Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106417 - 106417
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal of Dispersion Science and Technology, Год журнала: 2025, Номер unknown, С. 1 - 32
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
Asian Journal of Research in Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 44 - 56
Опубликована: Март 7, 2025
Niosomes, non-ionic surfactant-based vesicular systems, have garnered significant attention in recent years for their potential applications drug delivery, gene therapy, and vaccine development. This review article provides a comprehensive overview of current research on niosomes, focusing formulation, characterization, therapeutic applications. Various preparation methods, including thin-film hydration, reverse-phase evaporation, microfluidic techniques, are critically evaluated efficiency producing niosomes with controlled size, morphology, encapsulation efficiency. Recent advancements surface modification strategies, such as PEGylation targeting ligands, enhanced the biocompatibility capabilities facilitating delivery hydrophilic lipophilic drugs. The stability under physiological conditions behavior biological environments also discussed, highlighting influence formulation parameters release kinetics. Additionally, examines integration emerging fields nanomedicine personalized showcasing role overcoming barriers related to solubility bioavailability. clinical studies preclinical trials underscore various diseases, cancer, diabetes, infectious diseases. By synthesizing findings, this aims provide insights into future directions niosome research, emphasizing promise revolutionizing systems improving outcomes. challenges opportunities scaling up production regulatory considerations paving way translation technology from laboratory settings
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 572 - 572
Опубликована: Апрель 29, 2024
Despite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments lacking efficiency leading to severe side effects. Hence, it is imperative develop new, more efficient, safer therapies. Bee venom has proven have multiple synergistic bioactivities, including antitumor Nevertheless, some toxic effects been associated its administration. To tackle these issues, in this work, bee venom-loaded niosomes were developed, for treatment. The vesicles had small (150 nm) homogeneous (polydispersity index of 0.162) particle size, revealed good therapeutic efficacy vitro gastric, colorectal, breast, lung, cervical models (inhibitory concentrations between 12.37 ng/mL 14.72 ng/mL). Additionally, they also substantial anti-inflammatory activity concentration 28.98 ng/mL), complementary direct activity. Niosome safety was assessed, both (skin, liver, kidney cells) ex vivo (hen’s egg chorioallantoic membrane), results showed that compound encapsulation increased safety. small, successfully anticancer effects, making them potentially promising primary or adjuvant Future research should focus on evaluating the potential developed platform models.
Язык: Английский
Процитировано
2
Regenerative Engineering and Translational Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
Процитировано
2
Опубликована: Фев. 27, 2024
Despite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments many times lacking efficiency leading to severe side-effects. Hence, it is imperative develop new, more efficient, safer therapies. Bee venom has proven have multiple synergistic bioactivities, including antitumor effects. Nevertheless, some toxic effects been associated its administration. To tackle these issues, in this work, bee venom-loaded niosomes were developed, for treatment. The vesicles had small (150.4 ± 3.7 nm) homogeneous (PDI of 0.162 0.008) particle size, revealed good therapeutic efficacy vitro gastric, colorectal, breast, lung, cervical models, GI50 values between 12.37 ng/mL 14.72 ng/mL. Additionally, they also substantial anti-inflammatory activity, an IC50 28.98 ng/mL, that reported be complementary direct activity. Finally, the niosomes' safety was assessed, both vitro, on skin, liver kidney cells, ex vivo, HET-CAM assay, results showed compound encapsulation increased safety. successfully anticancer effects, making them potentially promising primary or adjuvant
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(7), С. 964 - 964
Опубликована: Июль 21, 2024
Targeting drugs to the central nervous system (CNS) is challenging due presence of blood-brain barrier (BBB). The cutting edge in nanotechnology generates optimism overcome growing challenges biomedical sciences through effective engineering nanogels. primary objective present report was develop and characterize a biocompatible natural chitosan (CS)-based NG that can be tracked thanks tricarbocyanine (CNN) fluorescent probe addition on biopolymer backbone. FTIR shed light chemical groups involved CS CNN interactions between CNN-CS tripolyphosphate, cross-linking agent. Both vitro vivo experiments were carried out determine if CS-NGs utilized as therapeutic delivery vehicles directed towards brain. An ionic gelation method chosen generate cationic CNN-CS-NG. DLS TEM confirmed these entities' sizes fell into nanoscale. CNN-CS-NG found non-cytotoxic, determined SH-SY5Y neuroblastoma cell line biocompatibility assays. After cellular internalization, occurrence an endo-lysosomal escape (a crucial event for efficient drug delivery) detected. Furthermore, administered intraperitoneally female CF-1 mice detected different brain regions after 2 h administration, using fluorescence microscopy. To conclude, obtained findings useful field neuro-nanomedicine when designing with purpose delivering CNS.
Язык: Английский
Процитировано
1
Bioengineering, Год журнала: 2024, Номер 11(11), С. 1078 - 1078
Опубликована: Окт. 28, 2024
Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high toxicity restrict clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body been verified as an effective approach enhance efficacy. However, are easily disassembled bloodstream, which can lead premature drug release. To broaden application scenarios mPEG PLA micelles, we utilized π–π stacking effect intermolecular force design a novel mPEG-PLA-Lys(Fmoc) micelle stability permeability drug-loaded micelles. result showed that for injection did not alter tissue selectivity docetaxel. Intravenous nude mice better antitumor efficacy than tumor recurrence rate is 0%, significantly lower (100%). designed by this research institute anticipated improve
Язык: Английский
Процитировано
1
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Фев. 26, 2024
Abstract Many drug molecules contain functional groups, resulting in a torsional barrier corresponding to rotation around the bond linking fragments. In medicinal chemistry and pharmaceutical sciences, inclusive of design studies, exact calculation potential energy surface these molecular torsions is extremely important precious. Machine learning, including deep currently one most rapidly evolving tools computer-aided discovery simulations. this work, we used ANI-1x neural network as quantum-level machine learning predict PESs Selegiline antiparkinsonian molecule. Also, DFT calculations at wB97X/6-31G(d) level theory have been study structural parameters vibrational normal modes We succeeded calculating frequencies, electronic optimization structure using dataset very short computing cost. From perspective, expect applied work be appreciably efficient effective computational structure-based studies.
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(12), С. 101057 - 101057
Опубликована: Авг. 5, 2024
A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β (Aβ) in
Язык: Английский
Процитировано
0
Colloids and Interfaces, Год журнала: 2024, Номер 8(5), С. 57 - 57
Опубликована: Окт. 17, 2024
New hexadecylpiperidinium surfactants, containing one or two butylcarbamate fragments, were synthesized. The antimicrobial activity, toxicity, aggregation behavior in aqueous solutions, and solubilization capacity of these surfactants towards the hydrophobic drug ibuprofen characterized. These demonstrated a high activity against wide range pathogenic bacteria, including both Gram-positive Gram-negative strains, as well fungi. By forming mixed-micellar compositions cationic surfactant 1-CB(Bu)-P-16 nonionic Brij®35, highly functional low-toxic formulations obtained. Furthermore, transition from mixed micelles to niosomes was accomplished, enhancing their potential delivery systems. Niosomes found be less toxic compared micelles, while also increasing solubility water. modification with made it possible increase stability system improve drug. data obtained indicate that new carbamate-containing have significant biomedical applications, particularly formulation advanced
Язык: Английский
Процитировано
0