Medicinal Chemistry Research, Год журнала: 2022, Номер 31(6), С. 905 - 915
Опубликована: Апрель 19, 2022
Язык: Английский
Probiotics and Antimicrobial Proteins, Год журнала: 2023, Номер 16(3), С. 763 - 783
Опубликована: Окт. 19, 2023
Язык: Английский
Процитировано
9
Chemistry & Biodiversity, Год журнала: 2023, Номер 20(3)
Опубликована: Янв. 23, 2023
The plant diseases caused by a variety of pathogens such as viruses, bacteria and fungi pose great threat to global food production safety. Therefore, the search for green, efficient pollution-free pesticides has become an important task. In this article, 23 myricetin derivatives containing thiazolebisamides active groups have been designed synthesized. Their activities were evaluated performing in vitro antibacterial vivo antiviral assays, microscale thermophoresis (MST) molecular docking assays. results assays showed that compounds A4 A23 exhibited good activity with EC
Язык: Английский
Процитировано
4
Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1407 - 1407
Опубликована: Окт. 3, 2023
Flavonoids are hydroxylated polyphenols that widely distributed in plants with diverse health benefits. Despite their popularity, the bioavailability of flavonoids is often overlooked, impacting efficacy and comparison products. The study discusses bioavailability-related physicochemical properties flavonoids, a focus on poorly soluble compounds commonly found dietary supplements herbal This review sums up values pKa, log P, solubility, permeability, melting temperature flavonoids. Experimental calculated data were compiled for various flavonoid subclasses, revealing variations properties. investigation highlights challenges posed by underscores need enabling formulation approaches to enhance therapeutic potential. Compared aglycones, glycosides (with sugar moieties) tend be more hydrophilic. Most reviewed aglycones exhibit relatively low P high points, making them “brick dust” candidates. To improve solubility absorption, strategies like size reduction, potential use solid dispersions carriers, as well lipid-based formulations have been discussed.
Язык: Английский
Процитировано
4
ChemistrySelect, Год журнала: 2024, Номер 9(12)
Опубликована: Март 21, 2024
Abstract Enantioselective synthesis, which yields one enantiomer in higher concentration or purity than the other, has transformed production of flavonoids. Flavonoids, are found large quantities nature and known to exhibit a diverse array physiological activities, an ideal choice for enantioselective synthesis due significance chirality their therapeutic effects. is used medicinal, nutraceutical, agrochemical sectors produce flavonoids, useful development novel therapeutics with improved effectiveness fewer adverse reactions. The ability obtain specific enantiomers flavonoids facilitates elucidation biochemical strategies relationship between structure activity, thereby providing avenues tailored drug design optimization. This review highlights critical role that plays achieving full potential variety non‐therapeutic applications. It also discusses challenges prospects syntheses create relevant classes flavonoid monomers, emphasizing applications field. focused on synthetic methods fabricating native analogs, highlighting maximizing enhancing human health wellbeing.
Язык: Английский
Процитировано
1
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер 397(9), С. 6351 - 6368
Опубликована: Апрель 29, 2024
Язык: Английский
Процитировано
1
International Journal of Applied Pharmaceutics, Год журнала: 2024, Номер unknown, С. 28 - 37
Опубликована: Ноя. 7, 2024
Cancer significantly impacts human health, affecting one in five people during their lifetime. While chemotherapeutic agents like doxorubicin are crucial treating various cancers, they also associated with severe side effects, including nephrotoxicity. This review examines the renoprotective potential of flavonoids against doxorubicin-induced renal damage animal models. Doxorubicin works by intercalating Deoxyribo Nucleic Acid (DNA) and making Reactive Oxygen Species (ROS), which cause apoptosis death cells. A thorough literature analysis was done to collect relevant papers on impact flavonoid-rich therapies as Databases such Google Scholar, Scopus, PubMed, Springer, Wiley Online Library, ScienceDirect were searched using keywords "flavonoids, doxorubicin, renoprotective, nephrotoxicity, model," focusing publications from 2014 2024. Flavonoids diverse polyphenolic compounds many plants significant pharmacological properties antioxidant, anti-inflammatory, anticancer effects. highlights quercetin, rutin, kaempferol, morin, luteolin, apigenin, hesperidin, naringenin, diosmin, anthocyanins. These reduce toxicity through mechanisms that decrease ROS, lipid peroxidation, mitochondrial permeability, apoptosis.
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113754 - 113754
Опубликована: Окт. 17, 2022
The PI3K/AKT and MAPK/ERK pathways are frequently mutated in metastatic melanoma. In a screen of over 2500 plant extracts, the dichloromethane extract Ericameria nauseosa significantly inhibited oncogenic activity AKT MM121224 human melanoma cells. This was analyzed by analytical HPLC, column effluent fractionated tested for to generate so-called HPLC-based profile. Compounds eluting within active time-windows chromatogram were subsequently isolated larger scale afford 11 flavones (1-11), four flavanones (12-15), two diterpenes (16, 17), seco-caryophyllene (18). All compounds activity, whereby only flavonoids found active. Of these, shown be more than flavanones. most potent flavone compound 9, that displaying an IC50 14.7 ± 1.4 µM on terpenoids (16-18) inactive assay. Both diterpenes, grindelic acid derivative (16) ent-neo-clerodane (17) identified as new natural products. Their absolute configuration established ECD. Compound 17 is first description clerodane type diterpene genus Ericameria.
Язык: Английский
Процитировано
7
Molecules, Год журнала: 2023, Номер 28(2), С. 873 - 873
Опубликована: Янв. 15, 2023
Hesperidin and narirutin are a class of flavanone glycosides, which the main active constituents in Citrus reticulata Blanco. In present study, chiral HPLC-UV method with amylose tris(3,5-dimethylphenylcarbamate) as stationary phase under normal-phase mode was used to achieve stereoselective separation C-2 diastereomers hesperidin simultaneously. The single epimer then successfully prepared by applying semi-preparative chromatography, whose absolute configuration (R/S) characterized combining experimental electronic circular dichroism (ECD) detection time-dependent density functional theory (TDDFT) calculations. composition these two glycosides Blanco determined, found be slightly different herbs from production regions. anti-inflammatory activity each further evaluated, some differences between one pair epimers were observed, suggested that presence should considered quality evaluation control natural medicine.
Язык: Английский
Процитировано
3
Genes, Год журнала: 2023, Номер 14(2), С. 420 - 420
Опубликована: Фев. 6, 2023
Natural antioxidants derived from plants exert various physiological effects, including antitumor effects. However, the molecular mechanisms of each natural antioxidant have not yet been fully elucidated. Identifying targets with properties in vitro is costly and time-consuming, results thus obtained may reliably reflect vivo conditions. Therefore, to enhance understanding regarding effects antioxidants, we focused on DNA, one anticancer drugs, evaluated whether e.g., sulforaphane, resveratrol, quercetin, kaempferol, genistein, which induce DNA damage using gene-knockout cell lines human Nalm-6 HeLa cells pretreated DNA-dependent protein kinase inhibitor NU7026. Our suggested that sulforaphane induces single-strand breaks or strand crosslinks quercetin double-strand breaks. In contrast, resveratrol showed ability cytotoxic other than damage. also kaempferol genistein via unknown mechanisms. Taken together, use this evaluation system facilitates analysis antioxidants.
Язык: Английский
Процитировано
3
Journal of Molecular Liquids, Год журнала: 2023, Номер 374, С. 121260 - 121260
Опубликована: Янв. 16, 2023
Язык: Английский
Процитировано
3