Research for development, Год журнала: 2024, Номер unknown, С. 313 - 336
Опубликована: Дек. 23, 2024
Язык: Английский
Biochemical Pharmacology, Год журнала: 2022, Номер 200, С. 115036 - 115036
Опубликована: Апрель 12, 2022
Язык: Английский
Процитировано
40
Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1042 - 1042
Опубликована: Март 23, 2023
Older adults represent the major target population for oral medications, due to high prevalence of multimorbidity. To allow successful pharmacological treatments, patients need adhere their medication and, thus, patient-centric drug products with a level acceptability by end users are needed. However, knowledge on appropriate size and shape solid dosage forms, as most commonly used forms in older adults, is still scarce. A randomized intervention study was performed including 52 (65 94 years) young (19 36 years). Each participant swallowed four coated placebo tablets differing weight (250 1000 mg) (oval, round, oblong) blinded manner three days. The choice tablet dimensions allowed systematic comparison between different sizes same shape, well shapes. Swallowability assessed using questionnaire-based method. All tested were ≥80% independent age. only 250 mg oval classified swallowable old participants. true participants; however, they also considered round 500 swallowable. Furthermore, swallowability seen influence willingness take daily basis, especially an intake over longer time periods.
Язык: Английский
Процитировано
20
British Journal of Clinical Pharmacology, Год журнала: 2022, Номер 88(12), С. 5128 - 5148
Опубликована: Июль 18, 2022
Solid oral dosage forms (SODFs) (often called pills by patients) are the default formulation to treat medical ailments. Beneficial therapeutic outcomes rely on patients taking them as directed. Up 40% of population experience difficulties swallowing SODFs, resulting in reduced adherence and impaired efficacy. Often associated with children, this also presents adults dysphagia, without any organic dysphagia (non-physiological-related or functional dysphagia). This review aims identify appraise current interventions used screen for overcome pill aversion dysphagia. A comprehensive search literature was conducted. Articles reporting aged ≥18 years no underlying cause, history of, existing were included. Study quality determined using STROBE tool observational studies. narrative synthesis findings prepared. We identified 18 relevant cohort studies, which demonstrate that is a global problem. Perceived ease and/or SODF swallowability appears be influenced female gender, younger age, co-morbidities (e.g., depression), physical properties. Patients often modify their medicines rather than raise issue healthcare team. Screening haphazard but controlled postural adjustments, coating SODFs behavioural appear successful solutions. barrier effective medication use. Healthcare professionals must recognise problem requiring identification through screening resolution training interventions, appropriate selection specialist referral.
Язык: Английский
Процитировано
27
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 195 - 195
Опубликована: Фев. 4, 2025
Background/Objectives: Oral administration of active pharmaceutical ingredients (APIs) is the most commonly used route administration. As dysphagia a prevalent problem, size swallowed dosage form could negatively influence patient adherence. Orally disintegrating tablets (ODTs) are beneficial forms because they disintegrate within few seconds in oral cavity without water. Lactose one excipients industry; it served as central concept recent publication on formulation milk-based ODTs despite lactose malabsorption being widespread worldwide. Consequently, plant-based alternative market has grown exponentially and become prevailing food trend, with various alternatives to choose from. For this reason, development nonsteroidal anti-inflammatory drug (NSAID)-containing ODT drinks (PBDs) was assessed for its innovative potential. Methods: Different PBDs were investigated compared traditional lactose-free milk. The liquids’ viscosity, pH, particle determined, an electronic tongue sensory evaluation. prepared freeze-drying method, then qualitative characteristics investigated. Results: Our different measurements show that plant beverages differ from each other these differences have impact technological processing. According HPLC-DAD measurements, all values required range. Conclusions: These suggest soya drink similar cow milk would be appropriate choice among carrier system ibuprofen-containing ODT.
Язык: Английский
Процитировано
0
International Journal of Clinical Pharmacy, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Patient Preference and Adherence, Год журнала: 2024, Номер Volume 18, С. 1281 - 1297
Опубликована: Июнь 1, 2024
Background: There is no consistent framework for patient-centric drug product design, despite the common understanding that acceptability and preferences influence adherence and, therefore, effectiveness. The aim of this review was to assess current patient solid oral dosage form (SODF) attributes, potential impact these attributes on behaviors outcomes. Patients Methods: A scoping conducted. Embase, Ovid MEDLINE ® , PubMed were searched full-text articles published between January 2013 May 2023. Following screening assessment against predefined inclusion criteria, data analyzed thematically. Results: Nineteen studies included. Four overarching domains identified summarized in a framework: appearance, swallowability, palatability, handling. Each domain informed by specific attributes: texture, form, size, shape, color, marking, taste, mouthfeel, smell. most frequently studied swallowability while texture. Smell, mouthfeel least attributes. Texture intersected all domains, size Swallowability appeared be key attribute, respectively, consider when designing products. Few explored Conclusion: While existing have focused appearance highlighted importance two less well-understood domains—palatability handling—in patients' SODF provides tool facilitate design products, organizing categorizing physical into four (appearance, handling), encouraging researchers comprehensively acceptability, preferences, Plain Language Summary: Medicines come variety types forms. These include tablets capsules. Factors, such as shape tablets, can affect how people take medicines. However, patients are rarely involved medicines they take. In study, 19 They wanted understand different factors, like ability, willingness Researchers "physical" aspects found 4 themes: 1) what look (appearance), 2) easy swallow (swallowability), 3) taste feel mouth (palatability), 4) handle (handling). Eight factors also found: markings, smell, medicine feels (mouthfeel). Most swallow. mostly looked at texture ages, though there may needs certain groups patients, including children, older adults, with diseases. Patient input should become part future ensure their acceptability. Keywords: preference, formulation,
Язык: Английский
Процитировано
3
Pharmaceutics, Год журнала: 2022, Номер 14(2), С. 320 - 320
Опубликована: Янв. 28, 2022
Swallowing problems and the required dose adaptations needed to obtain optimal pharmacotherapy may be a hurdle in use of tablets daily clinical practice. Tablet splitting, crushing, or grinding is often applied personalise medication, especially for elderly children. In this study, performance different types (commercially available) devices was studied. Included were splitters, screwcap crushers, manual grinders, electric grinders. Unscored without active ingredient prepared, with diameter 9 13 mm hardness 100-220 N. Tablets split into two parts difference weight measured. The time pulverise (crush time) recorded. residue remaining device (loss) powder sieved particle fraction >600 µm <600 µm. median size distribution later determined using laser diffraction analysis. Splitting equal appeared difficult tested. Most grinders yielded coarse containing larger chunks. Manual produced finer powder, making it suitable administration via an enteral feeding tube as well individualised preparations such capsules. conclusion, domestic incidental use, crusher provide sufficient reduction, while more demanding regular hospitals nursing residences, grinder preferred.
Язык: Английский
Процитировано
15
European Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 187, С. 106453 - 106453
Опубликована: Май 4, 2023
Older adults are the main users of medicine and due to common multimorbidity they often confronted with a complex medication management. This review article provides brief overview on aspects management, i.e., maintaining stock required medicine, understanding following instructions for use, coping primary secondary packaging, as well preparation prior use. However, focus is drug intake itself an current real life dosing conditions in older geriatric patients. It elaborates acceptability dosage forms, particular solid oral forms represent majority taken by this patient population. An improved needs patients, their various circumstances under which manage medications will allow design more patient-centric products.
Язык: Английский
Процитировано
6
European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2021, Номер 167, С. 65 - 72
Опубликована: Июль 21, 2021
Язык: Английский
Процитировано
15
Biointerface Research in Applied Chemistry, Год журнала: 2022, Номер 13(2), С. 177 - 177
Опубликована: Март 30, 2022
Stable drug-type tablets and capsules are painful to drink or chew for many pediatric geriatric patients. Accurate dosing is also an issue liquid orals (syrup, suspension, emulsion, so on). Several fast-dissolving drug delivery systems have been designed address these issues. One of the innovative methods rapid with self-administration without water chewing a thin polymer oral strip. Strip-forming polymers, plasticizers, active pharmaceutical ingredients, sweetening agents, saliva enhancing flavoring coloring stabilizing thickening agents all used form strips. The scope films expanded in this article.
Язык: Английский
Процитировано
10