World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(20)
Опубликована: Май 28, 2025
Skeletal
muscle
alterations
(SMA)
are
increasingly
recognized
as
both
contributors
and
consequences
of
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
affecting
progression
outcomes.
Sarcopenia
is
common
in
patients
with
MASLD,
a
prevalence
ranging
from
20%
to
40%
depending
on
the
population
diagnostic
criteria
used.
In
advanced
stages,
such
steatohepatitis
fibrosis,
its
even
higher.
exacerbates
insulin
resistance,
systemic
inflammation,
oxidative
stress,
all
which
worsen
MASLD.
It
an
independent
risk
factor
for
fibrosis
poor
outcomes
including
mortality.
Myosteatosis
refers
abnormal
accumulation
fat
within
tissue,
leading
decreased
quality.
prevalent
(>
30%)
especially
those
obesity
or
type
2
diabetes,
although
this
can
vary
imaging
techniques
reduces
strength
efficiency,
further
contributing
resistance
usually
associated
disease,
cardiovascular
complications,
lower
levels
physical
activity.
Altered
metabolism,
includes
mitochondrial
dysfunction
impaired
amino
acid
has
been
reported
syndromes,
actual
unknown.
metabolism
limits
glucose
uptake
oxidation,
worsening
hyperglycemia
lipotoxicity.
Reduced
perfusion
oxygenation
due
endothelial
MASLD
comorbidities,
obesity,
hypertension,
atherosclerosis.
decreases
capacity
aerobic
fatigue
reduced
activity
aggravating
dysfunction.
Various
SMA
hepatic
accumulation,
may
accelerate
cirrhosis,
increase
Management
strategies
include
training,
exercise,
nutritional
support
(e.g.
,
high-protein
diets,
vitamin
D,
omega-3
fatty
acids),
essential
mitigating
skeletal
loss
improving
However,
pharmacological
agents
that
target
(such
glucagon-like
peptide-1
receptor
agonists)
show
promise
but
have
not
yet
approved
treatment
Journal of Obesity & Metabolic Syndrome,
Год журнала:
2023,
Номер
32(3), С. 197 - 213
Опубликована: Сен. 13, 2023
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
the
latest
term
for
associated
with
metabolic
syndrome.
MASLD
most
common
cause
of
chronic
and
leading
liver-related
morbidity
mortality.
It
important
that
all
stakeholders
be
involved
in
tackling
public
health
threat
obesity
obesity-related
diseases,
including
MASLD.
A
simple
clear
assessment
referral
pathway
using
non-invasive
tests
essential
to
ensure
patients
severe
are
identified
referred
specialist
care,
while
less
remain
primary
where
they
best
managed.
While
lifestyle
intervention
cornerstone
management
MASLD,
cardiovascular
risk
must
properly
assessed
managed
because
No
pharmacological
agent
has
been
approved
treatment
but
novel
anti-hyperglycemic
drugs
appear
have
benefit.
Medications
used
diabetes
other
conditions
may
need
adjusted
as
progresses
cirrhosis,
especially
decompensated
cirrhosis.
Based
on
tests,
concepts
compensated
advanced
clinically
significant
portal
hypertension
provide
a
practical
approach
stratifying
according
complications
can
help
manage
such
patients.
Finally,
prevention
sarcopenia
should
considered
Abstract
Age-related
cognitive
impairment
and
dementia
pose
a
significant
global
health,
social,
economic
challenge.
While
Alzheimer’s
disease
(AD)
has
historically
been
viewed
as
the
leading
cause
of
dementia,
recent
evidence
reveals
considerable
impact
vascular
(VCID),
which
now
accounts
for
nearly
half
all
cases.
The
Mediterranean
diet—characterized
by
high
consumption
fruits,
vegetables,
whole
grains,
fish,
olive
oil—has
widely
recognized
its
cardiovascular
benefits
may
also
reduce
risk
decline
dementia.
To
investigate
protective
effects
diet
on
we
conducted
systematic
literature
review
using
PubMed,
Web
Science,
Google
Scholar,
focusing
studies
published
between
2000
2024.
included
in
meta-nalysis
examined
adherence
to
incidence
AD.
We
applied
random-effects
model
calculate
pooled
hazard
ratios
(HRs)
with
95%
confidence
intervals
(CIs)
assessed
heterogeneity
through
I
-square
statistics.
Forest
plots,
funnel
Z
-score
plots
were
used
visualize
study
outcomes.
Of
324
full-text
records
reviewed,
23
met
inclusion
criteria.
combined
HR
among
those
adhering
was
0.82
(95%
CI
0.75–0.89);
0.89
0.83–0.95);
AD,
0.70
0.60–0.82),
indicating
substantial
effects.
Significant
observed
across
studies,
though
suggested
sufficient
sample
sizes
support
reliable
conclusions
each
condition.
In
conclusion,
this
meta-analysis
confirms
that
is
associated
an
11–30%
reduction
age-related
disorders,
including
impairment,
These
findings
underscore
diet’s
potential
central
element
neuroprotective
public
health
strategies
mitigate
promote
healthier
aging.
American Journal of Clinical Nutrition,
Год журнала:
2023,
Номер
118(5), С. 852 - 864
Опубликована: Авг. 30, 2023
Sarcopenia
is
a
common
skeletal
muscle
disorder
characterized
by
loss
of
mass
and
impaired
function
that
associated
with
poor
health
outcomes.
Although
nutrition
considered
an
important
factor
in
the
etiology
sarcopenia,
preventive
potential
diet,
specifically
extent
to
which
differences
habitual
patterns
diet
and/or
nutrient
intakes
impact
risk
its
development,
poorly
understood.
This
narrative
review
research
evidence
on
dietary
mid-
(<60
y)
young-older
(60-70
adulthood
evaluate
how
they
relate
age-related
changes
function.
A
key
finding
was
current
adult
sarcopenia
older
age
limited
fragmented,
different
outcomes
reported
across
studies
(for
example,
lean
mass,
strength)
few
reporting
links
incident
diagnosed
sarcopenia.
As
these
are
not
interchangeable,
it
challenges
collation
evidence,
leaving
many
gaps
understanding.
There
also
information
about
(<70
longitudinal
repeated
assessments
enable
definition
cumulative
exposures
adulthood.
However,
despite
limitations,
findings
from
already
provide
reasonably
consistent
messages
benefits
diets
higher
quality
earlier
for
later
physical
performance,
although
whole-diet
intervention
trials
urgently
needed
understand
their
potential.
In
comparison,
there
little
individual
nutrients
need
be
addressed
future
research,
may
sufficient
data
promote
more
widely
-
healthier
adulthood,
known
range
outcomes,
linked
effective
preservation
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Апрель 24, 2024
Sarcopenia,
a
condition
characterized
by
diminished
skeletal
muscle
mass,
strength,
and
function,
accompanied
inflammation
oxidative
stress,
remains
an
area
of
limited
exploration
concerning
its
correlation
with
the
Oxidative
Balance
Score
(OBS).
European Journal of Nutrition,
Год журнала:
2024,
Номер
63(5), С. 1651 - 1662
Опубликована: Апрель 3, 2024
Although
numerous
studies
have
investigated
the
impact
of
dietary
factors
on
prevention
decreased
muscle
mass
and
function,
limited
research
has
examined
relationship
between
patterns
sarcopenia.
This
study
aimed
to
assess
associations
patterns,
sarcopenia,
strength,
in
adults
following
a
Mediterranean
diet
residing
southern
Italian
cities.
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 313 - 313
Опубликована: Янв. 16, 2025
The
loss
of
skeletal
muscle
mass
and
strength,
known
as
sarcopenia,
is
prevalent
in
older
adults
linked
to
an
increased
risk
disability,
frailty,
early
mortality.
Muscle
health
crucial
for
the
functionality
independence
adults.
As
aging
population
continuously
grows,
finding
cost-effective
strategies
preventing
treating
sarcopenia
important
public
priority.
While
nutrition
recognized
a
key
factor
development
its
role
condition
still
under
investigation.
In
recent
decades,
nutritional
research
has
shifted
from
focus
on
individual
nutrients
or
healthy
foods
examining
combination
dietary
patterns,
along
with
their
potential
synergistic
antagonistic
effects.
A
balanced
diet
regular
participation
physical
activity
are
essential
maintaining
musculoskeletal
health.
One
eating
patterns
greatest
evidence
multiple
benefits
Mediterranean
diet,
which
also
been
positive
effects
function
observational
studies.
However,
there
lack
intervention
This
review
explores
updated
longitudinal
prospective
studies
associations
between
adherence
order
promote
preventive
aging.
Obesity Pillars,
Год журнала:
2023,
Номер
8, С. 100087 - 100087
Опубликована: Сен. 7, 2023
In
the
U.S.,
children
and
adults
are
consuming
more
low-nutrient
foods
with
added
sugar
excess
fats
as
compared
to
healthy,
high-quality
calories
micronutrients.
This
diet
is
increasing
prevalence
of
malnutrition
nutritional
deficiencies,
despite
high
calorie
intake.
a
review
common
micronutrient
risk
factors
for
malnutrition,
dietary
plans,
health
consequences
in
obesity
U.S.
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Май 23, 2024
Abstract
Diet
is
one
of
the
lifestyle
factors
that
most
amenable
to
intervention,
and
has
a
substantial
effect
on
potential
for
successful
aging
mitigation
risk
disease.
Good
nutrition
pillar
healthy
aging,
large
body
evidence
attests
benefits
Mediterranean
diet
quality
process.
The
comprises
wide
range
nutrients
which,
both
individually
collectively,
exert
positive
effects
immunity,
in
part
mediated
by
gut
microbiota.
In
this
article,
we
review
how
its
beneficial
are
We
certain
key
components
dietary
pattern,
including
vitamins,
zinc,
selenium,
polyphenols.
Overall,
existing
convincingly
demonstrates
Mediterreanean
affects
immune
health
maintaining
weight
reducing
metabolic
cardiovascular
diseases;
inflammation
promoting
microbiota
profile.
