Skin Research and Technology,
Год журнала:
2024,
Номер
30(7)
Опубликована: Июль 1, 2024
Abstract
Background
Microneedles
are
tiny
needles,
typically
ranging
from
tens
to
hundreds
of
micrometers
in
length,
used
various
medical
procedures
and
treatments.
The
tested
device
named
“CELLADEEP
Patch”
a
dissolvable
microneedle
therapy
system
(MTS),
made
hyaluronic
acid
collagen.
And
the
iontophoresis
technique
is
also
applied
system.
study
aimed
evaluate
effectiveness
skin
improvement.
Methods
Ex
vivo
human‐derived
tissue
models
were
this
they
divided
into
three
different
groups,
namely,
Untreated
Group,
Negative
Control
Test
Group
respectively.
received
no
treatment
measures,
was
exposed
ultraviolet
B
radiation
(UVB)
irradiation,
UVB
irradiation
treated
with
Patch”.
Skin
moisture
content,
transdermal
water
loss,
elasticity
evaluated
by
clinical
devices.
Additionally,
histological
staining
related
mRNA
expression
levels
analyzed.
Results
results
evaluation
consistently
illustrated
that
application
led
remarkable
analysis
images
confirmed
Patch”,
especially
for
increasing
collagen
density.
Moreover,
upregulation
Collagen
type
1
(COL1A1)
hyaluronan
synthase
3
decrease
Matrix
metalloproteinase
(MMP‐1)
Interleukin‐1
beta
(IL‐1β)
reflected
its
wrinkle
improvement,
moisturizing
anti‐inflammation
function.
Conclusion
“CELLADEPP
MTS
combined
technique,
exhibits
moisturizing,
anti‐inflammatory
function
when
ex
experiments.
has
contributed
understanding
laid
foundation
subsequent
animal
experiments
trials.
Lab on a Chip,
Год журнала:
2024,
Номер
24(7), С. 1833 - 1866
Опубликована: Янв. 1, 2024
Wearable
devices
are
increasingly
popular
in
health
monitoring,
diagnosis,
and
drug
delivery.
Advances
allow
real-time
analysis
of
biofluids
like
sweat,
tears,
saliva,
wound
fluid,
urine.
Abstract
Diabetic
wounds
present
a
significant
challenge
in
clinical
treatment
and
are
characterized
by
chronic
inflammation,
oxidative
stress,
impaired
angiogenesis,
peripheral
neuropathy,
heightened
risk
of
infection
during
the
healing
process.
By
creating
small
channels
surface
skin,
microneedle
technology
offers
minimally
invasive
efficient
approach
for
drug
delivery
treatment.
This
article
begins
outlining
biological
foundation
normal
skin
wound
unique
pathophysiological
mechanisms
diabetic
wounds.
It
then
delves
into
various
types,
materials,
preparation
processes
microneedles.
The
focus
is
on
application
multifunctional
microneedles
treatment,
highlighting
their
antibacterial,
anti-inflammatory,
immunomodulatory,
antioxidant,
angiogenic
neural
repair
properties.
These
demonstrate
synergistic
therapeutic
effects
directly
influencing
microenvironment,
ultimately
accelerating
advancement
not
only
holds
promise
enhancing
outcomes
but
also
new
strategies
addressing
other
International Journal of Pharmaceutics,
Год журнала:
2023,
Номер
641, С. 123087 - 123087
Опубликована: Май 30, 2023
Chronic
wounds
occur
for
several
reasons,
such
as
trauma,
accidents,
and
diseases.
Diabetes
has
been
one
of
the
primary
causes
non-healing
wounds,
number
people
with
diabetes
is
increasing
in
most
countries.
Wounds
diabetic
have
a
complex
prolonged
treatment
process,
high
costs
to
both
healthcare
providers
patients.
They
often
severe
consequences,
pain,
wound
infection,
tissue
necrosis,
even
limb
amputation.
Various
methods
used
treat
chronic
but
clinical
success
limited
due
inefficient
delivery
bed.
Microneedles
(MNs),
new
platforms,
can
offer
an
effective
treatment,
easy
use
non-invasive
less
damage,
capable
delivering
wide
range
drugs
accelerate
healing
process.
Different
materials
be
this
technique,
there
are
different
geometric
parameters
needle
length,
tip
angle,
shape
radius,
together
array
density
optimize
treatment.
This
review
paper
will
investigate
role
MNs
discuss
recent
development
MN-based
devices
field
their
effectiveness.
The
manuscript
also
various
types
potential
applications
therapeutic
agents.
Finally,
challenges
associated
using
heal
future
directions
discussed.
Biofabrication,
Год журнала:
2024,
Номер
16(4), С. 042005 - 042005
Опубликована: Авг. 9, 2024
The
global
demand
for
an
enhanced
quality
of
life
and
extended
lifespan
has
driven
significant
advancements
in
tissue
engineering
regenerative
medicine.
These
fields
utilize
a
range
interdisciplinary
theories
techniques
to
repair
structurally
impaired
or
damaged
tissues
organs,
as
well
restore
their
normal
functions.
Nevertheless,
the
clinical
efficacy
medications,
materials,
potent
cells
used
at
laboratory
level
is
always
constrained
by
technological
limitations.
A
novel
platform
known
adaptable
microneedles
been
developed
address
abovementioned
issues.
offer
solution
localized
distribution
various
cargos
while
minimizing
invasiveness.
Microneedles
provide
favorable
patient
compliance
settings
due
effective
administration
ability
painless
convenient
process.
In
this
review
article,
we
summarized
most
recent
development
microneedles,
started
classifying
microneedle
systems,
advantages,
fundamental
properties.
Subsequently,
it
provides
comprehensive
overview
different
types
material
fabricate
properties
ideal
applications
medicine,
primarily
focusing
on
preserving
restoring
organs.
limitations
perspectives
have
discussed
concluding
future
therapeutic
medicines.
Health Science Reports,
Год журнала:
2024,
Номер
7(4)
Опубликована: Апрель 1, 2024
Abstract
Background
and
Aim
The
traditional
drug
delivery
approach
involves
systemic
administration
of
a
that
could
be
nonspecific
in
targeting,
low
on
efficacy,
with
severe
side‐effects.
To
address
such
challenges,
the
field
smart
has
emerged
aiming
at
designing
developing
systems
can
target
specific
cells,
tissues,
organs
have
minimal
off‐target
Methods
A
literature
search
was
done
to
collate
papers
reports
about
currently
available
various
strategies
for
nano‐inspired
delivery.
databases
searched
were
PubMed,
Scopus,
Google
Scholar.
Based
selection
criteria,
most
pertinent
recent
items
included.
Results
Smart
is
cutting‐edge
revolutionary
intervention
modern
medicines
ensure
effective
safe
therapeutics
sites.
These
hold
great
promise
targeted
controlled
therapeutic
agents
improve
efficacy
reduced
side‐effects
as
compared
conventional
approaches.
Current
approaches
include
nanoparticles,
liposomes,
micelles,
hydrogels,
each
its
own
advantages
limitations.
success
these
lies
engineering
them,
optimizing
their
pharmacokinetics
pharmacodynamics
properties.
Conclusion
Development
get
beyond
physiological
clinical
barriers,
observed
conventionally
administered
chemotherapeutics,
been
possible
through
advancements.
Using
multifunctional
targeting
methodologies,
tries
localize
therapy
location,
reduces
cytotoxicity,
improves
index.
Rapid
advancements
research
development
provide
wider
more
promising
avenues
guarantee
better
healthcare
system,
patient
outcomes,
achieve
higher
levels
medical
interventions
like
personalized
medicine.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Abstract
The
stratum
corneum,
which
acts
as
a
strong
barrier
against
external
agents,
presents
significant
challenge
to
transdermal
drug
delivery.
In
this
regard,
microneedle
(MN)
patches,
designed
modern
systems
for
delivery
via
permeation
through
the
skin
with
ability
pass
are
known
be
convenient,
painless,
and
effective.
fact,
MN
have
shown
breakthroughs
in
delivery,
among
various
types,
hydrogel
(HMNs)
demonstrated
desirable
inherent
properties.
Despite
advancements,
issues
such
limited
loading
capacity,
uncontrolled
release
rates,
non‐uniform
therapeutic
approaches
persist.
Conversely,
nanomaterials
(NMs)
promise
medical
applications,
however,
their
efficacy
applicability
constrained
by
challenges
including
poor
stability,
low
bioavailability,
payload
rapid
clearance
immune
system.
Incorporation
of
NMs
within
HMNs
offers
new
prospects
address
associated
NMs.
This
combination
can
provide
promising
field
research
improved
effective
agents
mitigate
certain
adverse
effects,
addressing
current
clinical
concerns.
review
highlights
use
diagnostic
applications.
