Expert Opinion on Drug Delivery,
Год журнала:
2022,
Номер
19(9), С. 1149 - 1163
Опубликована: Сен. 2, 2022
Introduction
Combination
therapies
continue
to
improve
therapeutic
outcomes
as
currently
achieved
by
polypharmacy.
Since
the
introduction
of
polypill,
there
has
been
a
significant
improvement
in
adherence
and
patient
outcomes.
However,
mass
production
polypills
presents
number
technical,
formulation,
clinical
challenges.
The
current
one-size-fits-all
approach
ignores
unique
demands
patients,
necessitating
adoption
more
versatile
tool.
That
will
be
novel,
but
not
so
3D
printing.Areas
covered
present
review
investigates
this
promising
paradigm
shift
from
one
medication
for
all,
customized
medicines,
providing
an
overview
state
3D-printed
multi-active
pharmaceutical
forms,
techniques
applied
printing
materials.
Details
on
cost
implications,
well
potential
limitations
challenges
are
also
elaborated.Expert
opinion
systems,
is
only
beneficial
essential.
With
growing
interest
field,
manufacturing,
prescribing,
administration
patterns
is,
at
point,
unavoidable.
Addressing
challenges,
data
presentation
trial
results,
aid
acceleration
technology's
implementation.
it
clear
that
end
it,
evidenced
emerging
4D
technology.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 313 - 313
Опубликована: Янв. 17, 2023
3D
printing
technologies
enable
medicine
customization
adapted
to
patients'
needs.
There
are
several
techniques
available,
but
majority
of
dosage
forms
and
medical
devices
printed
using
nozzle-based
extrusion,
laser-writing
systems,
powder
binder
jetting.
has
been
demonstrated
for
a
broad
range
applications
in
development
targeting
solid,
semi-solid,
locally
applied
or
implanted
medicines.
3D-printed
solid
allow
the
combination
one
more
drugs
within
same
form
improve
patient
compliance,
facilitate
deglutition,
tailor
release
profile,
fabricate
new
medicines
which
no
is
available.
Sustained-release
implants,
stents,
have
used
mainly
joint
replacement
therapies,
prostheses,
cardiovascular
applications.
Locally
medicines,
such
as
wound
dressing,
microneedles,
medicated
contact
lenses,
also
manufactured
techniques.
The
challenge
select
technique
most
suitable
each
application
type
pharmaceutical
ink
that
should
be
developed
possesses
required
physicochemical
biological
performance.
integration
biopharmaceuticals
nanotechnology-based
along
with
("nanoprinting")
brings
personalized
nanomedicines
innovative
perspectives
coming
years.
Continuous
manufacturing
through
use
microfluidic
chips
facilitates
their
translation
into
clinical
practice.
Biofabrication,
Год журнала:
2024,
Номер
16(3), С. 032001 - 032001
Опубликована: Апрель 3, 2024
Abstract
With
the
advent
of
personalized
medicine,
drug
delivery
system
will
be
changed
significantly.
The
development
medicine
needs
support
many
technologies,
among
which
three-dimensional
printing
(3DP)
technology
is
a
novel
formulation-preparing
process
that
creates
3D
objects
by
depositing
materials
layer-by-layer
based
on
computer-aided
design
method.
Compared
with
traditional
pharmaceutical
processes,
3DP
produces
complex
combinations,
dosage,
and
flexible
shape
structure
dosage
forms
(DFs)
demand.
In
future,
drugs
may
supplement
even
replace
their
counterpart.
We
systematically
introduce
applications
technologies
in
industry
summarize
virtues
shortcomings
each
technique.
release
behaviors
control
mechanisms
DFs
desired
structures
are
also
analyzed.
Finally,
benefits,
challenges,
prospects
to
discussed.
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
653, С. 123902 - 123902
Опубликована: Фев. 14, 2024
Three-dimensional
printing
(3DP)
is
an
emerging
technology,
offering
the
possibility
for
development
of
dose-customized,
effective,
and
safe
solid
oral
dosage
forms
(SODFs).
Although
3DP
has
great
potential,
it
does
come
with
certain
limitations,
traditional
drug
manufacturing
platforms
remain
industry
standard.
The
consensus
appears
to
be
that
technology
expected
benefit
personalized
medicine
most,
but
unlikely
replace
conventional
mass
production.
method,
on
other
hand,
could
prove
well-suited
producing
small
batches
as
adaptive
technique
enabling
clinical
trial
design
early
studies.
purpose
this
review
discuss
recent
advancements
in
technologies
SODFs
focus
applications
stages,
including
a
discussion
current
regulatory
challenges
quality
controls.
International Journal of Pharmaceutics,
Год журнала:
2023,
Номер
642, С. 123194 - 123194
Опубликована: Июль 1, 2023
Metabolic
syndrome
is
a
collection
of
abnormalities,
including
at
least
three
the
following
insulin
resistance,
hypertension,
dyslipidemia,
type
2
diabetes,
obesity,
inflammation,
and
non-alcoholic
fatty
liver
disease.
3D
printed
solid
dosage
forms
have
emerged
as
promising
tool
enabling
fabrication
personalized
medicines
offering
solutions
that
cannot
be
achieved
by
industrial
mass
production.
Most
attempts
found
in
literature
to
manufacture
polypills
for
this
contain
just
two
drugs.
However,
most
fixed-dose
combination
(FDC)
products
clinical
practice
required
use
or
more
In
work,
Fused
deposition
modelling
(FDM)
printing
technology
coupled
with
hot-melt
extrusion
(HME)
has
been
successfully
applied
containing
nifedipine
(NFD),
an
antihypertensive
drug,
simvastatin
(SMV),
antihyperlipidemic
gliclazide
(GLZ)
antiglycemic
drug.
Hanssen
solubility
parameters
(HSPs)
were
utilized
predictors
guide
formation
amorphous
dispersion
between
drug
polymer
ensure
miscibility
enhanced
oral
bioavailability.
The
HSP
varied
from
18.3
NFD,
24.6
SMV,
7.0
GLZ
while
total
parameter
excipient
mixture
was
27.30.5.
This
allowed
SMV
tablets
compared
NFD
which
partially
crystalline.
Popypill
showed
dual
release
profile
combining
faster
(<
6h)
24
h
sustained
NDF
GLZ.
work
demonstrated
transformation
FDC
into
dynamic
dose-personalized
polypills.
Polymers,
Год журнала:
2024,
Номер
16(4), С. 517 - 517
Опубликована: Фев. 14, 2024
Three-dimensional
(3D)
printing
in
the
pharmaceutical
field
allows
rapid
manufacturing
of
a
diverse
range
dosage
forms,
including
personalized
items.
The
application
this
technology
form
requires
judicious
selection
excipients
because
selected
materials
must
be
appropriate
to
working
principle
each
technique.
Most
techniques
rely
on
use
polymers
as
main
material.
Among
pharmaceutically
approved
polymers,
polyvinyl
alcohol
(PVA)
is
one
most
used,
especially
for
fused
deposition
modeling
(FDM)
technology.
This
review
summarizes
physical
and
chemical
properties
pharmaceutical-grade
PVA
its
applications
with
particular
focus
those
fabricated
through
FDM.
work
provides
evidence
diversity
forms
created
using
polymer,
highlighting
how
formulation
processing
difficulties
may
overcome
get
suitable
design
release
profile.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 390 - 390
Опубликована: Март 19, 2025
Three-dimensional
printing
technology
is
transforming
pharmaceutical
manufacturing
by
shifting
from
conventional
mass
production
to
additive
manufacturing,
with
a
strong
emphasis
on
personalized
medicine.
The
integration
of
bioinks
and
AI-driven
optimization
further
enhancing
this
innovation,
enabling
drug
precise
dosages,
tailored
drug-release
profiles,
unique
multi-drug
combinations
that
respond
individual
patient
needs.
This
advancement
significantly
impacting
healthcare
accelerating
development,
encouraging
innovative
designs,
treatment
efficacy.
Traditional
follows
one-size-fits-all
approach,
which
often
fails
meet
the
specific
requirements
patients
medical
conditions.
In
contrast,
3D
printing,
coupled
bioink
formulations,
allows
for
on-demand
production,
reducing
dependency
large-scale
storage.
AI-powered
design
process
refine
dosage
forms,
printability,
release
mechanisms,
ensuring
precision
efficiency
in
manufacturing.
These
advancements
have
potential
lower
overall
costs
while
improving
adherence
medication
regimens.
review
explores
potential,
challenges,
environmental
benefits
positioning
it
as
key
driver
next-generation
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 361 - 361
Опубликована: Янв. 20, 2023
Orodispersible
Films
(ODFs)
are
drug
delivery
systems
manufactured
with
a
wide
range
of
methods
on
big
scale
or
for
customized
medicines
and
small-scale
pharmacy.
Both
ODFs
their
fabrication
have
certain
limitations.
Many
pharmaceutical
companies
academic
research
centers
across
the
world
cooperate
in
order
to
cope
these
issues
also
find
new
formulations
array
APIs
what
could
make
work
profitable
them
beneficial
patients
as
well.
The
number
pending
patent
applications
granted
patents
innovative
approaches
makes
progress
manufacturing
unquestionable.
commercially
available
is
still
growing.
However,
some
were
discontinued
no
longer
markets.
This
review
aims
summarize
currently
marketed
those
withdrawn
from
sale
provides
an
insight
into
recently
published
studies
concerning
orodispersible
films,
emphasizing
utilized
APIs.
highlights
attempts
scientific
communities
overcome
ODF’s
Polymers,
Год журнала:
2023,
Номер
15(17), С. 3554 - 3554
Опубликована: Авг. 26, 2023
Three-dimensional
printing
has
revolutionized
drug
manufacturing
and
provided
a
solution
to
the
limitations
associated
with
conventional
method
by
designing
complex
delivery
systems
customized
release
profiles
for
personalized
therapies.
The
present
investigation
aims
design
gastric
floating
tablet
prolonged
time
sustained
profile.
In
study,
gastro
retentive
device
(GRFD)
was
designed
fabricated
using
fused
deposition
modelling
(FDM)-based
3D
technique.
This
acts
as
multifunctional
dosage
form
exhibiting
retention
profile
improved
oral
bioavailability
in
upper
gastrointestinal
tract.
Commercial
polyvinyl
alcohol
(PVA)
polylactic
acid
(PLA)
filaments
were
used
GRFD,
which
comprised
of
dual
compartments.
outer
sealed
compartment
an
air-filled
chamber
that
imparts
buoyancy
inner
is
filled
commercial
propranolol
hydrochloride
immediate-release
tablet.
round-shaped
shell
central
opening
varying
size
(1
mm,
2
3
4
mm),
window.
Scanning
electron
microscope
(SEM)
images
determine
morphological
characterization.
vitro
evaluated
USP
type
II
dissolution
apparatus.
All
GRFDs
exhibit
good
ability
profiles.
PLA
filament
show
maximum
(>24
h)
up
10
h.
from
developed
devices
governed
window
material
affinity
towards
fluid.
great
prospects
modifying
characteristics
could
be
applied
any
product.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 790 - 790
Опубликована: Июнь 11, 2024
Gastroretentive
drug
delivery
systems
(GRDDSs)
have
gained
substantial
attention
in
the
last
20
years
due
to
their
ability
retain
stomach
for
an
extended
time,
thus
promoting
release
and
high
bioavailability
a
broad
range
of
active
pharmaceutical
ingredients
(APIs)
that
are
pH-sensitive
and/or
narrow
absorption
window.
The
currently
existing
GRDDSs
include
floating,
expanding,
mucoadhesive,
magnetic,
raft-forming,
ion-exchanging,
high-density
systems.
Although
there
seven
types
systems,
main
focus
is
on
mucoadhesive
produced
by
various
techniques,
3D
printing
being
one
most
revolutionary
studied
ones.
This
review
assesses
newest
production
technologies
briefly
describes
vitro
vivo
evaluation
methods,
with
aim
providing
better
overall
understanding
as
novel
emerging
strategy
targeted
delivery.
