International Journal of Drug Delivery Technology,
Год журнала:
2023,
Номер
13(04), С. 1527 - 1532
Опубликована: Дек. 25, 2023
The
current
study
aimed
to
increase
the
stability
and
therapeutic
efficacy
of
antitubercular
medication
rifampicin
by
reducing
or
preventing
its
breakdown
in
stomach
pH
state.
Ascorbic
acid
was
used
as
an
antioxidant
preparation
rifampicin-loaded
Poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
for
investigation.
A
multistep
emulsion
process
create
dig-laden
nanoparticles,
different
techniques
were
then
assess
final
product.
Ten
kinds
formulations
created
this
study.
According
study’s
findings,
ascorbic
can
rifampicin’s
bioavailability
acidic
conditions.
results
also
show
that
changing
concentration
makes
a
statistically
important
difference
way
medicine
breaks
down.
Some
of
the
most
crucial
turning
points
in
treatment
strategies
for
some
major
infectious
diseases
including
AIDS,
malaria,
and
TB,
have
been
reached
with
introduction
antimicrobials
vaccines.
Drug
resistance
poor
effectiveness
are
key
limitations
that
need
to
be
overcome.
Conventional
liposomes
explored
as
a
delivery
system
bioactives
treat
provide
an
efficient
approach
maximize
therapeutic
outcomes,
drug
stability,
targetability,
reduce
side-effects
antimicrobials,
enhance
vaccine
performance
where
necessary.
However,
pathological
understanding
become
more
known,
advanced
liposomal
technologies
was
born
continue
having
profound
effect
on
targeted
chemotherapy
diseases.
This
review
therefore
provides
concise
incursion
into
recent
vogue
formulations
used
An
appraisal
immunological,
stimuli-responsive,
biomimetic
functionalized
other
novel
modifications
conventional
is
assimilated
sync
mutations
resistant
pathogens.
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
The
urgent
need
for
safer
and
innovative
antitubercular
agents
remains
a
priority
the
scientific
community.
In
pursuit
of
this
goal,
we
designed
evaluated
novel
5-phenylfuran-2-carboxylic
acid
derivatives
targeting
Mycobacterium
tuberculosis
(Mtb)
salicylate
synthase
(MbtI),
key
enzyme,
absent
in
humans,
that
plays
crucial
role
Mtb
virulence.
Several
potent
MbtI
inhibitors
demonstrating
significant
activity
favorable
safety
profile
were
identified.
Structure-guided
optimization
yielded
5-(3-cyano-5-isobutoxyphenyl)furan-2-carboxylic
(1e),
which
exhibited
strong
inhibition
(IC50
=
11.2
μM)
promising
vitro
(MIC99
32
μM
against
M.
bovis
BCG).
Esters
1e
effectively
loaded
into
poly(2-methacryloyloxyethyl
phosphorylcholine)-poly(2-(diisopropylamino)ethyl
methacrylate)
(PMPC-PDPA)
polymersomes
(POs)
delivered
to
intracellular
mycobacteria,
resulting
reduced
viability.
This
study
provides
foundation
use
POs
development
future
MbtI-targeted
therapies
tuberculosis.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Март 18, 2025
Tuberculosis
(TB),
caused
by
Mycobacterium
tuberculosis
remains
a
significant
global
health
challenge
aggravated
drug-resistant
strains
and
prolonged
treatment
regimens.
Innovative
strategies
to
enhance
efficacy,
improve
patient
adherence,
reduce
adverse
effects
are
urgently
required.
We
explored
combination
therapy
using
bedaquiline
pretomanid
encapsulated
in
polymeric
nanoparticles
(pNPs).
Further,
active
targeting
was
achieved
through
mannose-decorated
(Man-pNPs)
for
macrophage-specific
delivery.
The
drug-loaded
pNPs
Man-pNPs
were
spray-dried
into
dry
powder
particles
drug
solubility
enable
local
lung
delivery
via
inhalation.
prepared
target
macrophages,
wherein
TB
bacteria
reside.
Formulations
exhibited
high
loading
excellent
aerosolization
performance
(MMAD
1-5
µm,
FPF
>
75%)
Man-pNPs.
formulation
enhanced
macrophage
receptor-mediated
endocytosis
phagocytosis,
improving
bacterial
inhibition.
demonstrated
similar
MIC
vitro
intracellular
M.tb
inhibition
compared
free
pNPs.
In
addition,
spheroid
model
developed
screening,
mimicking
granulomas'
physiological
conditions.
showed
superior
This
research
underscores
the
potential
of
therapy,
particulate-based
inhaled
delivery,
advance
efficient
patient-friendly
treatments.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(2), С. 99 - 99
Опубликована: Фев. 5, 2025
Tuberculosis
(TB)
caused
by
Mycobacterium
tuberculosis
(M.tb)
remains
a
global
health
crisis,
with
over
10
million
people
affected
annually.
Despite
advancements
in
treatment,
M.tb
has
developed
mechanisms
to
evade
host
immune
responses,
complicating
efforts
eradicate
the
disease.
Two
emerging
cell
death
pathways,
ferroptosis
and
cuproptosis,
have
been
linked
TB
pathogenesis.
Ferroptosis,
an
iron-dependent
form
of
death,
is
driven
lipid
peroxidation
reactive
oxygen
species
(ROS)
accumulation.
This
process
can
limit
replication
depleting
intracellular
iron
inducing
macrophage
necrosis.
However,
excessive
may
lead
tissue
damage
aid
bacterial
dissemination.
Cuproptosis,
triggered
copper
accumulation,
disrupts
mitochondrial
metabolism,
leading
protein
aggregation
death.
exploits
both
metabolism
survive
within
macrophages,
manipulating
these
processes
resist
oxidative
stress
responses.
review
examines
roles
cuproptosis
TB,
discussing
how
manipulates
pathways
for
survival.
While
therapeutic
strategies
targeting
processes,
such
as
inducers
(Erastin,
RSL3)
inhibitors
(Ferrostatin-1)
ionophores
(Disulfiram,
Elesclomol)
chelators,
show
promise,
limited
understanding
potential
off-target
effects
significant
challenge.
Further
exploration
provide
insights
into
development
targeted
therapies
aimed
at
controlling
infection
while
minimizing
damage.
By
elucidating
complex
interactions
between
ferroptosis,
future
could
better
address
resistance
improve
clinical
outcomes.
Microorganisms,
Год журнала:
2025,
Номер
13(4), С. 722 - 722
Опубликована: Март 24, 2025
Multidrug-resistant
tuberculosis
(MDR-TB)
is
a
significant
public
health
challenge
globally,
exacerbated
by
the
limited
efficacy
of
existing
therapeutic
approaches,
prolonged
treatment
duration,
and
severe
side
effects.
As
drug
resistance
continues
to
emerge,
innovative
delivery
systems
strategies
are
critical
combating
this
crisis.
This
review
highlights
molecular
mechanisms
underlying
drugs
in
Mycobacterium
tuberculosis,
such
as
genetic
mutation,
efflux
pump
activity,
biofilm
formation,
contributing
persistence
difficulty
eradicating
MDR-TB.
Current
options,
including
second-line
drugs,
offer
effectiveness,
prompting
need
for
innovation
advanced
therapies
systems.
The
progression
discovery
has
resulted
approval
therapeutics,
bedaquiline
delamanid,
amongst
other
promising
candidates
under
investigation.
However,
overcoming
limitations
traditional
remains
challenge.
Nanotechnology
emerged
solution,
with
nanoparticle-based
offering
improved
bioavailability
targeted
controlled
release
delivery,
particularly
pulmonary
targeting
intracellular
macrophages.
Furthermore,
development
inhalable
formulations
potential
nanomedicines
bypass
presents
novel
approach
enhancing
efficacy.
Moreover,
adjunctive
therapies,
immune
modulation
host-directed
being
explored
improve
outcomes.
Immunotherapies,
cytokine
TB
vaccines,
complementary
use
antibiotics
Personalized
medicine
leveraging
genomic
profiling
both
pathogen
host,
promise
optimizing
regimens
minimizing
resistance.
underscores
importance
multidisciplinary
combining
discovery,
system
development,
address
complexities
treating
Continued
innovation,
global
collaboration,
diagnostics
essential
developing
practical,
accessible,
affordable
treatments
Polymer-Plastics Technology and Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Дек. 16, 2024
Polymers
have
become
a
versatile
tool
in
pharmaceutical
chemistry
through
techniques
and
new
formulation.
This
review
presents
an
overview
of
the
general
topic
drug
delivery
polymers,
places
particular
focus
on
their
specific
contributions,
discusses
significant
issues
like
biocompatibility,
controlled
release
targeted
delivery.
Unlike
previous
reviews,
it
captures
recent
development
biodegradable,
smart
stimuli-responsive
abilities
to
improve
therapy
outcomes
patient
adherence
treatments.
Furthermore,
this
work
also
has
enhanced
understanding
advanced
polymer-based
systems
such
as
polymeric
nanoparticles,
bioconjugation
strategies
natural
with
examples
various
therapeutic
areas.
The
stands
for
itself
by
expanding
discussion
regulatory
clinical
realism
difficulties
well
safety,
efficacy,
acceptance
considerations.
In
addition,
emphasizes
role
interdisciplinary
intersectoral
cooperation
cross-country
collaborations
developing
polymers-based
applications
precision
medicine.
way,
provides
fresh
view
both
present
advancements
future
possibilities
technologies
dedicated
achievements
globally
inspire
researchers
practitioners.
Egyptian Journal of Veterinary Science,
Год журнала:
2024,
Номер
56(2), С. 311 - 319
Опубликована: Май 8, 2024
This
study
aimed
to
validate
an
accurate,
precise
and
simple
method.
followed
green
chemistry
extract
lincomycin
from
its
liposomal
coat
determined
levels
in
the
serum
tissues
of
broiler
chickens.
Liposomes
are
natural
compounds
used
for
drug
delivery.
Nanomaterials
with
antibiotics
aim
improve
antibiotic
effects
reduce
side
effects.
The
global
trend
follows
analytical
guidelines
development
methods
quantify
materials.
extraction
depended
on
ultracentrifugation
samples
solvent
low
centrifugation
power
tissue
extraction.
A
C18
column
isocratic
mobile
phase
consisting
acetone
acidified
HPLC
water
glacial
acetic
acid
(2%)
following
ratio
(16:84)
was
used.
UV
detector
set
at
210
nm
detect
lincomycin.
method
had
a
short
retention
time
3.227
min.
relative
standard
deviation
(RSD)
<
2%.
High
recoveries
ranged
90.2
up
102.1%
different
extracted
biological
samples.
limits
detection
were
0.025
0.2
µg/gm,
which
measure
high
sensitivity
level
validated
quantification
0.077
0.67
µg/gm.
pooled
RSD
robustness
assay
did
not
exceed
3.3
%.
chemistry,
is
agreement
economic
requirements
developing
countries.
It
efficient
separation
nanoliposomecoat.
selective
sensitive,
reliable,
reproducible,
precise,
accurate
according
validation
methods.
