Nanoparticles incorporated hydrogels for delivery of antimicrobial agents: developments and trends

RSC Advances, Journal Year: 2024, Volume and Issue: 14(19), P. 13535 - 13564

Published: Jan. 1, 2024

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of nanoparticle-hydrogels system delivery antimicrobial agents.

Language: Английский

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Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

Biomimetics, Journal Year: 2024, Volume and Issue: 9(3), P. 154 - 154

Published: March 1, 2024

The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one the major complications such medical interventions. emergence novel technologies, especially 3D printing, represents promising avenue development for reducing risk eventualities. There are already host biomaterials, suitable being tested antimicrobial properties when they coated with bioactive compounds, as antibiotics, or combined hydrogels antioxidant properties, chitosan metal nanoparticles, among others. materials discussed context this paper comprise beta-tricalcium phosphate (β-TCP), biphasic calcium (BCP), hydroxyapatite, lithium disilicate glass, polyetheretherketone (PEEK), poly(propylene fumarate) (PPF), poly(trimethylene carbonate) (PTMC), zirconia. While recent research results promising, further required to address increasing antibiotic resistance exhibited by several common pathogens, potential fungal infections, toxicity some nanoparticles. Other solutions, like incorporation phytochemicals, should also be explored. Incorporating artificial intelligence (AI) certain implants use AI against bacterial might represent viable solutions these problems. Finally, there legal considerations associated biomaterials widespread which must taken into account.

Language: Английский

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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Parkinson’s disease is a progressive neurodegenerative that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment approaches primarily focus on symptom management, employing pharmacological, non-pharmacological, surgical methods. However, these treatments often result in fluctuating symptoms, side effects, progression. Here, the authors have reviewed emerging field of nanomedicine as promising path for treatment, emphasizing its potential to overcome limitations traditional therapies. Nanomedicine utilizes nanoparticles targeted drug delivery, leveraging their small size high surface area volume ratio cross blood-brain barrier deliver therapeutic agents directly affected brain regions. Various nanoparticles, including lipid-based, polymeric, metallic, carbon-based, shown treatment. Additionally, nanocarrier systems like liposomes, nanogels, dendrimers, solid lipid offer controlled sustained release agents, enhancing bioavailability reducing effects. This review provides insights into pathophysiology disease, highlighting mechanisms neurodegeneration, role alpha-synuclein, disruption pathways. It further discusses application gene therapy conjunction with interventions.

Language: Английский

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One-step green synthesis of collagen nanoparticles using Ulva fasciata, network pharmacology and functional enrichment analysis in hepatocellular carcinoma treatment

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139244 - 139244

Published: Jan. 1, 2025

Language: Английский

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Metal and metal oxide nanoparticles combined with ionic liquids and deep eutectic solvents and their practices in drug extraction and environmental processes: A review

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126955 - 126955

Published: Jan. 1, 2025

Language: Английский

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The role of NLRP3 inflammasome activation in proinflammatory and cytotoxic effects of metal nanoparticles

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126790 - 126790

Published: Aug. 29, 2024

Language: Английский

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A Comprehensive Review of Silver and Gold Nanoparticles as Effective Antibacterial Agents

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1134 - 1134

Published: Aug. 29, 2024

The increasing threat from antibiotic-resistant bacteria has necessitated the development of novel methods to counter bacterial infections. In this context, application metallic nanoparticles (NPs), especially gold (Au) and silver (Ag), emerged as a promising strategy due their remarkable antibacterial properties. This review examines research published between 2006 2023, focusing on leading journals in nanotechnology, materials science, biomedical research. primary applications explored are efficacy Ag Au NPs agents, synthesis methods, morphological properties, mechanisms action. An extensive literature synthesis, morphology, minimum inhibitory concentration (MIC), bactericidal (MBC), effectiveness against various Gram(+/-) confirms NPs. characteristics NPs, such size, shape, surface charge, crucial determining activity, these factors influence interactions with cells. Furthermore, underscores urgent necessity standardizing techniques, MICs, reporting protocols enhance comparability reproducibility future studies. Standardization is essential for ensuring reliability findings accelerating clinical NP-based antimicrobial approaches. aims propel strategies by elucidating properties that activity By highlighting effects strains relatively low cytotoxicity, work positions developing making significant contribution global efforts combat pathogens.

Language: Английский

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Exploring an Innovative Approach: Integrating Negative-Pressure Wound Therapy with Silver Nanoparticle Dressings in Skin Graft Procedures

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(2), P. 206 - 206

Published: Feb. 14, 2024

Skin grafting is a helpful instrument in plastic surgeon's arsenal. Several types of dressings were designed to facilitate the process graft integration. Negative-pressure wound therapy proven dressing method, enhancing survival through several mechanisms: aspiration secretions, stimulation neoangiogenesis, and promotion an anti-inflammatory environment. Silver nanoparticle also bring multiple benefits by bearing antimicrobial effect providing humid medium, which are favorable for epithelialization. The combination NPWT (negative-pressure therapy) with AgNPs (silver nanoparticles) has not been widely studied.

Language: Английский

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Nanoparticles in drinking water: Assessing health risks and regulatory challenges

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 174940 - 174940

Published: July 22, 2024

Language: Английский

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