Ketogenic Diet and Ketone Bodies against Ischemic Injury: Targets, Mechanisms, and Therapeutic Potential

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2576 - 2576

Опубликована: Янв. 30, 2023

The ketogenic diet (KD) has been used as a treatment for epilepsy since the 1920s, and its role in prevention of many other diseases is now being considered. In recent years, there an intensive investigation on using KD therapeutic approach to treat acute pathologies, including ischemic ones. However, contradictory data are observed effects various organs after injury. this review, we provide first systematic analysis studies conducted from 1980 2022 investigating main mechanisms mimetics ischemia-reperfusion injury brain, heart, kidneys, liver, gut, eyes. Our demonstrated high diversity both composition protocols animals, which could be reason different studies. It can concluded that true or mimetics, such β-hydroxybutyrate, considered positive exposure, protecting organ ischemia negative consequences, whereas shift rather similar high-calorie high-fat leads opposite effect.

Язык: Английский

---

The effect of a ketogenic diet on inflammation-related markers: a systematic review and meta-analysis of randomized controlled trials

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Янв. 14, 2024

Abstract Context Despite the important role of inflammation-related factors on occurrence chronic diseases, there is still conflicting evidence about effects ketogenic diet (KD) these factors. Objective In order to obtain a better viewpoint, this study aimed comprehensively investigate KD markers. Data Sources To find pertinent randomized controlled trials up August 2023, databases including PubMed/Medline, Web Science, Scopus, Cochrane Library, and Embase were searched. Extraction This included all investigating C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-8, IL-10 levels. Pooled weighted mean difference (WMD) 95% confidence intervals (CIs) achieved by random-effects model analysis for best estimation outcomes. Analysis Forty-four studies in article. The pooled findings showed that has an effect lowering TNF-α (WMD: −0.32 pg/mL; CI: −0.55, −0.09; P = 0.007) IL-6 −0.27 −0.52, −0.02; 0.036) compared with control groups. However, no significant was reported others inflammation marker–related results subgroup that, following ≤8 weeks people aged ≤50 years, reduction levels significantly higher than other addition, body mass index greater 30 kg/m2 ≤30 kg/m2, decreased extent after receiving KD. Conclusions Consequently, adherence appears improve some markers associated inflammation, IL-6.

Язык: Английский

---