Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2141 - 2150
Опубликована: Сен. 1, 2024
Acral melanoma presents distinct biological characteristics compared to cutaneous melanoma. While adjuvant therapeutic strategies for high-risk resected acral closely resemble those melanoma, the evidence supporting clinical application of therapy remains inadequate. Our aim was systematically analyze efficacy and safety profile in
Язык: Английский
Materials Today Bio, Год журнала: 2024, Номер 26, С. 101042 - 101042
Опубликована: Апрель 3, 2024
High oxidative stress and inflammatory cell infiltration are major causes of the persistent bone erosion difficult tissue regeneration in rheumatoid arthritis (RA). Triptolide (TPL) has become a highly anticipated anti-rheumatic drug due to its excellent immunomodulatory anti-inflammatory effects. However, sudden accumulation caused by binding "stimulus-response" "drug release" general smart delivery system is meet shortcoming extreme toxicity demand for long-term administration TPL. Herein, we developed dual dynamically cross-linked hydrogel (SPT@TPL), which demonstrated sensitive RA microenvironment regulation modulation-independent TPL release 30 days. The abundant borate ester/tea polyphenol units SPT@TPL possessed capability respond regulate high reactive oxygen species (ROS) levels on-demand. Meanwhile, based on dense crosslinked structure as well spontaneous healing behavior numerous intermolecular hydrogen bonds formed after breakage ester, could remain stable slowly under ROS environments RA, dramatically reduced risk exerting while maximized efficacy. Through effects sustained-release, alleviated reprogrammed macrophages into M2 phenotype, showing marked inhibition inflammation optimal articular cartilage rat model. In conclusion, this platform with both initiative sustained provides potential scheme arthritis.
Язык: Английский
Процитировано
6
International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113058 - 113058
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
4
Immunobiology, Год журнала: 2025, Номер unknown, С. 152875 - 152875
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Inflammopharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2024, Номер 22(1)
Опубликована: Март 8, 2024
Rheumatoid arthritis (RA) is a complex and challenging autoimmune disease characterized by chronic inflammation of the joints, discomfort, stiffness, functional impairment, systemic complications that affect millions people around world. Despite advances in medication, controlling RA remains difficult due to its complicated pathophysiology numerous clinical symptoms. Synthetic medications, while effective, frequently cause considerable adverse effects, necessitating investigation alternate therapeutic options. This study attempts provide complete overview synthetic medications natural items used treat RA. It specifically investigates pathophysiological mechanisms underpin efficacy safety profiles pharmaceuticals. such as disease-modifying antirheumatic drugs (DMARDs), biologics remain important treatments for RA, albeit with hazards. So explore safer more effective therapy treatment need exploit possible benefits antioxidants, plant secondary metabolites, traditional herbal remedies arises. By encompassing spectrum insights, from molecular level holistic practices, this review aims understanding role products medicines managerial landscape Furthermore, it effect nutrition regulating development Integrative techniques use present intriguing adjuvant therapy, delivering anti-inflammatory, analgesic, immunomodulatory effects potentially fewer side effects. Understanding interaction products, well nutrition, can help enhance regimens, improve patient outcomes, reduce treatment-related problems. valuable resource doctors, researchers, patients looking evidence-based methods care. The synthesis knowledge contributes ongoing pursuit enhanced strategies, fostering improved outcomes quality life individuals grappling rheumatoid arthritis.
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 402 - 402
Опубликована: Март 21, 2024
Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) demonstrated anti-inflammatory effects, but its macrophage not studied. This study aimed to investigate effect and mechanism CJB inhibiting pyroptosis. Using LPS/ATP-induced THP-1 model, we found that significantly inhibited reduced levels NLRP3, caspase 1, N-GSDMD, cytokines IL-1β IL-18. RNA sequencing analysis revealed interfered with gene expression, suggesting involvement anti-pyroptotic signaling pathways. Additionally, suppressed elevations TLRs, MyD88, pro-IL-1β, NF-κB blocked p65 nuclear translocation. In summary, inhibits NLRP3 activation through TLR/MyD88/NF-κB pathway, providing important evidence for development as treating pyroptosis-related
Язык: Английский
Процитировано
2
Brain and Behavior, Год журнала: 2024, Номер 14(7)
Опубликована: Июль 1, 2024
Abstract Background Patients with myocardial infarction (MI) frequently experience a heightened incidence of depression, thereby increasing the risk adverse cardiovascular events. Consequently, early detection and intervention in depressive symptoms among patients MI are imperative. Shexiang Baoxin Pills (SBP), Chinese patent medicine employed for treatment MI, exhibits diverse mechanisms targeting this condition. Nevertheless, its therapeutic efficacy on postmyocardial remains unclear. The aim study is to investigate effectiveness mechanism SBP managing depression during acute (AMI). Methods A rat model combining was established, rats were randomly divided into four groups: (MOD) group, Fluoxetine (FLX) Sham group. After 28 days drug intervention, cardiac function assessed using echocardiography while behavior evaluated through sucrose preference test (SPT), forced swimming (FST), open‐field (OFT). Additionally, levels inflammatory factors serum hippocampus measured along NLRP3 inflammasome‐related protein expression via Western blotting immunofluorescence. Results can enhance AMI significantly ameliorating depressive‐like behavior. Compared IL‐1β, IL‐18, TNF‐α, other markedly elevated MOD However, expressions these reduced varying degrees following or FLX. Analysis proteins revealed significant upregulation NLRP3, ASC, caspase‐1, GSDMD group; conversely, measures attenuated after intervention. Conclusion We have observed amelioration depression‐like upon administration AMI, suggesting that effect may be attributed inhibition NLRP3‐mediated pyroptosis. (The main findings summarized graphical abstract supplementary file.)
Язык: Английский
Процитировано
2
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2141 - 2150
Опубликована: Сен. 1, 2024
Acral melanoma presents distinct biological characteristics compared to cutaneous melanoma. While adjuvant therapeutic strategies for high-risk resected acral closely resemble those melanoma, the evidence supporting clinical application of therapy remains inadequate. Our aim was systematically analyze efficacy and safety profile in
Язык: Английский
Процитировано
0