Association between Dietary Niacin Intake and Migraine among American Adults: National Health and Nutrition Examination Survey

Nutrients, Год журнала: 2022, Номер 14(15), С. 3052 - 3052

Опубликована: Июль 25, 2022

Migraine is related to brain energy deficiency. Niacin a required coenzyme in mitochondrial metabolism. However, the relationship between dietary niacin and migraines remains uncertain. We aimed evaluate migraine. This study used cross-sectional data from people over 20 years old who took part National Health Nutrition Examination Survey 1999 2004, collecting details on their severe headaches or migraines, intake, several other essential variables. There were 10,246 participants, with 20.1% (2064/10,246) experienced migraines. Compared individuals lower consumption Q1 (≤12.3 mg/day), adjusted OR values for intake migraine Q2 (12.4−18.3 Q3 (18.4−26.2 Q4 (≥26.3 mg/day) 0.83 (95% CI: 0.72−0.97, p = 0.019), 0.74 0.63−0.87, < 0.001), 0.72 0.58−0.88, respectively. The association exhibited an L-shaped curve (nonlinear, 0.011). of developing was 0.975 0.956−0.994, 0.011) participants 21.0 mg/day. link US adults L-shaped, inflection point roughly

Язык: Английский

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Magnesium as an Important Factor in the Pathogenesis and Treatment of Migraine—From Theory to Practice

Nutrients, Год журнала: 2022, Номер 14(5), С. 1089 - 1089

Опубликована: Март 5, 2022

So far, no coherent and convincing theory has been developed to fully explain the pathogenesis of migraine, although many researchers experts emphasize its association with spreading cortical depression, oxidative stress, vascular changes, nervous excitement, neurotransmitter release, electrolyte disturbances. The contribution magnesium deficiency induction depression or abnormal glutamatergic neurotransmission is a likely mechanism magnesium-migraine relationship. Hence, there interest in various methods assessing ion attempts study relationship intra- extracellular levels migraine attacks. At same time, clinicians believe that supplementation right dose form can be treatment prevent attacks, especially those patients who have identified contraindications standard medications their different preferences. However, are reliable publications confirming role diet as factor causing It also seems interesting deepen research on administration high doses intravenously during aim was discuss probable mechanisms correlation well present current clinical proposals for use preparations complementary substitute pharmacotherapy migraine. summary results observations date gives hope finding trigger attacks (especially aura), which may turn out easy diagnose eliminate pharmacological dietary supplementation.

Язык: Английский

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Association between oxidative balance score and self-reported severe headache or migraine based on NHANES 1999 to 2004 data: A cross-sectional study

Heliyon, Год журнала: 2024, Номер 10(6), С. e27426 - e27426

Опубликована: Март 1, 2024

PurposeThe pathophysiological mechanisms underlying migraine remain elusive, with oxidative stress hypothesized as a potential etiological factor. The Oxidative Balance Score (OBS) is comprehensive tool for assessing the impact of diet and lifestyle on stress, thereby gauging an individual's overall antioxidant capacity. In this cross-sectional study, we explored correlation between OBS prevalence among cohort US adults.MethodsWe analyzed data from 6195 participants aged 20 years above, drawn National Health Nutrition Examination Survey (NHANES) conducted 1999 2004. We employed multiple logistic regression, coupled sensitivity analyses, to investigate relationship migraine. Subsequent subgroup analyses interaction tests were performed assess consistency association across population.ResultsMultiple regression revealed inverse likelihood experiencing migraines. Specifically, individuals in highest quartile exhibited significantly reduced risk compared those lowest (OR = 0.98, 95% Confidence Interval (CI): 0.97–0.99, P 0.0001). Furthermore, restricted cubic spline curves indicated non-linear dietary incidence (non-linear 0.0258).DiscussionOur findings suggest that adherence antioxidant-rich may be effective strategy mitigating migraine, potentially by influencing balance.

Язык: Английский

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Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation

The Journal of Headache and Pain, Год журнала: 2024, Номер 25(1)

Опубликована: Апрель 2, 2024

Abstract Background Migraine stands as a prevalent primary headache disorder, with prior research highlighting the significant involvement of oxidative stress and inflammatory pathways in its pathogenesis chronicity. Existing evidence indicates capacity Dl-3-n-butylphthalide (NBP) to mitigate inflammation, thereby conferring neuroprotective benefits many central nervous system diseases. However, specific therapeutic implications NBP context migraine remain be elucidated. Methods We established C57BL/6 mouse model chronic (CM) using recurrent intraperitoneal injections nitroglycerin (NTG, 10 mg/kg), prophylactic treatment was simulated by administering (30 mg/kg, 60 120 mg/kg) gavage each NTG injection. Mechanical threshold assessed von Frey fibers, photophobia anxious behaviours were light/dark box elevated plus maze. Expression c-Fos, calcitonin gene-related peptide (CGRP), Nucleus factor erythroid 2-related 2 (Nrf2) related pathway proteins spinal trigeminal nucleus caudalis (SP5C) detected Western blotting (WB) or immunofluorescence (IF). The expression IL-1β, IL-6, TNF-α, Superoxide dismutase (SOD) malondialdehyde (MDA) SP5C CGRP plasma ELISA. A reactive oxygen species (ROS) probe used detect ROS SP5C. Results At end modelling period, mice showed significantly reduced mechanical nociceptive thresholds, well photophobic behaviours. Pretreatment attenuated sensitization, photophobia, anxiety mice, levels c-Fos activated Nrf2 downstream HO-1 NQO-1. By measuring associated cytokines, we also found that inflammation. Most importantly, effect after administration ML385 inhibit Nrf2. Conclusions Our data suggest may alleviate activating reduce inflammation models, confirming it potential drug for migraine. Graphical

Язык: Английский

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Association between dietary niacin intake and kidney stones in American adults

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 15, 2025

The evidence regarding the relationship between dietary niacin intake and kidney stones is limited. This study aims to investigate association of with prevalence among adults in United States. present cross-sectional used data from National Health Nutrition Examination Survey (NHANES) 2007–2018. Dietary was obtained first 24-h recalls. history assessed by a questionnaire. Weighted logistic regression, restricted cubic splines (RCS) stratified analysis were evaluate risk stones. A total 28,508 participants included. In full adjusted model, an inverse observed. Compared individuals lowest group, those highest group had lower odds developing (OR = 0.78, 95% CI 0.63–0.97). RCS showed L-shaped (P for non-linearity 0.047). Stratified indicated that this associations appeared be stronger aged blew 60 years interaction < 0.05). associated decreased US adults, especially under age. Our findings suggest appropriate doses may reduce Further research required confirm our clarify casual relationship.

Язык: Английский

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The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Авг. 2, 2023

Glaucoma, an age-related neurodegenerative disease, is characterized by the death of retinal ganglion cells (RGCs) and corresponding loss visual fields. This disease leading cause irreversible blindness worldwide, making early diagnosis effective treatment paramount. The pathophysiology primary open-angle glaucoma (POAG), most common form remains poorly understood. Current available treatments, which target elevated intraocular pressure (IOP), are not at slowing progression in approximately 30% patients. There a great need to identify study options that other mechanisms aid neuroprotection for POAG. Increasingly, role mitochondrial injury development POAG has become emphasized area research interest. Disruption function mitochondria been linked problems with neurodevelopment systemic diseases. Recent studies have shown association between RGC damage cells' mitochondria. In particular, oxidative stress disrupted phosphorylation dynamics increased susceptibility secondary mechanical injury. Several mitochondria-targeted treatments suggested, including physical exercise, diet nutrition, antioxidant supplementation, stem cell therapy, hypoxia exposure, gene transplantation, light therapy. Studies therapeutics may potential slow protecting against decline associated age, genetic susceptibility, pathology. Further, these potentially already present neuronal symptom manifestations. this review, authors outline strategies discuss their utility use

Язык: Английский

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Energy metabolism disturbance in migraine: From a mitochondrial point of view

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Апрель 13, 2023

Migraine is a serious central nervous system disease with high incidence rate. Its pathogenesis very complex, which brings great difficulties for clinical treatment. Recently, many studies have revealed that mitochondrial dysfunction may play key role in migraine, affects the hyperosmotic of Ca 2+ , excessive production free radicals, decrease membrane potential, imbalance mPTP opening and closing, oxidative phosphorylation level, leads to neuronal energy exhaustion apoptosis, finally lessens pain threshold migraine attack. This article mainly introduces cortical spreading depression, then damages related function mitochondria, migraine. Oxidative tricarboxylic acid cycle are main ways provide body. 95 percent needed cell survival provided by respiratory chain. At same time, hypoxia can lead death The pathological permeability transition pore promote interaction between pro-apoptotic protein mitochondrial, destroy structure mPTP, further death. increase accumulation reactive oxygen species, series changes expression proteins metabolism. Both Nitric oxide Calcitonin gene-related peptide closely attack Recent shown their contents also affect metabolism body, so this paper reviews above mechanisms discusses mechanism brain new strategies prevention treatment development individualized accurate

Язык: Английский

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The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review

Pain and Therapy, Год журнала: 2024, Номер 13(4), С. 679 - 690

Опубликована: Май 14, 2024

Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines an aura. Previously, it was thought that CSD mainly driven by neurons, characteristic changes in neuronal swelling and increased extracellular potassium (K+) glutamate. However, the role astrocytes, member neurovascular unit, migraine has recently received increasing attention. In early stages CSD, astrocytes provide neurons energy support clear K+ glutamate from synaptic gaps. late release large amounts lactic acid to exacerbate hypoxia when demand exceeds astrocytes' compensatory capacity. Astrocyte endfoot are not similarly altered. It primarily due influx abnormally active calcium (Ca2+) signaling. Aquaporin 4 (AQP-4) only mediates little as aquaporin. Astrocytes causes perivascular space closure, slowing glymphatic system flow exacerbating neuroinflammation, leading persistent CSD. double-edged swords may be potential targets for interventions.

Язык: Английский

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SIRT1 activation by Ligustrazine ameliorates migraine via the paracrine interaction of microglia and neurons

Phytomedicine, Год журнала: 2024, Номер 135, С. 156069 - 156069

Опубликована: Сен. 17, 2024

Язык: Английский

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Omega-3 PUFAs improve cognitive function in heat-stressed mice by enhancing autophagy via inhibition of the phosphorylation of the PI3K-Akt-mTOR pathway

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The adverse effects of elevated temperatures on human health are becoming progressively severe.

Язык: Английский

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