Medicina,
Год журнала:
2025,
Номер
61(1), С. 73 - 73
Опубликована: Янв. 4, 2025
Background
and
Objectives:
Up
until
now,
behavioral
interventions
pharmacological
therapies
were
the
main
approach
available
for
management
of
obesity.
Diet
exercise,
when
used
as
a
singular
therapeutic
method,
are
inadequate
successful
outcome.
Research
shows
promising
results
surgical
treatment
obesity,
especially
in
area
bariatric
surgery
(BaS).
The
relevance
this
study
is
valuable
analysis
evolution
obese
patients
with
increased
cardiovascular
risk.
Materials
Methods:
eligible
BaS
commonly
suffer
from
multiple
chronic
conditions,
including
type
2
diabetes,
obstructive
sleep
apnea,
diseases,
non-alcoholic
fatty
liver
disease.
Additionally,
obesity
contributes
to
an
probability
developing
certain
types
cancer,
osteoarthritis,
urinary
incontinence,
kidney
In
review,
we
focused
on
status
who
underwent
procedures.
Results:
has
been
found
be
strongly
associated
reduced
incidence
severe
complications
individuals
history
myocardial
infarction
(MI)
Specifically,
procedure
linked
lower
occurrence
major
adverse
events
decrease
overall
mortality.
Also,
correlated
risk
recurrent
MI
development
new-onset
heart
failure.
Conclusions:
involve
significant
amelioration
BMI,
contributing
considerable
factors
notable
refinement
structure
function.
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(6), С. 757 - 757
Опубликована: Июнь 10, 2024
Obesity
reflects
excessive
fat
deposits.
At-risk
individuals
are
guided
by
healthcare
professionals
to
eat
fewer
calories
and
exercise
more,
often
using
body
mass
index
(BMI;
weight/height2)
thresholds
for
screening
guide
progress
prognosis.
By
conducting
a
mini-narrative
review
of
original
articles,
websites,
editorials,
commentaries,
guidelines,
we
sought
place
BMI
in
the
context
its
appropriate
use
population
health,
clinical
screening,
monitoring
care.
The
covers
studies
publications
through
2023,
encompassing
consensus
reviews
relevant
literature.
Recent
suggest
that
is
valuable
tool
surveys
primary
but
has
limitations
predicting
risk
chronic
diseases
assessing
excess
fat.
can
nutritional
counseling,
even
if
it
inadequate
reliable
individual
prediction.
cut-offs
must
be
reconsidered
populations
varying
build,
age,
and/or
ethnicity.
Since
BMI-diagnosed
overweight
persons
sometimes
physically
physiologically
fit
other
indicators,
who
on
should
more
fully
evaluated,
diagnosed,
monitored
with
combined
anthropometric
performance
metrics
better
clarify
risks.
involves
integrating
measurements
composition
assessments
physical
function
fitness
provide
comprehensive
evaluation
an
individual’s
health
status.
Eligibility
bariatric
surgery
or
semaglutide
satiety/appetite-reduction
medications
not
determined
alone.
Awareness
advantages
as
assess
adult
obesity
maximize
rapid
evaluation.
Lipids in Health and Disease,
Год журнала:
2025,
Номер
24(1)
Опубликована: Фев. 28, 2025
Various
research
in
the
past
has
indicated
that
NHHR,
which
represents
ratio
of
non-high-density
lipoprotein
cholesterol
(non-HDL-C)
to
high-density
(HDL-C),
and
body
mass
index
(BMI)
each
act
independently
as
contributors
depression
risk.
Nonetheless,
studies
exploring
combination
NHHR
with
BMI
relation
are
limited.
Consequently,
central
aim
this
study
is
investigating
joint
interactive
effects
on
risk,
well
mediating
role
NHHR.
Encompassing
participants
aged
20
years
or
over,
incorporated
a
total
39,704
individuals
from
National
Health
Nutrition
Examination
Survey
(NHANES),
covered
period
2005
2023.
To
analyze
impact
its
depression,
our
analytical
approach
included
multivariate
logistic
regression,
restricted
cubic
spline
modeling,
interaction
testing
subgroup
analyses.
Additionally,
we
studied
BMI.
Finally,
applied
four-way
decomposition
analysis
method
examine
interactions
within
aforementioned
relationships.
Among
all
study,
prevalence
depressive
disorder
(Patient
Questionnaire-9
score
≥
10)
was
9.2%.
Both
were
associated
remained
significant
even
after
full
adjustment
for
covariates
[NHHR,
OR
(95%
CI):
1.07
(1.04–1.09);
BMI,
1.02
(1.02–1.03)].
Compared
reference
group,
CI)
highest
groups
their
product
term
NHHR-BMI
1.41
(1.24–1.61),
1.35
(1.18–1.54),
1.59
(1.37–1.84),
respectively.
Participants
fourth
quartile
exceeding
30
kg/m²,
had
higher
risk
compared
other
first
below
25
kg/m²
[OR
1.64
(1.34-2.00)].
Results
analyses
played
association
between
effect
accounting
17.6%.
Similarly,
also
mediated
11.0%
PHQ-9
score.
However,
no
related
found
general
population.
After
stratifying
by
gender,
it
statistically
males.
Depression
linked
both
depression.
Notably,
there
non-negligible
male
participants.
considering
individually,
when
combined
terms
two
quartiles.
These
findings
suggest
assessment
these
indicators
may
help
deepen
understanding
evaluation
enhance
accuracy
stratification,
worthy
further
research.
Molecular Aspects of Medicine,
Год журнала:
2024,
Номер
97, С. 101273 - 101273
Опубликована: Апрель 8, 2024
Often
associated
with
obesity,
male
infertility
represents
a
widespread
condition
that
challenges
the
wellbeing
of
couple.
In
this
article,
we
provide
comprehensive
and
critical
analysis
studies
exploring
association
between
obesity
reproductive
function,
to
evaluate
frequency
association,
establish
effects
increased
body
weight
on
conventional
biofunctional
sperm
parameters
infertility.
an
attempt
find
possible
molecular
markers
in
obese
patients,
numerous
mechanisms
responsible
for
overweight/obese
patients
are
reviewed
depth.
These
include
obesity-related
functional
hypogonadism,
insulin
resistance,
hyperinsulinemia,
chronic
inflammation,
adipokines,
irisin,
gut
hormones,
microbiome,
transcriptome.
According
meta-analytic
evidence,
excessive
negatively
influences
health.
This
can
occurr
through
broad
array
mechanisms.
Some
these
not
yet
fully
understood
need
be
further
elucidated
future.
A
better
understanding
metabolic
disorders
spermatogenesis
fertilizing
capacity
is
very
useful
identifying
new
diagnostic
designing
therapeutic
strategies
clinical
management
Medicina,
Год журнала:
2024,
Номер
60(7), С. 1080 - 1080
Опубликована: Июнь 30, 2024
Background
and
Objectives:
The
thyroid
is
a
key
endocrine
gland
for
the
regulation
of
metabolic
processes.
A
body
composition
analysis
(BCA)
valuable
complement
to
assessment
mass
index,
which
derived
only
from
weight
height.
This
cross-sectional
retrospective
study
aimed
investigate
relationships
between
volume
(TV)
function
parameters,
anthropometric
measurements,
BCA
presence
syndrome
(MetS)
in
adults
without
clinically
overt
disease.
Material
Methods:
involved
45
people
(females:
57.8%;
MetS:
28.9%)
hospitalized
planned
diagnostics
signs
acute
illness
or
deterioration
their
health
disease,
who
underwent
ultrasound
scans,
biochemical
tests
assess
function,
MetS
assessments,
BCAs
using
bioelectrical
impedance
method.
Results:
TV
was
significantly
larger
with
compared
MetS.
higher
serum
thyrotropin
(TSH)
concentration
lower
overweight
obese
than
normal
underweight
people.
free
triiodothyronine
(FT3)
were
correlated
waist
circumference
some
parameters
BCA,
FT3
also
waist–hip
ratio,
waist–height
ratio.
No
significant
correlations
found
FT4
TSH
results
measurements.
Conclusions:
Even
population
euthyroid
patients
there
BCAs,
features.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Over
20
million
adults
and
6
children
in
the
United
States
(US)
have
asthma,
a
chronic
respiratory
disease
characterized
by
airway
inflammation,
bronchoconstriction,
mucus
hypersecretion.
Obesity,
another
highly
prevalent
US,
is
major
risk
factor
for
asthma
significant
cause
of
diminished
control,
increased
submucosal
eosinophilia,
reduced
quality
life.
A
large
subgroup
these
patients
experiences
severe
symptoms
recurrent
exacerbations
despite
maximal
dosage
standard
therapies.
In
past
two
decades,
development
biological
therapies
has
revolutionized
field
advanced
our
understanding
type
2
inflammatory
biomarkers.
However,
with
obesity
comorbid
are
not
principally
considered
clinical
trials
biologics.
Large
landmark
cluster
analyses
consistently
identified
specific
phenotypes
that
associate
but
may
be
differentiated
age
onset
cell
profiles
sputum.
These
patterns
suggest
biologic
processes
driving
pathology
heterogenous
among
obesity.
The
mechanisms
well
understood
likely
multifactorial.
Future
research
needs
to
done
elicit
cellular
metabolic
functions
relationship
yield
best
treatment
options
this
multiplex
condition.
review,
we
explore
key
features
inflammation
discuss
effectiveness,
safety
profile,
gaps
regarding
currently
approved
International Journal of Obesity,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 20, 2024
Abstract
Knowledge
of
human
body
composition
at
the
dawn
twentieth
century
was
based
largely
on
cadaver
studies
and
chemical
analyses
isolated
organs
tissues.
Matters
soon
changed
by
nineteen
twenties
when
Czech
anthropologist
Jindřich
Matiegka
introduced
an
influential
new
anthropometric
method
fractionating
mass
into
subcutaneous
adipose
tissue
other
major
components.
Today,
one
later,
investigators
can
not
only
quantify
every
component
in
vivo
atomic,
molecular,
cellular,
tissue-organ,
whole-body
organizational
levels,
but
go
far
beyond
to
organ
tissue-specific
metabolite
estimates.
These
advances
are
leading
improved
understanding
adiposity
structure-function
relations,
discovery
obesity
phenotypes,
a
mechanistic
basis
some
weight-related
pathophysiological
processes
adverse
clinical
outcomes.
What
factors
over
past
hundred
years
combined
generate
these
profound
measurement
capabilities
living
humans?
This
perspective
tracks
origins
scientific
innovations
with
aim
providing
insights
current
methodology
gaps
future
research
needs.
Medicine,
Год журнала:
2024,
Номер
103(17), С. e37946 - e37946
Опубликована: Апрель 26, 2024
Obesity
is
a
complex
chronic
metabolic
disorder
characterized
by
abnormalities
in
lipid
metabolism.
not
only
associated
with
various
diseases
but
also
has
negative
effects
on
physiological
functions
such
as
the
cardiovascular,
endocrine
and
immune
systems.
As
global
health
problem,
incidence
prevalence
of
obesity
have
increased
significantly
recent
years.
Therefore,
understanding
assessment
methods
measurement
indicators
for
critical
early
screening
effective
disease
control.
Current
measuring
adult
include
density
calculation,
anthropometric
measurements,
bioelectrical
impedance
analysis,
dual-energy
X-ray
absorptiometry,
computerized
imaging,
etc.
Measurement
mainly
weight,
hip
circumference,
waist
neck
skinfold
thickness,
This
paper
provides
comprehensive
review
literature
to
date,
summarizes
analyzes
obesity,
insights
guidance
innovation
indicators.
