Journal of Biomolecular Structure and Dynamics,
Год журнала:
2023,
Номер
42(5), С. 2586 - 2602
Опубликована: Июнь 16, 2023
Alzheimer's
disease
(AD)
is
a
chronic
neurodegenerative
condition
characterized
by
progressive
cognitive
impairment.
While
the
formation
of
β-amyloid
plaques
and
neurofibrillary
tangles
are
hallmarks
features
AD,
downstream
consequence
these
byproducts
disruption
cholinergic
glutamatergic
neural
systems.
Growing
evidence
for
existence
interplay
between
AChE
NMDARs
has
opened
up
new
venues
discovery
novel
ligands
endowed
with
anticholinesterase
NMDAR-blocking
activity.
Plants
belonging
to
stachys
genus
have
been
extensively
explored
having
broad
range
therapeutic
applications
used
traditionally
millennia,
treat
various
CNS-related
disorders,
which
makes
them
ideal
source
therapeutics.
The
present
study
was
designed
identify
natural
dual-target
inhibitors
NMDAR
deriving
from
their
potential
use
in
AD.
Using
molecular
docking,
drug-likeness-profiling,
MD
simulation
MMGBSA
calculations,
an
in-house
database
biomolecules
pertaining
shortlisted
based
on
binding
affinity,
overall
stability
critical
ADMET
parameters.
Pre-
post-MD
analysis
revealed
that
Isoorientin
effectively
binds
vital
interactions,
exhibits
stable
behavior
minor
fluctuations
relative
two
clinical
drugs
as
positive
control,
displays
strong
consistent
interactions
lasted
majority
simulation.
Findings
this
elucidated
rationale
behind
traditional
Stachys
plants
treatment
AD
could
provide
impetus
development
therapeutics
treatment.Communicated
Ramaswamy
H.
Sarma
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
65(2), С. 382 - 405
Опубликована: Ноя. 22, 2023
Seaweed
is
rich
in
many
unique
bioactive
compounds
such
as
polyphenols
and
sulfated
polysaccharides
that
are
not
found
terrestrial
plant.
The
discovery
of
numerous
biological
activities
from
seaweed
has
made
an
attractive
functional
food
source
with
the
potential
to
be
exploited
for
human
health
benefits.
During
processing
digestion,
cell
wall
polysaccharide
commonly
interact,
this
may
influence
nutritional
properties
food.
Interactions
between
plant-based
system
been
extensively
studied.
However,
similar
interactions
have
received
little
attention
despite
vast
disparity
structural
chemical
composition
plant
wall.
This
poses
a
challenge
extracting
intact
properties.
review
aims
summarize
present
brown,
red
green
seaweed,
current
knowledge
on
their
interactions.
Moreover,
gives
overview
gut
modulation
effect
polyphenol.
Deciphering
the
molecular
communications
along
gut-brain
axis
can
help
in
understanding
pathophysiology
of
neurodegenerative
diseases
and
exploiting
gut
microbiome
for
therapeutics.
However,
microbes
their
metabolites
have
a
multifaceted
role
mediating
both
brain
physiology
pathology.
There
is
lack
how
when
this
tipped
what
are
those
contributing
factors,
at
local
(gut)
distal
(neuronal)
levels,
that
drive
imbalance.
Here
we
reviewed
its
context
summarized
different
factors
such
as
gut-microbial
diversity,
metabolites,
native
immune
system
integrity
epithelial
blood-brain
barriers
interconnected
collectively
define
involvement
gut-microbiome
pathologies.
It
also
underlines
need
multidisciplinary
tools
animal
models
to
simultaneously
reflect
on
many
these
better
correlate
with
clinical
observations
data
obtained
from
human
biopsies
fecal
samples.
Harnessing
will
herald
paradigm
shift
medicine
aging,
emphasizing
significance
broader
spectrum
health
disease.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Дек. 4, 2024
Flavonoids,
a
class
of
polyphenolic
compounds,
are
widely
distributed
in
plant-based
foods
and
have
been
recognized
for
their
potential
to
promote
overall
health
well-being.
Flavonoids
fruits
vegetables
offer
various
beneficial
effects
such
as
anti-aging,
anticancer,
anti-inflammatory
properties.
extensively
studied
neuroprotective
properties,
which
attributed
ability
cross
the
blood-brain
barrier
interact
with
neural
cells.
Factors
like
gut
microbiota
composition,
age,
genetics,
diet
can
impact
how
well
flavonoids
absorbed
gut.
The
enhance
absorption
through
enzymatic
processes,
making
composition
key
factor
influenced
by
diet.
modulate
prebiotic
antimicrobial
effects,
affecting
production
microbial
metabolites
short-chain
fatty
acids
(SCFAs)
butyrate,
play
role
brain
function
health.
microbiome
also
modulates
immune
system,
is
critical
preventing
neuroinflammation.
Additionally,
benefit
mental
psychological
influencing
signaling
pathways
cells
increasing
tyrosine
tryptophan,
precursors
neurotransmitters
serotonin,
dopamine,
norepinephrine,
adrenaline,
gamma-aminobutyric
acid
(GABA).
flavonoid-gut
axis
complex
multifaceted
relationship
that
has
significant
implications
neurological
This
review
will
explore
genetic
environmental
factors
flavonoid
positive
on
network.
Foods,
Год журнала:
2024,
Номер
13(24), С. 4131 - 4131
Опубликована: Дек. 20, 2024
Though
ubiquitous
in
nature,
polyphenols
gained
scientific
prominence
only
after
the
pioneering
work
of
researchers
like
E.
Fischer
and
K.
Freudenberg,
who
demonstrated
their
potential
beyond
traditional
applications,
such
as
leather
industry.
Today,
these
bioactive
compounds
are
recognized
for
diverse
therapeutic
roles,
including
use
adjuvants
cancer
treatment,
prevention,
anti-inflammatory
antioxidant
properties.
Additionally,
have
benefits
managing
obesity,
cardiovascular
diseases,
neuromodulation.
Their
synthesis
is
influenced
by
environmental
genetic
factors,
with
concentrations
varying
based
on
intensity
variables,
well
stage
ripening.
This
review
provides
a
comprehensive
overview
polyphenols,
covering
classification,
chemical
structures,
bioavailability.
The
mechanisms
influencing
bioavailability,
bioaccessibility,
bioactivity
explored
detail,
alongside
an
introduction
to
effects
associated
metabolic
pathways.
Specific
examples,
bioavailability
coffee
various
types
onions,
analyzed.
Despite
promising
biological
activities,
significant
limitation
lies
inherently
low
oral
However,
systemic
circulation
by-products
formed
during
digestion
present
exciting
opportunities
further
research
application.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2040 - 2040
Опубликована: Март 17, 2025
Oncologists
increasingly
recognize
the
microbiome
as
an
important
facilitator
of
health
well
a
contributor
to
disease,
including,
specifically,
cancer.
Our
knowledge
etiologies,
mechanisms,
and
modulation
states
that
ameliorate
or
promote
cancer
continues
evolve.
The
progressive
refinement
adoption
“omic”
technologies
(genomics,
transcriptomics,
proteomics,
metabolomics)
utilization
advanced
computational
methods
accelerate
this
evolution.
academic
center
network,
with
its
immediate
access
extensive,
multidisciplinary
expertise
scientific
resources,
has
potential
catalyze
research.
Here,
we
review
our
current
understanding
role
gut
in
prevention,
predisposition,
response
therapy.
We
underscore
promise
operationalizing
network
uncover
structure
function
microbiome;
highlight
unique
microbiome-related
expert
resources
available
at
City
Hope
Comprehensive
Cancer
Center
example
team
science
achieve
novel
clinical
discovery.
Molecular Nutrition & Food Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 7, 2025
ABSTRACT
Breast
cancer
is
the
most
common
type
of
malignancy
among
women
worldwide.
Significant
achievements
have
been
made
in
diagnostic
tools
and
treatments
past
decade;
however,
complexity
heterogeneity
certain
breast
subtypes
often
lead
to
drug
resistance
metastatic
progression.
Owing
their
low
toxicity
high
variety,
natural
products
derivatives
are
becoming
increasingly
valuable
sources
for
small‐molecule
anticancer
drugs.
Polyphenols
more
widely
known
role
prevention
as
adjuvants
conventional
treatment
strategies.
Therefore,
this
review
focuses
on
antitumor
effects
curcumin,
resveratrol,
polydatin
cancer.
According
main
databases,
only
vitro
preclinical
studies
with
solid
scientific
backgrounds
reports
protective
were
included.
Curcumin,
antioxidant,
anti‐inflammatory,
effects;
indeed,
they
improve
efficacy;
reduce
chemoresistance,
angiogenesis,
tumor
growth;
induce
apoptosis,
autophagy,
cell
cycle
arrest
through
multiple
molecular
pathways,
including
suppression
epithelial–mesenchymal
transition
(EMT),
NF‐κB,
PI3K/Akt/mTOR,
c‐Jun
N‐terminal
kinase
(JNK),
MAPK,
ERK1/2,
STAT
signaling
pathways;
inhibition
cyclins
matrix
metalloproteinase
(MMP)‐2
MMP‐9;
activation
p53
microtubule‐associated
protein
light
chain
3
(LC3).
Journal of Functional Foods,
Год журнала:
2023,
Номер
104, С. 105531 - 105531
Опубликована: Апрель 5, 2023
Hypertension
is
a
systemic
health
condition
that
increases
the
risk
of
cardiovascular
disease.
The
etiology
hypertension
includes
pro-inflammatory
processes,
oxidative
stress
and
sympathetic
hyperactivity.
Gut
microbiota
dysbiosis
associated
with
mucosal
barrier
defects
increased
intestinal
permeability,
contributing
to
activation
an
inflammatory
cascade.
Phenolic
compounds
targeting
gut
stimulate
beneficial
strains
bacteria
increase
production
metabolites
capable
influencing
gut-brain
axis,
reducing
inflammation
improving
metabolic
outcomes.
available
literature
indicates
antihypertensive
effects
phenolic
or
phenolic-rich
extracts
may
vary
depending
on
intervention
group,
type
hypertension,
dose
administered.
In
general,
protect
nervous
system
from
neuroinflammation
as
consequence
microbiota,
suggesting
neuroprotective
effect
against
hypertensive
diseases.
Further
studies
should
focus
development
nutraceuticals
containing
elucidate
their
composition
metabolite
repercussions
