Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106239 - 106239
Опубликована: Сен. 1, 2024
Язык: Английский
Biotechnology Advances, Год журнала: 2024, Номер 73, С. 108362 - 108362
Опубликована: Апрель 12, 2024
Язык: Английский
Процитировано
8
Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 14
Опубликована: Янв. 12, 2025
Orodispersible film (ODF) is one of the novel formulations that disintegrate rapidly in mouth without requisite for water compared to other conventional oral solid dosage formulations. This delivery system serves as a convenient mode administration, especially patients who have dysphagia and fluid restriction, being beneficial pediatric, geriatric, bedridden patients. A sildenafil ODF containing citrate formulated be used with erectile dysfunction (ED). review discusses advantages improving compliance satisfaction these describes manufacturing techniques, evaluation tests, bioequivalence, stability studies ODF. formulation offers unique benefit ED by their acceptance respecting privacy need discreet treatment. Moreover, comparison pharmacokinetic parameters between administered film-coated tablet were similar. It also demonstrated reliable performance yielded consistent product, meeting all specifications at release after three weeks storage under stressed conditions (60°C). Sildenafil warrants improved ease intake, taste, portability, storage, among patients, making it potential most preferred drug choice.
Язык: Английский
Процитировано
1
Journal of Saudi Chemical Society, Год журнала: 2024, Номер 28(4), С. 101896 - 101896
Опубликована: Июнь 29, 2024
Complex, kinetically stable emulsions with an average droplet size of 50–100 nm and a mean diameter 50–1000 is known as nanoemulsions. They are often referred to tiny submicron, ultrafine, or finely dispersed emulsions; they have tyndal effect transparent the naked eye. Antimicrobial nanoemulsion type o/w emulsion system that stabilized by surfactants alcohols used co-surfactants. It effective against wide range microorganisms, such viruses (such herpes simplex HIV), fungi Candida dermatophytes), bacteria Escherichia coli, Salmonella, Staphylococcus aureus). The droplets were designed fuse electrostatic attraction thermodynamic mechanism lipid-coated microorganisms. active component trapped energy generated break down pathogen's lipid membrane when sufficient number nanoparticles pathogens, resulting in cell lysis eventual death invasion Because there less surfactant each droplet, targeted become unstable without endangering healthy cells, giving nanoemulsions safety margin. Nanoemulsion has many benefits, being clear, biocompatible, non-immunogenic, biodegradable, able hold drugs, release them slowly steadily, nanometrically small, having large surface area, easy make, thermodynamically stable.
Язык: Английский
Процитировано
6
Food Production Processing and Nutrition, Год журнала: 2025, Номер 7(1)
Опубликована: Янв. 10, 2025
Abstract Oral dissolving film (ODF) emerges as a novel active substance delivery system, offering portability, safety, and compliance. ODF presents superior gastrointestinal absorption compared to conventional food products, making it ideal for providing nutrition medication support vulnerable populations such children, the elderly, individuals with dysphagia. With promising applications in pharmaceuticals especially industry, ODFs offer highly absorbable method delivering nutritious healthy foods. This review underscores potential of orally films delivery, outlining their advantages over traditional oral methods current market status. Additionally, discusses formulation procedure, production methods, quality evaluation dosage forms ODFs. Lastly, examines limitations speculates on future trends industry. study serves valuable reference development utilization sector. Graphical
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 86 - 86
Опубликована: Янв. 13, 2025
Orodispersible thin film (ODF) is an innovative dosage form that allows for adjustable dosing and improved patient compliance. It administered by mouth, where it dissolves, making suitable children. Objectives: The aim of the study was to develop characterize optimal ODF formulation containing equivalent hydrocortisone at 0.5 mg/cm2 using solvent-casting method. A stability-indicating assay simultaneous quantification 21-hemissucinate (HMS) developed. ODFs were characterized organoleptic properties testing uniformity mass, content, stability, thickness, dissolution. Results: When optimized, thin, flexible, transparent, production in hospital pharmacies standard equipment. In contrast water-insoluble hydrocortisone, HMS-loaded cast gel successfully satisfied tests, including content uniformity. Disintegration appeared acceptable as compared commercial grade ondansetron (Setofilm®). physicochemical stability active ingredients (i.e., HMS, hydrocortisone) contained demonstrated least 84 days 23 °C. Conclusion: formulated with water-soluble prodrug HMS accurate drug level be achieved, thus opening up new opportunities use pediatric patients.
Язык: Английский
Процитировано
0
Clinical and Translational Science, Год журнала: 2025, Номер 18(2)
Опубликована: Фев. 1, 2025
ABSTRACT Schizophrenia is a serious mental disorder with high disability rates, and antipsychotics, especially second‐generation ones like aripiprazole, are the cornerstone of treatment. As novel formulation, oral soluble films (OSF) offer an alternative to tablets or capsules, improving patient compliance. This study aimed assess bioequivalence, pharmacokinetic (PK) properties, safety aripiprazole OSF orally disintegrating (ODT) in healthy Chinese participants. A single‐dose, randomized, open‐label, crossover was conducted. Participants received 10 mg test (Qilu Pharmaceutical) reference ODT (Otsuka under fasting fed states. The trial comprised three‐sequence, three‐period design, while two‐sequence, two‐period design. In trial, after single dosing (with water), (without ODT, C max were 55 ± ng/mL, 54 48 13 respectively; AUC 0‐72h 1857 377 h·ng/mL, 1823 350 1745 405 respectively. water, 43 9 ng/mL 2024 387 h·ng/mL 1994 426 terms bioequivalence evaluation, 90% confidence intervals geometric mean ratio main PK parameters states all within acceptable equivalence range (80%–125%). Both formulations well‐tolerated. conclusion, reached demonstrates significant potential for application treatment psychiatric disorders.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1063 - 1063
Опубликована: Июль 26, 2023
Mental disorders are increasing worldwide, and efforts have been developed by multidisciplinary research groups to combine knowledge from different areas such as psychology, neuroscience, medicine, biotechnology develop strategies products promote the prevention of mental disorders. Excessive antipsychotic consumption is a public health problem, innovative must be devised. The development and, if possible, natural one combat this problem. Oral films recent delivery systems that with several advantages should applied in area. This review intends draw attention these new dosage forms drugs bioactive molecules pertinent field therapy need for regulatory guidelines ensure their quality safety. critical overview about strengths, weaknesses, opportunities, threats related oral film implementation disorder treatment.
Язык: Английский
Процитировано
4
International Journal of Pharmaceutics, Год журнала: 2024, Номер 658, С. 124188 - 124188
Опубликована: Май 3, 2024
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(6), С. 712 - 712
Опубликована: Май 26, 2024
Paediatric infectious diseases contribute significantly to global health challenges. Conventional therapeutic interventions are not always suitable for children, as they regularly accompanied with long-standing disadvantages that negatively impact efficacy, thus necessitating the need effective and child-friendly pharmacotherapeutic interventions. Recent advancements in drug delivery technologies, particularly oral formulations, have shown tremendous progress enhancing effectiveness of paediatric medicines. Generally, these methods target, address challenges associated palatability, dosing accuracy, stability, bioavailability, patient compliance, caregiver convenience, which important factors can influence successful treatment outcomes children. Some emerging trends include moving away from creating liquid systems developing solid most explored being orodispersible tablets, multiparticulate dosage forms using film-coating chewable products. Other ongoing innovations gastro-retentive, 3D-printed, nipple-shield, milk-based, nanoparticulate (e.g., lipid-, polymeric-based templates) systems, possessing potential improve effectiveness, age appropriateness, pharmacokinetics, safety profiles relate population. This manuscript therefore highlights evolving landscape leading diseases, crediting role innovative technologies. By focusing on current trends, pointing out gaps, identifying future possibilities, this review aims towards efforts directed at improving management ailments through accessible efficacious treatments.
Язык: Английский
Процитировано
1
Опубликована: Июль 29, 2024
Abstract: Orodispersible film (ODF) is one of the novel formulations that have been currently made available disintegrates rapidly in mouth without requisite for water and offer several benefits over conventional oral solid dosage formulations. This delivery system serves as a discreet convenient mode administration, especially patients who dysphagia, fluid restriction, being beneficial to pediatric, geriatric, bedridden patients. A sildenafil ODF containing citrate formulated be used with erectile dysfunction (ED). review discusses advantages improving compliance satisfaction these describes bioequivalence stability studies ODF. formulation offers unique benefit ED by their acceptance, compliance, respecting privacy. Moreover, comparison pharmacokinetic parameters between administered film-coated tablet were similar. It also demonstrated reliable performance yielded consistent product, meeting all specifications at release after three weeks storage under stressed conditions (60oC). Sildenafil warrants improved ease intake, taste, portability, storage, among patients, making it potential most preferred drug choice.
Язык: Английский
Процитировано
1