Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms
Journal of Ethnopharmacology,
Год журнала:
2023,
Номер
318, С. 117022 - 117022
Опубликована: Авг. 10, 2023
Язык: Английский
Salvianolic Acid B Inhibits Thrombosis and Directly Blocks the Thrombin Catalytic Site
Research and Practice in Thrombosis and Haemostasis,
Год журнала:
2024,
Номер
8(4), С. 102443 - 102443
Опубликована: Май 1, 2024
Salvianolic
acid
B
(SAB)
is
a
major
component
of
Язык: Английский
Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective
Arash Amin,
Ahmad Mohajerian,
Sara Rashki Ghalehnoo
и другие.
Cardiovascular Toxicology,
Год журнала:
2024,
Номер
24(12), С. 1381 - 1394
Опубликована: Окт. 14, 2024
Язык: Английский
Anti-atherosclerotic effects and molecular targets of salvianolic acids from Salvia miltiorrhiza Bunge
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 21, 2025
Salvia
miltiorrhiza
Bunge
[Lamiaceae;
Salviae
miltiorrhizae
radix
et
rhizoma]
is
a
traditional
Chinese
medication
used
extensively
as
therapeutic
agent
against
atherosclerosis
(AS)
because
of
its
substantial
cardiovascular
protective
properties
well
ability
to
regulate
the
signaling
cascades
and
molecular
targets
involved
in
AS.
Preclinical
research
has
shown
that
hydrophilic
metabolites
S.
represented
by
danshensu
(DSS),
salvianolic
acid
A
(SAA),
B
(SAB)
can
reduce
endothelial
dysfunction,
inhibit
smooth
muscle
cell
migration
proliferation,
block
platelet
aggregation,
have
antithrombotic
properties,
modulate
vascular
tone.
Furthermore,
studies
clinically
beneficial,
while
some
evidence
also
supports
safety
effectiveness
diseases
linked
The
present
study
review
anti-atherosclerotic
pharmacological
activities,
pharmacokinetic
characteristics,
drug
interactions,
evaluations
over
last
20
years.
Herein,
we
focus
on
cellular
AS;
clarify
mechanisms
activities
DSS,
SAA,
SAB;
discuss
future
needs
priorities
light
limitations
existing
studies.
This
intended
establish
groundwork
offer
thorough
perspective
for
deeper
investigations
studies,
clinical
uses,
product
development
efforts
natural
modulator
Язык: Английский
Elemental, phytochemical analysis and determination of antibacterial, antioxidant, and cytotoxic activities of leaves extracts of eleven Eucalyptus species
South African Journal of Botany,
Год журнала:
2024,
Номер
171, С. 1 - 9
Опубликована: Июнь 1, 2024
Язык: Английский
Potential chemoprotective effects of active ingredients in Salvia miltiorrhiza on doxorubicin-induced cardiotoxicity: a systematic review of in vitro and in vivo studies
Frontiers in Cardiovascular Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Окт. 17, 2023
Background
Recently,
attention
has
been
paid
to
the
protective
properties
of
active
ingredients
in
Salvia
miltiorrhiza
(AISM)
against
organ
toxicity
induced
by
chemotherapy
drugs.
Purpose
present
systematic
review
is
evaluate
chemoprotective
effects
and
mechanisms
AISM
on
vitro
vivo
models
doxorubicin-induced
cardiotoxicity
(DIC).
Methods
According
PRISMA
guideline,
current
was
conducted
Web
Science,
PubMed,
Embase,
Cochrane
Library
collect
all
relevant
studies
“the
role
DIC”
published
up
until
May
2023.
The
SYRCLE's
tool
used
identify
potential
risk
bias.
Results
Twenty-two
eligible
articles
were
included
this
review.
Eleven
types
for
DIC,
which
have
following
effects:
improvement
physical
signs
biochemical
indicators,
reduction
cardiac
function
damage
caused
protection
heart
tissue
structure,
enhancement
myocardial
cell
viability,
prevention
cardiomyocyte
apoptosis,
increase
chemosensitivity
cancer
cells
Doxorubicin,
etc
.
cardioprotective
mechanism
involves
inhibiting
attenuating
oxidative
stress,
suppressing
endoplasmic
reticulum
(ER)
decreasing
inflammation,
improving
mitochondrial
structure
function,
affecting
cellular
autophagy
calcium
homeostasis.
quality
scores
ranged
from
4
7
points
(a
total
10
points),
according
bias
tool.
Conclusion
This
demonstrated
that
DIC
through
several
main
such
as
anti-apoptosis,
antioxidant
effects,
anti-ER
anti-inflammatory.
Язык: Английский
Recent Advances in the Mechanisms of Cell Death and Dysfunction in Doxorubicin Cardiotoxicity
Reviews in Cardiovascular Medicine,
Год журнала:
2023,
Номер
24(11), С. 336 - 336
Опубликована: Ноя. 27, 2023
Despite
recent
advances
in
cancer
therapy,
anthracycline-based
combination
therapy
remains
the
standardized
first-line
strategy
and
has
been
found
to
have
effective
antitumor
actions.
Anthracyclines
are
extremely
cardiotoxic,
which
limits
use
of
these
powerful
chemotherapeutic
agents.
Although
numerous
studies
conducted
on
cardiotoxicity
anthracyclines,
precise
mechanisms
by
doxorubicin
causes
cardiomyocyte
death
myocardial
dysfunction
remain
incompletely
understood.
This
review
highlights
updates
therapies
involved
doxorubicin-induced
death,
including
autophagy,
ferroptosis,
necroptosis,
pyroptosis,
apoptosis,
as
well
cardiovascular
resulting
atrophy,
defects
calcium
handling,
thrombosis,
cell
senescence.
We
sought
uncover
potential
therapeutic
approaches
manage
anthracycline
via
manipulation
crucial
targets
dysfunction.
Язык: Английский