Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2681 - 2681
Опубликована: Дек. 1, 2022
The
use
of
natural
compounds
is
becoming
increasingly
popular
among
patients,
and
there
a
renewed
interest
scientists
in
nature-based
bioactive
agents.
Traditionally,
herbal
drugs
can
be
taken
directly
the
form
teas/decoctions/infusions
or
as
standardized
extracts.
However,
disadvantages
compounds,
especially
essential
oils,
are
their
instability,
limited
bioavailability,
volatility,
often
irritant/allergenic
potential.
these
active
substances
stabilized
by
encapsulation
administered
nanoparticles.
This
brief
overview
summarizes
latest
results
application
nanoemulsions,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers
used
drug
delivery
systems
oils
for
individual
secondary
metabolites
applicable
cancer
therapy.
Although
discussed
agents
not
typical
anticancer
agents,
after
inclusion
into
aforesaid
formulations
improving
stability
bioavailability
and/or
therapeutic
profile,
they
indicated
anti-tumor
activity
became
interesting
with
treatment
In
addition,
co-encapsulation
synthetic
nanoformulations
aim
to
achieve
synergistic
effect
chemotherapy
discussed.
Vaccines,
Год журнала:
2022,
Номер
10(11), С. 1946 - 1946
Опубликована: Ноя. 17, 2022
Vaccination
is
still
the
most
cost-effective
way
to
combat
infectious
illnesses.
Conventional
vaccinations
may
have
low
immunogenicity
and,
in
situations,
only
provide
partial
protection.
A
new
class
of
nanoparticle-based
has
shown
considerable
promise
addressing
majority
shortcomings
traditional
and
subunit
vaccines.
This
due
recent
breakthroughs
chemical
biological
engineering,
which
allow
for
exact
regulation
nanoparticle
size,
shape,
functionality,
surface
characteristics,
resulting
improved
antigen
presentation
robust
immunogenicity.
blend
physicochemical,
immunological,
toxicological
experiments
can
be
used
accurately
characterize
nanovaccines.
narrative
review
will
an
overview
current
scenario
nanovaccine.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 976 - 976
Опубликована: Март 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
RSC Advances,
Год журнала:
2023,
Номер
13(31), С. 21345 - 21364
Опубликована: Янв. 1, 2023
Nanoparticle-modified
hydrogels
exhibit
substantial
promise
in
the
realm
of
wound
healing,
with
their
ability
to
expedite
tissue
regeneration,
mitigate
infection
risks,
and
facilitate
enhanced
therapeutic
outcomes.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 889 - 889
Опубликована: Март 9, 2023
Anticancer
drugs
in
monotherapy
are
ineffective
to
treat
various
kinds
of
cancer
due
the
heterogeneous
nature
cancer.
Moreover,
available
anticancer
possessed
hurdles,
such
as
drug
resistance,
insensitivity
cells
drugs,
adverse
effects
and
patient
inconveniences.
Hence,
plant-based
phytochemicals
could
be
a
better
substitute
for
conventional
chemotherapy
treatment
properties:
lesser
effects,
action
via
multiple
pathways,
economical,
etc.
Various
preclinical
studies
have
demonstrated
that
combination
with
is
more
efficacious
than
individually
because
plant-derived
compounds
lower
efficacy
drugs.
suffer
from
poor
aqueous
solubility
reduced
bioavailability,
which
must
resolved
Therefore,
nanotechnology-based
novel
carriers
employed
codelivery
These
include
nanoemulsion,
nanosuspension,
nanostructured
lipid
carriers,
solid
nanoparticles,
polymeric
micelles,
dendrimers,
metallic
carbon
nanotubes
provide
benefits
improved
solubility,
higher
efficacy,
dose,
dosing
frequency,
bioavailability
compliance.
This
review
summarizes
cancer,
therapy
deliver
Abstract
Cancer
nanovaccines
represent
a
promising
frontier
in
cancer
immunotherapy,
utilizing
nanotechnology
to
augment
traditional
vaccine
efficacy.
This
review
comprehensively
examines
the
current
state‐of‐the‐art
nanovaccine
development,
elucidating
innovative
strategies
and
technologies
employed
their
design.
It
explores
both
preclinical
clinical
advancements,
emphasizing
key
studies
demonstrating
potential
elicit
robust
anti‐tumor
immune
responses.
The
study
encompasses
various
facets,
including
integrating
biomaterial‐based
nanocarriers
for
antigen
delivery,
adjuvant
selection,
impact
of
nanoscale
properties
on
performance.
Detailed
insights
into
complex
interplay
between
tumor
microenvironment
responses
are
provided,
highlighting
challenges
opportunities
optimizing
therapeutic
outcomes.
Additionally,
presents
thorough
analysis
ongoing
trials,
presenting
snapshot
landscape.
By
curating
latest
scientific
findings
developments,
this
aims
serve
as
comprehensive
resource
researchers
clinicians
engaged
advancing
immunotherapy.
Integrating
design
holds
immense
promise
revolutionizing
treatment
paradigms,
provides
timely
update
evolving
landscape
nanovaccines.
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
93, С. 105401 - 105401
Опубликована: Янв. 25, 2024
Cancer
is
a
major
public
health
concern
worldwide;
it
the
second-highest
cause
of
death
in
United
States.
According
to
projections
cancer
incidence
and
mortality
rates
throughout
world
for
year
2023,
triple-negative
breast
(TNBC)
expected
be
leading
related
among
women
worldwide.
Traditional
strategies
treatment
TNBC
have
many
drawbacks,
such
as
drug
resistance,
toxicity
etc.
Discovering
novel
delivery
techniques
researching
innovative,
efficient
methods
important.
This
review
discusses
types
subtypes
TNBC.
The
problems
associated
with
standard
therapies,
mechanism
resistance
highlights
need
develop
therapeutic
strategies.
It
provides
information
on
relative
prevalence
severity
cancer.
Several
approaches
viz.
targeted
therapy,
gene
bacterial-mediated
nanomedicine,
immune
checkpoint
inhibitors,
theranostic,
radiotherapy,
chemotherapy,
immunotherapy,
herbal
AI-based
TNBC,
are
discussed
detail.
Additionally,
diagnostic
techniques,
including
imaging
biopsy,
expression
profiling,
mammography,
magnetic
resonance
imaging,
ultrasound,
computed
tomography
scan,
positron
emission
immunohistochemistry,
been
effective
treatment.
in-depth
analysis
innovative
individualized
care
serve
patients
better.
Life,
Год журнала:
2023,
Номер
13(2), С. 446 - 446
Опубликована: Фев. 4, 2023
Polymeric
micelles
combining
the
advantages
of
biocompatible
poly-
and
oligosaccharides
with
classical
micellar
amphiphilic
systems
represent
a
promising
class
drug
carriers.
In
this
work,
based
on
chitosan
(or
cyclodextrin)
oleic
acid
various
modification
degrees
were
synthesized-the
most
optimal
grafting
degree
is
15-30%
in
terms
CMC.
According
to
NTA
data,
have
hydrodynamic
diameter
main
fraction
60-100
nm.
The
inclusion
antibacterial
agents:
moxifloxacin
or
rifampicin
was
studied
by
FTIR
spectroscopy
fluorescence
using
pyrene
label
(using
monomer-excimer
approach).
When
aromatic
molecules
are
incorporated
into
micelles,
absorption
bands
C-H
bonds
fatty
tails
shift
towards
smaller
wavenumbers,
indicating
stabilization
structure,
microenvironment
molecule
changes
according
low
frequencies
intensity
oscillation
1450
cm-1
corresponding
fragment.
Loading
leads
change
fluorescent
properties:
maximum
emission
long-wavelength
region
an
increase
anisotropy
due
drastic
volume
fluorophore-containing
rotating
Using
label,
critical
micelle
concentrations
determined:
from
4
30
nM
depending
polymer
composition.
Micellar
enhance
effect
antibiotic
increasing
penetration
bacterial
cells
storing
protective
coat.
As
part
supramolecular
remains
active
for
more
than
four
days,
while
free
form,
activity
decreases
after
two
days.
pharmacokinetic
experiments,
vivo
show
1.7
times
efficiency
compared
form;
moreover,
higher
maximal
concentration
blood
achieved.
advantage
comparison
simple
cyclodextrins
chitosan,
which
do
not
so
significantly
contribute
parameters,
shown.
Thus,
polymeric
one
key
approaches
improving
effectiveness
drugs
solving
problems
resistant
infections
multidrug
resistance.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 879 - 879
Опубликована: Март 8, 2023
Despite
recent
advances,
cancer
remains
the
primary
killer
on
a
global
scale.
Numerous
forms
of
research
have
been
conducted
to
discover
novel
and
efficient
anticancer
medications.
The
complexity
breast
is
major
challenge
which
coupled
with
patient-to-patient
variations
heterogeneity
between
cells
within
tumor.
Revolutionary
drug
delivery
expected
provide
solution
that
challenge.
Chitosan
nanoparticles
(CSNPs)
prospects
as
revolutionary
system
capable
enhancing
activity
reducing
negative
impacts
normal
cells.
use
smart
systems
(SDDs)
delivering
materials
improve
bioactivity
NPs
understand
intricacies
has
garnered
significant
interest.
There
are
many
reviews
about
CSNPs
present
various
points
view,
but
they
not
yet
described
series
in
therapy
from
cell
uptake
death.
With
this
description,
we
will
more
complete
picture
for
designing
preparations
SDDs.
This
review
describes
SDDSs,
targeting
stimulus
response
using
their
mechanism.
Multimodal
chitosan
SDDs
medication
therapeutic
results.
Frontiers in Pharmacology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 22, 2023
Breast
cancer
(BC)
is
the
most
frequently
diagnosed
malignant
tumor
among
women
in
world.
BC
heterogeneous
with
different
subtypes
including
luminal
A-like,
B-like
(HER2-/HER2+),
HER2
enriched,
and
triple-negative
BC.
The
therapeutic
strategies
surgery,
chemotherapy,
radiotherapy,
targeted
therapy,
endocrine
therapy
are
well
developed
commonly
used
treatment
of
However,
some
adverse
effects
these
conventional
treatments
limited
their
wide
application
clinical.
Therefore,
it
necessary
to
develop
more
safe
efficient
individualized
Nanomedicine,
as
promising
strategy
for
controlled
drug
delivery,
widely
multiple
aspects
therapy.
Importantly,
accumulative
evidences
show
that
nanomedicine
has
achieved
good
outcomes
a
huge
amount
patients
benefited
from
related
treatments.
In
this
review,
we
summarized
discussed
major
problems
occurred
during
administration
potential
roles
promoting
efficacy
by
overcoming
obstacles
current
