Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2681 - 2681
Опубликована: Дек. 1, 2022
The
use
of
natural
compounds
is
becoming
increasingly
popular
among
patients,
and
there
a
renewed
interest
scientists
in
nature-based
bioactive
agents.
Traditionally,
herbal
drugs
can
be
taken
directly
the
form
teas/decoctions/infusions
or
as
standardized
extracts.
However,
disadvantages
compounds,
especially
essential
oils,
are
their
instability,
limited
bioavailability,
volatility,
often
irritant/allergenic
potential.
these
active
substances
stabilized
by
encapsulation
administered
nanoparticles.
This
brief
overview
summarizes
latest
results
application
nanoemulsions,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers
used
drug
delivery
systems
oils
for
individual
secondary
metabolites
applicable
cancer
therapy.
Although
discussed
agents
not
typical
anticancer
agents,
after
inclusion
into
aforesaid
formulations
improving
stability
bioavailability
and/or
therapeutic
profile,
they
indicated
anti-tumor
activity
became
interesting
with
treatment
In
addition,
co-encapsulation
synthetic
nanoformulations
aim
to
achieve
synergistic
effect
chemotherapy
discussed.
Journal of Nanotheranostics,
Год журнала:
2023,
Номер
4(3), С. 299 - 322
Опубликована: Июль 24, 2023
The
introduction
of
cancer
therapeutics
and
nanotechnology
has
resulted
in
a
paradigm
shift
from
conventional
therapy
to
precision
medicine.
Nanotechnology,
an
interdisciplinary
field
with
focus
on
biomedical
applications,
holds
immense
promise
bringing
about
novel
approaches
for
detection,
diagnosis,
therapy.
past
decade
witnessed
significant
research
material
applications
related
nanoparticles
(NPs).
NPs
differ
small-molecule
drugs
as
they
possess
unique
physicochemical
characteristics,
such
large
surface-to-volume
ratio,
enabling
them
penetrate
live
cells
efficiently.
Traditional
therapies,
chemotherapy,
radiation
therapy,
targeted
immunotherapy,
have
limitations,
cytotoxicity,
lack
specificity,
multiple
drug
resistance,
which
pose
challenges
effective
treatment.
However,
nanomaterials
properties
that
enable
new
therapeutic
modalities
beyond
delivery
the
fight
against
cancer.
Moreover,
(1–100
nm)
numerous
benefits,
biocompatibility,
reduced
toxicity,
excellent
stability,
enhanced
permeability
retention
effect,
precise
targeting,
making
ideal
purpose
this
article
is
provide
consolidated
information
various
bio-inspired
aid
theranostics.
Gels,
Год журнала:
2024,
Номер
10(3), С. 157 - 157
Опубликована: Фев. 20, 2024
We
have
developed
a
micellar
formulation
of
anticancer
drugs
based
on
chitosan
and
heparin
grafted
with
lipoic
oleic
acids
that
can
release
the
cytotoxic
cargo
(doxorubicin)
in
response
to
external
stimuli,
such
as
increased
glutathione
concentration—a
hallmark
cancer.
Natural
polysaccharides
(heparin
chitosan)
provide
pH
sensitivity
nanocarrier:
doxorubicin
(Dox)
is
enhanced
slightly
acidic
environment
(tumor
microenvironment).
Fatty
acid
residues
are
necessary
for
formation
nanoparticles
(micelles)
solubilization
cytostatics
hydrophobic
core.
Lipoic
labile
S-S
cross-linking
between
polymer
chains
(the
first
variant)
or
covalently
attached
molecules
through
glutathione-sensitive
bridges
second
variant)—both
determine
Redox
carriers
stable
blood
circulation
disintegrate
after
intracellular
uptake
tumor
cells.
The
from
micelles
occurs
slowly
(20%/6
h)
an
7.4
absence
glutathione,
while
presence
10
mM
rate
increases
up
6
times,
increase
effective
concentration
5
times
7
h.
permeability
formulations
(covalent
cross-linked
not)
into
Raji,
K562,
A875
cancer
cells
was
studied
using
FTIR,
fluorescence
spectroscopy
confocal
laser
scanning
microscopy
(CLSM).
shown
dramatically
improved
accumulation,
decreased
efflux,
cytotoxicity
compared
control
three
cell
lines:
A875.
At
same
time,
non-tumor
(HEK293T)
significantly
lower,
increasing
selectivity
index
against
by
several
times.
Future Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 1, 2024
Abstract
Background
The
purpose
of
the
present
study
was
to
enhance
memory-boosting
activity
standardized
hydroalcoholic
Camellia
sinensis
extract
(CSE)
by
formation
nanophytosomes
with
Leciva
S70
phospholipid.
central
composite
design
used
optimize
solvent
evaporation
method
for
formulation
C.
sinesis
phytosomes
(CSP).
Results
optimized
had
a
mean
particle
size
212.3
nm
±
0.39,
PDI
0.238
0.0197,
and
zeta
potential
−42.02
0.995
mV.
phytosome
confirmed
analytical
techniques.
aqueous
solubility
developed
CSP
95.92
0.31,
which
is
7.34
times
greater
than
that
pure
CSE
(13.07
0.19).
found
more
effective
either
(26.42
0.4654%)
or
physical
mixture
(32.15
0.4596%)
in
releasing
from
(72.16
0.5248%).
Acute
toxicity
corroborated
safety
rats.
demonstrated
significant
(
p
<
0.05
)
reduction
escape
transferred
latency
on
both
days
(15th
16th)
as
compared
CSE,
indicating
improvement
activity.
Furthermore,
CSP-treated
rats
significantly
improved
acetylcholine
(Ach)
levels
brain
tissue
concentration
CSE.
Moreover,
phytosomal
exhibited
its
rationality
an
bioavailability
3.21
folds
Conclusion
presence
phospholipids
smaller
particles
may
aid
crossing
blood–brain
barrier,
increasing
bioavailability.
This,
turn,
leads
increase
Graphical
abstract
Pharmaceutics,
Год журнала:
2022,
Номер
14(12), С. 2681 - 2681
Опубликована: Дек. 1, 2022
The
use
of
natural
compounds
is
becoming
increasingly
popular
among
patients,
and
there
a
renewed
interest
scientists
in
nature-based
bioactive
agents.
Traditionally,
herbal
drugs
can
be
taken
directly
the
form
teas/decoctions/infusions
or
as
standardized
extracts.
However,
disadvantages
compounds,
especially
essential
oils,
are
their
instability,
limited
bioavailability,
volatility,
often
irritant/allergenic
potential.
these
active
substances
stabilized
by
encapsulation
administered
nanoparticles.
This
brief
overview
summarizes
latest
results
application
nanoemulsions,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers
used
drug
delivery
systems
oils
for
individual
secondary
metabolites
applicable
cancer
therapy.
Although
discussed
agents
not
typical
anticancer
agents,
after
inclusion
into
aforesaid
formulations
improving
stability
bioavailability
and/or
therapeutic
profile,
they
indicated
anti-tumor
activity
became
interesting
with
treatment
In
addition,
co-encapsulation
synthetic
nanoformulations
aim
to
achieve
synergistic
effect
chemotherapy
discussed.
