Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 317 - 344
Опубликована: Янв. 1, 2024
Язык: Английский
Polymers, Год журнала: 2023, Номер 15(13), С. 2928 - 2928
Опубликована: Июль 1, 2023
The limitations associated with the conventional treatment of cancer have necessitated design and development novel drug delivery systems based mainly on nanotechnology. These include various kinds nanoparticles, such as polymeric solid lipid nanostructured carriers, hydrogels, micelles. Among systems, chitosan-based nanoparticles attracted attention researchers to treat cancer. Chitosan is a polycationic polymer generated from chitin characteristics biocompatibility, biodegradability, non-toxicity, mucoadhesiveness, making it an ideal fabricate systems. However, chitosan poorly soluble in water acidic aqueous solutions. Furthermore, owing presence reactive amino groups, can be chemically modified improve its physiochemical properties. derivatives employed which are used most frequently pharmaceutical sector due their possession nanosize, appropriate pharmacokinetic pharmacodynamic properties, non-immunogenicity, improved stability, loading capacity. capable delivering nucleic acids, chemotherapeutic medicines, bioactives using chitosan. derivative-based targeted specific sites via active passive mechanisms. Based many anticancer drugs now better effectiveness, potency, cytotoxicity, or biocompatibility. tailored derivatives, well use therapy, will examined this review.
Язык: Английский
Процитировано
49
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 541 - 569
Опубликована: Янв. 1, 2024
Natural products have proven to significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, treatment. Compared with synthetic drugs, natural not only diverse structures but also exhibit a range of biological activities against different disease states molecular targets, making them attractive development in the field medicine. Despite advancements use purposes, there remain obstacles that hinder their full potential. These challenges include issues such limited solubility stability when administered orally, well short durations effectiveness. To address these concerns, nano-drug delivery systems emerged promising solution overcome barriers faced application products. offer notable advantages, large specific surface area, enhanced targeting capabilities, ability achieve sustained controlled release. Extensive vitro vivo studies provided further evidence supporting efficacy safety nanoparticle-based delivering preclinical models. This review describes limitations product applications current status combined nanotechnology. The latest advances from three aspects: connecting warheads, self-assembly, co-delivery. Finally, translation nano-drugs discussed.
Язык: Английский
Процитировано
42
Cancer Medicine, Год журнала: 2024, Номер 13(5)
Опубликована: Март 1, 2024
Cancer remains a leading cause of death worldwide, necessitating the development innovative and more effective treatment strategies. Conventional cancer treatments often suffer from limitations such as systemic toxicity, poor pharmacokinetics, drug resistance. Recently, there has been growing attention to utilizing natural compounds derived various sources possible therapeutics. Natural have demonstrated diverse bioactive properties, including antioxidant, anti-inflammatory, antitumor effects, making them attractive candidates for treatment. However, their limited solubility bioavailability present challenges delivery cells. To overcome these limitations, researchers turned nanotechnology-based systems. Nanoparticles, with small size unique can encapsulate therapeutic agents offer benefits improved solubility, prolonged release, enhanced cellular uptake, targeted delivery. Functionalizing nanoparticles specific ligands further enhances precision in recognizing binding Combining nanotechnology holds great promise achieving efficient safe by enhancing bioavailability, selectivity toward This review article provides an overview advancements substances systems It discusses drawbacks types nanoparticles, well characteristics that make appealing therapy. Additionally, current research on preclinical clinical settings is highlighted. Finally, future perspectives developing compound-nanoparticle-based therapies are discussed.
Язык: Английский
Процитировано
40
Pharmaceuticals, Год журнала: 2023, Номер 16(10), С. 1360 - 1360
Опубликована: Сен. 26, 2023
The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such heavy pill regimen, prolonged treatment duration, and strict schedule, to multidrug-resistant (MDR) extensively drug-resistant (XDR) strains. rise of MDR strains endangers future control. Despite these concerns, the hunt an efficient continues. One breakthrough has been use nanotechnology in medicines, presenting novel approach treatment. Nanocarriers, lipid nanoparticles, nanosuspensions, liposomes, polymeric micelles, facilitate targeted delivery anti-TB drugs. benefits nanocarriers include reduced drug doses, fewer side effects, improved solubility, better bioavailability, patient compliance, speeding up recovery. Additionally, can be made even more linking them ligands mannose or hyaluronic acid. This review explores innovative treatments, including studies on containing drugs related patents.
Язык: Английский
Процитировано
22
Aquaculture Reports, Год журнала: 2024, Номер 36, С. 102034 - 102034
Опубликована: Март 18, 2024
Phytochemicals are used in fish farming to reduce stress and combat diseases during intensification. Recently, nanotechnology has represented a paradigm shift the aquatic feed industry improve solubility, availability, efficacy of phytochemicals. The purpose this research was investigate effects dietary supplementation with nano-curcumin (CUNE) on growth, utilization, body composition, blood biochemistry, antioxidant status, disease resistance Vibrio parahaemolyticus (V. parahaemolyticus), expression insulin-like growth factor 1 (IGF-1), hormone (GH), interleukin-10 (IL-10), interlukin-1β (IL-1β) genes European Seabass (Dicentrarchus labrax) fingerlings. Fish (6.02±0.01) were randomly divided into four equal groups fed varying levels CUNE: 0 (CUNE0), 50 (CUNE1), 60 (CUNE2), 70 mg/kg (CUNE3) for 56 days, respectively. inclusion CUNE significantly improved indices (final weight gain, specific rate) utilization (improved intake lower FCR) seabass fingerlings (p<0.05). However, had no significant effect composition including percentages dry mater, crude protein, lipid, ash (p>0.05). All established an enhancement hematology dose-dependent manner, CUNE3 demonstrating highest values. (70 diet) produced total albumin, globulin, triglycerides, as well lowest glucose, hepatic enzymes (ALT, AST, ALP; p<0.05) compared other groups. Furthermore, CUNE-supplemented showed improvements superoxide dismutase, catalase, glutathione peroxidase, while reducing malondialdehyde Additionally, consumption increased IGF-1, GH, IL-10 manner Interestingly, mg their diets IL-1β gene When challenged V. parahaemolyticus, addition resulted reduced mortality rates. Therefore, could be considered natural additive promote bacteria via supporting serum metabolites, regulation IL-10, IGF-1 tissues
Язык: Английский
Процитировано
15
Journal of Nanomaterials, Год журнала: 2024, Номер 2024, С. 1 - 48
Опубликована: Апрель 12, 2024
Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis been given eco-friendly techniques for developing nanomaterials enhance their applications minimize health environmental risks. With the help of green nanotechnology, wide range metal, metal oxide, bimetallic nanoparticles distinct chemical compositions, sizes, morphologies have manufactured which are safe, economical, environment friendly. Due biocompatibility vast potential biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) other fields such (nanofertilizers, fermentative, food, bioethanol production, construction field), garnered significant interest worldwide. The precursors combined natural extracts plants, algae, fungi, bacteria get potent novel Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, Co-Bi2O3. These plant-mediated possess excellent antibacterial anticancer activity when tested against several microorganisms cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared sources (bacteria, algae) higher concentration that play vital role development because these plant-phytoconstituents act reducing, stabilizing, capping agent helps nanoparticles. After concluding all findings, this review designed first time way it imparts satisfactory knowledge about together, along mechanisms. Additionally, provides information characterization (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed nanoparticles, applications, industries. Hence, various types versatile application diverse is not covered pieces literature.
Язык: Английский
Процитировано
13
Particle & Particle Systems Characterization, Год журнала: 2024, Номер unknown
Опубликована: Июнь 28, 2024
Abstract Despite progress in cancer treatments, it remains a leading cause of death worldwide. Current chemotherapy is often hampered by side effects, tissue damage, and drug resistance. To overcome these limitations, research exploring new approaches to improve efficacy reduce its effects. A promising strategy involves combining chemotherapeutic drugs with phytochemicals, which are active compounds derived from plants. Nanotechnology plays crucial role delivering often‐hydrophobic drugs, enhancing their bioavailability solubility. This area represents significant convergence nanotechnology both conventional pharmaceuticals botanical compounds. Global studies increasingly demonstrating the potential combination therapies inhibit cell growth laboratory preclinical models. These suggest synergistic or additive effects that lead improved treatment outcomes. article focuses on recent advancements nano‐drug delivery systems, specifically those designed for simultaneous phytochemicals. It explores selection phytochemicals based anticancer properties, outlines design considerations nanocarriers, discusses how physicochemical characteristics influence release kinetics. Additionally, review examines nanoformulations integrate synthetic natural components, highlighting herbal oils medicines treatment.
Язык: Английский
Процитировано
8
Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер 6
Опубликована: Янв. 3, 2025
Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer. Surgery, chemotherapy, immunotherapy, and radiation have mostly failed to These drugs may damage quickly dividing healthy tissues, structural anomalies, bodily toxicity, long-term side effects, tumor cell resistance, psychiatric disturbances. Researchers developing nanoscale medicines using medications like Malva sylvestris Curcumin lower concentrations improve target specificity. Nanoparticles' small size unique properties make them beneficial. They encapsulate medicinal ingredients, improving solubility, medication release, cellular absorption, delivery. Nanoparticles better identify bind cancer cells when functionalized with ligands. Natural chemicals nanotechnology availability, distribution, targeting cells, making treatments more effective safe. Nanomedicine, which employs nanoparticles malignant has grown rapidly because nanodrugs fewer effects than current commercial drugs. Nanotechnology-based pharmaceutical delivery methods therapy covered in this review article. The paper discusses nanoparticle pros cons chemicals' cancer-fighting appeal.
Язык: Английский
Процитировано
1
Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1108 - 1108
Опубликована: Авг. 4, 2023
Resistance to isoniazid (INH) is common and increases the possibility of acquiring multidrug-resistant tuberculosis. For this study, isoniazid-loaded nanostructured lipid carriers (INH-NLCs) were developed effectively functionalized with mannose (Man) enhance residence time drug within lungs via specific delivery increase therapeutic efficacy formulation. The mannose-functionalized carrier (Man-INH-NLC) formulation was evaluated respect various parameters, namely, encapsulation efficiency (EE), loading (DL), average particle size (PS), zeta potential (ZP), polydispersity index (PDI), in vitro release (DR), kinetics. inhalation behavior after nebulization investigated using an Andersen cascade impactor estimation mass median aerosolized diameter (MMAD) geometric aerodynamic (GAD) subsequently found be suitable for effective lung delivery. An vivo pharmacokinetic study carried out a guinea pig animal model, it demonstrated that Man-INH-NLC has longer improved pharmacokinetics when compared unfunctionalized INH-NLC, indicating enhanced Histopathological analysis led us determine extent tissue damage more severe case pure solution nebulization. Thus, safe, forming sound basis enhancing management treatment pulmonary
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9824 - 9824
Опубликована: Июнь 6, 2023
The awareness of the existence plant bioactive compounds, namely, phytochemicals (PHYs), with health properties is progressively expanding. Therefore, their massive introduction in normal diet and food supplements use as natural therapeutics to treat several diseases are increasingly emphasized by sectors. In particular, most PHYs possessing antifungal, antiviral, anti-inflammatory, antibacterial, antiulcer, anti-cholesterol, hypoglycemic, immunomodulatory, antioxidant have been isolated from plants. Additionally, secondary modification new functionalities further improve intrinsic beneficial effects has extensively investigated. Unfortunately, although idea exploiting amazing, its realization far simple, possibility employing them efficient clinically administrable drugs almost utopic. Most insoluble water, and, especially when introduced orally, they hardly manage pass through physiological barriers scarcely reach site action therapeutic concentrations. Their degradation enzymatic microbial digestion, well rapid metabolism excretion, strongly limits vivo activity. To overcome these drawbacks, nanotechnological approaches used, many nanosized PHY-loaded delivery systems developed. This paper, reporting various case studies, reviews foremost nanosuspension- nanoemulsion-based techniques developed for formulating relevant into more bioavailable nanoparticles (NPs) that suitable or promising clinical application, mainly oral administration. addition, acute chronic toxic due exposure NPs reported so far, possible nanotoxicity could result employment, ongoing actions knowledge this field discussed. state art concerning actual application both nanotechnologically engineered also reviewed.
Язык: Английский
Процитировано
17