The roles of epigallocatechin gallate in the tumor microenvironment, metabolic reprogramming, and immunotherapy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Янв. 29, 2024

Cancer, a disease that modern medicine has not fully understood and conquered, with its high incidence mortality, deprives countless patients of health even life. According to global cancer statistics, there were an estimated 19.3 million new cases nearly 10 deaths in 2020, the age-standardized mortality rates 201.0 100.7 per 100,000, respectively. Although remarkable advancements have been made therapeutic strategies recently, overall prognosis remains optimistic. Consequently, are still many severe challenges be faced difficult problems solved therapy today. Epigallocatechin gallate (EGCG), natural polyphenol extracted from tea leaves, received much attention for antitumor effects. Accumulating investigations confirmed EGCG can inhibit tumorigenesis progression by triggering apoptosis, suppressing proliferation, invasion, migration, altering tumor epigenetic modification, overcoming chemotherapy resistance. Nevertheless, regulatory roles biomolecular mechanisms immune microenvironment, metabolic immunotherapy remain obscure. In this article, we summarized most recent updates about effects on microenvironment (TME), reprogramming, anti-cancer immunotherapy. The results demonstrated promote response cytotoxic lymphocytes dendritic cells (DCs), attenuate immunosuppression myeloid-derived suppressor (MDSCs) T (Tregs), tumor-promoting functions tumor-associated macrophages (TAMs), neutrophils (TANs), various stromal including cancer-associated fibroblasts (CAFs), endothelial (ECs), stellate cells, mesenchymal stem/stromal (MSCs). Additionally, suppress multiple reprogramming pathways, glucose uptake, aerobic glycolysis, glutamine metabolism, fatty acid anabolism, nucleotide synthesis. Finally, EGCG, as immunomodulator checkpoint blockade, enhance immunotherapeutic efficacy may promising candidate conclusion, plays versatile TME which provides novel insights combined

Язык: Английский

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Role of natural products in tumor therapy from basic research and clinical perspectives

Acta Materia Medica, Год журнала: 2024, Номер 3(2)

Опубликована: Янв. 1, 2024

Cancer is the leading cause of morbidity and mortality worldwide an important barrier to lengthening life expectancy in every country. Natural products are receiving increased attention from researchers globally increasing numbers natural approved for clinical studies involving cancer recent years. To gain more insight into that have undergone trials treatment, a comprehensive search was conducted. The https://clinicaltrials.gov website searched relevant product information up December 2022. terms included different types cancers, such as colorectal, lung, breast, gynecologic, kidney, bladder, melanoma, pancreatic, hepatocellular, gastric haematologic. Then, PubMed Web Science were articles February 2024. Hence, we listed existing about used treatment cancers discussed preclinical some promising their targets, indications, underlying mechanisms action. Our intent provide basic readers who interested or majoring obtain deeper understanding progress actions

Язык: Английский

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Flavonoids in Treatment of Chronic Kidney Disease

Molecules, Год журнала: 2022, Номер 27(7), С. 2365 - 2365

Опубликована: Апрель 6, 2022

Chronic kidney disease (CKD) is a progressive systemic disease, which changes the function and structure of kidneys irreversibly over months or years. The final common pathological manifestation chronic renal fibrosis characterized by glomerulosclerosis, tubular atrophy, interstitial fibrosis. In recent years, numerous studies have reported therapeutic benefits natural products against modern diseases. Substantial attention has been focused on biological role polyphenols, in particular flavonoids, presenting broadly plants diets, referring to thousands plant compounds with basic structure. Evidence-based pharmacological data shown that flavonoids play an important preventing managing CKD These can prevent dysfunction improve blocking suppressing deleterious pathways such as oxidative stress inflammation. this review, we summarize beneficial properties for treatment relative risk factors CKD.

Язык: Английский

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Anticarcinogenic potentials of tea catechins

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Дек. 5, 2022

Catechins are a cluster of polyphenolic bioactive components in green tea. Anticarcinogenic effects tea catechins have been reported since the 1980s, but it has controversial. The present paper reviews advances studies on anticarcinogenic activities and catechins, including epidemiological evidence mechanism. Tea showed antagonistic many cancers, such as gynecological digestive tract incident glioma, liver gallbladder lung cancer, etc. mechanism underlying involves inhibiting proliferation growth cancer cells, scavenging free radicals, suppressing metastasis improving immunity, interacting with other anticancer drugs, regulating signaling pathways. inconsistent results their causes also discussed this paper.

Язык: Английский

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Cancer-Associated Adipocytes and Breast Cancer: Intertwining in the Tumor Microenvironment and Challenges for Cancer Therapy

Cancers, Год журнала: 2023, Номер 15(3), С. 726 - 726

Опубликована: Янв. 24, 2023

Adipocytes are the main components in breast tissue, and cancer-associated adipocytes (CAAs) one of most important tumor microenvironment cancer (BC). Bidirectional regulation was found between CAAs BC cells. facilitates dedifferentiation adjacent to form with morphological biological changes. increase secretion multiple cytokines adipokines promote tumorigenesis, progression, metastasis by remodeling extracellular matrix, changing aromatase expression, metabolic reprogramming, shaping immune microenvironment. also associated therapeutic response provide potential targets therapy. The present review provides a comprehensive description crosstalk discusses strategies target overcome treatment resistance.

Язык: Английский

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Insulin/IGF Axis and the Receptor for Advanced Glycation End Products: Role in Meta-inflammation and Potential in Cancer Therapy

Endocrine Reviews, Год журнала: 2023, Номер 44(4), С. 693 - 723

Опубликована: Март 4, 2023

Abstract In metabolic conditions such as obesity and diabetes, which are associated with deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation plays a dominant role. cancer, IIGFs is implicated in disease progression, particularly during diabetes; however, further mediators may act concert to trigger meta-inflammation. The receptor for advanced glycation end-products (RAGE) its ligands bridge together metabolism obesity, cancer. Herein, we summarize main mechanisms meta-inflammation malignancies provide our readers most recent understanding conceptual advances on role RAGE at crossroad between impaired inflammation, toward aggressiveness. We inform potential hubs cross-communications driven by aberrant axis dysfunctional tumor microenvironment. Furthermore, offer rationalized view opportunity terminate via targeting pathway, possibility shut molecular connections IIGFs, better control diabetes- obesity-associated cancers.

Язык: Английский

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The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(13), С. 10737 - 10737

Опубликована: Июнь 27, 2023

Breast cancer is one of the most diagnosed cancers worldwide, with an incidence 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality 13.6%. tumor development driven by variety signaling pathways high heterogeneity surface receptors, which makes difficult. Epigallocatechin-3-gallate (EGCG) natural polyphenol isolated as main component in green tea; it has shown multiple beneficial effects breast cancer, controlling proliferation, invasion, apoptosis, inflammation, demethylation DNA. These properties were proved vitro vivo together synergistic combination traditional increasing effectiveness treatment. This review focuses on EGCG functional capabilities acquired cells during its multistep development, molecular signal involved, current drugs, how nanomaterials can improve bioavailability

Язык: Английский

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Natural compounds and mesenchymal stem cells: implications for inflammatory-impaired tissue regeneration

Stem Cell Research & Therapy, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 7, 2024

Abstract Inflammation is a common and important pathological process occurring in any part of the body relating to variety diseases. Effective tissue repair critical for survival impaired organisms. Considering side effects currently used anti-inflammatory medications, new therapeutic agents are urgently needed improvement regenerative capacities inflammatory-impaired tissues. Mesenchymal stromal stem/progenitor cells (MSCs) characterized by capabilities self-renewal multipotent differentiation exhibit immunomodulatory capacity. Due ability modulate inflammatory phenotypes immune responses, MSCs have been considered as potential alternative therapy autoimmune Natural compounds (NCs) complex small multiple-target molecules mostly derived from plants microorganisms, exhibiting many disorders, such osteoporosis, diabetes, cancer, inflammatory/autoimmune Recently, increasing studies focused on prominent NCs MSCs, including regulation cell response, well osteogenic/adipogenic capacities, which indicate roles MSC-based cytotherapy several Their fewer numerous physiological processes, compared chemosynthetic drugs, made them be avenue combined with regeneration. Here we summarize current understanding influence related downstream signaling pathways, specifically conditions. In addition, emerging concepts through combination expand perspectives highlighted. A promising MSC source oral/dental tissues also discussed, remarkable future clinical applications.

Язык: Английский

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Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells, Obesity and the Tumor Microenvironment of Breast Cancer

Cancers, Год журнала: 2022, Номер 14(16), С. 3908 - 3908

Опубликована: Авг. 12, 2022

Breast cancer is the most frequently diagnosed and a common cause of cancer-related death in women. It well recognized that obesity associated with an enhanced risk more aggressive breast as reduced patient survival. Adipose tissue major microenvironment cancer. Obesity changes composition, structure, function adipose tissue, which inflammation metabolic dysfunction. Interestingly, rich ASCs/MSCs, alters properties functions these cells. As key component mammary stroma, ASCs play essential roles microenvironment. The crosstalk between cells multilateral can occur both directly through cell–cell contact indirectly via secretome released by ASC/MSC, considered to be main effector their supportive, angiogenic, immunomodulatory functions. In this narrative review, we aim address impact on summarize current knowledge regarding potential pathological ASCs/MSCs development cancer, discuss related molecular mechanisms, underline possible clinical significance, highlight research perspectives. particular, underscore cell progression, including proliferation survival, angiogenesis, migration invasion, epithelial–mesenchymal transition, stem development, immune evasion, therapy resistance, ASCS/MSCs educating them become cancer-associated fibroblasts. We conclude especially obese may players Targeting provide new path effective treatment.

Язык: Английский

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Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer

Molecules, Год журнала: 2023, Номер 28(2), С. 740 - 740

Опубликована: Янв. 11, 2023

Breast cancer is a common in women worldwide. The existing clinical treatment strategies have been able to limit the progression of breast and metastasis, but abnormal metabolism, immunosuppression, multidrug resistance involving multiple regulators remain major challenges for cancer. Adenosine 5'-monophosphate (AMP)-Activated Protein Kinase (AMPK) can regulate metabolic reprogramming reverse "Warburg effect" via signaling pathways Previous studies suggest that activation AMPK suppresses growth metastasis cells, as well stimulating responses immune cells. However, some other reports claim development poor prognosis are related overexpression aberrant AMPK. Thus, role still controversial. In this review, we summarize current understanding AMPK, particularly comprehensive bidirectional functions progression; discuss pharmacological activators specific molecules, including natural products (including berberine, curcumin, (-)-epigallocatechin-3-gallate, ginsenosides, paclitaxel) influence efficacy these therapy; elaborate potential therapeutic target

Язык: Английский

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