The Beneficial Effects of Lactobacillus Strains on Gut Microbiome in Alzheimer’s Disease: A Systematic Review
Healthcare,
Год журнала:
2025,
Номер
13(1), С. 74 - 74
Опубликована: Янв. 3, 2025
Background/Objectives:
Growing
evidence
suggests
that
the
gut–brain
axis
influences
brain
function,
particularly
role
of
intestinal
microbiota
in
modulating
cognitive
processes.
Probiotics
may
alter
function
and
behavior
by
gut
microbiota,
with
implications
for
neurodegenerative
diseases
like
Alzheimer’s
disease
(AD).
The
purpose
this
review
is
to
systematically
current
literature
exploring
effects
probiotic
supplementation
on
AD
mild
impairment
(MCI).
Methods:
A
comprehensive
search
was
conducted
across
PubMed/Medline,
Embase,
Scopus
identify
relevant
randomized
controlled
trials
(RCTs)
from
inception
20
August
2024.
focused
comparing
outcomes
between
intervention
control/placebo
groups.
Data
searches,
article
selection,
data
extraction,
risk
bias
assessment
were
performed
accordance
Cochrane
guidelines.
Systematic
Review
Registration:
PROSPERO
registration
no:
CRD42023446796.
Results:
four
RCTs
involving
293
Individuals
(AD
MCI
patients)
receiving
mainly
Lactobacillus
Bifidobacterium
strains
showed
some
beneficial
altered
composition,
positively
affected
metabolic
biomarkers.
However,
variability
studies
limits
interpretation
results.
limited
number
quality
existing
make
it
difficult
draw
definitive
conclusions
data.
Additional
high-quality
research
clearly
needed.
Conclusions:
show
promise
as
an
adjunctive
decline,
but
larger,
long-term
are
needed
confirm
their
efficacy
clinical
applicability
AD.
Язык: Английский
The Power of Environment: A Comprehensive Review of the Exposome’s Role in Healthy Aging, Longevity, and Preventive Medicine—Lessons from Blue Zones and Cilento
Nutrients,
Год журнала:
2025,
Номер
17(4), С. 722 - 722
Опубликована: Фев. 18, 2025
Aging
and
longevity
are
shaped
by
the
exposome,
a
dynamic
network
of
environmental,
social,
biological
factors.
Understanding
how
these
exposures
interact
with
mechanisms
can
inform
strategies
for
healthier
aging.
Background/Objectives:
This
review
explores
exposome
as
system
encompassing
both
protective
risk
factors,
specific
focus
on
beneficial
environmental
exposures,
microbiome
diversity,
lifestyle
behaviors,
resilience
contribute
to
successful
By
analyzing
high-longevity
populations,
such
Blue
Zones
Cilento,
it
aims
identify
common
determinants
Methods:
A
mixed-method
study
was
conducted,
combining
systematic
English
literature
(2003-2024)
comparative
analysis
regions.
structured
search
performed
in
PubMed,
Scopus,
Google
Scholar
using
keywords
"longevity",
"Blue
Zones",
"Cilento",
"microbiome",
"environmental
factors",
related
terms.
Additionally,
qualitative
quantitative
were
applied
assess
key
factors
across
different
aging
models.
Results:
identified
contributing
hotspots,
including
sustained
exposure
biodiverse
natural
environments,
adherence
Mediterranean
or
plant-based
diet
rich
polyphenols
probiotics,
regular
physical
activity,
strong
social
networks,
psychological
resilience.
novel
aspect
this
is
role
gut
mediator
between
immune-metabolic
health,
influencing
inflammation
modulation
cellular
Despite
geographic
cultural
differences,
case
studies
reveal
shared
pattern
that
collectively
enhance
lifespan
healthspan.
Conclusions:
The
critical
determinant
trajectories,
acting
through
complex
interactions
mechanisms.
integrating
insights
from
proposes
comprehensive
framework
optimizing
enhancing
resilience,
promoting
exposures.
These
findings
provide
translational
perspective
guide
future
interventions
research
global
health
initiatives.
Язык: Английский
Colombian centenarians: A Geohealth approach to longevity study
PLoS ONE,
Год журнала:
2025,
Номер
20(2), С. e0311690 - e0311690
Опубликована: Фев. 21, 2025
Population
longevity
is
a
global
phenomenon
influenced
by
various
factors
including
social,
economic
transitions,
and
medical
advancements.
The
study
focused
on
the
population
over
95
years
old,
adopting
an
approach
that
integrates
data
from
2018
Census
geospatial
analysis
techniques.
An
ecological
was
conducted
using
anonymized
microdata
National
Housing
(CNPV).
Geographic
analysis,
choropleth
maps,
Kernel
density
estimation
were
employed
to
identify
clusters
of
individuals
aged
years.
identified
43,427
or
older
in
Colombia,
with
concentrations
observed
departments
such
as
Antioquia
Bogotá.
Analysis
department
municipality
revealed
variations
rates
sex
distribution.
highlighted
Valle
de
Tenza
area
other
regions.
This
sheds
light
geographical
distribution
centenarians
emphasizing
certain
More
research
needed
understand
individual
contextual
underlying
successful
aging
Colombia
inform
policies
improve
quality
life
populations.
Язык: Английский
The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10757 - 10757
Опубликована: Окт. 6, 2024
With
the
aging
of
global
population,
neurodegenerative
diseases
are
emerging
as
a
major
public
health
issue.
The
adoption
less
sedentary
lifestyle
has
been
shown
to
have
beneficial
effect
on
cognitive
decline,
but
molecular
mechanisms
responsible
clear.
Here
we
provide
detailed
analysis
complex
molecular,
cellular,
and
systemic
underlying
age-related
decline
how
choices
influence
these
processes.
A
review
evidence
from
animal
models,
human
studies,
postmortem
analyses
emphasizes
importance
integrating
physical
exercise
with
cognitive,
multisensory,
motor
stimulation
part
multifaceted
approach
mitigating
decline.
We
highlight
potential
non-pharmacological
interventions
address
key
hallmarks,
such
genomic
instability,
telomere
attrition,
neuroinflammation,
underscore
need
for
comprehensive
personalized
strategies
promote
resilience
healthy
aging.
Язык: Английский
Nutritional Barriers to the Adherence to the Mediterranean Diet in Non-Mediterranean Populations
Foods,
Год журнала:
2024,
Номер
13(11), С. 1750 - 1750
Опубликована: Июнь 2, 2024
Adherence
to
the
Mediterranean
diet
has
been
shown
lower
risk
of
developing
chronic
non-communicable
diseases
like
cardiovascular
and
neurodegenerative
cancer.
Improvements
in
depression,
participation
daily
activities
older
individuals,
weight
loss
a
reduction
adverse
pregnancy
outcomes
are
associated
with
adherence
diet.
The
number
studies
that
have
evaluated
barriers
US
and,
particular,
racial
ethnic
minority
populations
within
few.
Among
Native
American
Alaskan
populations,
evaluating
traditional
or
alternative
for
non-infectious
is
unavailable.
scoring
instruments
used
European
countries
among
white
participants
fail
capture
dietary
patterns
populations.
In
this
narrative
review,
food
components
discussed,
examined
non-Mediterranean
preventing
reviewed.
Recommendations
improving
nutrition
education
intervention
increasing
cultural
adaptions
provided.
Язык: Английский
Food waste behaviors of the families of the Cilento Bio-District in comparison with the national data: elements for policy actions
Frontiers in Sustainable Food Systems,
Год журнала:
2024,
Номер
8
Опубликована: Июнь 20, 2024
Introduction
Consumer
food
waste
at
the
household
level
results
from
a
complex
set
of
behaviors
depending
on
local
environment,
among
other
factors.
This
study
mainly
aimed
comparing
in
Cilento
Bio-District
with
those
recorded
national
to
explore
if
organic
district
model
had
an
impact
attitude
as
sustainability
element.
Methods
Household
behavior
indicators
performed
better
than
Bio-District,
some
relevant
exceptions,
such
avoidance
having
too
much
home
and
impulse
buying.
Results
The
suggest
that
attitudes
rural
community
might
be
so
embedded
everyday
practices
they
are
no
longer
perceived
descriptors,
considering
lower
(FW)
levels
compared
data.
key
findings
were
interpreted
for
policy
action
development.
Discussion
overall
priority
actions
would
enhancement
consumers’
abilities
prevention.
Community
engagement
aspects
products’
promotion
should
particularly
pursued
while
broader
proposed
involvement
different
sectors
chain
proposition
regulatory
(e.g.,
labels).
Future
research
characteristics
comparison
data
need
more
comprehensive
examination
additional
factors
affecting
system,
dietary
patterns
or
product
consumption,
understand
their
potential
influence
and,
general,
choices.
Язык: Английский
Potential Impact of Physical Activity on Measures of Well-Being and Quality of Life in People with Rare Diseases: A Nationwide Cross-Sectional Study in Italy
Healthcare,
Год журнала:
2024,
Номер
12(18), С. 1822 - 1822
Опубликована: Сен. 11, 2024
Background:
Rare
diseases
constitute
a
heterogeneous
group
of
approximately
7000–8000
conditions,
distinguished
by
their
low
prevalence.
Collectively,
they
present
significant
global
health
challenge,
affecting
millions
people
worldwide.
It
is
estimated
that
rare
affect
10%
the
population,
which
places
burden
on
individuals,
families,
and
society.
is,
therefore,
important
to
consider
strategies
improve
overall
well-being
quality
life
individuals
with
diseases.
One
potential
avenue
for
exploration
incorporation
physical
activity
(PA).
The
scope
this
study
was
ascertain
whether
PA
has
positive
impact
measures
determine
its
enhance
these
individuals.
Methods:
data
were
collected
via
an
online
survey.
one-way
ANOVA
test
multiple
groups
multivariate
Poisson
models
employed
identify
predictors
outcomes
interest.
Results:
protective
effects
become
evident
minimum
six
hours
per
week.
Our
confirm
weekly
devoted
can
serve
as
factor
QoL.
also
provided
some
insights
into
motivations
behind
patients’
engagement
in
PA.
These
included
improving
QoL
well-being,
well
desire
interact
socially,
goal
meeting
friends
or
making
new
acquaintances.
Finally,
adults
older
adults,
engaging
be
way
control
weight.
Conclusions:
becoming
increasingly
clear
stand
benefit
greatly
from
PA,
so
it
only
sensible
educate
them
advantages
active
lifestyle.
Язык: Английский
Age Differences and Prevalence of Comorbidities for Death and Survival in Patients with COVID-19: A Single-Center Observational Study in a Region of Southern Italy
Life,
Год журнала:
2024,
Номер
14(11), С. 1376 - 1376
Опубликована: Окт. 25, 2024
The
SARS-CoV-2
outbreak
has
resulted
in
a
considerable
number
of
deaths
worldwide.
virus
damages
the
pulmonary
artery
endothelium,
leading
to
condition
known
as
microvascular
inflammatory
thrombotic
syndrome
(MPITS),
which
can
be
fatal
and
cause
multiple
organ
failure.
presence
preexisting
comorbidities
been
shown
significantly
impact
severity
prognosis
patients
with
infection.
objective
this
study
was
compare
age
groups
coronavirus
disease
2019
(COVID-19)
identify
prevalence
associated
death
survival
an
area
southern
Italy.
data
set
consisted
1985
confirmed
cases
infection
who
were
admitted
A.O.U.
San
Giovanni
di
Dio
e
Ruggi
d'Aragona
Hospital
Salerno
between
January
2021
December
2022.
results
presented
for
overall
population
stratified
by
outcome
group.
All
analyses
performed
using
XLSTAT
(Lumivero,
2024,
Paris,
France)
STATA
software
(release
16.1,
StataCorp
LLG,
College
Station,
TX,
USA,
2019)
packages.
In
study,
population,
636
(32%)
death,
higher
60-79
group,
followed
≥80
30-59
groups.
most
prevalent
diseases
among
deceased
surviving
those
affecting
circulatory
system
(61.5%
vs.
55.5%),
respiratory
(55.8%
26.2%),
metabolic
(25.9%
25.4%).
aged
30-79,
primary
mortality,
whereas
≥80,
more
prevalent.
Among
survivors,
cardiovascular
common
across
all
groups,
endocrine,
metabolic,
immune
disorders.
Moreover,
these
elevated
risk
mortality.
emphasizes
substantial
influence
on
mortality
These
findings
highlight
necessity
targeted
interventions
manage
comorbid
conditions
infection,
particularly
older
adults.
Язык: Английский
Revealing the secrets of Blue Zones
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Aging
is
influenced
by
cellular
senescence
mechanisms
that
are
associated
with
oxidative
stress.
Oxidative
stress
the
imbalance
between
antioxidants
and
free
radicals.
This
affects
enzyme
activities
causes
mitochondrial
dysfunction.
It
also
slows
down
energy
production
disrupts
homeostasis.
Additionally,
stimulates
inflammation,
increases
number
of
point
mutations,
alters
intercellular
communication.
can
lead
to
epigenetic
alterations,
genomic
instability,
telomere
attrition,
loss
proteostasis.
Ultimately,
these
factors
contribute
aging
development
chronic
diseases.
Glucose-6-phosphate
dehydrogenase
(G6PD)
an
antioxidant
protects
cells
from
nitrosative
damage.
helps
restore
redox
balance,
preserve
macromolecule
function,
rescue
senescence,
autophagy,
stress-induced
apoptosis.
G6PD
considered
anti-senescence
enzyme.
The
World
Health
Organization
classifies
variants
into
five
groups
based
on
enzyme’s
residual
activity.
first
four
classes
categorized
according
degree
deficiency,
while
fifth
class
includes
greater
than
normal.
Increased
activity
does
not
exhibit
clinical
manifestations.
Consequently,
full
spectrum
mutations
prevalence
increased
in
population
remain
unknown.
world’s
oldest
healthiest
people
live
Blue
Zones.
These
comprise
isolated
populations,
there
may
be
a
geographic
high-activity
protect
against
senescence.
To
uncover
secret
centenarians’
longevity,
additional
research
needed
determine
whether
hidden
factor
Язык: Английский
Plant-based diets in chronic kidney disease: Potential benefits and risks in renal function management
Paweł Godlewski,
Anna Gwóźdź-Broczkowska,
Bartosz Górecki
и другие.
Medical Science,
Год журнала:
2024,
Номер
28(154), С. 1 - 7
Опубликована: Дек. 30, 2024
A
slow
decline
in
kidney
function
characterize
chronic
disease
(CKD),
which
impacts
about
10%
of
the
global
population.Dietary
methods,
particularly
plant-based
diets
(PBD),
are
gaining
popularity
as
a
possible
means
managing
illness,
given
limited
availability
existing
therapy
choices.The
primary
objective
this
review
is
to
evaluate
impact
diet
on
health
patients
with
CKD
and
its
potential
role
slowing
progression.This
based
an
analysis
literature
from
2019
2024,
selected
using
keywords
such
"plant-based
diet",
"vegetarian
"chronic
vegetarian
diet".It
includes
findings
clinical
studies,
systematic
reviews,
meta-analyses.Results
suggest
that
limiting
animal
protein
favor
plant
may
positively
affect
by
reducing
filtration
load
improving
metabolic
parameters
patients.A
PBD,
rich
antioxidants
anti-inflammatory
components,
support
health,
though
it
requires
careful
balancing
avoid
deficiencies
vitamins
minerals
(e.g.,
B12,
D,
iron).The
reason
for
emphasizes
need
additional
study
confirm
long-term
benefits
patients.
Язык: Английский