Enhancing antiretroviral efficacy: a comprehensive exploration of liposomal and receptor-targeted drug delivery for HIV DOI Creative Commons
Minyahil Alebachew Woldu

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 11, 2024

Antiretroviral Therapy (ART) has revolutionized Human Immunodeficiency Virus (HIV) treatment, yet challenges remain, such as drug toxicity, resistance, and inadequate access to infected tissues. Novel delivery systems, liposomes receptor-targeted mechanisms, offer promising solutions improve ART efficacy minimize its limitations. This study aims evaluate the potential of liposomal systems (DDS) for enhancing bioavailability, selectivity, therapeutic outcomes ART, with a focus on targeting HIV-infected cells reducing resistance. A systematic review published articles was conducted, drawing from electronic databases PubMed, Scopus, Web Science. Keywords "liposomes," "receptor-targeted delivery," "HIV" were used identify preclinical clinical studies relevant ART. The evaluated their design, intervention specifics, key findings. Data synthesized narratively highlight efficacy, safety, pharmacokinetics these systems. Liposomal formulations significantly improved zidovudine (AZT) showing an 85% increase, lamivudine (3TC) 90%, efavirenz (EFV) 80%, indinavir (IDV) 75%. Galactosylated highly effective in (92%) showed strong preventing drug-resistant strains (85%). Receptor-targeted approaches, those Cluster Differentiation 4 (CD4), Chemokine Receptor Type 5 (CCR5), (CXCR4), enhance precision reduce viral load HIV reservoirs. DDS significant improving by increasing Further research is needed optimize technologies translate success into practice, paving way more therapies.

Language: Английский

3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment DOI
Suyash M. Patil,

Apoorva Daram,

Nitesh K. Kunda

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 18, 2025

Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a significant global health challenge aggravated drug-resistant strains and prolonged treatment regimens. Innovative strategies to enhance efficacy, improve patient adherence, reduce adverse effects are urgently required. We explored combination therapy using bedaquiline pretomanid encapsulated in polymeric nanoparticles (pNPs). Further, active targeting was achieved through mannose-decorated (Man-pNPs) for macrophage-specific delivery. The drug-loaded pNPs Man-pNPs were spray-dried into dry powder particles drug solubility enable local lung delivery via inhalation. prepared target macrophages, wherein TB bacteria reside. Formulations exhibited high loading excellent aerosolization performance (MMAD 1-5 µm, FPF > 75%) Man-pNPs. formulation enhanced macrophage receptor-mediated endocytosis phagocytosis, improving bacterial inhibition. demonstrated similar MIC vitro intracellular M.tb inhibition compared free pNPs. In addition, spheroid model developed screening, mimicking granulomas' physiological conditions. showed superior This research underscores the potential of therapy, particulate-based inhaled delivery, advance efficient patient-friendly treatments.

Language: Английский

Citations

2
Mitochondrial signaling pathways and their role in cancer drug resistance DOI
Ashwani Sharma, Tarun Virmani, Girish Kumar

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111329 - 111329

Published: Aug. 5, 2024

Language: Английский

Citations

9
Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review DOI Creative Commons
Popat Mohite, Abhijeet Puri, Shubham Munde

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 719 - 719

Published: Nov. 7, 2024

Microneedle (MN) technology has emerged as a promising approach for delivering therapeutic agents to the skin, offering significant potential in treating various dermal conditions. Among these technologies, hydrogel-forming microneedles (HFMNs) represent transformative advancement management of diseases through non-invasive drug delivery. These innovative devices consist micrometer-sized needles made native or crosslinked hydrophilic polymers, capable penetrating stratum corneum without damaging underlying tissues. Upon insertion, HFMNs rapidly absorb interstitial fluid, swelling form hydrogel conduit that enables efficient transport directly into microcirculation. The nature enhances patient compliance by eliminating pain and discomfort associated with traditional hypodermic needles. This allows delivery wide range drugs, including macromolecules biomacromolecules, which are often difficult administer dermally due their size polarity. Moreover, provide controlled regulated release profiles, enabling sustained effects while minimizing systemic side effects. Additionally, can be used both real-time fluid monitoring, valuable insights disease states treatment responses. dual functionality positions versatile dermatology tool effectively addressing complications. review explores use polymeric biomaterials HFMN fabrication application major disorders, such acne, psoriasis, other skin Furthermore, highlights MN-based treatments, underscoring reduce improve adherence, supported recent literature.

Language: Английский

Citations

9
The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases DOI Creative Commons
Nnamdi Ikemefuna Okafor, Omobolanle A. Omoteso, Yahya E. Choonara

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 30, 2025

Some of the most crucial turning points in treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with introduction antimicrobials vaccines. Drug resistance poor effectiveness are key limitations that need to be overcome. Conventional liposomes explored as a delivery system bioactives treat provide an efficient approach maximize therapeutic outcomes, drug stability, targetability, reduce side-effects antimicrobials, enhance vaccine performance where necessary. However, pathological understanding become more known, advanced liposomal technologies was born continue having profound effect on targeted chemotherapy diseases. This review therefore provides concise incursion into recent vogue formulations used An appraisal immunological, stimuli-responsive, biomimetic functionalized other novel modifications conventional is assimilated sync mutations resistant pathogens.

Language: Английский

Citations

1
Recent advances in nanogels for drug delivery and biomedical applications DOI Creative Commons
Arti Vashist, Gonzalo Álvarez,

Vianessa Andion Camargo

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(23), P. 6006 - 6018

Published: Jan. 1, 2024

Nanotechnology has shown great promise for researchers to develop efficient nanocarriers better therapy, imaging, and sustained release of drugs.

Language: Английский

Citations

5
“Innovative Polymers in Pharmaceutical Chemistry: Revolutionizing Drug Delivery Systems” DOI
Sudharshan Reddy Dachani, Ankur Vashi, Anand B. Mundada

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: Dec. 16, 2024

Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.

Language: Английский

Citations

4
The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic Strategies DOI Creative Commons
John Dawi,

Stephen Affa,

Kevin Kafaja

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 99 - 99

Published: Feb. 5, 2025

Tuberculosis (TB) caused by Mycobacterium tuberculosis (M.tb) remains a global health crisis, with over 10 million people affected annually. Despite advancements in treatment, M.tb has developed mechanisms to evade host immune responses, complicating efforts eradicate the disease. Two emerging cell death pathways, ferroptosis and cuproptosis, have been linked TB pathogenesis. Ferroptosis, an iron-dependent form of death, is driven lipid peroxidation reactive oxygen species (ROS) accumulation. This process can limit replication depleting intracellular iron inducing macrophage necrosis. However, excessive may lead tissue damage aid bacterial dissemination. Cuproptosis, triggered copper accumulation, disrupts mitochondrial metabolism, leading protein aggregation death. exploits both metabolism survive within macrophages, manipulating these processes resist oxidative stress responses. review examines roles cuproptosis TB, discussing how manipulates pathways for survival. While therapeutic strategies targeting processes, such as inducers (Erastin, RSL3) inhibitors (Ferrostatin-1) ionophores (Disulfiram, Elesclomol) chelators, show promise, limited understanding potential off-target effects significant challenge. Further exploration provide insights into development targeted therapies aimed at controlling infection while minimizing damage. By elucidating complex interactions between ferroptosis, future could better address resistance improve clinical outcomes.

Language: Английский

Citations

0
Nanotherapeutics in tuberculosis: Pulmonary and extrapulmonary applications DOI
Shradha Bisht, V. P. Jaiswal, Mamta F. Singh

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 239 - 268

Published: Jan. 1, 2025

Language: Английский

Citations

0
Use of plants in the search for drugs to treat tuberculosis DOI
Luiza Helena da Silva Martins, Philip G. Kerr

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 137 - 153

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy DOI Creative Commons
Giulia Cazzaniga, Matteo Mori, Anna Griego

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

The urgent need for safer and innovative antitubercular agents remains a priority the scientific community. In pursuit of this goal, we designed evaluated novel 5-phenylfuran-2-carboxylic acid derivatives targeting Mycobacterium tuberculosis (Mtb) salicylate synthase (MbtI), key enzyme, absent in humans, that plays crucial role Mtb virulence. Several potent MbtI inhibitors demonstrating significant activity favorable safety profile were identified. Structure-guided optimization yielded 5-(3-cyano-5-isobutoxyphenyl)furan-2-carboxylic (1e), which exhibited strong inhibition (IC50 = 11.2 μM) promising vitro (MIC99 32 μM against M. bovis BCG). Esters 1e effectively loaded into poly(2-methacryloyloxyethyl phosphorylcholine)-poly(2-(diisopropylamino)ethyl methacrylate) (PMPC-PDPA) polymersomes (POs) delivered to intracellular mycobacteria, resulting reduced viability. This study provides foundation use POs development future MbtI-targeted therapies tuberculosis.

Language: Английский

Citations

0