Caralluma fimbriata Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet DOI Open Access
V. B. S. C. Thunuguntla, Laura Kate Gadanec,

C. McGrath

и другие.

Nutrients, Год журнала: 2024, Номер 16(24), С. 4296 - 4296

Опубликована: Дек. 12, 2024

Background: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. Caralluma fimbriata extract (CFE) has been shown control appetite promote weight loss; however, its effect on function remains poorly understood. This study aimed determine that CFE had loss mice fed high-fat diet (HFD) induce obesity, comparing this of lorcaserin (LOR) (an anti-obesity pharmaceutical) treatment. Methods: C57BL/6J male (n = 80) were 16-week HFD obesity prior being treated with LOR as standalone treatments or conjunction. Body composition data, such gain fat mass content measured, isometric tension analyses performed isolated abdominal aortic rings relaxation responses acetylcholine, immunohistochemistry studies utilized expression profiles endothelial nitric oxide synthase (eNOS) cell stress markers (nitrotyrosine (NT) 78 kDa glucose-regulated protein (GRP78)) endothelial, medial adventitial layers rings. Results: The results demonstrated + significantly reduced (17%; 24%) deposition (14%; 16%). A markedly acetylcholine-mediated (p < 0.05, p 0.0001) eNOS 0.0001, 0.01) increased NT GRP78 0.01, 0.001). Obese exhibited improved ACh-induced responses, expression. Conclusions: Thus, alone combination could serve an alternative strategy preventing obesity-related diseases.

Язык: Английский

Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018 DOI Creative Commons
Yan Jiang, Yingying Shen

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and atherosclerotic CVD (ASCVD). The composite dietary antioxidant index (CDAI), an emerging measure of combined exposure, may provide insights into the relationship between diet CVD/ASCVD outcomes. We aimed to explore association CDAI prevalence CVD/ASCVD, as well mortality in individuals with dyslipidemia. was assessed by integrating vitamins A, C, E, zinc, selenium, carotenoids. diagnosed according widely established criteria. Data on were obtained through self-reports, while prospective matching participant records National Death Index database. Multivariate logistic regression analysis Cox proportional hazards used these associations calculate odds ratios [OR], hazard [HR], 95% confidence intervals [CI], respectively. A total 23,126 participants dyslipidemia from NHANES 2001-2018 included. After adjusting potential confounders, inversely associated both ASCVD populations (OR CI 0.979 (0.964, 0.995) 0.977 (0.961, 0.993), respectively). Similar observed specific types CVD. also (HR = 0.957, 0.939-0.976, p < 0.0001). Restricted cubic spline threshold effects analyses indicated that nonlinearly significant occurring only when CDAI≤0; however, > -2. Furthermore, age, sex, drinking found modify body mass influenced mortality. events dyslipidemic populations. These findings highlight patterns alleviate burden underscore importance personalized strategies.

Язык: Английский

Процитировано

4
Efficacy of Traditional Chinese Medicine combined with Conventional Western Medicine on Metabolic Syndrome: A Bayesian Network Meta-Analysis DOI
Yanmin Zhang, Yixuan Fang, Nannan Xing

и другие.

Journal of Herbal Medicine, Год журнала: 2025, Номер unknown, С. 100998 - 100998

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Current Insights on the Effects of Medicinal Plants in the Management of Obesity and Infectious Diseases: An Update from 2020. DOI Creative Commons

Ofoezie Ezichi Favour,

Ogbonna Chinwendu Angela,

George Tiffany Ezinne

и другие.

Aspects of Molecular Medicine, Год журнала: 2025, Номер unknown, С. 100075 - 100075

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Regulation of adipokine and batokine secretion by dietary flavonoids, as a prospective therapeutic approach for obesity and its metabolic complications DOI Creative Commons
Khanyisani Ziqubu, Sithandiwe E. Mazibuko-Mbeje, Phiwayinkosi V. Dludla

и другие.

Biochimie, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Traditionally recognised as the energy reservoir and main site of adaptive thermogenesis, white brown adipose tissues are complex endocrine organs regulating systemic metabolism via secretion bioactive molecules, termed "adipokines" "batokines", respectively. Due to its significant role in whole-body other physiological processes, tissue has been increasingly explored a feasible therapeutic target for obesity. Flavonoids one most plant polyphenolic compounds holding great potential agents combating However, understanding their mechanisms action remains largely insufficient formulate theories. This review critically discusses scientific evidence highlighting flavonoids ameliorating obesity-related metabolic complications, including dysfunction, inflammation, insulin resistance, hepatic steatosis, cardiovascular comorbidities part by modulating release adipokines batokines. Further discussion advocates use therapeutics targeting these molecules avenue developing effective treatment obesity adverse diseases such type 2 diabetes.

Язык: Английский

Процитировано

2
Heat shock proteins (HSPs) in non-alcoholic fatty liver disease (NAFLD): from molecular mechanisms to therapeutic avenues DOI Creative Commons

Zhenbang Nie,

Congshu Xiao,

Jenny Wang

и другие.

Biomarker Research, Год журнала: 2024, Номер 12(1)

Опубликована: Окт. 12, 2024

Abstract Non-alcoholic fatty liver disease (NAFLD), a spectrum of conditions characterized by fat accumulation without excessive alcohol consumption, represents significant global health burden. The intricate molecular landscape underlying NAFLD pathogenesis involves lipid handling, inflammation, oxidative stress, and mitochondrial dysfunction, with endoplasmic reticulum (ER) stress emerging as key contributor. ER triggers the unfolded protein response (UPR), impacting hepatic steatosis in contributing to fibrosis, progression NASH eventually hepatocellular carcinoma (HCC). Heat shock proteins (HSPs), including small HSPs such HSP20 HSP27, HSP60, HSP70, GRP78, HSP90, are integral cellular responses. They aid folding, prevent aggregation, facilitate degradation, thus mitigating damage under conditions. In NAFLD, aberrant HSP expression function contribute pathogenesis. Understanding specific roles subtypes offers insights into potential therapeutic interventions. This review discusses involvement pathophysiology highlights their potential. By elucidating mechanisms HSP-mediated protection this article aims pave way for development targeted therapies prevalent disorder.

Язык: Английский

Процитировано

1
Caralluma fimbriata Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet DOI Open Access
V. B. S. C. Thunuguntla, Laura Kate Gadanec,

C. McGrath

и другие.

Nutrients, Год журнала: 2024, Номер 16(24), С. 4296 - 4296

Опубликована: Дек. 12, 2024

Background: Obesity is a risk factor for developing cardiovascular diseases (CVDs) by impairing normal vascular function. Natural products are gaining momentum in the clinical setting due to their high efficacy and low toxicity. Caralluma fimbriata extract (CFE) has been shown control appetite promote weight loss; however, its effect on function remains poorly understood. This study aimed determine that CFE had loss mice fed high-fat diet (HFD) induce obesity, comparing this of lorcaserin (LOR) (an anti-obesity pharmaceutical) treatment. Methods: C57BL/6J male (n = 80) were 16-week HFD obesity prior being treated with LOR as standalone treatments or conjunction. Body composition data, such gain fat mass content measured, isometric tension analyses performed isolated abdominal aortic rings relaxation responses acetylcholine, immunohistochemistry studies utilized expression profiles endothelial nitric oxide synthase (eNOS) cell stress markers (nitrotyrosine (NT) 78 kDa glucose-regulated protein (GRP78)) endothelial, medial adventitial layers rings. Results: The results demonstrated + significantly reduced (17%; 24%) deposition (14%; 16%). A markedly acetylcholine-mediated (p < 0.05, p 0.0001) eNOS 0.0001, 0.01) increased NT GRP78 0.01, 0.001). Obese exhibited improved ACh-induced responses, expression. Conclusions: Thus, alone combination could serve an alternative strategy preventing obesity-related diseases.

Язык: Английский

Процитировано

0