Advances in chemical and materials engineering book series,
Год журнала:
2024,
Номер
unknown, С. 355 - 378
Опубликована: Окт. 25, 2024
This
chapter
discusses
the
importance
of
antifungal
finishing
for
natural
fiber
textiles
to
combat
fungal
growth.
Natural
fibers,
which
are
valued
their
versatility
and
sustainability,
susceptible
contamination
require
appropriate
treatments.
The
fibers
in
negative
consequences
growth
on
textile
materials
emphasize
need
strong
procedures.
Anti-fungal
drugs,
application
methods,
performance
evaluation
methodologies
examined,
highlighting
advances
traditional
chemical
treatments
nanoencapsulation.
fabrics
used
clothing,
healthcare,
other
industries,
analyzes
market
developments
regulations.
concludes
that
industry
is
developing
sustainable
effective
methods
keep
free
fungi.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 20, 2024
Introduction:
Aged-related
brain
damage
and
gut
microbiome
disruption
are
common.
Research
affirms
that
modulating
the
microbiota-gut-brain
axis
can
help
reduce
age-related
damage.
Methods:
Ginseng,
esteemed
in
traditional
Chinese
medicine,
is
recognized
for
its
anti-aging
capabilities.
However,
previous
Ginseng
studies
have
largely
focused
on
diseased
animal
models.
To
this
end,
efforts
were
hereby
made
to
explore
potential
neuroprotective
effects
of
fecal
microbiota
transplantation
(FMT)
from
Ginseng-supplemented
aged
mice
those
pre-treated
with
antibiotics.
Results:
As
a
result,
FMT
specific
modifications
natural
aging
improved
weight
gain,
extended
telomere
length,
anti-oxidative
stress
tissue,
regulated
serum
levels
cytokine,
balanced
proportion
Treg
cells.
Besides,
increased
abundance
beneficial
bacteria
Lachnospiraceae
,
Dubosiella
Bacteroides
etc.
decreased
pathogenic
Helicobacter
Lachnoclostridium
samples
mice.
This
revealed
remarkably
reshaped
microbiome.
Additionally,
FMT-treated
showed
metabolites
Ursolic
acid,
β-carotene,
S-Adenosylmethionine,
Spermidine,
Guanosine,
Celecoxib,
Linoleic
etc.,
which
significantly
positively
correlated
critical
above.
these
identified
mainly
enriched
pathways
Amino
acid
metabolism,
Lipid
Nucleotide
Furthermore,
downregulated
p53/p21/Rb
signaling
upregulated
p16/p14,
ATM/synapsin
I/synaptophysin/PSD95,
CREB/ERK/AKT
following
aging.
Discussion:
Overall,
study
demonstrates
reprogramming
by
impedes
process,
possibly
through
regulation
axis.
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 348 - 348
Опубликована: Фев. 1, 2024
Our
current
understanding
of
skin
cell
senescence
involves
the
role
environmental
stressors
(UV,
O3,
cigarette
smoke,
particulate
matter,
etc.),
lifestyle
(diet,
exercise,
etc.)
as
well
genetic
factors
(metabolic
changes,
hormonal,
etc.).
The
common
mechanism
action
these
is
disturbance
cellular
redox
balance
characterized
by
increased
free
radicals
and
reactive
oxygen
species
(ROS),
when
overload
intrinsic
antioxidant
defense
system,
it
can
lead
to
an
oxidative
stress
condition.
main
mechanisms
that
activate
in
involve
(1)
damage
telomeres
causing
their
shortening;
(2)
oxidation
proteomes
DNA
damage;
(3)
a
lysosomal
mass
through
activity
resident
enzymes
such
senescence-associated
β-galactosidase
(SA-β-gal)
other
proteins
are
products
activity;
(4)
expression
SASP,
particular
pro-inflammatory
cytokines
transcriptionally
regulated
NF-κB.
However,
targets
ROS
on
proteome
(oxi-proteome),
followed
telomeres,
nucleic
acids
(DNAs),
lipids,
proteins,
cytoplasmic
organelles.
As
result,
cycle
arrest
pathways,
lipid
peroxidation,
content
dysfunctional
mitochondria,
SASP
synthesis
occur.
Furthermore,
cells
increases
p16INK4A
p53
inhibitors
Rb
CDks,
which
important
for
maintaining
cycle.
also
promotes
inactivation
mTOR-mediated
autophagic
apoptotic
leading
senescence.
markers
alone
cannot
establish
state
senescence,
multiple
analyses
encouraged
confirmation.
An
updated
more
comprehensive
approach
investigating
should
include
further
assays
ox-inflammatory
molecular
pathways
consolidate
cutaneous
Cosmetics,
Год журнала:
2025,
Номер
12(2), С. 85 - 85
Опубликована: Апрель 21, 2025
This
study
explores
the
potential
of
ginseng-derived
peptides
(GPs)
as
multifunctional
bioactive
agents
for
skincare.
Unlike
previous
research
into
ginseng
saponins
and
polysaccharides,
we
identified
that
extracts
containing
water-soluble
small
molecules
polypeptides
exhibit
potent
antioxidant,
anti-inflammatory,
anti-aging
properties.
In
vitro
assays
revealed
peptide
extract
(GPE)
reduced
reactive
oxygen
species
(ROS)
inflammatory
cytokines
(IL-6,
TNF-α,
IL-1β)
in
RAW264.7
macrophages
while
enhancing
collagen
synthesis
human
skin
fibroblasts
(HSFs).
Validation
using
3D
epidermal
dermal
models
further
confirmed
GPE’s
ability
to
mitigate
UV-induced
damage,
restore
barrier
proteins
(filaggrin,
loricrin),
increase
content.
addition,
screened
19
candidate
from
machine
learning
prioritized
their
interaction
with
aging
inflammation-related
targets.
Three
(QEGIYPNNDLYRPK,
VDCPTDDATDDYRLK,
ADEVVHHPLDKSSEVE)
demonstrated
significant
collagen-promoting,
anti-inflammatory
effects
cellular
models.
These
findings
highlight
efficacy
computational
approaches
identifying
natural
ingredients,
positioning
promising
candidates
innovative
cosmeceutical
formulations
targeting
inflammaging
rejuvenation.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 25, 2024
The
pathogenesis
of
age-related
macular
degeneration
(AMD),
a
degenerative
retinopathy,
remains
unclear.
Administration
anti-vascular
endothelial
growth
factor
agents,
antioxidants,
fundus
lasers,
photodynamic
therapy,
and
transpupillary
warming
has
proven
effective
in
alleviating
symptoms;
however,
these
interventions
cannot
prevent
or
reverse
AMD.
Increasing
evidence
suggests
that
AMD
risk
is
linked
to
changes
the
composition,
abundance,
diversity
gut
microbiota
(GM).
Activation
multiple
signaling
pathways
by
GM
metabolites,
including
lipopolysaccharides,
oxysterols,
short-chain
fatty
acids
(SCFAs),
bile
(BAs),
influences
retinal
physiology.
Traditional
Chinese
medicine
(TCM),
known
for
its
multi-component
multi-target
advantages,
can
help
treat
altering
composition
regulating
levels
certain
substances,
such
as
reducing
increasing
SCFA
BA
contents.
This
review
explores
correlation
between
two
provide
new
perspectives
on
treating
with
TCM.
Poultry Science,
Год журнала:
2024,
Номер
103(3), С. 103467 - 103467
Опубликована: Янв. 21, 2024
In
this
study,
a
total
of
312
Hyline
brown
laying
hen
1.92±
0.12
kg
acquired
at
24-weeks
old
were
employed
to
evaluate
the
pharmaceutical
effect
Korean
wild
ginseng
residue
extract
administered
via
drinking
water
on
performance,
microbiota
quality,
cytokine
expression,
and
ginsenoside
saponin
(GS)
content
for
12
weeks.
experiments,
basic
feed
(CON)
was
compared
with
+
0.05%
in
(WGD1),
0.1%
(WGD2),
0.5%
(WGD3).
At
end
hen-day
egg
production
(HDEP),
average
weight
(AEW),
mass
(EM)
linearly
higher
(p<0.05)
WGD3
weeks
30-33,
34-37
weeks,
cumulative
CON.
Feed
conversion
ratio
(FCR)
lower
Relative
expression
tumour
necrosis
factor
alpha
(TNF-α)
The
GS
yolk
hens
supplemented
treatment
34-37,
while
faecal
microflora
quantity
Lactobacillus
till
Escherichia
coli
(E.
coli)
WGD2
from
26-37
We
concluded
result
HDEP,
AEW,
EM,
FCR
due
increase
content,
tentatively
leading
an
improvement
TNF-α,
quality
such
as
E.
WGD3.
therefore
recommend
use
application
level
optimum
performance
30-37
Experimental Gerontology,
Год журнала:
2024,
Номер
195, С. 112554 - 112554
Опубликована: Авг. 23, 2024
Mountain
cultivated
ginseng
(MCG)
is
planted
in
mountain
forests
to
simulate
traditional
wild
ginseng;
therefore,
it
has
a
greater
pharmacological
effect
than
(CG)
the
garden;
however,
insufficient
evidence
confirms
this
theory.
In
light
of
health-promoting
and
life-extending
properties
ginseng,
we
analyzed
efficacy
MCG
CG.
Initial
observations
revealed
that
phytosterols
content
was
higher
CG,
with
positive
correlation
duration
growth.
The
distinction
between
CG
predominately
determined
by
stigmasterol
using
High-Performance
Liquid
Chromatography
(HPLC).
lifespan
Drosophila
melanogaster
(fruit
flies)
aged
naturally
prolonged
stigmasterols.
Further,
they
healthy
ageing
as
measured
progeny
numbers,
length
sleep,
climbing
distance,
survival
following
oxidative
damage.
findings
behavioral
were
more
efficacious
promoting
health
maintenance
life
extension;
moreover,
indicated
these
effects
dose-dependent.
Stigmasterols,
have
restored
age-associated
decreases
steroid
hormone
levels.
Notably,
molecular
docking
predicted
promote
stigmasterol's
binding
receptor
ECR
due
its
similarity
hormones.
addition,
stigmasterols
triggered
signaling
pathway
increasing
activity
key
genes
Eip75B
Br
20E
Jhamt,
HmGR,
Met,
Kr-h1
JH
signaling.
Phytosterols,
natural
product,
regulated
longevity
dietary
supplement
similar
steroids,
which
supported
social
requirements
ageing.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 13, 2024
Panax
ginseng
(
P.
),
a
traditional
and
highly
valued
botanical
drug,
has
been
used
for
thousands
of
years
is
known
around
the
world
its
uses
in
food,
medicine,
healthcare.
The
comprehensive
study
crucial
quality
assurance
medicinal
materials
optimal
resource
utilization.
Despite
being
present
trace
amounts,
volatile
oil
wide
range
chemical
metabolites
with
important
potential.
shown
promise
defending
cardiovascular
system,
as
well
terms
ability
antibacterial,
anti-aging,
anti-platelet
coagulation,
anti-inflammatory,
support
nervous
system
nutritionally,
shield
it
from
harm.
Due
to
low
composition
lack
thorough
investigation,
oil’s
therapeutic
applicability
still
restricted
although
exhibited
many
benefits.
This
review
aims
provide
insights
into
composition,
extraction
processes,
pharmacological
effects,
mechanisms
action
oil,
theoretical
guidelines
future
research
clinical
application.
