Recent Advances in the Mechanisms of Cell Death and Dysfunction in Doxorubicin Cardiotoxicity DOI Creative Commons
Tianhu Wang,

Yan Ma,

Shan Gao

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(11), P. 336 - 336

Published: Nov. 27, 2023

Despite recent advances in cancer therapy, anthracycline-based combination therapy remains the standardized first-line strategy and has been found to have effective antitumor actions. Anthracyclines are extremely cardiotoxic, which limits use of these powerful chemotherapeutic agents. Although numerous studies conducted on cardiotoxicity anthracyclines, precise mechanisms by doxorubicin causes cardiomyocyte death myocardial dysfunction remain incompletely understood. This review highlights updates therapies involved doxorubicin-induced death, including autophagy, ferroptosis, necroptosis, pyroptosis, apoptosis, as well cardiovascular resulting atrophy, defects calcium handling, thrombosis, cell senescence. We sought uncover potential therapeutic approaches manage anthracycline via manipulation crucial targets dysfunction.

Language: Английский

Adjuvant role of Salvia miltiorrhiza bunge in cancer chemotherapy: A review of its bioactive components, health-promotion effect and mechanisms DOI
Jiayan Huang, Jiaojiao Zhang, Chengtao Sun

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 117022 - 117022

Published: Aug. 10, 2023

Language: Английский

Citations

23
Salvianolic Acid B Inhibits Thrombosis and Directly Blocks the Thrombin Catalytic Site DOI Creative Commons
Miguel A. D. Neves, Tiffany Ni, Daniel Thomas MacKeigan

et al.

Research and Practice in Thrombosis and Haemostasis, Journal Year: 2024, Volume and Issue: 8(4), P. 102443 - 102443

Published: May 1, 2024

Salvianolic acid B (SAB) is a major component of

Language: Английский

Citations

4
Anti-atherosclerotic effects and molecular targets of salvianolic acids from Salvia miltiorrhiza Bunge DOI Creative Commons

Qingzhi Liang,

Xiaoqin Liu,

Xin Xu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 21, 2025

Salvia miltiorrhiza Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma] is a traditional Chinese medication used extensively as therapeutic agent against atherosclerosis (AS) because of its substantial cardiovascular protective properties well ability to regulate the signaling cascades and molecular targets involved in AS. Preclinical research has shown that hydrophilic metabolites S. represented by danshensu (DSS), salvianolic acid A (SAA), B (SAB) can reduce endothelial dysfunction, inhibit smooth muscle cell migration proliferation, block platelet aggregation, have antithrombotic properties, modulate vascular tone. Furthermore, studies clinically beneficial, while some evidence also supports safety effectiveness diseases linked The present study review anti-atherosclerotic pharmacological activities, pharmacokinetic characteristics, drug interactions, evaluations over last 20 years. Herein, we focus on cellular AS; clarify mechanisms activities DSS, SAA, SAB; discuss future needs priorities light limitations existing studies. This intended establish groundwork offer thorough perspective for deeper investigations studies, clinical uses, product development efforts natural modulator

Language: Английский

Citations

0
Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective DOI

Arash Amin,

Ahmad Mohajerian,

Sara Rashki Ghalehnoo

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(12), P. 1381 - 1394

Published: Oct. 14, 2024

Language: Английский

Citations

3
Elemental, phytochemical analysis and determination of antibacterial, antioxidant, and cytotoxic activities of leaves extracts of eleven Eucalyptus species DOI

Direshnee Shenelle Naidoo,

Garland K. More, Ramakwala Christinah Chokwe

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 171, P. 1 - 9

Published: June 1, 2024

Language: Английский

Citations

2
Potential chemoprotective effects of active ingredients in Salvia miltiorrhiza on doxorubicin-induced cardiotoxicity: a systematic review of in vitro and in vivo studies DOI Creative Commons
Qingqing Wang, Jiaxian Li, Xuelei Chu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Oct. 17, 2023

Background Recently, attention has been paid to the protective properties of active ingredients in Salvia miltiorrhiza (AISM) against organ toxicity induced by chemotherapy drugs. Purpose present systematic review is evaluate chemoprotective effects and mechanisms AISM on vitro vivo models doxorubicin-induced cardiotoxicity (DIC). Methods According PRISMA guideline, current was conducted Web Science, PubMed, Embase, Cochrane Library collect all relevant studies “the role DIC” published up until May 2023. The SYRCLE's tool used identify potential risk bias. Results Twenty-two eligible articles were included this review. Eleven types for DIC, which have following effects: improvement physical signs biochemical indicators, reduction cardiac function damage caused protection heart tissue structure, enhancement myocardial cell viability, prevention cardiomyocyte apoptosis, increase chemosensitivity cancer cells Doxorubicin, etc . cardioprotective mechanism involves inhibiting attenuating oxidative stress, suppressing endoplasmic reticulum (ER) decreasing inflammation, improving mitochondrial structure function, affecting cellular autophagy calcium homeostasis. quality scores ranged from 4 7 points (a total 10 points), according bias tool. Conclusion This demonstrated that DIC through several main such as anti-apoptosis, antioxidant effects, anti-ER anti-inflammatory.

Language: Английский

Citations

3
Recent Advances in the Mechanisms of Cell Death and Dysfunction in Doxorubicin Cardiotoxicity DOI Creative Commons
Tianhu Wang,

Yan Ma,

Shan Gao

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(11), P. 336 - 336

Published: Nov. 27, 2023

Despite recent advances in cancer therapy, anthracycline-based combination therapy remains the standardized first-line strategy and has been found to have effective antitumor actions. Anthracyclines are extremely cardiotoxic, which limits use of these powerful chemotherapeutic agents. Although numerous studies conducted on cardiotoxicity anthracyclines, precise mechanisms by doxorubicin causes cardiomyocyte death myocardial dysfunction remain incompletely understood. This review highlights updates therapies involved doxorubicin-induced death, including autophagy, ferroptosis, necroptosis, pyroptosis, apoptosis, as well cardiovascular resulting atrophy, defects calcium handling, thrombosis, cell senescence. We sought uncover potential therapeutic approaches manage anthracycline via manipulation crucial targets dysfunction.

Language: Английский

Citations

3